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Vitamin D and autoimmune thyroid diseases

Cellular & Molecular Immunology 2011年第3期8卷 243-247页

作者： Shaye Kivity Nancy Agmon-Levin Michael Zisappl Yinon Shapira Endre V Nagy katalin Danko Zoltan Szekanecz Pnina Langevitz Yehuda Shoenfeld The Zabludovicz Center for Autoimmune Diseases Sheba Medical CenterTel-Hashomeraffiliated to Sackler Faculty of MedicineTel Aviv UniversityTel AvivIsrael Department of Medicine‘A&C’ Sheba Medical CenterTel-HashomerIsrael Rheumatic Disease Unit Sheba Medical CenterTel-HashomerIsrael Department of Medicine‘B’ Sheba Medical CenterTel-HashomerIsrael University of Debrecen.Medical and Health Science Center DebrecenHungary Incumbent of the Laura Schwarz-Kip Chair for Research of Autoimmune Diseases Tel Aviv UniversityTel AvivIsrael

The role of vitamin D as an immune modulator has been emphasized in recent years,and low levels of the hormone were observed in several autoimmune diseases including multiple sclerosis and systemic lupus *** D mediates its effect though binding to vitamin D receptor(VDR),and activation of VDR-responsive *** VDR gene polymorphism was found to associate with autoimmune thyroid diseases(AITDs),few studies examined levels of vitamin D in these patients and those that did yielded conflicting *** therefore undertook to evaluate the levels of vitamin D in patients with AITDs compared to patients with non-AITDs and healthy *** vitamin D(25-OH)levels were measured in 50 patients with AITDs,42 patients with non-AITDs and 98 healthy subjects,utilizing the LIAISON chemiluminescence immunoassay(DiaSorin,Saluggia,Italy).VitaminD deficiency was designated at levels lower than 10 ng/*** antibodies,thyroid functions and demographic parameters were evaluated in all *** prevalence of vitamin D deficiency was significantly higher in patients with AITDs compared with healthy individuals(72% versus 30.6%;P<0.001),as well as in patients with Hashimoto’s thyroiditis compared to patients with non-AITDs(79% versus 52%;P<0.05).Vitamin D deficiency also correlated to the presence of antithyroid antibodies(P=0.01)and abnormal thyroid function tests(P=0.059).Significantly low levels of vitamin D were documented in patients with AITDs that were related to the presence of anti thyroid antibodies and abnormal thyroid function tests,suggesting the involvement of vitamin D in the pathogenesis of AITDs and the advisability of supplementation.

关键词： autoantibodies autoimmune thyroid disease Graves’disease Hashimoto’s thyroiditis vitamin D

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Morphological and microcirculatory evaluation of the rat testis after detorsion with or without a capsular release with a tunica vaginalis flap

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Asian Journal of Andrology 2016年第3期18卷 462-466,I0010,I0011页

作者： Tamas Jozsat Zoltan Klarik Ferenc kiss Eniko Toth Anita Mester Zoltan Hargitai Yi-Che Changchien Magdalena Fossum Norbert Nemeth Department of Women's and Children's Health Karolinska Institutet Stockholm Sweden Department of Pediatric Surgery Division of Urology Astrid Lindgren Children's Hospital. Karolinska University Hospital Stockholm Sweden Department of Operative Techniques and Surgical Research Institute of Surgery Faculty ot MedicineUniversity of Debrecen Hungary Department of Pathology Kenezy Gyula Hospital Uebrecen Hungary

Testicular torsion may lead to serious ischemia, and the viability depends on the duration of torsion and the effect of ischemia-reperfusion. Testicular decompression and tunica vaginalis flap application technique were introduced in 2008 by Kutikov et al. We aimed to examine the impact of this method on the testicular microcirculation and hemorheological parameters in a rat model. Six adult rats underwent bilateral scrotal exploration. Intravaginal torsion of the testis was created by 720° rotation on both sides for 2 h. After detorsion, the right testes underwent tunica albuginea incision and tunica vaginalis flap application. Testicular microcirculation was monitored and hematological parameters, erythrocyte deformability, and aggregation were determined. Measurements were performed before and after torsion, directly after detorsion, on the 1^st-2^nd and 8^th postoperative day. After the last sampling, testicles were removed to determine their volume for histological examinations. The microcirculatory parameters demonstrated slight differences between testicles. Apical zone of the left （nondecompressed） testicles had elevated compared to the middle zone （P 〈 0.05）. On the 2^nd and 8^th day, the microcirculation of the testes normalized but not equally. The erythrocyte aggregation and deformability decreased by the 8^th day. Both testicles underwent atrophy and epithelial necrosis, but the volume of the decompressed ones was lower （1.07±0.08 vs 1.25 ± 0.31）. Histologically, there was no significant difference in epithelial damage score between decompressed and nondecompressed testes. In conclusion, 2-h ischemia led to alteration in testicular microcirculation, reduction in volume, changes in hemorheological parameters and serious epithelial necrosis both in decompressed and nondecompressed testicles without remarkable differences.

关键词： ischemia rat model reperfusion spermatic cord torsion surgical flaps testicular compartment syndrome testis

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Lactate reloaded–reevaluation of the importance of lactate monitoring in the management of adult sepsis in the emergency department

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BIOCELL 2021年第3期45卷 445-449页

作者： GABOR XANTUS BALINT kiss GYULA MOLNAR CANDICE MATHESON V.A NNA GYARMATHY PETER L.KANIZSAI Cardiff University CardiffCF103ATUK Semmelweis University Budapest1085Hungary Dalhuis University Halifax HalifaxNS B3H 4R2Canada EpiConsult Biomedical Consulting and Medical Communications Agency DoverDE 19901USA Pecs University Clinical CentrePecs7626Hungary

For about a quarter of a century,monitoring lactate levels and/or lactate clearance has been an unquestionable cornerstone in sepsis *** elevated lactate level appeared to be an independent predictor of mortality,and the consequent metabolic acidosis was thought to explain a number of pathophysiological changes seen in septic *** physiological and clinical findings seem to challenge the adverse role of lactic acidosis in *** suggests that lactate levels are not necessarily directly proportional to either tissue or cellular hypoxia,and conversely,despite high lactate levels,increased peripheral tissue oxygen pressure can be measured in adult patients with septic *** to the most recent understanding of in vitro and in vivo evidence,the elevated lactate level in sepsis might be a normal reaction due to adrenergic stress with potential beneficial/protective physiological effects,as *** the one hand,burning lactic may help fuel the body during critical illness,but on the other hand,with a slight drop in pH,the body may counteract certain deleterious changes during the dysregulated host response;reduce the chances of reperfusion myocardial injury,and improve tissue oxygenation by shifting the haemoglobin dissociation curve to the *** the pathophysiological process in sepsis resulting in elevated lactate levels may aid management in an emergency,medicine,and intensive care *** more in-depth physiological knowledge,physicians may inevitably surpass normalisation heuristics and deliver personalized rather than protocolised sepsis resuscitation.

关键词： Reevaluation Lactate Sepsis Resuscitation

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利用GRACE重力卫星求解南极洲冰川质量变化的精度研究

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地学前缘 2015年第4期22卷 239-246页

作者： Lorant FOLDVARY Annamaria kiss 苏子校王广才王林 Department of Geodesy and Surveying Budapest University of Technology and Economics Faculty of Geoinformatics University of West Hungary 中国地质大学(北京)水资源与环境学院北京100083 Faculty of Science Technology and CommunicationUniversity of Luxembourg

GRACE重力卫星可用于观测南极洲冰川的质量变化。由GRACE重力卫星提供的月解重力场能有效探测质量的年变化及长期变化(周期和非周期性)。通过GRACE观测的质量变化时间序列,计算得到南极洲质量的长期变化及周期性年变化。计算结果受多种... 详细信息

GRACE重力卫星可用于观测南极洲冰川的质量变化。由GRACE重力卫星提供的月解重力场能有效探测质量的年变化及长期变化(周期和非周期性)。通过GRACE观测的质量变化时间序列,计算得到南极洲质量的长期变化及周期性年变化。计算结果受多种误差影响,其中GRACE模型误差的影响较小,而研究时段及其跨度的影响较为显著,以不同宽度的时间窗口进行平移,得到无穷时间序列下该误差的参考值为±14.89mm/a。南极地区的气压修正误差可达±10mm/a,GIA修正误差与其量级相同。由此我们认为,目前对于南极洲冰川质量变化的一些认识仍需商榷。南极洲西部地区冰川加速消融,Dronning Maud Land和Enderby Land等地区的质量持续累积;其他地区的质量变化情况仍需进一步研究。

关键词：南极洲地表质量变化误差分析质量变化时间序列

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YOUNG DREAM

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青年与社会（中） 2009年第5期 42-43页

作者： kiss&sigua

kiss的人物链头号闺蜜:sigua。喜欢浪漫的狮子座女王,表面闪亮奢华,内心极简纯良。相熟八年,一起嬉笑怒骂,疯狂天真,荒唐无数,长成现在的"young"子。08年夏天,觉得是时候一起做点事了……miss夏:商场招商部专员。亲和力强,能言善辩,且... 详细信息

kiss的人物链头号闺蜜:sigua。喜欢浪漫的狮子座女王,表面闪亮奢华,内心极简纯良。相熟八年,一起嬉笑怒骂,疯狂天真,荒唐无数,长成现在的"young"子。08年夏天,觉得是时候一起做点事了……miss夏:商场招商部专员。亲和力强,能言善辩,且颇有点姿色。Me:藏起来的自我。God:天知道,老天也来这个故事里插一脚。

关键词：生活风格策划商场云南关键词创业原创设计策略集结形象定位

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Sustainability Aspects of the Wheat Sector

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Chinese Business Review 2012年第5期11卷 451-459页

作者： Istvan kiss Szilvia Bencze University ofDebrecen DebrecenHungary BEN-KG Lp. CsomorHungary

In the frame of the present study, we examined the wheat sector with respect to economic and social sustainability. Accordingly, two research questions were formulated：（1） Is wheat production sustainable in economic terms？ and （2） Is wheat production sustainable in social terms？ Our view is that the content of sustainability can be defined on a case-by-case basis, and in our case, wheat production provides this content. To answer the research questions, we collected statistical data on the production area, average yield, production volume, selling price, consumption of wheat, and evaluated the tendencies prevalent in the sector. We suppose that in social terms, sustainability means maintaining consumption at least at a constant level, knowing that this sector produces considerable share of the direct and indirect food raw materials. A chief dilemma is that world population is continuously growing, although the size of the cultivated area in the wheat sector has not indicated significant changes over the past few decades. Unless increasing the yields, severe decrease may occur in the per capita production of wheat in the long run. In this case, the current consumption level will not be sustainable in the medium run. In addition, in the long run, it may even have influence on the consumption level of other commodities.

关键词： wheat sector sustainability competitiveness production consumption level

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Real-world performance analysis of a novel computational method in the precision oncology of pediatric tumors

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World Journal of Pediatrics 2023年第10期19卷 992-1008页

作者： Barbara Vodicska Júlia Déri Dóra Tihanyi Edit Várkondi EnikőKispéter Róbert Dóczi Dóra Lakatos Anna Dirner Mátyás Vidermann Péter Filotás Réka Szalkai-Dénes István Szegedi katalin Bartyik Krisztina Míta Gábor Réka Simon Péter Hauser György Péter Csongor kiss Miklós Garami István Peták Oncompass Medicine Hungary Kft Retek Str.34Budapest 1024Hungary Division of Pediatric Hematology-Oncology Department of PediatricsFaculty of MedicineUniversity of DebrecenDebrecenHungary Department of Pediatrics Albert Szent-Györgyi Medical SchoolUniversity of SzegedSzegedHungary Onco-Hematology Department Velkey LászlóPaediatric Health CentreMiskolcHungary Department of Paediatrics Semmelweis UniversityBudapestHungary Onco-Hematology Department Heim Pál Children’s HospitalBudapestHungary Department of Pharmacology and Pharmacotherapy Semmelweis UniversityBudapestHungary Department of Pharmaceutical Sciences University of Illinois at ChicagoChicagoUSA Genomate Health CambridgeMAUSA

Background The utility of routine extensive molecular profiling of pediatric tumors is a matter of debate due to the high number of genetic alterations of unknown significance or low evidence and the lack of standardized and personalized decision support *** drug assignment(DDA)is a novel computational method to prioritize treatment options by aggregating numerous evidence-based associations between multiple drivers,targets,and targeted *** has been validated to improve personalized treatment decisions based on the outcome data of adult patients treated in the SHIVA01 clinical *** aim of this study was to evaluate the utility of DDA in pediatric *** Between 2017 and 2020,103 high-risk pediatric cancer patients(<21 years)were involved in our precision oncology program,and samples from 100 patients were eligible for further *** or blood samples were analyzed by whole-exome(WES)or targeted panel sequencing and other molecular diagnostic modalities and processed by a software system using the DDA algorithm for therapeutic decision ***,a molecular tumor board(MTB)evaluated the results to provide therapy *** Of the 100 cases with comprehensive molecular diagnostic data,88 yielded WES and 12 panel sequencing *** identified matching off-label targeted treatment options(actionability)in 72/100 cases(72%),while 57/100(57%)showed potential drug *** reached 88%(29/33)by 2020 due to the continuous updates of the evidence *** approved the clinical use of a DDA-top-listed treatment in 56 of 72 actionable cases(78%).The approved therapies had significantly higher aggregated evidence levels(AELs)than dismissed *** of WES results for targeted panels missed important mutations affecting therapy *** DDA is a promising approach to overcome challenges associated with the interpretation of extensive molecular profiling in the routine car

关键词： Computational decision support Pediatric tumors Precision oncology Tumor board

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Discrepancies between clinical and autopsy findings in patients who had an acute stroke

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Stroke & Vascular Neurology 2022年第3期7卷 215-221页

作者： Lilla Hudák Attila Csaba Nagy Sarolta Molnár Gábor Méhes katalin Erzsébet Nagy LászlóOláh LászlóCsiba Department of Neurology University of Debrecen Faculty of MedicineDebrecenHungary Department of Preventive Medicine University of Debrecen Faculty of Public HealthDebrecenHungary Department of Pathology University of Debrecen Clinical CenterDebrecenHungary Doctoral School of Neuroscience University of Debrecen Faculty of MedicineDebrecenHungary

Objectives According to international observations,the incidence of clinical autopsies is declining worldwide,plummeting below 5%in the USA and many European *** is an unfavourable trend as,in 7%-12%of cases,recent clinicopathological studies found discrepancies that might have changed the therapy or the outcome if known *** previous large-scale observations have examined varied patient populations,we aimed to focus on the differences between the clinical and pathological diagnostic findings in only patients who had a *** and methods We assessed the postmortem non-neuropathological and neuropathological findings of 534 consecutive patients who had a stroke who passed *** neoplasms,pneumonias,thromboembolisms and haemorrhagic transformations revealed only by autopsy were considered severe abnormalities;in addition,benign abnormalities important from an educational or scientific point of view were also *** In 26 of the 534 cases(4.9%),the presence of systemic neoplasms had already been confirmed in the clinical stage;however,8(1.5%)malignant tumours were only detected during ***,80(15%)thromboembolic events,73(13.6%)pneumonias and 66(18%)haemorrhagic transformations were only diagnosed at *** hospital stay(from admission to death)resulted in fewer discrepancies between clinical and autopsy diagnosis of thromboembolic events and pneumonias(p<0.01).In 169 cases,benign findings were *** While the type of acute stroke is reliably diagnosed with imaging techniques,postmortem autopsies are also important in patients who had a stroke as autopsies may reveal clinically silent diseases(eg,tumour),and contribute to knowing the actual incidence of stroke-related thromboembolic and pneumonia complications.

关键词： neoplasms clinical finding

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Graphene Oxide Application in Cement-Bound Materials-State of the Art

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材料科学与工程（中英文B版） 2021年第4期11卷 144-155页

作者： katalin Kopecskó Zaid Ali Abdulhussein Khaiqani Faculty of Civil Engineering Budapest University of Technology and EconomicsMűegyetem rakpart 3Budapest 1111Hungary

In recent years,the incorporation of nanoparticles in the cementitious matrix has been regarded as a prominent strategy in the research *** paper reviews the influences of the nanomaterial GO(graphene oxide)in cement bound materials,as GO has become one of the most well-known inclusion nanoparticles in the cementitious matrix in the last few *** study describes(i)the influences of the GO on enhancing hydration mechanism in the cementitious materials;and(ii)the improved performance of the cementitious materials,which are highly dependent on the functionalizing behavior of the *** this improves the properties of the *** paper reports the influences of GO on the workability of the mixtures and the durability enhancement of the cementitious ***,it demonstrates promising results of employing GO in the fabrication of novel building ***,tremendous progress in utilizing GO in scientific domains like materials technology has achieved a significant *** progress has been achieved by applying the GO in different fields such as solar cells and super ***,more intensive research is required to achieve comparable improvement in building materials which constitutes a significant future challenge.

关键词： materials. durability utilizing

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基于短视频平台的企业广告内容特征对用户品牌认知的影响研究

基于短视频平台的企业广告内容特征对用户品牌认知的影响研究

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作者： katalin CHEN 上海交通大学

学位级别：硕士

随着移动互联网的迅速发展,用户的触媒习惯也在逐渐发生改变,集碎片化和内容化于一体的移动短视频成为用户接受各类信息的主要载体。用户对优质内容的巨大需求及其时间碎片化现象的日趋明显,使短视频与短视频平台在有效传递信息及提升... 详细信息

随着移动互联网的迅速发展,用户的触媒习惯也在逐渐发生改变,集碎片化和内容化于一体的移动短视频成为用户接受各类信息的主要载体。用户对优质内容的巨大需求及其时间碎片化现象的日趋明显,使短视频与短视频平台在有效传递信息及提升用户认知方面极具潜力;因此,本研究从企业广告内容的角度出发,旨在探讨企业广告内容特征对用户品牌认知的影响。本研究使用实证研究法,设计了两组组间实验,探讨了企业广告内容的关键特征(幽默和热情)与用户品牌认知之间的主效应关系;此外还将沉浸体验与卷入度纳入研究,探讨两者在主关系中是否具有中介作用与调节作用。通过对实验数据的分析,证实了企业广告内容关键特征对用户的品牌认知具有显著且直接的影响;实验1通过独立样本T检验证明了幽默特征与热情特征的广告内容分别对用户的品牌认知存在直接影响。此外通过实验2验证了沉浸体验在该关系中具有中介作用,即企业广告内容关键特征显著正向影响个体的沉浸体验,进而显著正向影响其品牌认知。但对调节作用的分析表明,卷入度在该关系中仅起到部分调节作用,即在热情特征对用户的品牌认知的影响中,卷入度具有显著的调节作用;但在幽默特征对用户品牌认知的影响中,卷入度不具有显著性,亦说明其不具有调节作用。

关键词：短视频广告内容特征沉浸体验卷入度品牌认知

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