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Nuclear receptor coactivator 6 is a critical regulator of NLRP3 inflammasome activation and gouty arthritis

Cellular & Molecular Immunology 2024年第3期21卷 227-244页

作者： kang-gu Lee Bong-Ki Hong Saseong Lee Naeun Lee Seung-Whan Kim Donghyun Kim Wan-Uk Kim Center for Integrative Rheumatoid Transcriptomics and Dynamics The Catholic University of KoreaSeoul 06591Republic of Korea Department of Biomedicine&Health Sciences The Catholic University of KoreaSeoul 06591Republic of Korea Department of Pharmacology Asan Medical CenterUniversity of Ulsan College of MedicineSeoul 05505Republic of Korea Bio-Medical Institute of Technology University of UlsanSeoul 05505Republic of Korea Department of Microbiology and Immunology Seoul National University College of MedicineSeoul 03080Republic of Korea Institute of Infectious Diseases Seoul National University College of MedicineSeoul 03080Republic of Korea Division of Rheumatology Department of Internal MedicineThe Catholic University of KoreaSeoul 06591Republic of Korea

Transcriptional coactivators regulate the rate of gene expression in the nucleus.Nuclear receptor coactivator 6(NCOA6),a coactivator,has been implicated in embryonic development,metabolism,and cancer pathogenesis,but its role in innate immunity and inflammatory diseases remains unclear.Here,we demonstrated that NCOA6 was expressed in monocytes and macrophages and that its level was increased under proinflammatory conditions.Unexpectedly,nuclear NCOA6 was found to translocate to the cytoplasm in activated monocytes and then become incorporated into the inflammasome with NLRP3 and ASC,forming cytoplasmic specks.Mechanistically,NCOA6 associated with the ATP hydrolysis motifs in the NACHT domain of NLRP3,promoting the oligomerization of NLRP3 and ASC and thereby instigating the production of IL-1βand active caspase-1.Of note,Ncoa6 deficiency markedly inhibited NLRP3 hyperactivation caused by the Nlrp3^(R258W) gain-of-function mutation in macrophages.Genetic ablation of Ncoa6 substantially attenuated the severity of two NLRP3-dependent diseases,folic-induced acute tubular necrosis and crystal-induced arthritis,in mice.Consistent with these findings,NCOA6 was highly expressed in macrophages derived from gout patients,and NCOA6-positive macrophages were significantly enriched in gout macrophages according to the transcriptome profiling results.Conclusively,NCOA6 is a critical regulator of NLRP3 inflammasome activation and is therefore a promising target for NLRP3-dependent diseases,including gout.

关键词： Nuclear receptor coactivator 6 Nuclear-to-cytoplasmic translocation NLRP3 inflammasome NACHT domain Gouty arthritis

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Enhancement of porcine in vitro embryonic development through luteolin‑mediated activation of the Nrf2/Keap1 signaling pathway

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Journal of Animal Science and Biotechnology 2024年第2期15卷 600-613页

作者： Se-Been Jeon Pil-Soo Jeong Min Ju Kim Hyo-gu kang Bong-Seok Song Sun-Uk Kim Seong-Keun Cho Bo-Woong Sim Futuristic Animal Resource&Research Center(FARRC) Korea Research Institute of Bioscience and Biotechnology(KRIBB)Cheongju 28116Republic of Korea Department of Animal Science College of Natural Resources&Life SciencePusan National UniversityMiryang 50463Republic of Korea Department of Animal Science and Biotechnology College of Agriculture and Life ScienceChungnam National UniversityDaejeon 34134Republic of Korea Department of Functional Genomics University of Science and TechnologyDaejeon 34113Republic of Korea Department of Animal Science Life and Industry Convergence Research Institute(RICRI)College of Natural Resources&Life SciencePusan National UniversityMiryang 50463Republic of Korea

Background Oxidative stress,caused by an imbalance in the production and elimination of intracellular reactive oxygen species(ROS),has been recognized for its detrimental effects on mammalian embryonic development.Luteolin(Lut)has been documented for its protective effects against oxidative stress in various studies.However,its specific role in embryonic development remains unexplored.This study aims to investigate the influence of Lut on porcine embryonic development and to elucidate the underlying mechanism.Results After undergoing parthenogenetic activation(PA)or in vitro fertilization,embryos supplemented with 0.5μmol/L Lut displayed a significant enhancement in cleavage and blastocyst formation rates,with an increase in total cell numbers and a decrease in the apoptosis rate compared to the control.Measurements on D2 and D6 revealed that embryos with Lut supplementation had lower ROS levels and higher glutathione levels compared to the control.Moreover,Lut supplementation significantly augmented mitochondrial content and membrane potential.Intriguingly,activation of the Nrf2/Keap1 signaling pathway was observed in embryos supplemented with Lut,leading to the upregulation of antioxidant-related gene transcription levels.To further validate the relationship between the Nrf2/Keap1 signaling pathway and effects of Lut in porcine embryonic development,we cultured PA embryos in a medium supplemented with brusatol,with or without the inclusion of Lut.The positive effects of Lut on developmental competence were negated by brusatol treatment.Conclusions Our findings indicate that Lut-mediated activation of the Nrf2/Keap1 signaling pathway contributes to the enhanced production of porcine embryos with high developmental competence,and offers insight into the mechanisms regulating early embryonic development.

关键词： Luteolin Mitochondrial function Nrf2/Keap1 signaling pathway Oxidative stress Porcine embryo development

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Autogenous healing mechanism of cement-based materials

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结构与土木工程前沿:英文版 2023年第6期17卷 948-963页

作者： Desheng LI Hao ZHENG kang gu Lei LANG Shang SHI Bing CHEN Department of Civil Engineering School of ScienceNanjing University of Science and TechnologyNanjing210094China School of Transportation Science and Engineering Harbin Institute of TechnologyHarbin150090China State Key Laboratory of Ocean Engineering Shanghai Jiao Tong UniversityShanghai200240China State Key Laboratory of Geomechanics and Geotechnical Engineering Institute of Rock and Soil MechanicsWuhan430071China

Autogenous self-healing is the innate and fundamental repair capability of cement-based materials for healing cracks.Many researchers have investigated factors that influence autogenous healing.However,systematic research on the autogenous healing mechanism of cement-based materials is lacking.The healing process mainly involves a chemical process,including further hydration of unhydrated cement and carbonation of calcium oxide and calcium hydroxide.Hence,the autogenous healing process is influenced by the material constituents of the cement composite and the ambient environment.In this study,different factors influencing the healing process of cement-based materials were investigated.Scanning electron microscopy and optical microscopy were used to examine the autogenous healing mechanism,and the maximum healing capacity was assessed.Furthermore,detailed theoretical analysis and quantitative detection of autogenous healing were conducted.This study provides a valuable reference for developing an improved healing technique for cement-based composites.

关键词： autogenous healing cement-based materials healing mechanism aggregation effect

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Investigation on Thermal Insulation and Mechanical Strength of Lightweight Aggregate Concrete and Porous Mortar in Cold Regions

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Journal of Renewable Materials 2022年第12期10卷 3167-3183页

作者： Jianan Wu Ke Xue Zhaowei Ding Lei Lang kang gu Xiaolin Li Mingli Zhang Desheng Li Ningbo City College of Vocational Technology NingboChina College of Water Conservancy and Hydropower Engineering Sichuan Agricultural UniversityYa’anChina State Key Laboratory of Ocean Engineering Shanghai Jiao Tong UniversityShanghaiChina College of Civil Engineering and Architecture Jiaxing UniversityJiaxingChina Department of Civil Engineering Lanzhou University of TechnologyLanzhouChina Department of Civil Engineering College of ScienceNanjing University of Science and TechnologyNanjingChina

Thermal insulation is an important indicator to evaluate the construction material in cold region engineering.As we know,adding the industrial waste as lightweight aggregate or creating the pore inside the cement-based composite could make the texture loose,and the thermal insulating capacity of the material would be improved with this texture.Using these methods,the industrial by-product and engineering waste could be cycled in an efficient way.Moreover,after service the fragmented cement composites paste could be used as aggregate in the thermal insulating concrete again.While the porous texture is not favorable for the mechanical strength and long-term durability in a cold environment.To balance the above three requirements from two opposite directions,different processing methods were applied to create the thermal insulation concrete/mortar.Firstly,the organic/inorganic lightweight aggregate,including the Expanded Polystyrene(EPS),Expanded Perlite(EP),and Ceramsite(CRMST)particles,were applied to create the Lightweight Aggregate Concrete(LWAC).As the comparative tests,the expanded Superabsorbent Polymer(SAP)hydrogel and Air-Entraining Agent(AEA)were also introduced to create the porous mortar.The above concrete/mortar was tested in the normal state and under the Freeze-Thaw cycle to explore the engineering performance in cold regions.During the experimenting process,the thermal insulation,mechanical strength,and frost resistance of these cement-based composites were investigated,and an optimal thermal insulation concrete/mortar was determined.

关键词： Thermal insulation mechanical strength cement-based composite freeze-thaw cycle frost resistance

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乡村景观治理模式的演变路径及动力学机制研究

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中国园林 2024年第2期40卷 57-63页

作者：谷康王怡舞王浩南京林业大学风景园林学院南京210037

运用历史比较法、内容分析法,对中华人民共和国成立以来我国乡村景观及其治理体系的演进历程进行全景式分析。将治理模式分为起步阶段、改革阶段和完善阶段,结合各时期乡村景观建设成效,归纳治理影响因素与对景观的调节机制,认为国家对... 详细信息

运用历史比较法、内容分析法,对中华人民共和国成立以来我国乡村景观及其治理体系的演进历程进行全景式分析。将治理模式分为起步阶段、改革阶段和完善阶段,结合各时期乡村景观建设成效,归纳治理影响因素与对景观的调节机制,认为国家对乡村的定位决定景观治理目标与重点,土地、人口管理、经济产业等制度改革引导乡村治理的潜力挖掘,行政财政体制制约乡镇的治理效能,社会文化嬗变加速治理程序的价值转向。最后,基于演变路径提出建议,以期探索更加规范化、法制化的乡村景观建设与治理模式。

关键词：风景园林乡村景观治理模式历史变迁演变路径动力学机制

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Superior electrocatalytic negative electrode with tailored nitrogen functional group for vanadium redox flow battery

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Journal of Energy Chemistry 2023年第3期78卷 148-157,I0005页

作者： Min gu kang Wook Ahn Joonhee kang Shin Ae Song Kiyoung Kim Ju Young Woo Yong-Cheol Jeong Bonwook Koo Dae Soo Jung Sung Nam Lim Micro/Nano Scale Manufacturing Group Korea Institute of Industrial Technology143 HanggaulroSangrok-guAnsan-siGyeonggi-do 15588Republic of Korea Department of Energy Systems Engineering Soonchunhyang University22 Soonchunhyang-roShinchang-myeonAsan-siChungcheongnam-do 31538Republic of Korea Department of Nanoenergy Engineering Pusan National UniversityBusan 46241Republic of Korea Department of Nano Fusion Technology Pusan National UniversityBusan 46241Republic of Korea Energy Storage Materials Center Energy&Environmental DivisionKorea Institute of Ceramic Engineering&Technology(KICET)101 Soho-roJinju-siGyeongsangnam-doRepublic of Korea

Development of electrodes with high electrocatalytic activity and stability is essential for solving problems that still restrict the extensive application of vanadium redox flow batteries(VRFBs).Here,we designed a novel negative electrode with superior electrocatalytic activity by tailoring nitrogen functional groups,such as newly formed nitro and pyridinic-N transformed to pyridonic-N,from the prenitrogen-doped electrode.It was experimentally confirmed that an electrode with pyridonic-N and nitro fuctional groups(tailored nitrogen-doped graphite felt,TNGF) has superior electrocatalytic acivity with enhanced electron and mass transfer.Density functional theory calulations demonstrated the pyridonic-N and nitro functional groups promoted the adsorption,charge transfer,and bond formation with the vanadium species,which is consistent with expermental results.In addition,the V2+/V3+redox reaction mechanism on pyridonic-N and nitro functional groups was estabilised based on density functional theory(DFT) results.When TNGF was applied to a VRFB,it enabled enhanced-electrolyte utilization and energy efficiencies(EE) of 57.9% and 64.6%,respectively,at a current density of 250 mA cm^(-2).These results are 18.6% and 8.9% higher than those of VRFB with electrode containing graphitic-N and pyridinicN groups.Interestingly,TNGF-based VRFB still operated with an EE of 59% at a high current density of300 mA cm^(-2).The TNGF-based VRFB exhibited stable cycling performance without noticeable decay of EE over 450 charge-discharge cycles at a current density of 250 mA cm^(-2).The results of this study suggest that introducing pyridonic-N and nitro groups on the electrode is effective for improving the electrochemical performance of VRFBs.

关键词： Tailored nitrogen functional group Pyridonic-N Nitro Negative electrode Density functional theory Vanadium redoxﬂow batteries

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Accelerated biodegradation of iron-based implants via tantalum-implanted surface nanostructures

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Bioactive Materials 2022年第3期7卷 239-250页

作者： Min-Kyu Lee Hyun Lee Cheonil Park In-gu kang Jinyoung Kim Hyoun-Ee Kim Hyun-Do Jung Tae-Sik Jang Department of Materials Science and Engineering Seoul National UniversitySeoul08826Republic of Korea Querrey Simpson Institute for Bioelectronics Northwestern UniversityEvanstonIL60208USA Department of Biomedical-Chemical Engineering Catholic University of KoreaBucheon14662Republic of Korea Department of Biotechnology The Catholic University of KoreaBucheon14662Republic of Korea Department of Materials Science and Engineering Chosun UniversityGwangju61452Republic of Korea

In recent years,pure iron(Fe)has attracted significant attention as a promising biodegradable orthopedic implant material due to its excellent mechanical and biological properties.However,in physiological conditions,Fe has an extremely slow degradation rate with localized and irregular degradation,which is problematic for practical applications.In this study,we developed a novel combination of a nanostructured surface topography and galvanic reaction to achieve uniform and accelerated degradation of an Fe implant.The target-ion induced plasma sputtering(TIPS)technique was applied on the Fe implant to introduce biologically compatible and electrochemically noble tantalum(Ta)onto its surface and develop surface nano-galvanic couples.Electrochemical tests revealed that the uniformly distributed nano-galvanic corrosion cells of the TIPS-treated sample(nano Ta-Fe)led to relatively uniform and accelerated surface degradation compared to that of bare Fe.Furthermore,the mechanical properties of nano Ta-Fe remained almost constant during a long-term in vitro immersion test(~40 weeks).Biocompatibility was also assessed on surfaces of bare Fe and nano Ta-Fe using in vitro osteoblast responses through direct and indirect contact assays and an in vivo rabbit femur medullary cavity implantation model.The results revealed that nano Ta-Fe not only enhanced cell adhesion and spreading on its surface,but also exhibited no signs of cellular or tissue toxicity.These results demonstrate the immense potential of Ta-implanted surface nanostructures as an effective solution for the practical application of Fe-based orthopedic implants,ensuring long-term biosafety and clinical efficacy.

关键词： Iron Tantalum Ion implantation Biodegradation Orthopedic implants

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In-situ constructed three-dimensional MoS_(2)–MoN heterostructure as the cathode of lithium–sulfur battery

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Rare Metals 2022年第5期41卷 1743-1752页

作者： Jing-Han Zuo Peng-Bo Zhai Qian-Qian He Lei Wang Qian Chen Xiao-kang gu Zhi-Lin Yang Yong-Ji Gong School of Materials Science and Engineering Beihang UniversityBeijing 100191China

Lithium-sulfur batteries are recognized as one of the most promising next-generation high-performance energy storage systems. However, obstacles like the irreversible capacity loss hinder its broad application. Herein,we fabricated an interconnected three-dimensional MoS_(2)-MoN heterostructure(3D-MoS_(2)-MoN) via a facile salttemplate method, overcoming the intrinsic shortcomings such as poor conductivity and compact morphology of traditionally-synthesized transition metal sulfides(TMSs).Furthermore, excellent electrocatalysis ability and hierarchical pore structure effectively accelerate the sluggish lithium polysulfides conversions during cycling. As a result, 3D-MoS_(2)-MoN showed a high initial specific capacity of 1466 mAh·g^(-1)and excellent high-rate capability up to 4℃. A stable cycling performance with a sulfur loading of 2 mg·cm^(-2) was realized with a low decay rate of 0.069% per cycle. This work introduced a rational design route for the appliance of TMSs in the lithiumsulfur batteries.

关键词： Heterostructure Transition metal sulfides Three-dimensional Electrocatalysis

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外军无人蜂群作战概念研究进展及分析

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航空兵器 2022年第1期29卷 52-57页

作者：谷康陆军炮兵防空兵学院合肥230000

无人蜂群作战概念近几年来一直是世界各国竞相发展的重点。本文列举了近几年国外在蜂群作战方面的最新研究进展和取得的阶段性成果,并总结分析了目前国外蜂群作战概念的主要技术发展方向,包括群体控制、通用性系统设计、智能化以及人机... 详细信息

无人蜂群作战概念近几年来一直是世界各国竞相发展的重点。本文列举了近几年国外在蜂群作战方面的最新研究进展和取得的阶段性成果,并总结分析了目前国外蜂群作战概念的主要技术发展方向,包括群体控制、通用性系统设计、智能化以及人机协作等。在此基础上,进一步指出蜂群作战技术发展存在的不足和难点,为国内下一步蜂群作战发展提供思路。

关键词：蜂群作战群体控制通用性智能化人机协作无人机

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Do microRNA 96, 145 and 221 expressions really aid in Lhe prognosis of prostate carcinoma？

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Asian Journal of Andrology 2012年第5期14卷 752-757页

作者： Sung gu kang Young Ran Ha Seo Jin Kim Seok Ho kang Hong Seok Park Jeong gu Lee Jun Cheon Department of Urology Korea University College of Medicine Seou1136-705 Republic of Korea and 2Department of Pathology Korea University College of Medicine Seoul 136 705 Republic of Korea Department of Pathology Korea University College of Medicine Seoul 136705 Republic of Korea

MicroRNAs （miRs） are small noncoding RNAs that have been reported to be premising diagnostic tools. We used quantitative real-time reverse transcription PCR （RT-qPCR） to analyze differentially expressed miRNAs in prostate tumor samples to determine its prognostic value. From 2007 to 2009, tumor tissues were obtained from 73 radical prostatectomy specimens. Differentially expressed miR-96, -145 and -221 were validated by TaqMan RT-qPCR using all 73 tissues. The prognostic value was assessed in terms of biochemical recurrence using Kaplan-Meier and Cox regression analyses. For our patient cohort, the mean age was 64.7 years （50-76 years） and the mean prostate-specific antigen （PSA） was 7.5 ng m1-1. During the follow-up period （mean, 19.4 months）, 14 of 73 （19.2%） patients developed biochemical recurrence. Expression of miR-96, -145 and -221 correlated strongly with each other, but there were no correlations between miRNA expression and clinicopathologic parameters. Kaplan-Meier survival curves using the log-rank test showed a decreased biochemical recurrence-free interval with pathologic stage （P〈O.O01）. In addition, patients with Gleason scores over 8, compared with those with a Gleason score of 6, showed a decreased biochemical recurrence-free interval in Kaplan-Meier analysis （P=O.O01）. However, expression of miR-96, -145 and -221 did not correlate with the biochemical recurrence interval in Kaplan-Meier survival curves or by multivariate analysis using the Cox proportional hazard regression model, either. In conclusion, we did not observe a significant correlation between the expression of miR-96, -145 and -221 and clinicopathologic parameters. To utilize miRNA as a diagnostic tool in clinical practice, more research is needed to understand miRNA mechanisms, identify miRNA targets, and further characterize miRNA function.

关键词： microRNA prognosis prostate cancer recurrence

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