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World Journal of Clinical Cases 2021年第13期9卷 3147-3156页

作者： Qian-Dong Yang Mi-Duo Mu Xu Tao kang-lai Tang Sports Medicine Center The First Affiliated Hospital of Army Medical UniversityChongqing 400038China

BACKGROUND Giant cell tumors(GCT)are most commonly seen in the distal *** tumors are uncommon in the small bones of the hand and feet,and a very few cases have been reported.A giant cell tumor of the talus is rarely seen clinically and could be a challenge to *** SUMMARY We report a rare case of GCT of the talus in one patient who underwent a new reconstructive surgery technique using a three-dimensional(3D)printing talar *** prosthesis shape was designed by tomographic image processing and segmentation using technology to match the intact side by mirror symmetry with 3D post-processing *** patient recovered nearly full range of motion of the ankle after 6 *** visual analogue scale and American Orthopaedic Foot and Ankle Society scores were 1 and 89 points,*** We demonstrated that 3D printing of a talar prosthesis is a beneficial option for GCT of the talus.

关键词： Three-dimensional printing technology Giant cell tumor Talar prosthesis Case report

Synthesis and Biological Evaluation of Novel Uracil and 5-Fluorouracil-l-yl Acetic Acid-Colchicine Conjugate

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Chemical Research in Chinese Universities 2015年第3期31卷 367-371页

作者： SHEN Lihong HU Junping WANG Haixian WANG Aibing lai Yisheng kang Yanhui Handan Key Laboratory of Organic Small Molecule Materials Handan College Handan 056005 P. R. China Center of Drug Discovery China Pharmaceutical University Nanjing 210009 P. R. China Medical College of Hebei University of Engineering Handan 056002 P. R. China

A series of novel uracil and 5-fluorouracil-l-yl-acetic acid-colchicine derivatives（6a--6n） was synthe- sized via coupling and 5-fluorouracil（5-FU） with C-10 analogues of colchicine. The antitumor activities of the target compounds against human hepatocellular earcinoma（BEL7402） cells, human ovary carcinoma（A2780） cells, human lung adenocarcinoma（A549） cells and human breast carcinoma（MCF7） cells were tested in vitro, and the structure-activity relationship（SAR） of the compounds was also studied. The bioassay results demonstrate that most of the tested compounds display significant activity and particularly, compounds 6a, 6e, 6h and 61 show more potent cytotoxic activities than 5-fluorouracil and colchicine. The results show that the new derivatives of colchicine are potential suppressors on human cancer.

关键词： Colchicine Uracil 5-Fluorouraeil Antitumor activity

More than softer-when-brighter: The X-ray powerlaw spectral variability in NGC 4051

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Science China(Physics,Mechanics & Astronomy) 2020年第12期63卷 102-112页

作者： Yun-Jing Wu Jun-Xian Wang Zhen-Yi Cai Jia-lai kang Teng Liu Zheng Cai CAS Key Laboratory for Research in Galaxies and Cosmology Department of AstronomyUniversity of Science and Technology of ChinaHefei 230026China School of Astronomy and Space Science University of Science and Technology of ChinaHefei 230026China Department of Astronomy Tsinghua UniversityBeijing 100084China Max-Planck-Institut für Extraterrestrische Physik Garching bei Munchen D-85748Germany

The powerlaw X-ray spectra of active galactic nuclei at moderate to high accretion rates normally appear softer when they brighten,for which the underlying mechanisms are yet *** XMM-Newton observations and excluding photonslain the observed spectral variabilities,and intervals deviated from the empirical relation are clearly visible in the light curve of 2-4 ke V/4-10 keV count rate *** deviations are seen not only between but also within individual XMM-Newton exposures,consistent with random variations of the corona geometry or inner structure(with timescales as short as^1 ks),in addition to those behind the smooth"softer-when-brighter"*** further find the"softer-when-brighter"trend gradually weakens with the decreasing timescale(from^100 ks down to 0.5 ks).These findings indicate that the powerlaw spectral slope is not solely determined by its *** propose a two-tier geometry,including flares/nano-flares on top of the inner disc and an embedding extended corona(heated by the flares,in analogy to solar corona)to explain the observations together with other observational clues in *** spectral variabilities could be due to individual flares/nano-flares,while slow ones are driven by the variations in the global activity of inner disc region(akin to the variation of solar activity,but not the accretion rate)accompanied with heating/cooling and inflation/contraction of the extended corona.

关键词： active galaxies X-ray Seyfert galaxies

Fact-condition statements and super relation extraction for geothermic knowledge graphs construction

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Geoscience Frontiers 2023年第5期14卷 384-395页

作者： Qizhi Chen Hong Yao Shengwen Li Xinchuan Li Xiaojun kang Wenwen lai Jian Kuang School of Computer Science China University of GeosciencesWuhan 430074China State Key Laboratory of Biogeology and Environmental Geology China University of GeosciencesWuhan 430074China School of Geography and Information Engineering China University of GeosciencesWuhan 430074China

Researchers utilize information from the geoscience literature to deduce the regional or global geological *** this process has relied on the labor of *** the number of papers continues to increase,acquiring domain-specific knowledge becomes a heavy *** Graph(KG)is proposed as a new knowledge representation technology to change this ***,the super relation is not considered in the previous KG,which bridges the geological phenomenon(fact)and its precondition(condition).For instance,in the statement(“the late Archean was a crucial transition period in the history of global geodynamics”),the condition statement(“crucial transition for global geodynamics”)works as the complementary fact statement(“the late Archean was a crucial transition period”),which defines the scale of crucial transition accurately in the late *** this study,fact-condition statement extraction is introduced to construct a geological knowledge graph.A rule-based multi-input multi-output model(R-MIMO)is proposed for information *** the R-MIMO,fact-condition statements and their super relation are considered and extracted for the first *** verify its performances,a GeothCF dataset with 1455 fact tuples and 789 condition tuples is *** experiments,the R-MIMO model achieves the best performance by using BERT as encoder and LSTM-d as decoder,achieving F180.24%in tuple extraction and F170.03%in tag prediction ***,the geothermic KG with super relation is automatically constructed for the first time by trained R-MIMO,which can provide structured data for further geothermic research.

关键词： Fact-condition statements Super relation Knowledge graph Rule-based multi-input multi-output model

Study of crust-mantle transitional zone along the northeast margin of Qinghai-Xizang plateau

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Acta Seismologica Sinica(English Edition) 2004年第2期17卷 144-151页

作者： lai Xiao-ling(赖晓玲) ZHANG Xian-kang(张先康) FANG Sheng-ming(方盛明) Geophysical Exploration Center China Earthquake Administration Zhengzhou 450002 China Geophysical Exploration Center China Earthquake Administration Zhengzhou 450002 China Geophysical Exploration Center China Earthquake Administration Zhengzhou 450002 China

This study deals with complexity, frequency spectrum and velocity model of the crust-mantle transitional zone in different tectonic units along the northeast margin of Qinghai-Xizang plateau, based on PmP waveform data from two deep seismic sounding profiles passing through the area. It reveals that Moho has stable tectonic features in Ordos and Lingzhong basins, where crust and mantle are coupled as first-order discontinuity. Moho shows obvious signs of activity in Haiyuan seismic region and in the contact zone between Bayanhar block and Qaidam block. Crust and mantle in these two areas are coupled as complicated crust-mantle transitional zone consisting of multiple laminae with alternate high and low velocities, totaling 20 km in thickness. The difference between Moho of different tectonic units reflects heterogeneity of the coupled crust-mantle zone; the difference between fine structures of Haiyuan seismic region and Maqin fault zone reflects different deep material composition of the two continent-continent collision zones and the interaction between blocks.

关键词： crust-mantle transitional zone tectonic units Haiyuan seismic region Maqin fault zone

Comparisons of Condylar Movements with the Functional Occlusal Clutch and Tray Clutch Recording Methods in CADIAX~ system

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International Journal of Oral Science 2010年第4期2卷 208-214页

作者： Bi-jie Han Hong kang lai-kui Liu Xin-zhu Yi Xiao-qing Li Department of Oral Anatomy and Physiology West China College of Stomatology Sichuan University Chengdu China Institute of Stomatology Lanzhou University Lanzhou China College of Stomatology Nanjing Medical Science University Nanjing China

Aim The purpose of this study is to compare the effects of the two clutches on recording the condylar movement. Methodology Ten subjects （6 women,4 men; mean age 25.4 years） participated in the study. The mandibular move-ment,sagittal condylar inclination angle,and transversal condylar inclination angle of each subject were recorded with the CADIAX？ using the two clutches,respectively. The characteristics of the tracings of the protrusion,opening,and mediotrusion were analyzed with the t-test statistics at α = 0.05 level. The Kappa values were calculated for an assessment of the congruence of the tracings. Results The results showed that the contour,direction,and dimension of the tracings in the two clutches were approxi-mately same,but the tracings determined by the functional occlusal clutch were more regular and congruent. In the group segment recorded with the tray clutch,opening/ closing paths of one subject showed crossed and time curves of three subjects appeared peak-like changes of velocity,but none were statistically different （P0.05）. Conclusion The research suggests that the functional occlusal clutch should be preferred in the evaluation of the mandibular function,as the tracings with the tray clutch are more likely to produce false positive results.

关键词： CADIAX temporomandibular joint mandibular movement functional clutch occlusion

Investigation of pore structure alteration and permeability enhancement of shale matrix by supercritical water treatment after hydraulic fracturing

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Petroleum 2024年第2期10卷 265-274页

作者： Yili kang Peisong Li Wangkun Cao Mingjun Chen Lijun You Jiang Liu Zhehan lai State Key Laboratory of Oil and Gas Reservoir Geology and Exploitation Southwest Petroleum UniversityChengdu610500China Institute of Engineering Technology Petro China Coalbed Methane Company LimitedXi'an710082China Chemical and Petroleum Engineering University of CalgaryCalgaryT2N 1N4Canada

Shale gas reservoirs are unconventional tight gas reservoirs,in which horizontal wells and hydraulic fracturing are required to achieve commercial *** fracture networks created by hydraulic fracturing can increase the drainage area extensively to enhance shale gas ***,large volumes of fracturing fluid that is difficult to flow back to the surface and remained in the shale formation,will inevitably lead to damages of the shale formations and limit the effectiveness of *** water(SCW)treatment after hydraulic fracturing is a new method to enhance shale gas recovery by using appropriate heat treatment methods to the specific formation to convert the retained fracturing fluid into a supercritical state(at temperatures in excess of 373.946°C and pressures in excess of 22.064 MPa).An experiment was conducted to simulate the reaction between shale and SCW,and the capacity of SCW treatment to enhance the permeability of the shale was evaluated by measuring the response of the shale porosity and permeability on SCW *** experimental results show that the shale porosity and permeability increase by 213.43%and 2198.37%,*** pore structure alteration and permeability enhancement of the shale matrix were determined by analyzing the changes in pore structure and mineral composition after SCW *** mechanisms that affect pore structure and mineral composition include oxidative catalysis decomposition of organic matters and reducing minerals,acid-catalyzed decomposition of carbonate minerals and feldspar minerals,hydrothermal catalysis induced fracture extension and cementation weakening induced fracture *** treatment converts harm into a benefit by reducing the intrusion of harmful substances into the shale formation,which will broaden the scope and scale of shale formation stimulation.

关键词： Shale gas Formation damage control Formation heat treatment Supercritical water

Graphene oxide-composited chitosan scaffold contributes to functional recovery of injured spinal cord in rats

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Neural Regeneration Research 2021年第9期16卷 1829-1835页

作者： Bing Yang Pang-Bo Wang Ning Mu kang Ma Shi Wang Chuan-Yan Yang Zhong-Bing Huang ying lai Hua Feng Guang-Fu Yin Tu-Nan Chen Chen-Shi Hu College of Biomedical Engineering Sichuan UniversityChengduSichuan ProvinceChina Department of Neurosurgery Southwest HospitalThird Military Medical University(Army Medical University)ChongqingChina

The study illustrates that graphene oxide nanosheets can endow materials with continuous electrical conductivity for up to 4 weeks. Conductive nerve scaffolds can bridge a sciatic nerve injury and guide the growth of neurons;however, whether the scaffolds can be used for the repair of spinal cord nerve injuries remains to be explored. In this study, a conductive graphene oxide composited chitosan scaffold was fabricated by genipin crosslinking and lyophilization. The prepared chitosan-graphene oxide scaffold presented a porous structure with an inner diameter of 18–87 μm, and a conductivity that reached 2.83 mS/cm because of good distribution of the graphene oxide nanosheets, which could be degraded by peroxidase. The chitosan-graphene oxide scaffold was transplanted into a T9 total resected rat spinal cord. The results show that the chitosan-graphene oxide scaffold induces nerve cells to grow into the pores between chitosan molecular chains, inducing angiogenesis in regenerated tissue, and promote neuron migration and neural tissue regeneration in the pores of the scaffold, thereby promoting the repair of damaged nerve tissue. The behavioral and electrophysiological results suggest that the chitosan-graphene oxide scaffold could significantly restore the neurological function of rats. Moreover, the functional recovery of rats treated with chitosangraphene oxide scaffold was better than that treated with chitosan scaffold. The results show that graphene oxide could have a positive role in the recovery of neurological function after spinal cord injury by promoting the degradation of the scaffold, adhesion, and migration of nerve cells to the scaffold. This study was approved by the Ethics Committee of Animal Research at the First Affiliated Hospital of Third Military Medical University(Army Medical University)(approval No. AMUWEC20191327) on August 30, 2019.

关键词： angiogenesis chitosan electrical conduction graphene oxide regeneration repair scaffold spinal cord injury

Simulation and experiment of vortex transport properties in a Type Ⅱ superconductor with grain boundary

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Science China(Technological Sciences) 2015年第3期58卷 493-498页

作者： JIANG lai XU WeiWei HUA Tao YU Mei AN DeYue CHEN Jian JIN BiaoBing kang Lin WU PeiHeng Research Institute of Superconductor Electronics School of Electronic Science and Engineering Nanjing University

We firstly described a simulation model to investigate the influence of grain boundary(GB)on the vortex transport properties in YBCO *** is found that the size of inhomogeneous area caused by GB as well as the average velocity in transverse and longitudinal directions shows an angular dependence when the angle between the GB and the sample edge *** have also studied the impact of magnetic field intensity on dynamic behavior of vortex lattice and found that a lower vortex density makes it difficult for the vortex lattice to transfer from pinning state to flow *** the magnetic field is decreased beyond a critical value,sharp jumps and strong fluctuations were observed in the I-V ***,we conducted measurements on a thin film YBa2Cu3O7 with an individual artificial grain boundary to support the simulation process.

关键词： high-Tc superconductor grain boundary vortex dynamic

Effcient transesterifcation resolution of 2-(4-chlorophenyl)-4-hydroxytetrahydropyran with magnetically separable immobilized lipase

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Chinese Chemical Letters 2013年第12期24卷 1112-1114页

作者： Ping Xue Zhen-Zhen kang Xiao-Yong lai Guan-Qun Qu Yuan-Yuan Li State Key Laboratory Cultivation Base of Natural Gas Conversion Ningxia University

We report an efficient kinetic resolution of racemic 2-（4-chlorophenyl）-4-hydroxytetrahydro-pyran （CLP-4-HTHP） via Pseudomonas cepacia lipase （PSL）-catalyzed transesterification, where PSL is immobilized on a core-shell MnFe204@SiO2-（CH2）3-NH2 carrier and used as a magnetically separable catalyst. The as-synthesized PSL/MnFe204@SiO2-（CH2）3-NH2 catalyst exhibits enhanced catalytic activity for resolving racemic CLP-4-HTHP to the corresponding optically pure （2R,4S）-CLP-4-HTHP compared to the free PSL. The ees for the former is 2.3 times larger than that for the latter under optimized conditions （99.4% and 44.1%, respectively）, although the eep for them are same （99.2%）. Meanwhile, the PSL/MnFe204@SiO2-（CH2）3-NH2 catalyst possesses a high saturate magnetization of 59.7 emu/g and could be easily recovered by magnetic separation and reused. The catalytic activity in six recycling tests did not significantly decrease, suggesting its great potential for industrial applications.

关键词： Optically pure 2-(4-chlorophenyl)-4- hydroxytetrahydropyran Magnetically immobilized lipase Enanatioselectivity Asymmetric transesterification