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Virologica Sinica 2024年第3期39卷 513-515页

作者： Shuo Zhang Yu Leng Fa-Xue Zhang bo-kang Fu Bing-Zheng Wu Jia-Hao Chen Ning Cui Ning Zhao Wei Liu Hao Li College of Life Sciences Southwest Forestry UniversityKunming650224China State Key Laboratory of Pathogen and Biosecurity Beijing Institute of Microbiology and EpidemiologyBeijing Key Laboratory of Vector Borne and Natural Focus Infectious DiseasesBeijing100071China School of Public Health Wuhan UniversityWuhan430071China The First Affiliated Hospital of Anhui Medical University Hefei230022China Xinyang 154 Hospital Xinyang464000China

Dear Editor,Severe fever with thrombocytopenia syndrome(SFTS)is an emerging tick-borne infectious disease caused by a novel bunyavirus called SFTS virus(SFTSV).It was initially identified in China in 2009(Yu et al.,2011).Since then,the number of reported SFTS cases has rapidly increased in China,South Korea,and Japan(Li,et al.,2018;Takahashi et al.,2014;Kim et al.,2018).Sporadic SFTS cases have also been identified in several other Asian countries,such as Vietnam,Pakistan,Myanmar,and Thailand(Takahashi et al.,2014;Tran et al.,2019;Li et al.,2021).This disease is recognized as a highly lethal viral hemorrhagic fever with a mortality rate ranging from 12%to 50%(Yu et al.,2011;Li et al.,2018;Takahashi et al.,2014;Kim et al.,2013).SFTS primarily spreads to humans through bites from ticks infected with SFTSV,with the Haemaphysalis longicornis tick acting as the predominant vector for SFTSV(Zhuang et al.,2018).

关键词： attributed initially predominant

Artificial parasin I protein (API) supplementation improves growth performance and intestinal health in weaned piglets challenged with enterotoxigenic Escherichia coli

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ANIMAL NUTRITION 2024年第3期18卷 154-165页

作者： Zou, Congzhi Zhao, Wanxin Yin, Shenggang Xiang, Xiaoyu Tang, Jiayong Jia, Gang Che, Lianqiang Liu, Guangmang Chen, Xiaoling Tian, Gang Cai, Jingyi kang, bo Zhao, Hua Sichuan Agr Univ Anim Nutr Inst Key Lab Anim Dis Resistance Nutr Minist Agr & Rura Key Lab Anim Dis Resistance NutrMinist EducKey L Chengdu 611130 Peoples R China Sichuan Agr Univ Coll Anim Sci & Technol Chengdu 611130 Peoples R China

Diarrheas are common risks faced by piglets during the weaning period. This study investigated the alleviating effects of artificial parasin I protein (API) on growth performance and intestinal health of weaned pigs upon enterotoxigenic Escherichia coli (ETEC) challenge. Sixty piglets were randomly divided into five groups and fed a basal diet (CON) or basal diet supplemented with API at 0, 750, and 1500 mg/kg or antibiotics for 5 weeks. On d 15 and 25, piglets were challenged with ETEC K88 except for the CON group. Before the ETEC challenge (d 1-14), dietary API supplementation improved growth performance, and 750 mg API increased (P < 0.05) the average daily gain (ADG), decreased (P < 0.05) feed to gain ratio (F/G) and diarrhea index of weaned piglets. ETEC challenge (during d 15-35) reduced growth performance and increased (P < 0.01) the F/G, diarrhea rate, and diarrhea index. This event was accompanied by the numerically increased malondialdehyde (MDA) levels in serum and ileum, the decreased (P < 0.05) zonula-occludens-1 (ZO-1) and interleukin-6 (IL-6) in the ileum, and the increased (P 1/4 0.04) secretory immunoglobulin A (sIgA) protein in the ileum. Artificial parasin I protein supplementation alleviated the negative impact of ETEC. The 750 mg/kg API inclusion elevated (P < 0.05) ADG and decreased (P < 0.05) F/G. Two levels of API decreased (P < 0.01) the diarrhea rate and diarrhea index. Meanwhile, API inclusion decreased (P < 0.01) the crypt depth in the jejunum, elevated (P < 0.05) villus height in the duodenum and villus height to crypt depth ratio in the duodenum and ileum, up-regulated (P < 0.05) ZO-1 gene, and down-regulated (P < 0.05) mucin-2 gene in the jejunum, and 1500 mg/kg API decreased (P < 0.01) sIgA level and down-regulated (P < 0.05) IL-1b gene in the ileum. Furthermore, 750 mg/kg API elevated (P < 0.01) Bifidobacteria population and acetic acid concentrations in the cecal chyme. In conclusion, API supplementation alleviates the negative impa

关键词： Artificial parasin I protein Growth performance Intestinal barrier Diarrhea Weaned piglet IMMUNOGLOBULIN-A ANTIboDIES TIGHT JUNCTION PROTEINS MICROBIAL-POPULATIONS BARRIER FUNCTION HISTONE H2A FATTY-ACID SYSTEM INFLAMMATION HOMEOSTASIS MORPHOLOGY

Selenomethionine alleviates chronic heat stress-induced breast muscle injury and poor meat quality in broilers via relieving mitochondrial dysfunction and endoplasmic reticulum stress

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动物营养学报 2024年第1期16卷 363-375页

作者： Jinzhong Jing Jiayi Wang Xiaoyu Xiang Shenggang Yin Jiayong Tang Longqiong Wang Gang Jia Guangmang Liu Xiaoling Chen Gang Tian Jingyi Cai bo kang Lianqiang Che Hua Zhao Key Laboratory for Animal Disease-Resistance Nutrition of Ministry of Education of China Ministry of Agriculture and Rural Affairs of Sichuan Province Animal Nutrition Institute Sichuan Agricultural University Chengdu 611130 Sichuan China College of Animal Science and Technology Sichuan Agricultural University Chengdu 611130 Sichuan China

In the present study, the chronic heat stress (CHS) broiler model was developed to investigate the potential protection mechanism of organic selenium (selenomethionine, SeMet) on CHS-induced skeletal muscle growth retardation and poor meat quality. Four hundred Arbor Acres male broilers (680 ± 70 g, 21 d old) were grouped into 5 treatments with 8 replicates of 10 broilers per replicate. Broilers in the control group were raised in a thermoneutral environment (22 ± 2 °C) and fed with a basal diet. The other four treatments were exposed to hyperthermic conditions (33 ± 2 °C, 24 h in each day) and fed on the basal diet supplied with SeMet at 0.0, 0.2, 0.4, and 0.6 mg Se/kg, respectively, for 21 d. Results showed that CHS reduced ( P 0.05) the growth performance, decreased ( P 0.05) the breast muscle weight and impaired the meat quality of breast muscle in broilers. CHS induced protein metabolic disorder in breast muscle, which increased ( P 0.05) the expression of caspase 3, caspase 8, caspase 9 and ubiquitin proteasome system related genes, while decreased the protein expression of P-4EBP1. CHS also decreased the antioxidant capacity and induced mitochondrial stress and endoplasmic reticulum (ER) stress in breast muscle, which increased ( P 0.05) the ROS levels, decreased the concentration of ATP, increased the protein expression of HSP60 and CLPX, and increased ( P 0.05) the expression of ER stress biomarkers. Dietary SeMet supplementation linearly increased ( P 0.05) breast muscle Se concentration and exhibited protective effects via up-regulating the expression of the selenotranscriptome and several key selenoproteins, which increased ( P View The PDF

关键词： Broiler Chronic heat stress Skeletal muscle Meat quality Mitochondrial dysfunction Endoplasmic reticulum stress

Lecithin-cholesterol acyltransferase is a potential tumor suppressor and predictive marker for hepatocellular carcinoma metastasis

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World Journal of Gastrointestinal Oncology 2024年第8期16卷 3651-3671页

作者： Yan Li Li-Na Jiang bo-kang Zhao Mei-Ling Li Yi-Yun Jiang Yi-Si Liu Shu-Hong Liu Li Zhu Xin Ye Jing-Min Zhao Department of Pathology and Hepatology The Fifth Medical Center of Chinese PLA General HospitalBeijing 100039China Department of Hepatology Center of Infectious Diseases and Pathogen BiologyThe First Hospital of Jilin UniversityChangchun 130061Jilin ProvinceChina First Department of Liver Disease Center Beijing Youan HospitalCapital Medical UniversityBeijing 100069China Key Laboratory of Pathogenic Microbiology and Immunology Institute of MicrobiologyChinese Academy of SciencesBeijing 100101China Savaid Medical School University of Chinese Academy of SciencesBeijing 100190China Department of Pathology The Fifth Medical Center of Chinese PLA General HospitalBeijing 100039China

BACKGROUND Hepatocellular carcinoma(HCC)is a major cause of cancer mortality worldwide,and metastasis is the main cause of early recurrence and poor ***,the mechanism of metastasis remains poorly *** To determine the possible mechanism affecting HCC metastasis and provide a possible theoretical basis for HCC *** The candidate molecule lecithin-cholesterol acyltransferase(LCAT)was screened by gene microarray and bioinformatics *** expression levels of LCAT in clinical cohort samples was detected by quantitative realtime polymerase chain reaction and western *** proliferation,migration,invasion and tumor-forming ability were measured by Cell Counting Kit-8,Transwell cell migration,invasion,and clonal formation assays,*** formation was detected in nude mice after LCAT gene knockdown or *** immunohistochemistry for Ki67,E-cadherin,N-cadherin,matrix metalloproteinase 9 and vascular endothelial growth factor were performed in liver tissues to assess the effect of LCAT on *** set enrichment analysis(GSEA)on various gene signatures were analyzed with GSEA version *** machine-learning algorithms(random forest,support vector machine,and logistic regression)were applied to predict HCC metastasis in The Cancer Genome Atlas and GEO *** LCAT was identified as a novel gene relating to HCC metastasis by using gene microarray in HCC *** was significantly downregulated in HCC tissues,which is correlated with recurrence,metastasis and poor outcome of HCC *** analysis indicated that LCAT inhibited HCC cell proliferation,migration and invasion both in vitro and in *** data showed that LCAT was negatively associated with HCC size and metastasis(HCC size≤3 cm vs 3-9 cm,P9 cm,P<0.01;metastatic-free HCC vs extrahepatic metastatic HCC,P<0.05).LCAT suppressed the growth,migration and invasion of HCC cell lines via PI3K/A

关键词： Lecithin-cholesterol acyltransferase Tumor suppressor gene Hepatocellular carcinoma PI3K/AKT/mTOR Predicting model

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基于抽象关系场景图的图像情感识别

智能系统学报 2024年第2期19卷 335-343页

作者：康博钱艺文益民桂林电子科技大学广西图像图形与智能处理重点实验室广西桂林541004

图像情感识别是通过分析视觉刺激来预测人类情感的抽象过程。现有方法大多缺乏对对象间关系以及对象与场景间相互作用的关注,并且对象间复杂多样的关系难以得到充分利用,进而导致难以正确对图像情感进行预测。为解决上述问题,提出一种... 详细信息

图像情感识别是通过分析视觉刺激来预测人类情感的抽象过程。现有方法大多缺乏对对象间关系以及对象与场景间相互作用的关注,并且对象间复杂多样的关系难以得到充分利用,进而导致难以正确对图像情感进行预测。为解决上述问题,提出一种基于抽象关系场景图的图像情感识别方法。首先,构建对象和属性检测器来提取图像中对象及其属性的特征。其次,使用对象特征推理对象间的亲密度和抽象关系特征,进而构建抽象关系场景图。再次,提出抽象关系图卷积网络来推理抽象关系场景图。最后,设计渐进式注意力机制对多个对象特征进行融合,以得到图像的整体对象特征。在FI、EmotionRoI和Twitter I公开数据集上的试验结果表明,该方法的分类准确率优于现有方法。

关键词：图像情感识别抽象关系场景图图卷积网络注意力机制卷积神经网络视觉情感分析深度学习

冻融循环作用下MICP固化铅污染土的强度与浸出特性研究

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工程地质学报 2024年第2期32卷 440-447页

作者：李杰康博查甫生合肥工业大学资源与环境工程学院合肥230000

微生物诱导碳酸钙沉淀(MICP)技术可用于重金属污染土固化稳定修复。本文通过开展无侧限抗压强度、离子浸出及微观试验,主要研究MICP固化铅污染土在冻融循环作用下的强度与化学稳定性,并揭示其微观作用机理。结果表明:随着铅离子浓度的增... 详细信息

微生物诱导碳酸钙沉淀(MICP)技术可用于重金属污染土固化稳定修复。本文通过开展无侧限抗压强度、离子浸出及微观试验,主要研究MICP固化铅污染土在冻融循环作用下的强度与化学稳定性,并揭示其微观作用机理。结果表明:随着铅离子浓度的增加,土体的无侧限抗压强度先增大后减小,铅离子浸出浓度增大;随冻融循环次数的增加,土体的强度逐渐降低并趋于稳定,铅离子浸出浓度增大。冻融循环作用后,固化土的主要矿物成分未发生变化;土中的小孔隙数量增加,大孔隙数量基本保持不变。冻融循环作用损伤固化土的碳酸钙胶结与铅离子沉淀结构,致使土体性能劣化。

关键词：重金属污染土微生物诱导碳酸钙沉淀(MICP) 冻融循环强度及浸出特性劣化机理

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化工电气设备检修及运行维护要点分析与研究

全面腐蚀控制 2024年第7期38卷 47-49页

作者：康勃中国石化青岛液化天然气有限责任公司山东青岛266000

为确保化工设备的正常运行,企业的生产目标能够按时完成,需要及时发现化工设备的安全隐患,本文对化工设备维护与检查点和化工电气设备检修和运行维护工作中存在的安全风险进行了详细分析,以此为基础对化工设备维护与检修工作的优化及创... 详细信息

为确保化工设备的正常运行,企业的生产目标能够按时完成,需要及时发现化工设备的安全隐患,本文对化工设备维护与检查点和化工电气设备检修和运行维护工作中存在的安全风险进行了详细分析,以此为基础对化工设备维护与检修工作的优化及创新进行了深度研究,以期能够为化工设备的稳定运行提供有效参考。

关键词：化工产业电气设备检修维护

新时代我国乡村警务模式创新建设的思考——基于对湖南省新化县乡村警务的实践考察

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北京警察学院学报 2024年第3期 57-64页

作者：陈永辉康博湖南警察学院长沙410138 湖南省娄底市公安局湖南娄底417000

新时代乡村警务工作不断深入实践,凸显时代要求。湖南省新化县乡村警务凸显了党建引领、齐抓共管;警力前置、服务前移;平安共建、全民联防等工作特色。但在一些乡镇也存在为民服务意识不强、督管机制不健全、联动不足等现象。新时代乡... 详细信息

新时代乡村警务工作不断深入实践,凸显时代要求。湖南省新化县乡村警务凸显了党建引领、齐抓共管;警力前置、服务前移;平安共建、全民联防等工作特色。但在一些乡镇也存在为民服务意识不强、督管机制不健全、联动不足等现象。新时代乡村警务模式创新建设,要加强基层党组织引领作用,抓好警民党员干部主力军建设;要强化村民委员会与派出所两个中枢的结合,抓好警民联动建设;要加强宣传教育,抓好乡风文明系统、法治科普系统和社区联防系统三个系统的全覆盖建设。

关键词：乡村警务党建引领警民联动宣传教育

基于生成式人工智能的体育教师跨学科教学能力培育价值及未来取向

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体育文化导刊 2024年第6期 95-101,110页

作者：王博王庆军康博华胡灿灿邹馥凯无锡市辅仁高级中学江苏无锡214112 南京师范大学体育科学学院南京210023 西安体育学院研究生部西安710068 无锡市第一中学江苏无锡214112 江苏省梅村高级中学江苏无锡214112

运用文献资料、逻辑分析等方法,剖析基于生成式人工智能的体育教师跨学科教学能力培育的价值、未来取向,并提出培育路径。价值:发展认知能力,提升设计能力,创新实施能力,优化评价能力。未来取向:加强教学资源供给,促进教学认知发展;重... 详细信息

运用文献资料、逻辑分析等方法,剖析基于生成式人工智能的体育教师跨学科教学能力培育的价值、未来取向,并提出培育路径。价值:发展认知能力,提升设计能力,创新实施能力,优化评价能力。未来取向:加强教学资源供给,促进教学认知发展;重塑教学开展方式,增强教学设计效能;增强教育场景转换,推动教学实施研究;推动人机观念转变,创新多元教学评价。培育路径:推进教学资源建设,创造教学认知发展条件;搭建制度保障框架,推动实现教学设计变革;强化智能技术培训,助力教学实施研究落实;激发协同育人活力,升级完善教学评价体系。

关键词：体育教育体育教师跨学科教学能力生成式人工智能

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村落体育空间助力乡村振兴思考

体育文化导刊 2024年第7期 16-23页

作者：丛荣蒋全虎康博舒范尧东北师范大学体育学院长春130024 南京师范大学体育科学学院南京210023

运用文献资料、实地调查等方法,探究村落体育空间助力乡村振兴的价值、困境与路径。价值:优化乡村产业结构,助推产业兴旺;构建现代治理体系,促进治理有效;传承优秀传统文化,培育文明乡风;提高村民生活品质,实现生活富裕;推进生态环境修... 详细信息

运用文献资料、实地调查等方法,探究村落体育空间助力乡村振兴的价值、困境与路径。价值:优化乡村产业结构,助推产业兴旺;构建现代治理体系,促进治理有效;传承优秀传统文化,培育文明乡风;提高村民生活品质,实现生活富裕;推进生态环境修复,打造宜居乡村。困境:产业发展较为脆弱,基层治理协同不畅,文化传承动力缺失,吸纳农民就业有限,生态建设耦合不足。路径:筑牢产业发展基石,赋能产业持续发展;厘清多元主体地位,构建协同治理体系;增强文化传承动力,赓续优秀传统文化;拓宽农民就业岗位,提高农民生活品质;嵌入聚落生态环境,助推生态文明建设。

关键词：乡村振兴村落体育空间乡村体育