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Stretching Induces the Rearrangement of the Periodontal Ligament Cells without Altering the Orientation of Oxytalan Fibers Relative to the Cell Axis in Vitro

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Open Journal of Stomatology 2016年第12期6卷 252-260页

作者： Sachio Tamaoki Kazuki Nakashima Yoshinori Yamauchi kaori yamanouchi Takahiro Fujita Eichi Tsuruga Hiroyuki Ishikawa Section of Orthodontics Department of Oral Growth & Development Division of Clinical Dentistry Fukuoka Dental College Fukuo-ka Japan Department of Radiation Science Graduate School of Health Sciences Hirosaki University Hirosaki Japan Fukuoka Dental College Fukuoka Japan

The periodontal ligament (PDL) contains oxytalan fibers as well as collagen fibers, which helps it to withstand the mechanical stress to which it is constantly exposed. The oxytalan fibers are produced by PDL fibroblasts. However, the arrangement of PDL fibroblasts and the orientation of oxytalan fibers relative to the fibroblast cell axis have not been investigated under the condition of mechanical stress. We hypothesized that such stress would alter the arrangement and orientation of these cells and their oxytalan fibers. The aim of this study was to evaluate the effects of stretching strain on PDL fibroblasts, focusing on the cellular arrangement and orientation of oxytalan fibers relative to the long cell axis in cell/matrix layers by staining the major component of the fibers, fibrillin-1. The angle between the long cell axis and the oxytalan fibers was approximately 70 degrees under both non-stretching and stretching conditions. Moreover, stretching induced the rearrangement of the cells. This is the first study to demonstrate that stretching induces the rearrangement of the PDL fibroblasts without altering the angle between the long cell axis and the oxytalan fibers. These results may reflect the orientation of oxytalan fibers in the PDL under the condition of mechanical stress.

关键词： Oxytalan Fibers Mechanical Stress Fibrillin Microfibrils Periodontal Ligament

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A novel approach in preventing vascular leakage and angiogenesis in wet age-related macular degeneration

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Neural Regeneration Research 2022年第8期17卷 1751-1752页

作者： kaori H.Yamada Department of Pharmacology and Regenerative Medicine Department of Ophthalmology and Visual SciencesUniversity of Illinois College of MedicineChicagoILUSA

Vascular leakage and angiogenesis in diseases:The vascular system carries blood throughout the body to supply oxygen and nutrients to tissues and remove waste from *** of the vascular system worsens many *** this perspective,vascular function in blinding eye diseases,current therapies,and our developing approach will be *** blood vessels are composed of the monolayer of the endothelial cells,and the outer layer made by pericytes and smooth muscle cells provide structural support and shape to the *** monolayers function as a *** barrier function of endothelial monolayers controls plasma protein uptake and the infiltration of immune cells by regulating adherence of cell-cell *** leakage causes unwanted plasma leak,accumulation of immune cells,and tissue inflammation.

关键词： degeneration approach remove

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Toll-like receptor 9 gene mutations and polymorphisms in Japanese ulcerative colitis patients

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World Journal of Gastroenterology 2010年第46期16卷 5815-5821页

作者： kaori Fuse Kyoko Katakura Natsumi Sakamoto Hiromasa Ohira Department of Gastroenterology and Rheumatology School of MedicineFukushima Medical University

Abnormal innate immune responses toward luminal bacteria play an important role in the pathogenesis of inflammatory bowel *** has been demonstrated that bacteria having CpG DNA ameliorate experimental colitis in mice,and Toll-like receptor 9 (TLR9) signaling mediates the anti-inflammatory effects in mouse colonic inflammation.A gene variation in NOD2/CARD15 has been reported in Crohn's disease (CD) patients in Western countries,but this variation has not been identified in Japanese CD ***,we hypothesized that TLR9 is a key factor in the development of ulcerative colitis (UC),and we investigated gene mutations and polymorphisms of TLR9 in Japanese UC *** single nucleotide polymorphisms (SNPs) in TLR9 were identified in healthy controls,and were assessed in 48 UC patients and 47 healthy *** subjects were matched for age,sex and date of blood sampling from among a subgroup of *** found that TLR9-1486CC,1174GG and 2848AA increase the risk of UC [odds ratio (OR) 2.64,95% confidence interval (95% CI):1.73-6.53,P=0.042],and TLR9-1486TT,1174AA and 2848GG decrease the risk of UC (OR 0.30,95% CI:0.10-0.94,P=0.039),although there were no correlations between SNPs and disease phenotype or TLR9 mRNA *** findings suggest that TLR9 polymorphisms are associated with increased susceptibility to UC.

关键词： Toll-like receptor 9 Single nucleotide polymorphism Ulcerative colitis Inflammatory bowel disease Innate immunity

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Meningoencephalitis due to Listeria monocytogenes in a Young Immunocompetent Patient: Case Report with Literature Review

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Advances in Infectious Diseases 2024年第1期14卷 213-219页

作者： Janette Alejandra Gamiño Gutierrez Gustavo Adolfo Hernández Valdez Arleth Anahí Montaño Gómez Jorge Morales Rojas Graciela Gaddy Robles Martinez Anahi Herrera Ruelas Alin kaori Ferreyra Gudiño Jocelin Celeste Jurado Cardona Jimena Jexabeth Ibáñez Núñez Anahí Fierros Ramos Departmento de Neurocirugia Hospital Civil de Guadalajara Fray Antonio Alcalde Guadalajara México Departamento de Medicina Interna ISSSTE Tepic General Hospital APP Tepic México

Meningoencephalitis secondary to Listeria monocytogenes (L. monocytogenes) mainly affects newborns, the elderly and immunocompromised people;there are extremely rare cases in which said infection occurs in immunocompetent individuals. We present the case of a young adult patient without immunocompromise, who developed meningoencephalitis due to L. monocytogenes;This case is exceptional, since it occurred in an individual outside the classic age group, in addition to not having risk factors, which is why it should be considered an atypical causal agent.

关键词： Meningitis Encephalitis Rhombencephalitis Listeria monocytogenes Immunocompetent

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Dirac reduction of binary asteroid systems with symmetry and stability of relative equilibria

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Theoretical & Applied Mechanics Letters 2013年第1期3卷 81-88页

作者： kaori Onozaki Hiroaki Yoshimura Major in Applied Mechanics Graduate School of Fundamental Science and Engineering Waseda University Department of Applied Mechanics and Aerospace Engineering Waseda University

In this paper, we study symmetry reduction for a binary asteroid system modeled by a rigid body and a particle. In particular, we demonstrate how translational and rotational symmetry reduction appeared in the binary asteroid system can be carried out in the context of Dirac reduction by stages and with the associated reduction of implicit Hamiltonian systems. Then we investigate Stability of relative equilibria of the asteroid pair and show stability regions by using the energy-momentum method. Lastly, we illustrate some numerical simulations for stable and unstable orbits near from relative equilibria of the Collinear and T configurations.C 2013 The Chinese Society of Theoretical and Applied Mechanics. [doi：10.1063/2.1301311]

关键词： binary asteroid dirac reduction stability

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Simultaneously disrupting AtPrx2,AtPrx25 and AtPrx71 alters lignin content and structure in Arabidopsis stem

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Journal of Integrative Plant Biology 2015年第4期57卷 349-356页

作者： Jun Shigeto Yoshitaka Itoh Sakie Hirao kaori Ohira Koki Fujita Yuji Tsutsumi Faculty of Agriculture Kyushu University

Plant class III heme peroxidases catalyze lignin polymerization. Previous reports have shown that at least three Arabidopsis thaliana peroxidases, AtPrx2, AtPrx25 and AtPrx71, are involved in stem lignification using T-D NA insertion mutants, atprx2, atprx25, and atprx71. Here, we generated three double mutants, atprx2/atprx25, atprx2/atprx71, and atprx25/atprx71, and investigated the impact of the simultaneous deficiency of these peroxidases on lignins and plant growth. Stem tissue analysis using the acetyl bromide method and derivatization followed by reductive cleavage revealed improved lignin characteristics, such as lowered lignin content and increased arylglycerol-β-aryl （β-O-4） linkage type, especially β-O-4 linked syringyl units, in lignin, supporting the roles of these genes in lignin polymerization. In addition, none of the double mutants oexhibited severe growth defects, such as shorter plant stature, dwarfing, or sterility, and their stems had improved ceil wall degradability. This study will contribute to progress in lignin bioengineering to improve iignocellulosic biomass.

关键词： Arabidopsis knockout mutant lignin biosynthesis plantperoxidase

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Comparison of imo and Humphrey field analyzer perimeters in glaucomatous eyes

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International Journal of Ophthalmology(English edition) 2021年第12期14卷 1882-1887页

作者： Yoshinori Nakai Kyoko Bessho Yuko Shono kaori Taoka Yoshihide Nakai Tokai Eye Clinic 399-Hadokoro-choTsu 514-0009Japan

AIM:To compare the imo perimeter,a new portable head-mounted perimeter unit that enables both eyes to be examined quickly and simultaneously,with the Humphrey field analyzer(HFA)perimeter to investigate correlations and their diagnostic ability in glaucomatous ***:The performance of the equipment in 128 glaucomatous eyes and 40 normal eyes were *** investigated the correlations of mean deviation,pattern standard deviation,visual field index,and the ***:Measurements of mean deviation(r=0.886,P<0.001),pattern standard deviation(r=0.814,P<0.001),and visual field index(r=0.871,P<0.001)in both perimeters were strongly and positively *** sensitivities in the imo perimeter were 80.5%for mean deviation,81.2%for pattern standard deviation,and 80.5%in visual field index;those in the HFA were 63.3%for mean deviation,74.5%for pattern standard deviation,and 80.5%for visual field *** perimeters demonstrated high diagnostic ***:The parameters by the imo and HFA in glaucomatous eyes show strong positive correlations with favorable sensitivity,specificity,and diagnostic ***,the difference between imo and HFA results increases with the increase in visual field disturbance.

关键词： imo perimeter visual field diagnosis diagnostic validation

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Transcriptional regulation of human polo-like kinases and early mitotic inhibitors

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Journal of Genetics and Genomics 2008年第4期35卷 215-224页

作者： Moe Tategu Hiroki Nakagawa kaori Sasaki Rieko Yamauchi Sota Sekimachi Yuka Suita Naoko Watanabe Kenichi Yoshida Department of Life Sciences Meiji University School of Agriculture 1-1-1 Higashimita Tama-ku Kawasaki Kanagawa 214-8571 Japan

Human polo-like kinases （PLK1-PLK4） have been implicated in mitotic regulation and carcinogenesis. PLK1 phosphorylates early mitotic inhibitor 1 （Emil） to ensure mitosis entry, whereas Emi2 plays a key role during the meiotic cell cycle. Transcription factor E2F is primarily considered to regulate the G1/S transition of the cell cycle but its involvement in the regulation of mitosis has also been recently suggested. A gap still exists between the molecular basis of E2F and mitotic regulation. The present study was designed to characterize the transcriptional regulation of human PLK and Emi genes. Adenoviral overexpression of E2F1 increased PLK1 and PLK3 mRNA levels in A549 cells. A reporter gene assay revealed that the putative promoter regions of PLK1, PLK3, and PLK4 genes were responsive to activators E2F, E2F1-E2F3. We further characterized the putative promoter regions of Emil and Emi2 genes, and these could be regulated by activators E2F and E2F1-E2F4, respectively. Finally, PLK1-PLK4, Emil, and Emi2 mRNA expression levels in human adult, fetal tissues, and several cell lines indicated that each gene has a unique expression pattern but is uniquely expressed in common tissues and cells such as the testes and thymus. Collectively, these results indicate that E2F can integrate G1/S and G2/M to oscillate the cell cycle by regulating mitotic genes PLK and Emi, leading to determination of the cell fate.

关键词： polo-like kinase early mitotic inhibitor cell cycle E2F promoter gene regulation

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Family empowerment and associated factors in Japanese families raising a child with severe motor and intellectual disabilities

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International Journal of Nursing Sciences 2018年第4期5卷 370-376页

作者： Rie Wakimizu Hiroshi Fujioka kaori Nishigaki Akemi Matsuzawa Department of Child Healthcare Nursing Division of Health Innovation and NursingFaculty of MedicineUniversity of TsukubaIbarakiJapan Department of Nursing Faculty of Health SciencesIbaraki Prefectural University of Health SciencesIbarakiJapan Department of Child Health Nursing Graduate School of Nursing SciencesSt.Luke's International UniversityTokyoJapan Department of Nursing Ibaraki Christian UniversityIbarakiJapan

Objectives:Family caregivers raising children with severe motor and intellectual disabilities(SMID)experience the enormous burden of *** concept of family empowerment is one of the important assessment indexes of family nursing from the perspective of providing comprehensive support for these *** objective of this study was to identify the factors associated with the empowerment of families raising a child with SMID in ***:We conducted a nationwide questionnaire survey involving 1659 primary caregivers raising a child with SMID through 89 special *** assessed the main outcomes using the Family Empowerment Scale(FES).We then conducted a multiple linear regression analysis to reveal the factors associated with family ***:In total,1362 primary caregivers were included in our *** results show that factors contributing to high FES scores are higher age of the primary caregiver,higher education,greater recognition of regional support,lower childcare burden,higher utilization of home visit services,higher usage of a childcare institution,higher household income,and stronger family ***:Healthcare professionals should carefully assess the state of family empowerment of the primary caregivers who are younger and those who have low education,low household income,high childcare burden,and fragile bonding with the ***,they should encourage such families to use regional support resources for *** is,policy makers should consider ways to promote home visits and institutional services for the care of children with SMID,aiming especially for the provision of well-coordinated care and services.

关键词： Caregivers Child care Disabled children Family empowerment Home nursing Intellectual disability Japan Social supports

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Response of Rice to Insect Elicitors and the Role of OsJAR1 in Wound and Herbivory-Induced JA-lle Accumulation

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Journal of Integrative Plant Biology 2013年第8期55卷 775-784页

作者： kaori Fukumoto Kabir Md Alamgir Yuko Yamashita Izumi C.Mori Hideyuki Matsuura Ivan Galis Institute of Plant Science and Resources Okayama University Division of Applied Bioscience Research Faculty of AgricultureHokkaido University

Plants produce jasmonic acid （JA） and its amino acid conjugate, jasmonoyI-L-isoleucine （JA-Ile） as major defense signals in response to wounding and herbivory. In rice （Oryza sativa）, JA and JA-Ile rapidly increased after mechanical damage, and this increase was further amplified when the wounds were treated with oral secretions from generalist herbivore larvae, lawn armyworms （Spodoptera mauritia）, revealing for the first time active perception mechanisms of herbivore-associated elicitor（s） in rice. In the rice genome, two OsJAR genes can conjugate JA and lie and form JA-Ile in vitro; however, their function in herbivory- induced accumulation of JA-Ile has not been investigated. By functional characterization of TOS17 retrotransposon-tagged Osjarl plants and their response to simulated herbivory, we show that OsJAR1 is essential for JA-Ile production in herbivore-attacked, field-grown plants. In addition, OsJAR1 was required for normal seed development in rice under field conditions. Our results suggest that OsJAR1 possesses at least two major functions in rice defense and development that cannot be complemented by the additional OsJAR2 gene function, although this gene previously showed overlapping enzyme activity in vitro.

关键词： JAR enzyme jasmonate signaling jasmonic acid jasmonoyl-L-isoleucine rice Oryza sativa.

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