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A decoy receptor derived from alternative splicing fine-tunes cytokinin signaling in Arabidopsis

Molecular Plant 2024年第12期17卷 1850-1865页

作者： Michaela Králová Ivona Kubalová Jakub Hajný karolina Kubiasová karolína vagaská Zengxiang Ge Michelle Gallei Hana Semerádová Anna Kuchařová Martin Hönig Aline Monzer Martin Kovačik JiříFriml Ondřej Novák Eva Benková Yoshihisa Ikeda David Zalabák Laboratory of Growth Regulators Faculty of Science of PalackýUniversity and Institute of Experimental Botany AS CRŠlechtitelů2778371 OlomoucCzech Republic Department of Molecular Biology Centre of the Region Hanáfor Biotechnological and Agricultural ResearchFaculty of SciencePalackýUniversityŠlechtitelů2778371 OlomoucCzech Republic Institute of Science and Technology Austria(ISTA) 3400 KlosterneuburgAustria Department of Chemical Biology Faculty of SciencePalackýUniversityŠlechtitelů2778371 OlomoucCzech Republic Institute of Experimental Botany of the Czech Academy of Sciences Centre of Plant Structural and Functional GenomicsŠlechtitelů3177900 OlomoucCzech Republic These authors contributed equally to this article.

Hormone perception and signaling pathways have a fundamental regulatory function in the physiological processes of ***,a class of plant hormones,regulate cell division and meristem *** cytokinin signaling pathway is well established in the model plant *** negative feedback mechanisms,tightly controlling cytokinin signaling output,have been described *** this study,we identified a new feedback mechanism executed through alternative splicing of the cytokinin receptor AHK4/CRE1.A novel splicing variant named CRE1int7 results from seventh intron retention,introducing a premature termination codon in the *** showed that CRE1int7 is translated in planta into a truncated receptor lacking the C-terminal receiver domain essential for signal ***1int7 can bind cytokinin but cannot activate the downstream *** present a novel negative feedback mechanism of the cytokinin signaling pathway,facilitated by a decoy receptor that can inactivate canonical cytokinin receptors via dimerization and compete with them for ligand *** proper plant growth and development requires precise control of the cytokinin signaling pathway at several ***1int7 represents a so-far unknown mechanism for fine-tuning the cytokinin signaling pathway in Arabidopsis.

关键词： splicing Arabidopsis decoy

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Maximizing biomass utilization: An integrated strategy for coproducing multiple chemicals

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Journal of Energy Chemistry 2025年第1期100卷 180-191页

作者： Byeongchan Ahn Sua Jo Jonggeol na J.Jay Liu Young-Ju Kim Wangyun Won Department of Chemical and Biological Engineering Korea University Department of Chemical Engineering (Integrated process) Kyung Hee University Department of Chemical Engineering and Materials Science Ewha Womans University Department of Chemical Engineering Pukyong National University Resources Engineering Plant Research Department Korea Institute of Geoscience and Mineral Resources

Lignocellulosic biomass is one of the viable solutions to alleviate the global warming. However, the limited utilization of biomass majorly focused on cellulose and hemicellulose restricts the economic and environmental feasibilities. To cope with this issue, we proposed an integrated process of co-producing 1,6-hexanediol（1,6-HDO） with tetrahydrofuran and adipic acid from biomass, referred to as Strategy A. To compare the impacts of lignin upgrading and feedstock, Strategy B, which co-produces tetrahydrofuran alone, and Strategy C, which is the traditional route to produce 1,6-HDO from fossil fuels, were used. Heat networks are also designed to reduce operating costs and indirect carbon emissions due to energy consumption, saving 87% and 83% of the heat and cooling requirements, respectively, in Strategy A. The market competitiveness of Strategy A was evaluated by determining the minimum selling price through techno-economic analysis, and sustainability was thoroughly investigated by quantifying the environmental impacts through both midpoint and endpoint life-cycle assessments（LCAs）.Strategy A was found to be the most favorable both economically（USRDSCHARDOLLAR3,402/ton） and environmentally（-26.9 kg CO2eq.）. This indicates that lignin valorization is not only economically but also environmentally preferred. Finally, changes in economic and environmental feasibilities depending on economic, process, and environmental parameters were investigated using sensitivity and uncertainty analyses. The results of these analyses provide valuable insight into bio-based chemical production.

关键词： Biorefinery Carbon mitigation Climate change Global warming Lignin utilization Bioeconomy

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Boosting Oxygen Evolution Reaction Performance on NiFe‑Based Catalysts Through d‑Orbital Hybridization

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nano-Micro Letters 2025年第1期17卷 281-292页

作者： Xing Wang Wei Pi Sheng Hu Haifeng Bao na Yao Wei Luo State Key Laboratory of New Textile Materials and Advanced Processing Technology Key Laboratory of New Textile Materials and Applications of Hubei ProvinceSchool of Materials Science and EngineeringWuhan Textile UniversityWuhan 430200People’s Republic of China College of Chemistry and Molecular Sciences Wuhan UniversityWuhan 430072People’s Republic of China

Anion-exchange membrane water electrolyzers(AEMWEs)for green hydrogen production have received intensive attention due to their feasibility of using earth-abundant NiFe-based *** introducing a third metal into NiFe-based catalysts to construct asymmetrical M-NiFe units,the d-orbital and electronic structures can be adjusted,which is an important strategy to achieve sufficient oxygen evolution reaction(OER)performance in ***,the ternary NiFeM(M:La,Mo)catalysts featured with distinct M-NiFe units and varying d-orbitals are reported in this *** and theoretical calculation results reveal that the doping of La leads to optimized hybridization between d orbital in NiFeM and 2p in oxygen,resulting in enhanced adsorption strength of oxygen intermediates,and reduced rate-determining step energy barrier,which is responsible for the enhanced OER *** critically,the obtained NiFeLa catalyst only requires 1.58 V to reach 1 A cm^(−2) in an anion exchange membrane electrolyzer and demonstrates excellent long-term stability of up to 600 h.

关键词： NiFe-based catalysts d-orbital coupling Oxygen evolution reaction Anion exchange membrane electrolyzer

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FK506 contributes to peripheral nerve regeneration by inhibiting neuroinflammatory responses and promoting neuron survival

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Neural Regeneration Research 2025年第7期20卷 2108-2115页

作者： Yuhui Kou Zongxue Jin Yusong Yuan Bo Ma Wenyong Xie na Han Department of Trauma and Orthopedics Peking University People’s HospitalBeijingChina national Center for Trauma Medicine Peking University People’s HospitalBeijingChina Key Laboratory of Trauma and Neural Regeneration(Peking University) Ministry of EducationBeijingChina Trauma Medicine Center Peking University People’s HospitalBeijingChina Department of Orthopedics China-Japan Friendship HospitalBeijingChina

FK506(Tacrolimus)is a systemic immunosuppressant approved by the *** and Drug ***506 has been shown to promote peripheral nerve regeneration,however,its precise mechanism of action and its pathways remain *** this study,we established a rat model of sciatic nerve injury and found that FK506 improved the morphology of the injured sciatic nerve,increased the numbers of motor and sensory neurons,reduced inflammatory responses,markedly improved the conduction function of the injured nerve,and promoted motor function *** findings suggest that FK506 promotes peripheral nerve structure recovery and functional regeneration by reducing the intensity of inflammation after neuronal injury and increasing the number of surviving neurons.

关键词： FK506 inflammation motor neurons nerve regeneration neuron peripheral nerve injury sensory neurons

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Determination of coefficients of friction for laminated veneer lumber on steel under high pressure loads

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Friction 2021年第2期9卷 367-379页

作者： Michael DORN karolína HABROVÁ Radek KOUBEK Erik SERRANO Department of Building Technology Linnaeus UniversityVäxjö35252Sweden Czech University of Life Sciences Prague-Department of Materials and Engineering Technology Prague 16521Czech Republic Daikin UK The HeightsBrooklandsWeybridgeKT130NYUnited Kingdom Division of Structural Mechanics Lund UniversityLund 22100Sweden

In this study,static coefficients of friction for laminated veneer lumber on steel surfaces were determined *** focus was on the frictional behaviors at different pressure levels,which were studied in combination with other influencing parameters:fiber orientation,moisture content,and surface *** of friction were obtained as 0.10–0.30 for a smooth steel surface and as high as 0.80 for a rough steel *** influenced the measured coefficients of friction,and lower normal pressures yielded higher *** influence of fiber angle was observed to be moderate,although clearly detectable,thereby resulting in a higher coefficient of friction when sliding perpendicular rather than parallel to the *** specimens contained higher coefficients of friction than oven-dry *** results provide realistic values for practical applications,particularly for use as input parameters of numerical simulations where the role of friction is often wrongfully considered.

关键词： laminated veneer lumber(LVL) wood static friction high pressure angle-to-grain moisture content

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Mesospheric tide comparisons at low latitudes observed by two collocated meteor radars

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Earth and Planetary Physics 2025年第1期9卷 54-68页

作者： Jian Li Wen Yi XiangHui Xue Jie Zeng HaiLun Ye JianYuan Wang JinSong Chen na Li TingDi Chen Chinese Academy of Sciences(CAS)Key Laboratory of Geospace Environment Department of Geophysics and Planetary SciencesUniversity of Science and Technology of ChinaHefei 230026China CAS Center for Excellence in Comparative Planetology Anhui Mengcheng Geophysics National Observation and Research StationUniversity of Science and Technology of ChinaHefei 230026China Hefei national Laboratory University of Science and Technology of ChinaHefei 230026China Collaborative Innovation Center of Astronautical Science and Technology Harbin 150001China national Key Laboratory of Electromagnetic Environment China Research Institute of Radiowave PropagationQingdao 266107China Yunnan Kunming Electromagnetic Environment national Observation and Research Station Qujing Kunming 655000China

Accurate knowledge of mesospheric winds and waves is essential for studying the dynamics and climate in the mesosphere and lower thermosphere(MLT)*** this study,we conduct a comparative analysis of the mesosphere tidal results obtained from two adjacent meteor radars at low latitudes in Kunming,China,from November 2013 to December *** two radars operate at different frequencies of 37.5 MHz and 53.1 MHz,***,overall good agreement is observed between the two radars in terms of horizontal winds and tide *** results show that the dominant tidal waves of the zonal and meridional winds are diurnal and semidiurnal ***,we conduct an exhaustive statistical analysis to compare the tidal amplitudes and vertical wavelengths recorded by the dual radar systems,which reveals a high degree of alignment in tidal *** investigation includes variances and covariances of tidal amplitudes,which demonstrate remarkable consistency across measurements from both *** finding highlights clear uniformity in the mesospheric tidal patterns observed at low latitudes by the two neighboring meteor *** of the comparative analysis specifically underscore the significant correlation in vertical wavelength measurements,validating the robustness of radar observations for tidal research.

关键词： mesosphere and lower thermosphere region meteor radar mesospheric winds tides

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基于粒子群优化算法的农业机器人控制策略研究

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农机化研究 2025年第1期47卷 205-209页

作者：王娜吴延凯许娜河南工业职业技术学院河南南阳473000

介绍了粒子群优化算法的概念,并由数学模型、边界约束和环境约束对农业机器人优化约束模型进行了分析,实现了对农业机器人的动态避障和路径规划。仿真实验表明:针对复杂的作业环境,农业机器人可以进行最优避障路径规划,且算法收敛速度较... 详细信息

介绍了粒子群优化算法的概念,并由数学模型、边界约束和环境约束对农业机器人优化约束模型进行了分析,实现了对农业机器人的动态避障和路径规划。仿真实验表明:针对复杂的作业环境,农业机器人可以进行最优避障路径规划,且算法收敛速度较快,能够满足设计要求,证明系统具有一定的可行性。

关键词：农业机器人粒子群优化约束模型避障路径规划

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Inhibitory gamma-aminobutyric acidergic neurons in the anterior cingulate cortex participate in the comorbidity of pain and emotion

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Neural Regeneration Research 2025年第10期20卷 2838-2854页

作者： Lu Guan Mengting Qiu na Li Zhengxiang Zhou Ru Ye Liyan Zhong Yashuang Xu Junhui Ren Yi Liang Xiaomei Shao Jianqiao Fang Junfan Fang Junying Du Department of Neurobiology and Acupuncture Research Third School of Clinical MedicineZhejiang Chinese Medical UniversityHangzhouZhejiang ProvinceChina Key Laboratory for Research of Acupuncture Treatment and Transformation of Emotional Diseases Third School of Clinical MedicineZhejiang Chinese Medical UniversityHangzhouZhejiang ProvinceChina Fuchun Community Health Service Center of Fuyang District HangzhouZhejiang ProvinceChina

Pain is often comorbid with emotional disorders such as anxiety and *** of the anterior cingulate cortex has been implicated in pain and pain-related negative emotions that arise from impairments in inhibitory gamma-aminobutyric acid *** review primarily aims to outline the main circuitry(including the input and output connectivity)of the anterior cingulate cortex and classification and functions of different gamma-aminobutyric acidergic neurons;it also describes the neurotransmitters/neuromodulators affecting these neurons,their intercommunication with other neurons,and their importance in mental comorbidities associated with chronic pain *** understanding on their role in pain-related mental comorbidities may facilitate the development of more effective treatments for these ***,the mechanisms that regulate gamma-aminobutyric acidergic systems remain *** is also unclear as to whether the mechanisms are presynaptic or *** exploration of the complexities of this system may reveal new pathways for research and drug development.

关键词： anterior cingulate cortex anxiety chronic pain circuit communication comorbidity depression gamma-aminobutyric acidergic neurons parvalbumin neurons synaptic transmission

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Mathematical Modelling of the Transient Response of Pipeline

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Journal of Thermal Science 2016年第6期25卷 549-557页

作者： Dawid Taler karol Kaczmarski Cracow University of Technology Faculty of Environmental Engineering Cracow University of Technology Faculty of Mechanical Engineering

Steam pipelines applied in power units operate at high pressures and *** addition,to stress from the pipeline pressure also arise high thermal stresses in transient states such as start-up,shutdown or a load change of the power ***-varying stresses are often the cause of the occurrence of fatigue cracks since the plastic deformations appear at the stress concentration *** determine the transient temperature of the steam along the steam flow path and axisymmetric temperature distribution in the pipeline wall,a numerical model of pipeline heating was *** determine the transient temperature of the steam and pipeline wall the finite volume method(FVM) was used Writing the energy conservation equations for control areas around all the nodes gives a system of ordinary differential equations with respect to *** system of ordinary differential equations of the first order was solved by the Runge-Kutta method of the fourth order to give the time-temperature changes at the nodes lying in the area of the wall and *** steam pressure distribution along pipeline was determined from the solution of the momentum conservation *** on the calculated temperature distribution,thermal stresses were *** friction factor was calculated using the correlations of Churchill and Haaland,which were proposed for pipes with a rough inner *** assess the accuracy of the proposed model,numerical calculations were also performed for the thin-walled pipe,and the results were compared to the exact analytical *** of the results shows that the accuracy of the proposed model of pipeline heating is very *** paper presents examples of the determination of the transient temperature of the steam and the wall.

关键词： pipeline steam heating walled satisfactory Pipeline conservation lying Kutta Runge

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Influence of Biomass Co-combustion on Heating Surfaces Thermal Efficiency

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Journal of Thermal Science 2018年第5期27卷 427-432页

作者： GRADZIEL Slawomir WITKOWSKI karol Institute of Thermal Power Engineering Cracow University of Technology31-864 Kraków Poland European Institute for Energy Research 76131 Karlsruhe Germany

Pulverized coal-fired(PCF) boilers were first and foremost intended to fire pulverized hard or brown coal. However, biomass co-firing has become a fairly common practice in the Polish power generation system and many existing boilers have been modernized to serve this purpose. This paper presents calculations of the coefficient of thermal efficiency of the boiler heating surfaces and of the time needed for complete reconstruction of deposits on the second-stage steam reheater(RHII) of an OP-380 boiler with the output of 380×10~3 kg/h. The boiler was equipped with a purpose-designed installation of direct feeding of biomass. The main co-fired fuels were wood and sunflower husk pellets. Intense formation of deposits on the steam reheater tubes and problems related to a reduction in the diameters of the tubes were identified during the power unit operation.

关键词： biomass co-combustion ash deposit coefficient of thermal efficiency

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