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Efficacy of interferon alpha-2b and lamivudine therapy for chronic hepatitis B in children

中华医学杂志(英文版) 2003年第4期 114-117页

作者： Bahar Arif,Iscan Selim,karademir ferhan,Gocmen Ismail Department of Pediatrics GMMA Haydarpaa Training Hospital Kadiky Department of Pediatrics GMMA Haydarpaa Training Hospital Kadiky Department of Pediatrics GMMA Haydarpaa Training Hospital Kadiky Department of Pediatrics GMMA Haydarpaa Training Hospital Kadiky Istanbul 81327 Turkey Istanbul 81327 Turkey Istanbul 81327 Turkey Istanbul 81327 Turkey

To evaluate the efficacy of interferon (IFN) alpha-2b and lamivudine therapy in children with chronic hepatitis B virus (HBV) infection Method Ten children who developed chronic hepatitis B infection received IFN alpha-2b 10 million international units (IU)/m 2 body surface area, subcutaneously three times a week for six months IFN+lamivudine therapy began to be used in the cases who were unresponsive to IFN treatment Results Among 27 HBsAg (+) subjects in this study, interferon treatment was given to 11 subjects who developed chronic hepatitis One case was excluded from the study due to detection of Herpes type 1 encephalitis At the end of six months of follow-up, complete response was obtained in three (30%) patients and partial response in four (40%) patients, whereas no response was detected in three (30%) patients Fifty percent of the cases experienced serological response, 70% biochemical response, and all (100%) had histological response In three cases started concomitant IFN+lamivudine therapy, HBV-DNA became negative at the second month of treatment Conclusions IFN-alpha and lamivudine can be used for the treatment of chronic hepatitis B infection in children

关键词： Hepatitis B · interferon · children · hepati tis B virus · lamivudine

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Efficacy of interferon alpha-2b and lamivudine therapy for chronic hepatitis B in children

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Chinese Medical Journal 2003年第4期116卷 593-596页

作者： Bahar Arif Iscan Selim karademir ferhan Gocmen Ismail Department of Pediatrics GMMA Haydarpaa Training HospitalKadikyDepartment of PediatricsGMMA Haydarpaa Training HospitalKadikyDepartment of PediatricsGMMA Haydarpaa Training HospitalKadikyDepartment of PediatricsGMMA Haydarpaa Training HospitalKadiky Istanbul 81327TurkeyIstanbul 81327TurkeyIstanbul 81327TurkeyIstanbul 81327Turkey

关键词： Hepatitis B interferon children hepati tis B virus lamivudine

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