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Cognitive function and adherence to anticoagulation treatment in patients with atrial fibrillation

Journal of Geriatric Cardiology 2016年第7期13卷 559-565页

作者： Beata Jankowska-Polanska Lomper katarzyna Alberska Lidia Jaroch Joanna Krzysztof Dudek Uchmanowicz Izabella Department of Clinical Nursing Wroctaw Medical University Bartla Wroclaw Poland Emergency Medicine Centre Anesthesiology Unit Marciniak Lower-Silesian Specialist Hospital Fieldorfa Wroctaw Poland Emergency Medicine Centre Cardiology Unit Marciniak Lower-Silesian Specialist Hospital Fieldorfa Wroelaw Poland Department of Logistic and Transport Systems University of Technology Wybrzeze Stanistawa Wyspianskiego Wroctaw Poland

Background Medication adherence is an integral part of the comprehensive care of patients with atrial fibrillation （AF） receiving oral anticoagulations （OACs） therapy. Many patients with AF are elderly and may suffer from some form of cognitive impairment. This study was conducted to investigate whether cognitive impairment affects the level of adherence to anticoagulation treatment in AF patients. Me- thods The study involved 111 AF patients （mean age, 73.5±8.3 years） treated with OACs. Cognitive function was assessed using the Mini Mental State Examination （MMSE）. The level of adherence was assessed by the 8-item Mot^sky Medication Adherence Scale （MMAS-8）. Scores on the MMAS-8 range from 0 to 8, with scores 〈 6 reflecting low adherence, 6 to 〈 8 medium adherence, and 8 high adherence. Re- sults 46.9% of AF patients had low adherence, 18.8% had moderate adherence, and 33.3% had high adherence to OACs. Patients with lower adherence were older than those with moderate or high adherence （76.6 ±8.7 vs. 71.3 ~ 6.4 vs. 71.1 ± 6.7 years） and obtained low MMSE scores, indicating cognitive disorders or dementia （MMSE = 22.3 ± 4.2）. Patients with moderate or high adherence obtained high MMSE test results （27.5 ±1.7 and 27,5 ± 3.6）. According to Spearman＇s rank correlation, worse adherence to treatment with OACs was determined by older age （rs = -0.372） and lower MMSE scores （rs = 0.717）. According to multivariate regression analysis, the level of cognitive function was a significant independent predictor of adherence （b = 1.139）. Conclusions Cognitive impairment is an independent determinant of compliance with pharmacological therapy in elderly patients with AF. Lower adherence, beyond the assessment of cognitive function, is related to the age of patients.

关键词： Anticoagulation treatment Atrial fibrillation Cognitive impairment Medication adherence

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Development tendencies of moulding and core sands

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China Foundry 2011年第4期8卷 438-446页

作者： Stanisaw M.Dobosz Petr Jelinek katarzyna Major-Gabry AGH University of Science and Technology Faculty of Foundry Engineering Department of Moulding Materials Mould Technology and Foundry of Non-ferrous Metals al. A.Mickiewicza 30 30-059 Krakow Poland VB–Ostrava University of Technology FMMI Foundry Department Czech Republic

Further development of the technology for making moulding and core sands will be strictly limited by tough requirements due to protection of the natural environment. These tendencies are becoming more and more tense, so that we will reach a point when even processes, that from technological point of view fulfill high requirements of the foundry industry, must be replaced by more ecologically-friendly solutions. Hence, technologies using synthetic resins as binding materials will be limited. This paper presents some predictable development tendencies of moulding and core sands. The increasing role of inorganic substances will be noticed, including silicate binders with significantly improved properties, such as improved knock-out property or higher reclamation strength. Other interesting solutions might also be moulding sands bonded by geo-polymers and phosphate binders or salts and also binders based on degradable biopolymers. These tendencies and the usefulness of these binders are put forward in this paper.

关键词： moulding sand core sand development tendencies

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Exceptionally rare cause of a total stomach resection

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World Journal of Gastroenterology 2012年第20期18卷 2582-2585页

作者： Jadwiga Snarska Krzysztof Jacyna Jacek Janiszewski Danuta Shafie katarzyna Iwanowicz Anna Zurada Department of General Surgery Faculty of Medical Sciences University of Warmia and Mazury in Olsztyn10561 Olsztyn Poland Department of Internal Diseases Medical Care Centre of the Ministry of the Interior and Administration with the Warmia and Mazury Centre of Oncology in Olsztyn 10561 OlsztynPoland Department of Pathology Faculty of Medical SciencesUniversity of Warmia and Mazury in Olsztyn10561 OlsztynPoland Department of Anatomy Faculty of Medical SciencesUniversity of Warmia and Mazury in Olsztyn10561 OlsztynPoland

The first-ever case of a 54-year-old woman who overdosed on non-steroidal anti-inflammatory drugs in an attempt at *** that incident,she had not been treated for coexisting diseases such as rheumatoid arthritis or *** the time of admission to the General Surgery Department,the patient reported pains in the epigastric region with accompanying nausea and vomiting with mucous content as well as the inability to ingest food *** parenteral and enteral feeding,the patient exhibited a drop in body *** histopathologic examination of a sample taken from the stomach during gastroscopy showed some non-specific necrotic and inflammatory masses with ***,a very small,infiltrated stomach with an initial section of duodenum was identified.A total stomach resection together with the reconstruction of digestive tract continuity was performed using the Roux-Y *** examination of the stomach revealed a deep,chronic and exacerbated inflammatory condition with an extensive ulceration over the entire length of the stomach,reaching up to the ***,numerous lymphatic glands with inflammatory reaction changes were observed.

关键词： Non-steroidal anti-inflammatory drugs poisoning Total stomach resection Roux-Y anastomosis

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Liver steatosis correlates with iron overload but not with HFE gene mutations in chronic hepatitis C

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Hepatobiliary & Pancreatic Diseases International 2013年第4期12卷 377-384页

作者： katarzyna Sikorska Piotr Stalke Tomasz Romanowski Robert Rzepko Krzysztof Piotr Bielawski Department of Infectious Diseases Medical University of GdanskSmoluchowskiego 18 80-214 Gdansk Poland Department of Biotechnology Intercollegiate Faculty of Biotechnology University of Gdansk and Medical University of GdanskKladki 24 80-822 Gdansk Poland Department of Pathology Medical University of GdanskDebinki 7 80-952 Gdansk Poland

BACKGROUND: Liver steatosis and iron overload, which are frequently observed in chronic hepatitis C (CHC), may contribute to the progression of liver injury. This study aimed to evaluate the correlation between liver steatosis and iron overload in Polish patients with CHC compared to non- alcoholic fatty liver disease (NAFLD) and HFE-hereditary hemochromatosis (HH) patients. METHODS: A total of 191 CHC patients were compared with 67 NAFLD and 21 HH patients. Liver function tests, serum markers of iron metabolism, cholesterol and triglycerides were assayed. The inflammatory activity, fibrosis, iron deposits and steatosis stages were assessed in liver specimens. HFE gene polymorphisms were investigated by PCR-RFLP. RESULTS: Liver steatosis was associated with obesity and diabetes mellitus. This disease was confirmed in 76/174 (44%) CHC patients, most of whom were infected with genotype 1. The average grade of steatosis was higher in NAFLD patients. CHC patients had significantly higher iron concentrations and transferrin saturations than NAFLD patients. Compared with CHC patients, HH patients had higher values of serum iron parameters and more intensive hepatocyte iron deposits without differences in the prevalence and intensity of liver steatosis. In the CHC group, lipids accumulation in hepatocytes was significantly associated with the presence of serummarkers of iron overload. No correlation between the HFE gene polymorphism and liver steatosis in CHC patients was found. CONCLUSIONS: Liver steatosis was diagnosed in nearly half of CHC patients, most of whom were infected with genotype 1. The intensity of steatosis was lower in CHC patients than that in NAFLD patients because of a less frequent diagnosis of metabolic syndrome. Only in CHC patients were biochemical markers of iron accumulation positively correlated with liver steatosis; these findings were independent of HFE gene mutations.

关键词： hepatitis C virus iron overload fatty liver hemochromatosis metabolic syndrome X

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Changes in expression of inhibitory substances in the intramural neurons of the stomach following streptozotocininduced diabetes in the pig

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World Journal of Gastroenterology 2017年第33期23卷 6088-6099页

作者： Michal Bulc katarzyna Palus Lukasz Zielonka Magdalena Gajecka Jaroslaw Całka Department of Clinical Physiology Faculty of Veterinary Medicine University of Warmia and Mazury Department of Veterinary Prevention and Feed Hygiene Faculty of Veterinary MedicineUniversity of Warmia and Mazury in Olsztyn

AIM Influence of chronic hyperglycemia on chemical coding of enteric neurons in stomach using pig as a model for human diabetic *** Ten pigs were divided into two groups: diabetic(D group,n = 5) and control(C group,n = 5). Pigs constituting the experimental group were given streptozotocin(150 mg/kg). Animals were euthanized six weeks after the induction of diabetes. The samples of stomach were collected from animals of both groups. The cryostat sections were processed for double immunofluorescence staining using primary antisera directed towards pan-neuronal marker(Hu C/D) proteins and/or neuronal isoform of nitric oxide synthase(n NOS),vasoactive intestinal peptide(VIP) and galanin(GAL). RESULTS In the control group in the myenteric ganglia(MG) of the corpus we have noted 22.28% ± 1.19% of n NOS positive neurons,while in diabetic group we have found 40.74% ± 2.22% of n NOS immunoreactive perikarya(increase by 82.85 %). In turn in the pylorus we have observed 15.91% ± 0.58% n NOS containing neurons in control animals and 35.38% ± 1.54% in the diabetes group(increase by 122.37%). In the MG of the antrum and submucosal ganglion(SG) in the corpus hyperglycemia did not cause statistically significant changes. With regard to VIP-positive cell bodies in the antrum MG in the control animals we have noted 18.38 ± 1.39% and 40.74% ± 1.77% in the experimental group(increase by 121.65%). While in the corpus we have observed 23.20% ± 0.23% in the control and 30.93% ± 0.86% in the diabetes group(increase by 33.31%). In turn in the pylorus VIP positive cells bodies constituted 23.64% ± 1.56% in the control group and 31.20% ± 1.10% in the experimental group(increase by 31.97%). In the submucosal ganglion in the corpus we have noted 43.61% ± 1.06% in the control animals and 37.00% ± 1.77% in the experimental group(decrease by 15.15%). Expression of GAL-positive perikarya showed statistically significant changes only in the MG of the antrum and pylorus. In the antr

关键词： Immunohistochemistry Inhibitory neurons Streptozotocin Hyperglycemia Pig

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One extraction tool for in vitro-in vivo extrapolation?SPME-based metabolomics of in vitro 2D,3D,and in vivo mouse melanoma models

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Journal of Pharmaceutical Analysis 2021年第5期11卷 667-674页

作者： Karol Jaroch Paulina Taczynska Marta Czechowska Joanna Bogusiewicz KamilŁuczykowski katarzyna Burlikowska Barbara Bojko Department of Pharmacodynamics and Molecular Pharmacology Faculty of PharmacyCollegium Medicum in BydgoszczNicolaus Copernicus University in Torun Poland85-089BydgoszczPoland

Solid phase microextraction(SPME)in combination with high-resolution mass spectrometry was employed for the determination of metabolomic profile of mouse melanoma growth within in vitro 2D,in vitro 3D,and in vivo *** multi-model approach had never been investigated *** to the low-invasiveness of SPME,it was possible to perform time-course analysis,which allowed building time profile of biochemical reactions in the studied *** approach does not require the multiplication of samples as subsequent analyses are performed from the very same cell culture or from the same *** already reduces the number of animals required for experiment;therefore,it is with good concordance with the 3Rs rule(replacement,reduction,and refinement).Among tested models,the largest number of compounds was found within the in vitro 2D cell culture model,while in vivo and in vitro 3D models had the lowest number of detected *** results may be connected with a higher metabolic rate,as well as lower integrity of the in vitro 2D model compared to the in vitro 3D model resulting in a lower number of compounds released into medium in the latter *** terms of in vitro-in vivo extrapolation,the in vitro 2D model performed more similar to in vivo model compared to in vitro 3D model;however,it might have been due to the fact that only compounds secreted to medium were ***,in further experiments to obtain full metabolome information,the intraspheroidal assessment or spheroid dissociation would be necessary.

关键词： Solid-phase microextraction In vitro-in vivo extrapolation Metabolomics Melanoma B16F0 C57BL6 mouse model

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System supporting behavioral therapy for children with autism

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Journal of Innovative Optical Health Sciences 2015年第3期8卷 64-71页

作者： Małgorzata Je˛drzejewska-Szczerska katarzyna Karpienko Agnieszka Landowska Department of Metrology and Optoelectronics Faculty of Electronics Telecommunications and Informatics Gdansk University of Technology Gabriela Narutowicza Street 11/1280-233 GdanskPoland Department of Software Engineering Faculty of Electronics Telecommunications and InformaticsGdansk University of Technology Gabriela Narutowicza Street 11/1280-233 GdanskPoland

In this paper,a system supporting behavioral therapy for autistic children is *** system consists of sensors network,base station and a brooch indicating person's ernotional *** system can be used to measure values of physiological parameters that are associated with changes in the emotional *** the future,it can be useful to inform the autistic child and the therapist about the emotional state of the interlocutor objectively,on the basis of performed *** selected physiological parameters were chosen during the experiment which was designed and conducted by *** this experiment,a group of volunteers under con-trolld conditions was exposed to a stressful situation caused by the picture or *** each of the volunteers,a set of physiological parameters,was recorded,including:skin conductance,heart rate,peripheral temperature,respiration rate and *** bio statistical analysis allowved us to discern the proper plhysiological paraneters that are most associated to changes due to emotional state of a patient,such as:skin conductance,temperatures and res-piration *** allowed us to design electronic sensors network for supporting behavioral therapy for children with autism.

关键词： Autism spectrum disorder biomedical sensors physiological parameters sensor network.

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Systemic interleukin-9 in inflammatory bowel disease: Association with mucosal healing in ulcerative colitis

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World Journal of Gastroenterology 2017年第22期23卷 4039-4046页

作者： Malgorzata Matusiewicz katarzyna Neubauer Iwona Bednarz-Misa Sabina Gorska Malgorzata Krzystek-Korpacka Department of Medical Biochemistry Wroclaw Medical University Department of Gastroenterology and Hepatology Wroclaw Medical University Laboratory of Medical Microbiology Ludwik Hirszfeld Institute of Immunology and Experimental TherapyPolish Academy of Sciences

To evaluate circulating IL9 in inflammatory bowel disease and disease-associated anemia/cachexia and assess its potential as a mucosal healing *** IL9 as well as other cytokines (IL1β, IL6, IL13, IFNγ, TNFα, and VEGF-A) were determined in 293 individuals: 97 patients with Crohn’s disease (CD) and 74 with ulcerative colitis (UC) and in 122 apparently healthy controls. The clinical activity of CD and UC was expressed in terms of the Crohn’s Disease Activity Index (CDAI) and the Mayo Scoring System (MDAI), respectively, and the severity of bowel inflammation in UC patients was assessed using Mayo endoscopic score. Cytokine concentrations were measured by a flow cytometry-based method using Luminex xMAP® technology. High-sensitive C-reactive protein concentrations (hsCRP) were determined in CD and UC patients using the enhanced immunoturbidimetric *** IL9 was significantly lower in healthy individuals [9 pg/mL (95%CI: 8.2-10)] than in patients with inflammatory bowel disease (IBD): both inactive [14.3 pg/mL (11.9-19.9)] and active [27.6 pg/mL (24.5-32), P < 0.0001]. Cytokine concentrations were significantly higher in active CD [27.4 pg/mL (23.4-32.2)] and in active UC [32.7 pg/mL (27-38.9)] compared to inactive diseases [15.9 pg/mL (10.8-23.4) in CD and 19.4 pg/mL (13.9-27.1) in UC, P = 0.001]. IL9 correlated weakly with CDAI (ρ = 0.32, P = 0.003) and MDAI (ρ = 0.35, P = 0.002) and strongly with endoscopic inflammation in UC (ρ = 0.74, P < 0.0001). As a negative marker of mucosal healing (MH), IL9 had an accuracy superior to hsCRP and IL6 [97% (P < 0.0001), 67% (P = 0.071), and 55% (P = 0.525), respectively]. IL9 was significantly higher in cachectic IBD patients [30.25 pg/mL (24.4-37.5) vs 21.88 pg/mL (18-26.5), P = 0.026] and negatively correlated with hemoglobin concentrations (ρ = -0.27, P < 0.001). Multiple regression showed IL1β and IL13 to be the independent predictors of circulating IL9 in healthy individuals, IFNγ

关键词： Interleukin 9 Mucosal healing Biomarker Inflammatory bowel disease Crohn’s disease Ulcerative colitis Cachexia Anemia

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A Proposed Methodological Approach for Considering Community Resilience in Technology Development and Disaster Management Pilot Testing

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International Journal of Disaster Risk Science 2022年第3期13卷 342-357页

作者： Ioannis Benekos Evangelos Bekiaris katarzyna Wodniak Waleed Serhan Łukasz Sułkowski Hana Gharrad Ansar Yasar Centre for Research&Technology Hellas(CERTH) Hellenic Institute of Transport(HIT)15125MarousiGreece Department of Management University of Social SciencesWarsaw00-842WarsawPoland Transportation Research Institute(IMOB) Hasselt University3590DiepenbeekBelgium

Nowadays,resilience has become an indispensable term in several aspects and areas of research and *** consensus on what actually constitutes"resilience,""community,"and"community resilience"is still a task that guarantees a vivid exchange of opinions,sometimes escalating into debates,both in the scientific community and among *** out how to practically apply resilience principles goes even a step *** study attempts to circumvent the need for a universal agreement on the definition of"community resilience,"which may still be immature,if not impossible,at this *** accomplish this by proposing a practical methodological approach with concrete methods on how to agree and implement commonly accepted community resilience principles in the context of technology development and pilot testing for disaster *** proposed approach was developed,tested,and validated in the context of the Horizon 2020 EU-funded project Search and *** aspects of the approach,along with considerations for further improvement and adaptation in different contexts,are addressed in the article.

关键词： Community resilience Crisis management Disaster preparedness and response Disaster risk management Search and rescue

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Iron overload and HFE gene mutations in Polish patients with liver cirrhosis

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Hepatobiliary & Pancreatic Diseases International 2011年第3期10卷 270-275页

作者： katarzyna Sikorska Piotr Stalke Tomasz Romanowski Ewa Izycka-Swieszewska Krzysztof Piotr Bielawski Department of Infectious Diseases Medical University of Gdanskul.Smoluchowskiego 1880-218 GdanskPoland Department of Biotechnology Intercollegiate Faculty of BiotechnologyUniversity of Gdansk and Medical University of Gdanskul.Kladki 2480-822 GdańskPoland Department of Pathology Medical University of Gdanskul.Debinki 780-952 GdanskPoland

BACKGROUND:Increased liver iron stores may contribute to the progression of liver injury and fibrosis,and are associated with a higher risk of hepatocellular carcinoma ***-transplant symptoms of iron overload in patients with liver cirrhosis are associated with higher risk of infectious and malignant complications in liver transplant *** gene mutations may be involved in the pathogenesis of liver iron overload and influence the progression of chronic liver diseases of different *** study was designed to determine the prevalence of iron overload in relation to HFE gene mutations among Polish patients with liver ***:Sixty-one patients with liver cirrhosis included in the study were compared with a control group of 42 consecutive patients subjected to liver biopsy because of chronic liver *** function tests and serum iron markers were assessed in both *** patients were screened for HFE mutations (C282Y,H63D,S65C).Thirty-six of 61 patients from the study group and all controls had liver biopsy performed with semiquantitative assessment of iron deposits in ***:The biochemical markers of iron overload and iron deposits in the liver were detected with a higher frequency (70% and 47% respectively) in patients with liver *** were no differences in the prevalence of all HFE mutations in both *** patients with a diagnosis of hepatocellular carcinoma,no significant associations with iron disorders and HFE gene mutations were ***:Iron disorders were detected in patients with liver cirrhosis frequently but without significant association with HFE gene *** the homozygous C282Y mutation seems to occur more frequently in the selected population of patients with liver *** elevated biochemical iron indices accompanied liver iron deposits more frequently in liver cirrhosis compared to controls with chronic liver disease,there is a need for more extensive s

关键词： liver cirrhosis iron overload gene mutations iron deposits hepatocytes

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