A novel approach in preventing vascular leakage and angiogenesis in wet age-related macular degeneration

作     者：Kaori H.Yamada Kaori H.Yamada

作者机构：Department of Pharmacology and Regenerative MedicineDepartment of Ophthalmology and Visual SciencesUniversity of Illinois College of MedicineChicagoILUSA 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2022年第17卷第8期

页      面：1751-1752页

核心收录：

学科分类：1002[医学-临床医学] 100212[医学-眼科学] 10[医学] 

基　　金：supported by NIH 1R01EY029339-01A1(to KHY) 

主　　题：degeneration approach remove 

摘      要：Vascular leakage and angiogenesis in diseases:The vascular system carries blood throughout the body to supply oxygen and nutrients to tissues and remove waste from *** of the vascular system worsens many *** this perspective,vascular function in blinding eye diseases,current therapies,and our developing approach will be *** blood vessels are composed of the monolayer of the endothelial cells,and the outer layer made by pericytes and smooth muscle cells provide structural support and shape to the *** monolayers function as a *** barrier function of endothelial monolayers controls plasma protein uptake and the infiltration of immune cells by regulating adherence of cell-cell *** leakage causes unwanted plasma leak,accumulation of immune cells,and tissue inflammation.