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SARS-CoV-2 in the ocular surface of COVID19 patients

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Eye and Vision 2020年第3期7卷 229-231页

作者： Hua-Tao Xie Shi-Yun Jiang kang-kang xu Xin Liu Bing xu Lin Wang Ming-Chang Zhang Department of Ophthalmology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Department of Clinical Laboratory Research Center for Tissue Engineering and Regenerative MedicineUnion HospitalHuazhong University of Science and TechnologyWuhan 430022China

The 2019 novel coronavirus disease(COVID-19)caused by severe acute respiratory syndrome coronavirus 2(SARSCoV-2)has spread globally,while the routes of transmission of this virus are still *** enrolled 33 patients,without any ocular manifestation,with their ocular surface swabs collected for virus *** was detected strong positive in samples of both eyes from two ***,SARS-CoV-2 may exist in the normal ocular surface of COVID-19 patients,suggesting that this virus might be spread through conjunctival contact.

关键词： SARS-CoV-2 COVID-19 Ocular surface

MicroR-9c-5p and novel-mir50 co-target Akt to regulate Lasioderma serricorne reproduction

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Insect Science 2024年第1期31卷 106-118页

作者： Yi Yan Dong-Dong Qin Hong Yang kang-kang xu Can Li Wen-Jia Yang Provincial Key Laboratory for Agricultural Pest Management of Mountainous Region Institute of EntomologyGuizhou UniversityGuiyangChina Guizhou Provincial Key Laboratory for Rare Animal and Economic Insect of the Mountainous Region College of Biology and Environmental EngineeringGuiyang UniversityGuiyangChina

High fecundity is a common characteristic of insect pests which increases the difficulty of population ***/threonine kinase Akt is an indispensable component of the insulin signaling *** of LsAkt severely hinders reproduction in Lasioderma serricorne,a stored product insect ***,the post-transcriptional pathway of LsAkt in *** remains *** study identified 2 binding sites of miR-9c-5p and novel-mir50 in the coding sequences of *** expression profiles of 2 microRNAs(miRNAs)and LsAkt displayed an opposite pattern during the adult *** reporter assay showed that novel-mir50 and miR-9c-5p could downregulate the expression of *** of miR-9c-5p and novel-mir50 by injection of mimics inhibited the expression of LsAkt and reduced oviposition,decreased egg hatchability,and blocked ovarian *** also decreased the expression of genes involved in ovarian development(LsVg and LsVgR)and the nutritional signaling pathway(LsTOR,LsS6K,and Ls4EBP),and reduced the phosphorylation of ***,injection of miR-9c-5p and novel-mir50 inhibitors induced the expressions of LsAkt,LsVg,LsVgR,LsTOR,LsS6K,and Ls4EBP,enhanced Akt phosphorylation level,and accelerated ovarian *** of bovine insulin downregulated the expression of miR-9c-5p and novel-mir50 and upregulated the LsAkt *** also rescued the reproductive development defects associated with miR-9c-5p/novel-mir50 overexpression,forming a positive regulatory loop of insulin *** results indicate that miR-9c-5p/novel-mir50 regulates the female reproduction of *** by targeting Akt in response to insulin *** data also demonstrate the effects of the insulin/miRNA/Akt regulatory axis in insect reproduction.

关键词： Akt insulin Lasioderma serricorne microRNA reproduction

Effects of smartphone-based interventions and monitoring on bipolar disorder:A systematic review and meta-analysis

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World Journal of Psychiatry 2020年第11期10卷 272-285页

作者： Jia-Yuan Liu kang-kang xu Guang-Lin Zhu Qi-Qi Zhang Xiao-Ming Li Department of Medical Psychology Chaohu Clinical Medical CollegeAnhui Medical UniversityHefei 230032Anhui ProvinceChina Department of Anesthesia First Clinical Medical CollegeAnhui Medical UniversityHefei 230032Anhui ProvinceChina Department of Clinical Medicine Second Clinical Medical CollegeAnhui Medical UniversityHefei 230032Anhui ProvinceChina Department of Clinical Medicine First Clinical Medical CollegeAnhui Medical UniversityHefei 230032Anhui ProvinceChina

BACKGROUND Recently,there has been a range of studies about smartphone-based interventions and monitoring for reducing symptoms of bipolar disorder(BD).However,their efficacy for BD remains *** To compare the effect of smartphone-based interventions and monitoring with control methods in treating patients with *** A systematic literature search was performed on PubMed,Embase,Clinical trials,psycINFO,Web of Science,and Cochrane *** clinical trials(RCTs)or single-group trials in which smartphone-based interventions and monitoring were compared with control methods or baseline in patients with symptoms of BD were *** were synthesized using a random-effects or a fixed-effects model to analyze the effects of psychological interventions and monitoring delivered via smartphone on psychiatric symptoms in patients with *** primary outcome measures were set for mania and depression *** were created to explore which aspects of smartphone interventions are relevant to the greater or lesser efficacy of treating *** We identified ten articles,including seven RCTs(985 participants)and three single-group trials(169 participants).Analysis of the between-group study showed that smartphone-based interventions were effective in reducing manic[g=-0.19,95%confidence interval(CI):-0.33 to-0.04,P=0.01]and depressive(g=-0.28,95%CI:-0.55 to-0.01,P<0.05)*** within-group analysis,smartphone-based interventions significantly reduced manic(g=0.17,95%CI:0.04 to 0.30,P<0.01)and depressive(g=0.48,95%CI:0.18 to 0.78)symptoms compared to the ***,smartphone-based monitoring systems significantly reduced manic(g=0.27,95%CI:0.02 to 0.51,P<0.05)but not depressive *** analysis indicated that the interventions with psychoeducation had positive effects on depressive(g=-0.62,95%CI:-0.81 to-0.43,P<0.01)and manic(g=-0.24,95%CI:-0.43 to-0.06,P=0.01)symptoms compared to the controlled conditions,while t

关键词： Smartphone Bipolar disorder Monitoring Interventions Meta-analysis Systematic review

Characteristics of B,Zn and Se in stream sediments of Tanzania and their agricultural applications:Based on 1∶1000000 geochemical survey

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China Geology 2023年第1期6卷 1-14页

作者： kang-kang xu Hong-wei Sun Wei Xie Fu-qing He Xiao-yang Liu Kai Sun Sheng-fei He Xing-yuan Wu Peng-hui Gong Godfrey Machumu Southern African Mining Research Institute China Geological SurveyTianjin 300170China North China Center of Geoscience Innovation Tianjin 300170China Tianjin Geological Mineral Testing Center Tianjin 300191China Geological Survey of Tanzania DodomaP.O Box 903Tanzania

Tanzania is located in eastern Africa with a predominantly agricultural ecomomy,the potential for developing and utilizing cultivated land are promising,but scientific guidance is required.B,Zn and Se are essential micronutrients for plants and human body with crucial biological functions,in particular,Se is significant for human health and considered as“the king of anti-cancer”.As these elements required by human or plants are mainly absorbed from soil directly or indirectly,therefore,it is important to understand the contents and distributions of them in the soil of cultivated land for guiding agricultural *** this work,low-density geochemical survey at the scale of 1∶1000000 was carried out in Tanzania,and the results show that the concentrations of B,Zn and Se in stream sediments are low and their distributions are *** to the distributions of geological units,the existing cultivated land resources can be divided into five regions in *** with the national background values,the concentrations of B,Zn and Se are insufficient overall but enriched locally in these *** general,element concentrations in stream sediments and soil have a positive correlation because of their similar sources,which is essential in agriculture *** on the information provided by low-density geochemical data and maps,the Se-sufficient and Se-rich regions were delineated in Tanzania,where can be used to develop Se-rich ***,this paper believes that geochemical survey is a powerful tool for cultivated land evaluation,agriculture management and land development.

关键词： Stream sediment Low-density geochemical survey Geochemical map Soil of cultivated land Agricultural applications Agricultural geological survey engineering Tanzania Selenium-rich agricultural products

Gold enrichment characteristics and exploration prospects in Zambia: Based on 1∶1000000 geochemical mapping

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China Geology 2022年第1期5卷 60-70页

作者： Jun-ping Ren Jie Wang A-lei Gu Li-bo Zuo Hong-wei Sun kang-kang xu Fu-Qing He Chipilauka Mukofu Alphet Phaskani Dokowe Ezekiah Chikambwe Tianjin Center China Geological SurveyMinistry of Natural ResourcesTianjin 300170China Geological Survey Department of Zambia Lusaka P.O.Box.50135Zambia

The 1∶1000000 geochemical mapping of Zambia provides catchment sediment geochemical data for 58elements including Au from 746 sediment samples at 736 sampling sites,corresponding to a sampling density of about one site per 1000 *** strict quality control using field duplicates,certified reference materials,and analytical replicate samples,the Au was determined by Inductively Coupled Plasma Mass Spectrometry(ICP-MS).The detection limit of Au was 0.20×10^(-9).The 95%range(2.5%–97.5%)of Au concentrations was from 0.24×10^(-9) to 1.36×10^(-9),and the median value was 0.40×10^(-9).The most noticeable Au distribution patterns shown on the map are mainly located between Lusaka and Ndola(Lufilian Arc Belt).In addition,several high Au value areas occurred in Mansa,Muyombe,Chipata,and *** spatial distribution patterns of Au in tectonic units,drainage basins,and geomorphological landscapes could be related to the Lufilian Arc Belt and Bangweulu *** Au concentrations show metallogenic belts between Muyombe and Mbala areas,between Mansa and Ndola areas,and between Lusaka and Kasempa areas.

关键词： Gold Geochemical mapping Enrichment characteristics Catchment sediment Metallogenic belt Mineral survey engineering Zambia

Investigating Müller glia reprogramming in mice: a retrospective of the last decade, and a look to the future

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Neural Regeneration Research 2025年第4期20卷 946-959页

作者： Zhiyuan Yin Jiahui kang xuan Cheng Hui Gao Shujia Huo Haiwei xu Key Lab of Visual Damage and Regeneration&Restoration of Chongqing Southwest Eye HospitalSouthwest HospitalThird Military Medical University(Army Medical University)ChongqingChina

Müller glia,as prominent glial cells within the retina,plays a significant role in maintaining retinal homeostasis in both healthy and diseased *** lower vertebrates like zebrafish,these cells assume responsibility for spontaneous retinal regeneration,wherein endogenous Müller glia undergo proliferation,transform into Müller glia-derived progenitor cells,and subsequently regenerate the entire retina with restored ***,Müller glia in the mouse and human retina exhibit limited neural reprogramming.Müller glia reprogramming is thus a promising strategy for treating neurodegenerative ocular disorders.Müller glia reprogramming in mice has been accomplished with remarkable success,through various *** in molecular,genetic,epigenetic,morphological,and physiological evaluations have made it easier to document and investigate the Müller glia programming process in ***,there remain issues that hinder improving reprogramming efficiency and ***,understanding the reprogramming mechanism is crucial toward exploring factors that will improve Müller glia reprogramming efficiency,and for developing novel Müller glia reprogramming *** review describes recent progress in relatively successful Müller glia reprogramming *** also provides a basis for developing new Müller glia reprogramming strategies in mice,including epigenetic remodeling,metabolic modulation,immune regulation,chemical small-molecules regulation,extracellular matrix remodeling,and cell-cell fusion,to achieve Müller glia reprogramming in mice.

关键词： cell fusion chemical small-molecules epigenetic extracellular matrix immune metabolic mice Müller glia neurodegenerative diseases reprogramming retina regeneration

Petrogenesis of Early Cretaceous Pandian high-Mg diorites from the eastern North China Craton within an intracontinental setting:Implications for the skarn Fe mineralization

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Journal of Earth Science 2024年

作者： Si-Yuan Li Chao Fu Qi-Wei Feng Xiao-Bo Zhao Zhi-Cai Dang kang-kang xu Ming-Bo Gao Ji-Lei Gao Zhuang Duan Ming Ma Tianjin Center China Geological Survey (North China Center for Geoscience Innovation) Shandong Engineering Research Center of High-Grade Iron Deposits Exploration and Exploitation China University of Geosciences (Beijing) No.1 Institute of Geology and Mineral Resources of Shandong Province Geological Exploration Institute of Shandong Zhengyuan China Metallurgical Geology Bureau Shandong Provincial Bureau of Geology & Mineral Resources Institute of Geophysical and Geochemical Exploration Chinese Academy of Geological Sciences

High-magnesium andesitic rocks （HMAs） were initially interpreted to have formed via interaction of slab melt with mantle in arc ***,high-magnesium diorites （HMDs,analogs of HMAs）have been recognized can be formed in intracontinental *** of the HMDs producedsignificant Fe skarn *** genesis of HMDs and how they earn high Fe mineralization fertilities remain *** Pandian HMDs,located in Luxi Block,eastern North China Craton（NCC）,formed in continental interior and show a close spatiotemporal and genetic relationship to Fe skarn *** contribution carried out a comprehensive geochemical study on the Pandian HMDs to constrain the genesis of HMDs and further shed light on the key factors leading to their high Feskarn mineralization *** rocks show high Mg#values （55–80）,andesitic compositions （SiO2:55.3–66.2 wt%）,and arc-like *** Pandian HMDs possess (87Sr/86Sr)iof0.70720–0.70737,εNd（t） values of-11.8–-12.6,(206Pb/204Pb)iof 17.3706–17.4575,(207Pb/204Pb)iof15.3945–15.4440,and (208Pb/204Pb)iof 36.6606–*** notably distinct geochemicalcharacteristics between the Pandian HMDs and ancient lower crust in the NCC make it unlikely that the Pandian HMDs were sourced from the ***,The chemical characteristics of Pandian HMDs are akin to the proximal and contemporaneous mantle-derived Ji’nan *** presentresults,combined with geological analysis,reveal that Pandian HMDs were most likely primarily derived from an ancient sub-continental lithospheric mantle （SCLM） experienced metasomatism related to the subducted Paleo-Pacific slab-released *** higher La/Sm and Hf/Sm ratios and more enriched radiogenic Sr-Pb isotopes of Pandian HMDs relative to Ji’nan gabbro indicate crustalmaterial involvement during magma *** of crustal material assimilation,based on Sr-Nd isotopes,suggests parental melts of the Pandian HMDs assimilated about 20%Archean TTG gneisses and 60%Ordovicia

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A low redox potential and long life organic anode material for sodium-ion batteries

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Journal of Energy Chemistry 2025年第1期100卷 557-564页

作者： Zhi Li Yang Wei kang Zhou Xin Huang Xing Zhou Jie xu Taoyi Kong Junwei Lucas Bao Xiaoli Dong Yonggang Wang Department of Chemistry and Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials Institute of New Energy Collaborative Innovation Center of Chemistry for Energy Materials (iChEM) Fudan University Department of Chemistry Boston College School of Materials Science and Engineering Anhui University of Technology

Sodium-ion batteries （SIBs） with organic electrodes are an emerging research direction due to the sustainability of organic materials based on elements like C,H,O,and sodium ***,organic electrode materials for SIBs are mainly used as cathodes because of their relatively high redox potentials（>1 V）.Organic electrodes with low redox potential that can be used as anode are ***,a novel organic anode material （tetrasodium 1,4,5,8-naphthalenetetracarboxylate,Na4TDC） has been developed with low redox potential （<0.7 V） and excellent cyclic *** three-sodium storage mechanism was demonstrated with various in-situ/ex-situ spectroscopy and theoretical calculations,showing a high capacity of 208 mAh/g and an average decay rate of merely 0.022%per ***,the Na4TDC-hard carbon composite can further acquire improved capacity and cycling stability for 1200 cycles even with a high mass loading of up to 20 mg *** pairing with a thick Na3V2（PO4）3cathode (20.6 mg cm-2),the as-fabricated full cell exhibited high operating voltage （2.8 V）,excellent rate performance and cycling stability with a high capacity retention of 88.7% after 200 cycles,well highlighting the Na4TDC anode material for SIBs.

关键词： Organic anode material Low redox potential Composite anode Sodium-ion batteries

Impacts of Nutlin-3a and exercise on murine double minute 2-enriched glioma treatment

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Neural Regeneration Research 2025年第4期20卷 1135-1152页

作者： Yisheng Chen Zhongcheng Fan Zhiwen Luo xueran kang Renwen Wan Fangqi Li Weiwei Lin Zhihua Han Beijie Qi Jinrong Lin Yaying Sun Jiebin Huang Yuzhen xu Shiyi Chen Department of Sport Medicine Huashan HospitalFudan UniversityShanghaiChina Department of Orthopedic Surgery Hainan Province Clinical Medical CenterHaikou Affiliated Hospital of Central South University Xiangya School of MedicineHaikouHainan ProvinceChina Department of Basic Medicine Shanghai Jiao Tong University School of MedicineShanghai Jiao Tong UniversityShanghaiChina Department of Neurosurgery Second Affiliated Hospital of Zhejiang University School of MedicineZhejiang UniversityHangzhouZhejiang ProvinceChina Department of Orthopedics Shanghai General HospitalSchool of Medicine Shanghai Jiao Tong UniversityShanghaiChina Department of Infectious Diseases Children’s Hospital of Fudan UniversityNational Children’s Medical CenterShanghaiChina Department of Rehabilitation The Second Affiliated Hospital of Shandong First Medical UniversityTaianShandong ProvinceChina

Recent research has demonstrated the impact of physical activity on the prognosis of glioma patients,with evidence suggesting exercise may reduce mortality risks and aid neural *** role of the small ubiquitin-like modifier(SUMO)protein,especially post-exercise,in cancer progression,is gaining attention,as are the potential anti-cancer effects of *** used machine learning to create the exercise and SUMO-related gene signature(ESLRS).This signature shows how physical activity might help improve the outlook for low-grade glioma and other *** demonstrated the prognostic and immunotherapeutic significance of ESLRS markers,specifically highlighting how murine double minute 2(MDM2),a component of the ESLRS,can be targeted by *** underscores the intricate relationship between natural compounds such as nutlin-3 and immune *** comprehensive CRISPR screening,we validated the effects of specific ESLRS genes on low-grade glioma *** also revealed insights into the effectiveness of Nutlin-3a as a potent MDM2 inhibitor through molecular docking and dynamic ***-3a inhibited glioma cell proliferation and activated the p53 *** efficacy decreased with MDM2 overexpression,and this was reversed by Nutlin-3a or *** using a low-grade glioma mouse model highlighted the effect of physical activity on oxidative stress and molecular pathway ***,both physical exercise and Nutlin-3a administration improved physical function in mice bearing tumors derived from MDM2-overexpressing *** results suggest the potential for Nutlin-3a,an MDM2 inhibitor,with physical exercise as a therapeutic approach for glioma *** research also supports the use of natural products for therapy and sheds light on the interaction of exercise,natural products,and immune regulation in cancer treatment.

关键词： exercise and SUMO-related gene signatures(ESLRS) glioblastoma management low-grade glioma natural bioactives neural regeneration physical exercise