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Candida endocarditis: Update on management considerations

World Journal of Cardiology 2023年第10期15卷 469-478页

作者： Yasser Jamil Akintayo Akinleye Mojtaba Mirzaei Matthew Lempel kassem farhat Samuel Pan Department of Internal Medicine Yale School of MedicineWaterburyCT 06708United States Department of Rheumatology Yale School of MedicineNew HavenCT 06510United States Department of Infectious Disease Yale School of MedicineWaterburyCT 06708United States

The rise in incidence rates of invasive candidiasis warrants an increase in atten-tion and efforts toward preventing and treating this virulent *** involvement is one of the most feared sequelae and has a poor *** the introduction of several novel antifungal agents over the past quarter century,complications and mortality rates due to Candida endocarditis have remained *** fungal endocarditis has a mechanism similar to bacterial endocar-ditis,no specific diagnostic criteria or algorithm exists to help guide its ***,recent data has questioned the current guidelines recommen-ding a combined approach of antifungal agents with surgical valve or indwelling prostheses *** the emergence of multidrug-resistant Candida auris,a focus on improved prophylactic measures and management strategies is nece-ssary.

关键词： Candida Candida endocarditis Fungal endocarditis Invasive fungal infection

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Effect of mucin production on survival in colorectal cancer:A case-control study

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World Journal of Gastroenterology 2008年第45期14卷 6981-6985页

作者： Mirna H farhat kassem A Barada Ayman N Tawil Doha M Itani Hassan A Hatoum Ali I Shamseddine Division of Hematology-Oncology Internal Medicine American University of Beirut Division of Gastroenterology Internal Medicine American University of Beirut Department of Pathology American University of Beirut

AIM: To investigate the impact of mucin production on prognosis in colorectal cancer, in terms of overall survival (OS) and time to disease progression (TTP) in patients with mucinous compared to those with non-mucinous colorectal cancer (NMCRC), matched for age, gender, and tumor ***: Thirty five patients with mucinous colorectal cancer (MCRC) were matched for age, gender, and tumor stage with 35 controls having NMCRC. OS and TTP were compared among 4 groups divided according to mucin content: group A (50%-75% mucin), group B (75%-100% mucin), group C or controls ( 75% of tumor volume. However, it tends to be more poorly differentiated. A larger study matching for stage and grade is needed.

关键词：结肠癌直肠癌癌细胞治疗临床

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Prognostic factors in patients with advanced cholangiocarcinoma: Role of surgery, chemotherapy and body mass index

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World Journal of Gastroenterology 2008年第20期14卷 3224-3230页

作者： Mirna H farhat Ali I Shamseddine Ayman N Tawil Ghina Berjawi Charif Sidani Wael Shamseddeen kassem A Barada Division of Hematology-Oncology Department of Internal Medicine American University of Beirut Medical Center Department of Pathology American Universityof Beirut Medical Center Department of Radiology American University of Beirut Medical Center Department of Public health American University of Beirut Medical Center Division of Gastroenterology Departmentof Internal Medicine American University of Beirut MedicalCenter

AIM: To study the factors that may affect survival of cholangiocarcinoma in Lebanon. METHODS: A retrospective review of the medical records of 55 patients diagnosed with cholangio- carcinoma at the American University of Beirut between 1990 and 2005 was conducted. Univariate and multivariate analyses were performed to determine the impact of surgery, chemotherapy, body mass index, bilirubin level and other factors on survival. RESULTS: The median survival of all patients was 8.57 mo (0.03-105.2). Univariate analysis showed that low bilirubin level (< 10 mg/dL), radical surgery and chemotherapy administration were significantly associated with better survival (P = 0.012, 0.038 and 0.038, respectively). In subgroup analysis on patients who had no surgery, chemotherapy administration prolonged median survival significantly (17.0 mo vs 3.5 mo, P = 0.001). Multivariate analysis identifiedonly low bilirubin level < 10 mg/dL and chemotherapy administration as independent predictors associated with better survival (P < 0.05). CONCLUSION: Our data show that palliative and postoperative chemotherapy as well as a bilirubin level < 10 mg/dL are independent predictors of a significant increase in survival in patients with cholangiocarcinoma.

关键词：胆红素胆管癌手术治疗化学疗法

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