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Post-fontan circulation hepatocellular carcinoma:Open and laparoscopic hepatectomy

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Hepatobiliary & Pancreatic Diseases International 2024年第1期23卷 90-93页

作者： karin KY Ho Wong Hoi She Simon HY Tsang Kevin S Lo Tan To Cheung Department of Surgery The University of Hong Kong102 Pok Fu Lam RoadHong KongChina Department of Anaesthesiology Queen Mary Hospital102 Pok Fu Lam RoadHong KongChina

To the Editor:Fontan-associated liver disease shows increasing incidence as advances in pediatric cardiology have prolonged life expectancy in patients with single ventricle congenital heart defects[1].Their unique physiology and procedure-related sequelae present an increasingly relevant challenge in hepatic *** hereby reported a series of patients suffering from hepatocellular carcinoma(HCC)who successfully underwent open and laparoscopic hepatectomy.

关键词： hepatocellular hepatectomy surgery

Participation of CD45,NKR-P1A and ANK61 antigen in rat hepatic NK cell(pit cell)-mediated target cell cytotoxicity

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World Journal of Gastroenterology 2000年第4期6卷 546-552页

作者： David Vermiilen Bülent Ahishali Vasilis Triantis karin Vanderkerken Peter J. K.Kuppen Eddie Wisse Laboratory for Cell Biology and Histology. Department of Hematology and immunology Free University of Brussels(VUB)Brussels-JetteBelgium K Vanderkerken is a postdoctoral researcher of the Fund for Scientific Research Flanders. Department of Surgery and Pathology Leiden University Medical CenterLeidenThe Netherlands

AIM Several triggering receptors have beendescribed to be involved in natural killer（NK）cell-mediated target *** these studies,NKcells derived from blood or spleen were *** are liver-specific NK cells that possess ahigher level of natural cytotoxicity and a differentmorphology when compared to blood NK *** aim of this study was to characterize the roleof the NK-triggering molecules NKR-P1A,ANK61antigen,and CD45 in pit cell-mediated killing oftarget *** 51Cr-release and DNA fragmentationwere used to quantify target cell lysis andapoptosis,*** Flow cytometric analysis showed thatpit cells expressed CD45,NKR-P1A,and *** of pit cells with monoclonalantibody（mAb）to CD45（ANK74）not onlyinhibited CC531s or YAC-1 target lysis but alsoapoptosis induced by pit *** mAbs to NKR-P1A（3.2.3）and ANK61 antigen（ANK61）had no effect on pit cell-mediated CC531s or YAC-1 targetcytolysis or apoptosis,while they did increase theFcγ receptor positive（FcγR+）P815 cytolysis *** enhanced cytotoxicity could beinhibited by 3,4-dichloroisocoumarin,an inhibitorof *** These results indicate that CD45participates in pit cell-mediated CC531s and YAC-1target cytolysis and ***-P1A andANK61 antigen on pit cells function as activationstructures against FcγR+ P815 cells,which wasmediated by the perforin/granzyme pathway.

关键词： hepatic NK cells pit cells cytolysis apoptosis perforin/granzyme pathway

Arbuscular mycorrhizal fungal colonization of Glycyrrhiza glabra roots enhances plant biomass,phosphorus uptake and concentration of root secondary metabolites

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Journal of Arid Land 2014年第2期6卷 186-194页

作者： HongLing LIU Yong TAN Monika NELL karin ZITTER-EGLSEER Chris WAWSCRAH Brigitte KOPP ShaoMing WANG Johannes NOVAK Normal College Shihezi University Institute of Applied Botany University of Veterinary Medicine College of Pharmacy Shihezi University College of Life Sciences Shihezi University

Arbuscular mycorrhizal （AM） fungi penetrate the cortical cells of the roots of vascular plants, and are widely distributed in soil. The formation of these symbiotic bodies accelerates the absorption and utilization of min- eral elements, enhances plant resistance to stress, boosts the growth of plants, and increases the survival rate of transplanted seedlings. We studied the effects of various arbuscular mycorrhizae fungi on the growth and devel- opment of licorice （Glycyrrhiza glabra）. Several species of AM, such as Glomus mosseae, Glomus intraradices, and a mixture of fungi （G. mosseae, G intraradices, G. cladoideum, G microagregatum, G caledonium and G. etunica- tum） were used in our study. Licorice growth rates were determined by measuring the colonization rate of the plants by the fungi, plant dry biomass, phosphorus concentration and concentration of secondary metabolites. We estab- lished two cloned strains of licorice, clone 3 （C3） and clone 6 （C6） to exclude the effect of genotypic variations. Our results showed that the AM fungi could in fact increase the leaf and root biomass, as well as the phosphorus con- centration in each clone. Furthermore, AM fungi significantly increased the yield of certain secondary metabolites in clone 3. Our study clearly demonstrated that AM fungi play an important role in the enhancement of growth and development of licorice plants. There was also a significant improvement in the secondary metabolite content and yield of medicinal compounds from the roots.

关键词： licorice arbuscular mycorrhizal fungi phosphorus medical compounds

Joint association of physical activity/screen time and diet on CVD risk factors in 10-year-old children

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Frontiers of Medicine 2012年第4期6卷 428-435页

作者： Clemens Drenowatz Joseph J.Carlson karin A.Pfeiffer Joey C.Eisenmann Department of Kinesiology Michigan State UniversityEast LansingMI 48824USA Department of Radiology Division of Sports and Cardiovascular NutritionMichigan State UniversityEast LansingMI 48824USA

The increasing prevalence of childhood overweight and obesity has been associated with an increased risk for cardiovascular disease(CVD).While several studies examined the effect of single behaviors such as physical activity(PA),sedentary behavior or diet on CVD risk,there is a lack of research on combined associations,specifically in ***,the purpose of this study was to examine the joint association of PA or screen time(ST)and diet on CVD risk factors in ***,STand diet were assessed via questionnaire in 210 fifth grade students(age:10.6±0.4 years).The healthy eating index(HEI)was subsequently calculated as indicator for diet ***,weight,% body fat,and resting blood pressure were measured according to standard procedures and blood samples obtained via fingerprick were assayed for blood *** cholesterol HDL ratio(TC:HDL),mean arterial pressure(MAP),and % body fat were used as indicators of CVD risk.55% of children did not meet current PA recommendations on at least 5 days/week and 70% exceeded current recommendations for ***,only 2.5% possessed a“good”diet(HEI>80).There was no significant association of PA or STand diet on CVD risk *** TC:HDL,MAP,and % body fat nor the total CVD risk score was significantly correlated with diet,PA,or *** in the high PA group,however,had significantly better diet *** the fact that self-reported PA,ST,or dietary intake were not directly related to CVD risk in this sample,higher activity levels were associated with a healthier diet and lower ST indicating an overall healthier lifestyle of this subgroup.

关键词： exercise sedentary behavior metabolic syndrome health behavior adolescents TV time healthy eating index

A single synonymous mutation determines the phosphorylation and stability of the nascent protein

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Journal of Molecular Cell Biology 2019年第3期11卷 187-199页

作者： Konstantinos Karakostis Sivakumar Vadivel Gnanasundram Ignacio Lopez Aikaterini Thermou Lixiao Wang karin Nylander Vanesa Ollvares-Iliana Robin Fahraeus Equipe Labellisee Ligue Contre le Cancer Universite Paris 7INSERM UMR 116227 Rue Juliette DoduParis 75010France Department of Medical Biosciences Umea UniversityUmea SE-90185Sweden Instituto de Ffsica Universidad Autonoma de San Luis Potosi78290 SLPMexico RECAMO Masaryk Memorial Cancer InstituteZluty kopec 7Brno 656 53Czech Republic

p53 is an intrinsically disordered protein with a large number of post-translational modifications and interacting *** hierarchical order and subcellular location of these events are still poorly *** activation of p53 during the DNA damage response(DDR)requires a switch in the activity of the E3 ubiquitin ligase MDM2 from a negative to a positive regulator of *** is mediated by the ATM kinase that regulates the binding of MDM2 to the p53 mRNA facilitating an increase in p53 *** we show that the binding of MDM2 to the p53 mRNA brings ATM to the p53 polysome where it phosphorylates the nascent p53 at serine 15 and prevents MDM2-mediated degradation of p53.A single synonymous mutation in p53 codon 22(L22L)prevents the phosphorylation of the nascent p53 protein and the stabilization of p53 following genotoxic *** ATM trafficking from the nucleus to the p53 polysome is mediated by MDM2,which requires its interaction with the ribosomal proteins RPL5 and *** results show how the ATM kinase phosphorylates the p53 protein while it is bang synthesized and offer a novel mechanism whereby a single synonymous mutation controls the stability and activity of the encoded protein.

关键词： synonymous mutations intrinsically disordered proteins cell signaling MDM2 p53 messenger RNA ATM kinase

In the Darkest Night-Swedish Saint Lucia

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时代教育 2005年第2期 73-74页

作者： karin Widengren

***,Midwinter,***-***-merandMidwinter,theVikingsheldfestivalsinhonorofthegodstheybelievedruledtheworld.

关键词： In the Darkest Night-Swedish Saint Lucia

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基于便携式坐标测量机的大齿轮测量方法

光学精密工程 2013年第7期21卷 1763-1770页

作者：林虎 Frank Hrtig karin Kniel 石照耀北京工业大学机械工程与应用电子技术学院 Physikalisch-Technische Bundesanstalt Braunschweig und Berlin 38116 BraunschweigGermany

针对目前便携式坐标测量机测量大齿轮的采样策略和评定算法存在的不足,设计了两种特殊的辅助标尺-渐开线标尺及螺旋线标尺。利用设计的两种标尺在大齿轮齿面上对齿廓及螺旋线的测量点进行标注,开展了齿轮的在位重复性测量的实验研究。... 详细信息

针对目前便携式坐标测量机测量大齿轮的采样策略和评定算法存在的不足,设计了两种特殊的辅助标尺-渐开线标尺及螺旋线标尺。利用设计的两种标尺在大齿轮齿面上对齿廓及螺旋线的测量点进行标注,开展了齿轮的在位重复性测量的实验研究。利用关节臂坐标测量机及激光跟踪仪测量系统在德国计量研究院研制的1m外径齿轮样板上开展了测量实验,采用INVOLUTE Pro对采样数据点进行评定,给出了测量结果及测量不确定度。测量实验表明,基于新的齿轮测量方法,关节臂坐标测量机比激光跟踪仪测量系统测量结果更为精确,测试结果与标定值最大相差8.16μm。实验结果验证了提出方法的有效性,为便携式坐标测量机在大齿轮测量领域的应用提供了依据。

关键词：大齿轮测量便携式坐标测量机大齿轮样板

Experience and Challenge of European Medicines Registration in China

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World Journal of Integrated Traditional and Western Medicine 2019年第3期5卷 52-54页

作者： karin Schleisiek Global Strategy and Business Development Division Dr. Willmar Schwabe GmbH & Co. KG

Thanks for the introduction. Good afternoon, ladies and gentleman and chairman. I would like to give you such a presentation of challenges, experiences of herbal medicine registration in China. My experiences are based on herbal medicines. I am responsible for the maintenance of herbal medicinal products. Additionally I am responsible for international regulatory framework. Also I have worked for other companies for 15 years. Working in an international environment means there are big and small challenges in our daily life. So do regulators and CPA.

关键词： European Medicines Registration China introduction

Distribution of Bacteria Injected in Body of Giant Black Shrimp, Penaeus Monodon

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Chinese Journal of Oceanology and Limnology 2004年第2期22卷 186-191页

作者：郭志勋 karin van de Braak Magriet Botterbloom South China Sea Fisheries Research Institute Guangzhou 510300China Wageningen Agricultural University Netherlands

Distribution of injected Vibrio anguillarum in body of Penaeus monodon was studied with immunohistochemical method. Bacteria could be detected throughout the experiment in some individuals; however in lymphoid tissue, gill, heart and haemolymph of all vibrio injected shrimp, the bacteria could be observed only 5 min after injection. The bacteria density in haemolymph, haemolymph of the hepatopancreas and gills decreased with time. In the lymphoid organ and heart, the bacteria density was the highest 48 h after injection, then decreased. Nodules could be formed in the heart, lymphoid organ and injection site.

关键词： Vibrio anguillarum Penaeus monodon lymphoid tissue haemolymph