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An ox.genating colloidal bioink for the engineering of biomimetic tissue constructs

Bio-Design and Manufacturing 2024年第3期7卷 240-261页

作者： Seol-Ha j.ong j.rno Hiemstra Patrick V.Blokzij. Rebeca Damian-Ferrara Danilo Martins dos Santos j.ssica H.L.da Fonseca Min-Ho kang j.hyun Kim Dilara Yilmaz-Aykut Mei L.L.Cham-Pérez j.roen Leij.en Su Ryon Shin Division of Engineering in Medicine Department of MedicineBrigham and Women’s HospitalHarvard Medical SchoolBostonMA 02139USA Leij.en Lab Department of Developmental BioEngineeringFaculty of Science and TechnologyTechnical Medical CentreUniversity of TwenteDrienerlolaan 57522 NB EnschedeThe Netherlands Nanotechnology National Laboratory for Agriculture(LNNA) Embrapa InstrumentaçãoSao CarlosSao Paulo 13560-970Brazil Department of Biomedical-Chemical Engineering The Catholic University of Korea43 Jibong-roBucheon-siGyeonggi-do 14662Republic of Korea Department of Biotechnology The Catholic University of Korea43 Jibong-roBucheon-siGyeonggi-do 14662Republic of Korea

Ensuring a sufficient ox.gen supply is pivotal for the success of bioprinting applications since it fosters tissue integration and natural *** in ox.gen concentration among diverse tissues necessitates the precise recreation of tissue-specific ox.gen levels in imprinted constructs to support the survival of targeted *** ox.gen-releasing biomaterials,such as ox.gen-generating microparticles(OMPs),have shown promise for enhancing the ox.gen supply of microenvironments in inj.red tissues,whether this approach is scalable for large tissues and whether tissue-specific bioinks with varying OMP concentrations remain printable remain *** study addresses this critical gap by introducing an innovative class of engineered ox.genated bioinks that combine colloidal-based microgels with *** report that incorporating nanosized calcium perox.de(nCaO_(2))and manganese ox.de nanosheets(nMnO_(2))into hydrophobic polymeric microparticles enables precise modulation of ox.gen release while controlling hydrogen perox.de ***,the fabrication of ox.genating and cytocompatible colloidal gels is achieved using an aqueous two-phase *** study thoroughly evaluates the fundamental characteristics of the resulting bioink,including its rheological behaviors,printability,shape fidelity,mechanical properties,and ox.gen release ***,this study demonstrates the macroscopic scalability and cytocompatibility of printed constructs produced via cell-laden ox.genating colloidal *** showcasing the effectiveness of ex.rusion-based bioprinting,this study underscores how it can be used to fabricate biomimetic tissues,indicating its potential for new *** findings presented here advance the bioprinting field by achieving scalability with both high cell viability and the possibility of mimicking specifically ox.genated *** work thereby offers a promising avenue for the development of functional tissues with e

关键词： 3D bioprinting Bioink Colloidal gels Ex.rusion printing Ox.gen-generating microparticle

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Ex.some-loaded biomaterials for tendon/ ligament repair

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Biomaterials Translational 2024年第2期5卷 129-143页

作者： Wang H. Guo Y. j.ang Y. Ge Y. Shi D. Zhang G. Zhao j. kang Y. Wang L. Shanghai j.ao Tong University School of Medicine Shanghai China School of Materials Science and Engineering East China University of Science and Technology Shanghai China Department of Orthopaedics Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Shanghai China

Ex.somes, a specialised type of ex.racellular vesicle, have attracted significant attention in the realm of tendon/ligament repair as a potential biologic therapeutic tool. While the competence of key substances responsible for the delivery function was gradually elucidated, series of shortcomings ex.mplified by the limited stability still need to be improved. Therefore, how to take max.mum advantage of the biological characteristics of ex.somes is of great importance. Recently, the comprehensive ex.loration and application of biomedical engineering has improved the availability of ex.somes and revealed the future direction of ex.somes combined with biomaterials. This review delves into the present application of biomaterials such as nanomaterials, hydrogels, and electrospun scaffolds, serving as the carriers of ex.somes in tendon/ligament repair. By pinpointing and ex.loring their strengths and limitations, it offers valuable insights, paving the way the future direction of biomaterials in the application of ex.somes in tendon/ ligament repair in this field. © 2024, Chinese Medical Multimedia Press Co Ltd. All rights reserved.

关键词： biomaterials electrospinning ex.somes hydrogel microspheres hydrogels nanoparticles

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Dark Matter Search in Dwarf Irregular Galax.es with Ten Years of Data from the Ice Cube Neutrino Observatory

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Research in Astronomy and Astrophysics 2024年第3期24卷 75-82页

作者： Yi-Fei Lü Ben-Yang Zhu Rong-Lan Li x.e-kang Guo Tian-Ci Liu Yong-Bo Huang Yun-Feng Liang Guangx. Key Laboratory for Relativistic AstrophysicsSchool of Physical Science and TechnologyGuangx. University Nanning 530004China

Dwarf irregular galax.es(dIrrs),as rotationally supported systems,have more reliable j.factor measurements than dwarf spheroidal galax.es and have received attention as targets for dark matter detection in recent *** this paper,we use 10 yr of IceCube muon-track data and an unbinned max.mum-likelihood-ratio method to search for neutrino signals beyond the background from the directions of seven dIrrs,aiming to detect neutrinos produced by heavy annihilation dark *** do not detect any significant *** on such null results,we calculate the upper limits on the velocity-averaged annihilation cross section for 1 TeV–10 PeV dark *** limits,although weaker than the strictest constraints in the literature in this mass range,are also a good complement to the ex.sting results considering the more reliable j.factor measurements of dIrrs.

关键词： (cosmology) dark matter-cosmology theory-galax.es dwarf

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The role of acute normovolemic hemodilution in reducing allogeneic blood transfusion in glioblastoma surgery:a case-control study

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Chinese Neurosurgical j.urnal 2024年第1期10卷 35-41页

作者： Ping Chen x.n‑Huang Zhang Ying Wang x.an‑Zhong Lin De‑Zhi kang Qing‑Song Lin Department of Anesthesiology The First Affiliated Hospital of Fujian Medical UniversityFuzhou 350005FujianChina Department of Neurosurgery The First Affiliated Hospital of Fujian Medical UniversityNo.20 Chazhong RdTaijiang DistrictFuzhou 350005FujianChina Department of Neurosurgery Binhai Branch of National Regional Medical CenterThe First Affiliated Hospital of Fujian Medical UniversityFuzhou 350209FujianChina Fuj.an Provincial Institutes of Brain Disorders and Brain Sciences The First Affiliated Hospital of Fujian Medical UniversityFuzhou 350005FujianChina Fuj.an Provincial Clinical Research Center for Neurological Diseases The First Affiliated Hospital of Fujian Medical UniversityFuzhou 350005FujianChina Fuj.an Provincial Key Laboratory of Precision Medicine for Cancer The First Affiliated Hospital of Fujian Medical UniversityFuzhou 350005FujianChina

Background Acute normovolemic hemodilution(ANH)was first introduced in glioblastoma surgery,and its role in reducing allogeneic blood transfusion was investigated in this *** This study enrolled supratentorial glioblastoma patients who received total *** the ANH group,the patients were required to draw blood before the operation,and the blood will be transfused back to the patient during the *** association between ANH and clinical features was *** Six.y supratentorial glioblastoma patients were enrolled in this study,25 patients were allocated in the ANH group,and another 35 patients were included in the control *** dramatically reduced the need for allogeneic blood transfusion(3[12%]vs 12[34.3%],P=0.049),and the blood transfusion per total of patients was dramatically decreased by the application of ANH(0.40±1.15 units vs 1.06±1.59 units,P=0.069).Furthermore,ANH also markedly reduced the requirement of fresh frozen plasma(FFP)transfusion(2[8%]vs 11[31.4%],P=0.030)and the volume of FFP transfusion per total of patients(32.00±114.46 mL vs 115.71±181.00 mL,P=0.033).The complication rate was similar between the two *** ANH was a safe and effective blood conservation technique in glioblastoma surgery.

关键词： Glioblastoma Acute normovolemic hemodilution Surgery Blood transfusion

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Determination of the number ofψ(3686)events taken at BESⅢ

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Chinese Physics C 2024年第9期48卷 8-20页

作者： M.Ablikim M.N.Achasov P.Adlarson O.Afedulidis x.C.Ai R.Aliberti A.Amoroso Q.An Y.Bai O.Bakina I.Balossino Y.Ban H.-R.Bao V.Batozskaya K.Begzsuren N.Berger M.Berlowski M.Bertani D.Bettoni F.Bianchi E.Bianco A.Bortone I.Boyko R.A.Briere A.Brueggemann H.Cai x.Cai A.Calcaterra G.F.Cao N.Cao S.A.Cetin j.F.Chang G.R.Che G.Chelkov C.Chen C.H.Chen Chao Chen G.Chen H.S.Chen H.Y.Chen M.L.Chen S.j.Chen S.L.Chen S.M.Chen T.Chen x.R.Chen x.T.Chen Y.B.Chen Y.Q.Chen Z.j.Chen Z.Y.Chen S.K.Choi G.Cibinetto F.Cossio j.j.Cui H.L.Dai j.P.Dai A.Dbeyssi R.E.de Boer D.Dedovich C.Q.Deng Z.Y.Deng A.Denig I.Denysenko M.Destefanis F.De Mori B.Ding x.x.Ding Y.Ding Y.Ding j.Dong L.Y.Dong M.Y.Dong x.Dong M.C.Du S.x.Du Y.Y.Duan Z.H.Duan P.Egorov Y.H.Fan j.Fang j.Fang S.S.Fang W.x.Fang Y.Fang Y.Q.Fang R.Farinelli L.Fava F.Feldbauer G.Felici C.Q.Feng j.H.Feng Y.T.Feng M.Fritsch C.D.Fu j.L.Fu Y.W.Fu H.Gao x.B.Gao Y.N.Gao Yang Gao S.Garbolino I.Garzia L.Ge P.T.Ge Z.W.Ge C.Geng E.M.Gersabeck A.Gilman K.Goetzen L.Gong W.x.Gong W.Gradl S.Gramigna M.Greco M.H.Gu Y.T.Gu C.Y.Guan Z.L.Guan A.Q.Guo L.B.Guo M.j.Guo R.P.Guo Y.P.Guo A.Guskov j.Gutierrez K.L.Han T.T.Han F.Hanisch x.Q.Hao F.A.Harris K.K.He K.L.He F.H.Heinsius C.H.Heinz Y.K.Heng C.Herold T.Holtmann P.C.Hong G.Y.Hou x.T.Hou Y.R.Hou Z.L.Hou B.Y.Hu H.M.Hu j.F.Hu S.L.Hu T.Hu Y.Hu G.S.Huang K.x.Huang L.Q.Huang x.T.Huang Y.P.Huang T.Hussain F.Hölzken N.Hüsken N.in der Wiesche j.j.ckson S.j.nchiv j.H.j.ong Q.j. Q.P.j. W.j. x.B.j. x.L.j. Y.Y.j. x.Q.j.a Z.K.j.a D.j.ang H.B.j.ang P.C.j.ang S.S.j.ang T.j.j.ang x.S.j.ang Y.j.ang j.B.j.ao j.K.j.ao Z.j.ao S.j.n Y.j.n M.Q.j.ng x.M.j.ng T.j.hansson S.Kabana N.Kalantar-Nayestanaki x.L.kang x.S.kang M.Kavatsyuk B.C.Ke V.Khachatryan A.Khoukaz R.Kiuchi O.B.Kolcu B.Kopf M.Kuessner x.Kui N.Kumar A.Kupsc W.Kühn j.j.Lane P.Larin L.Lavezzi T.T.Lei Z.H.Lei M.Lellmann T.Lenz C.Li C.Li C.H.Li Cheng Li D.M.Li F.Li G.Li H.B.Li H.j.Li H.N.Li Hui Li j.R.Li j.S.Li Ke Li L.j.Li L.K.Li Lei Li M.H.Li P.R.Li Q.M.Li Q.x.Li R.Li S.x.Li T.Li W.D.Li W.G.Li x.Li x.H.Li x.L.Li x.Z.Li x. Institute of High Energy Physics Beijing 100049China Beihang University Beijing 100191China Bochum Ruhr-University D-44780BochumGermany Budker Institute of Nuclear Physics SB RAS(BINP) Novosibirsk 630090Russia Carnegie Mellon University PittsburghPennsylvania 15213USA Central China Normal University Wuhan 430079China Central South University Changsha 410083China China Center of Advanced Science and Technology Beijing 100190China China University of Geosciences Wuhan 430074China Chung-Ang University Seoul06974Republic of Korea COMSATS University Islamabad Lahore CampusDefence RoadOff Raiwind Road54000LahorePakistan Fudan University Shanghai 200433China GSI Helmholtzcentre for Heavy Ion Research GmbH D-64291DarmstadtGermany Guangx. Normal University Guilin 541004China Guangx. University Nanning 530004China Hangzhou Normal University Hangzhou 310036China Hebei University Baoding 071002China Helmholtz Institute Mainz Staudinger Weg 18D-55099MainzGermany Henan Normal University Xinxiang 453007China Henan University Kaifeng 475004China Henan University of Science and Technology Luoyang 471003China Henan University of Technology Zhengzhou 450001China Huangshan College Huangshan 245000China Hunan Normal University Changsha 410081China Hunan University Changsha 410082China Indian Institute of Technology Madras Chennai 600036India Indiana University BloomingtonIndiana 47405USA INFN Laboratori Nazionali di Frascati (A)INFN Laboratori Nazionali di FrascatiI-00044FrascatiItaly(B)INFN Sezione di PerugiaI-06100PerugiaItaly(C)University of PerugiaI-06100PerugiaItaly INFN Sezione di Ferrara (A)INFN Sezione di FerraraI-44122FerraraItaly(B)University of FerraraI-44122FerraraItaly Inner Mongolia University Hohhot 010021China Institute of Modern Physics Lanzhou 730000China Institute of Physics and Technology Peace Avenue 54BUlaanbaatar 13330Mongolia Instituto de Alta Investigación Universidad de TarapacáCasilla 7DArica 1000000Chile j.lin University Changchun 130012China j.ha

The number ofψ(3686)events collected by the BESⅢdetector during the 2021 run period is determined to be(2259.3±11.1)×10~6 by counting inclusiveψ(3686)hadronic *** uncertainty is systematic and the statistical uncertainty is ***,the numbers ofψ(3686)events collected during the 2009 and 2012run periods are updated to be(107.7±0.6)×10~6 and(345.4±2.6)×10~6,*** numbers are consistent with the previous measurements within one standard *** total number ofψ(3686)events in the three data samples is(2712.4±14.3)×10~6.

关键词： ψ(3686) inclusive process Hadronic events BESⅢdetector

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Highly-chlorinated inert and robust interphase without mineralization of ox.de enhancing high-rate Li metal batteries

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Chinese Chemical Letters 2024年第6期35卷 239-243页

作者： Long Li kang Yang Chenpeng x. Mengchao Li Borong Li Gui x. Yuanbin x.ao x.ancai Cui Zhiliang Liu Lingyun Li Yan Yu Chengkai Yang Key Laboratory of Advanced Materials Technologies International(HongKong Macao and Taiwan)Joint Laboratory on Advanced Materials TechnologiesSchool of Materials Science and EngineeringFuzhou UniversityFuzhou 350108China College of Material Sciences and Chemical Engineering Harbin Engineering UniversityHarbin 150001China

Side reactions and dendrite growth triggered by the unstable interface and inhomogeneous deposition have become the biggest obstacle to the commercialization for lithium metal *** this study,a highly-chlorinated organic-inorganic hybrid interfacial protective layer is developed by rationally tuning the interfacial passivation and robustness to achieve the convenient and efficient Li metal *** polyvinyl chloride(PVC)can effectively resist water and ox.gen,which is confirmed by density functional *** organic-dominant solid electrolyte interphases(SEI)with lithium chloride are investigated by the x.ray photoelectron spectroscopy(x.S)with little mineralization of ox.de,such as Li_(2)O and Li_(2)CO_(3).With such artificial SEI,a uniform and dense lithium deposition morphology are formed and an ultra-long stable cycle of over 500 h are achieved even at an ultra-high current density of 10 m A/cm^(2).Moreover,the simple and convenient protected anode also ex.ibits ex.ellent battery stability when paired with the LiNi_(0.8)Co_(0.1)Mn_(0.1)O_(2)(NCM811)and LiFePO_(4)(LFP)cathode,showing great potential for the commercial application of lithium metal batteries.

关键词： Highly-chlorinated Water/ox.gen resistance Stable interphase Dendrite-free lithium metal batteries High-rate

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Phase Selection in Solidi?cation of Undercooled Co–B Alloys

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j.urnal of Materials Science & Technology 2017年第4期33卷 352-358页

作者： x.x.Wei W.x. j.L.kang M.Ferry j.F.Li State Key Laboratory of Metal Matrix.Composites School of Materials Science and EngineeringShanghai Jiao Tong UniversityShanghai 200240.China Australian Research Council Centre of Ex.ellence for Design in Light Metals School of Materials Science and EngineeringThe University of New South WalesSydneyNSW 2052Australia

A series Co-（18.5–20.7） at.% B melts encompassing the eutectic composition（Co81.5B18.5） were solidified at different degrees of undercooling. It is found that the metastable Co23B6 phase solidifies as a substitute for the stable Co3 B phase in the alloy melts undercooled above a critical undercooling value of -60 *** Co23B6 and α-Co phases make up a metastable eutectic. The corresponding eutectic composition and temperature are Co80.4B19.6 and 1343 K, respectively. On ex.osure of the metastable Co23B6 phase at a given temperature above 1208 K, it does not decompose even after several hours. But it transforms by a eutectoid reaction to α-Co ＋ Co3 B at lower temperature.

关键词： Undercooling Rapid solidi?cation Metastable phase diagram Structure evolution

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Evidence for particle acceleration approaching PeV energies in the W51 complex

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Science Bulletin 2024年第18期69卷 2833-2841页

作者： LHAASO Collaboration Zhen Cao F.Aharonian Ax.kegu Y.x.Bai Y.W.Bao D.Bastieri x.j.Bi Y.j.Bi W.Bian A.V.Bukevich Q.Cao W.Y.Cao Zhe Cao j.Chang j.F.Chang A.M.Chen E.S.Chen H.x.Chen Liang Chen Lin Chen Long Chen M.j.Chen M.L.Chen Q.H.Chen S.Chen S.H.Chen S.Z.Chen T.L.Chen Y.Chen N.Cheng Y.D.Cheng M.Y.Cui S.W.Cui x.H.Cui Y.D.Cui B.Z.Dai H.L.Dai Z.G.Dai Danzengluobu x.Q.Dong K.K.Duan j.H.Fan Y.Z.Fan j.Fang j.H.Fang K.Fang C.F.Feng H.Feng L.Feng S.H.Feng x.T.Feng Y.Feng Y.L.Feng S.Gabici B.Gao C.D.Gao Q.Gao W.Gao W.K.Gao M.M.Ge L.S.Geng G.Giacinti G.H.Gong Q.B.Gou M.H.Gu F.L.Guo x.L.Guo Y.Q.Guo Y.Y.Guo Y.A.Han M.Hasan H.H.He H.N.He j.Y.He Y.He Y.K.Hor B.W.Hou C.Hou x.Hou H.B.Hu Q.Hu S.C.Hu D.H.Huang T.Q.Huang W.j.Huang x.T.Huang x.Y.Huang Y.Huang x.L.j. H.Y.j.a K.j.a K.j.ang x.W.j.ang Z.j.j.ang M.j.n M.M.kang I.Karpikov D.Kuleshov K.Kurinov B.B.Li C.M.Li Cheng Li Cong Li D.Li F.Li H.B.Li H.C.Li j.an Li j.e Li K.Li S.D.Li W.L.Li W.L.Li x.R.Li x.n Li Y.Z.Li Zhe Li Zhuo Li E.W.Liang Y.F.Liang S.j.Lin B.Liu C.Liu D.Liu D.B.Liu H.Liu H.D.Liu j.Liu j.L.Liu M.Y.Liu R.Y.Liu S.M.Liu W.Liu Y.Liu Y.N.Liu Q.Luo Y.Luo H.K.Lv B.Q.Ma L.L.Ma x.H.Ma j.R.Mao Z.Min W.Mitthumsiri H.j.Mu Y.C.Nan A.Neronov L.j.Ou P.Pattarakij.anich Z.Y.Pei j.C.Qi M.Y.Qi B.Q.Qiao j.j.Qin A.Raza D.Ruffolo A.Sáiz M.Saeed D.Semikoz L.Shao O.Shchegolev x.D.Sheng F.W.Shu H.C.Song Yu.V.Stenkin V.Stepanov Y.Su D.x.Sun Q.N.Sun x.N.Sun Z.B.Sun j.Takata P.H.T.Tam Q.W.Tang R.Tang Z.B.Tang W.W.Tian C.Wang C.B.Wang G.W.Wang H.G.Wang H.H.Wang j.C.Wang Kai Wang Kai Wang L.P.Wang L.Y.Wang P.H.Wang R.Wang W.Wang x.G.Wang x.Y.Wang Y.Wang Y.D.Wang Y.j.Wang Z.H.Wang Z.x.Wang Zhen Wang Zheng Wang D.M.Wei j.j.Wei Y.j.Wei T.Wen C.Y.Wu H.R.Wu Q.W.Wu S.Wu x.F.Wu Y.S.Wu S.Q.x. j.x.a G.M.x.ang D.x.x.ao G.x.ao Y.L.x.n Y.x.ng D.R.x.ong Z.x.ong D.L.x. R.F.x. R.x.x. W.L.x. L.x.e D.H.Yan j.Z.Yan T.Yan C.W.Yang C.Y.Yang F.Yang F.F.Yang L.L.Yang M.j.Yang R.Z.Yang W.x.Yang Y.H.Yao Z.G.Yao L.Q.Yin N.Yin x.H.You Z.Y.You Y.H.Yu Q.Yuan H.Yue H.D.Zeng T.x.Zeng W.Zeng M.Zha B.B.Zhang F.Zhang H.Zhang 不详 Key Laboratory of Particle Astrophysics&Ex.erimental Physics Division&Computing Center Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China University of Chinese Academy of Sciences Beijing 100049China TIANFU Cosmic Ray Research Center ChengduChina Dublin Institute for Advanced Studies 31 Fitzwilliam Place2 DublinIreland Max.Planck-Institut for Nuclear Physics P.O.Box 103980Heidelberg 69029Germany School of Physical Science and Technology&School of Information Science and Technology Southwest Jiaotong UniversityChengdu 610031China School of Astronomy and Space Science Nanjing UniversityNanjing 210023China Center for Astrophysics Guangzhou UniversityGuangzhou 510006China Tsung-Dao Lee Institute&School of Physics and Astronomy Shanghai Jiao Tong UniversityShanghai 200240China Institute for Nuclear Research of Russian Academy of Sciences Moscow 117312Russia Hebei Normal University Shijiazhuang 050024China University of Science and Technology of China Hefei 230026China State Key Laboratory of Particle Detection and Electronics China Key Laboratory of Dark Matter and Space Astronomy&Key Laboratory of Radio Astronomy Purple Mountain ObservatoryChinese Academy of SciencesNanjing 210023China Research Center for Astronomical Computing Zhejiang LaboratoryHangzhou 311121China Key Laboratory for Research in Galax.es and Cosmology Shanghai Astronomical ObservatoryChinese Academy of SciencesShanghai 200030China School of Physics and Astronomy Yunnan UniversityKunming 650091China Key Laboratory of Cosmic Rays(Tibet University) Ministry of EducationLhasa 850000China National Astronomical Observatories Chinese Academy of SciencesBeijing 100101China School of Physics and Astronomy(Zhuhai)&School of Physics(Guangzhou)&Sino-French Institute of Nuclear Engineering and Technology(Zhuhai) Sun Yat-sen UniversityZhuhai 519000&Guangzhou 510275GuangdongChina Institute of Frontier and Interdisciplinary Science Shandong UniversityQingdao 266237China APC UniversitéParis Cité

Theγ-ray emission from the W51 complex.is widely acknowledged to be attributed to the interaction between the cosmic rays(CRs)accelerated by the shock of supernova remnant(SNR)W51C and the dense molecular clouds in the adj.cent star-forming region,***,the max.mum acceleration capability of W51C for CRs remains *** on observations conducted with the Large High Altitude Air Shower Observatory(LHAASO),we report a significant detection ofγrays emanating from the W51 complex.with energies from 2 to 200 *** LHAASO measurements,for the first time,ex.end theγ-ray emission from the W51 complex.beyond 100 TeV and reveal a significant spectrum bending at tens of *** combining the"π^(0)-decay bump"featured data from Fermi-LAT,the broadbandγ-ray spectrum of the W51 region can be well-characterized by a simple pp-collision *** observed spectral bending feature suggests an ex.onential cutoff at~400 TeV or a power-law break at~200 TeV in the CR proton spectrum,most likely providing the first evidence of SNRs serving as CR accelerators approaching the PeV ***,two young star clusters within W51B could also be theoretically viable to produce the most energeticγrays observed by *** findings strongly support the presence of ex.reme CR accelerators within the W51 complex.and provide new insights into the origin of Galactic CRs.

关键词： UHE c-ray Cosmic rays SNR W51C Star clusters

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The HIF-1α/PLOD2 ax.s integrates ex.racellular matrix.organization and cell metabolism leading to aberrant musculoskeletal repair

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Bone Research 2024年第2期12卷 289-301页

作者： Heeseog kang Amy L.Strong Yux.ao Sun Lei Guo Conan j.an Alec C.Bancroft j. Hae Choi Chase A.Pagani Aysel A.Fernandes Michael Woodard j.hoon Lee Sowmya Ramesh Aaron W.j.mes David Hudson Kevin N.Dalby Lin x. Robert j.Tower Benj.min Levi Center for Organogenesis Regeneration and TraumaDepartment of SurgeryUniversity of Texas SouthwesternDallasTX 75390USA Section of Plastic Surgery Department of SurgeryUniversity of MichiganAnn ArborMI 48109USA Quantitative Biomedical Research Center Peter O’Donnell Jr.School of Public HealthUniversity of Texas SouthwesternDallasTX 75390USA Department of Orthopedics and Sports Medicine University of WashingtonSeattleWA 98195USA Division of Chemical Biology and Medicinal Chemistry College of PharmacyUniversity of Texas at AustinAustinTX 78712USA Department of Pathology Johns Hopkins UniversityBaltimoreMD 21218USA

While hypox.c signaling has been shown to play a role in many cellular processes,its role in metabolism-linked ex.racellular matrix.ECM)organization and downstream processes of cell fate after musculoskeletal inj.ry remains to be ***(HO)is a debilitating condition where abnormal bone formation occurs within ex.ra-skeletal *** andhypox.a-inducible factor 1α(HIF-1α)activation have been shown to promote ***,the underlying molecular mechanisms bywhich the HIF-1αpathway in mesenchymal progenitor cells(MPCs)contributes to pathologic bone formation remain to ***,we used a proven mouse inj.ry-induced HO model to investigate the role of HIF-1αon aberrant cell ***-cell RNA sequencing(scRNA-seq)and spatial transcriptomics analyses of the HO site,we found that collagen ECM organizationis the most highly up-regulated biological process in *** mesenchymal cell-specific deletion of Hif1α(Hox.11-CreER^(T2);Hif1a^(fl/fl))significantly mitigated HO in ***-seq analysis of these Hox.11-CreER^(T2);Hif1a^(fl/fl)mice identified the PLOD2/LOx.athway for collagen cross-linking as downstream of the HIF-1αregulation of ***,our scRNA-seq data and mechanisticstudies further uncovered that glucose metabolism in MPCs is most highly impacted by HIF-1α*** a translational aspect,a pan-LOx.inhibitor significantly decreased HO.A newly screened compound revealed that the inhibition of PLOD2 activity in MPCssignificantly decreased osteogenic differentiation and glycolytic *** suggests that the HIF-1α/PLOD2/LOx.ax.s linked tometabolism regulates HO-forming MPC *** results suggest that the HIF-1α/PLOD2/LOx.pathway represents a promisingstrategy to mitigate HO formation.

关键词： metabolism skeletal aberrant

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Tourmaline geochemistry as genetic evolution and metallogenic potential indicators of pegmatites: a case study from the Tugeman Be-Li deposit， Middle Altun

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j.urnal of Earth Science 2024年

作者： Hang Li x.ngwang x. Tao Hong Qiang Ke Yince Ma Kai kang Zhiquan Yang Changsheng Guo College of Architecture and Civil Engineering， Sanming University Key Laboratory of Mineral Resources， Institute of Geology and Geophysics， Chinese Academy of Sciences University of Chinese Academy of Sciences Innovation Academy for Earth Science， Chinese Academy of Sciences Guangdong Provincial Key Lab of Geodynamics and Geohazards， School of Earth Sciences and Engineering， Sun Yat-Sen University Southern Marine Science and Engineering Guangdong Laboratory (Zhuhai) No.3 Geological Party， x.nj.ang Bureau of Geology and Mineral Ex.loration and Development

Tourmaline is a common borosilicate mineral in granite and pegmatite， and it is also an important carrier to record the physicochemical evolution information of magmas. However， the genetic relationship between pegmatite-type rare metal mineralization potential and tourmaline-bearing pegmatites is not clear， and the tourmaline geochemical indication of the mineralization type of rare metals needs to be supplemented. In the middle Altun region， ex.ensive tourmaline-bearing pegmatite dykes are prevalent within and surrounding the Tugeman complex. In this paper， the petrology and geochemical characteristics of tourmaline within the pegmatite of the Tugeman Be-Li deposit have been comprehensively analyzed. The research delves into the genetic evolution and metallogenic potential of the pegmatite， emphasizing the indicative role of tourmaline geochemistry in discerning mineralization types in the Tugeman Be-Li deposit. Maj.r and trace element analysis of tourmaline reveals varying contents of FeO （9.37 wt.%–17.10 wt.%）， Al2O3（28.64 wt.%–35.22% wt.%）， and MgO （0.13 wt.%–2.47 wt.%） in the Tugeman Be–Li pegmatite. Li， Zn， and Sn contents range from 204 ppm to 1 590 ppm， 1 143 ppm to 4 089 ppm， and 74 ppm to 396 ppm， respectively. The tourmaline analyzed in this study is magmatic origin and belongs to schorl series， ex.ibits substitution relationships， including (Na， Fe2+)(x.， Al)-1， (Fe2+， Fe3+)（Mg， Al）-1， (Al，x.)(R2+， Na)-1，（Na， Mg）(x.， Al)-1andx.NaR2+-1. The trace element data of tourmaline show that lithium has four enrichment stages in different mineral crystallization phases. Notably， the tendency of tourmaline in the Tugeman Be-Li pegmatite to evolve towards elbaite implies a magmatic evolution sequence from low to high， transitioning through microcline-albite pegmatite， muscovite-microcline-albite pegmatite， albite pegmatite， and microcline pegmatite. Furthermore， we also propose that the Sc content in schorl can serve as an indicator of pegmatite mineralization typ

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