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In silicoanalysis of influence of the missense mutation P629S on the molecular interaction and 3D properties of PIK3R5

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Advances in Biological Chemistry 2013年第4期3卷 408-417页

作者： Jameela shinwari Asma I. Tahir Saeed Bohlega Nada AlTassan Department of Genetics King Faisal Specialist Hospital and Research Centre Riyadh KSA Department of Neurosciences King Faisal Specialist Hospital and Research Centre Riyadh KSA

PIK3R5 is the regulatory subunit of Phosphoinositide 3-kinase γ (PI3Kγ) that is responsible for phosphory-lating membrane lipids to activate the AKT pathway. PIK3R5 binds Gβγ and facilitates the interaction with p110γ catalytic subunit (PIK3CG) during PI3Kγ activation. The identification of PIK3R5 P629S mutation in AOA2 patients indicated a potential defect in the AKT pathway resulting from impaired PIK3R5 interaction with Gβγ and PIK3CG, defective AKT pathway can result in cerebellar cell death causing neurological symptoms. Our in silico macromolecular docking of the wild type and mutant PIK3R5 protein models with ligand revealed an energy requirement to maintain the mutant complexes compared to no energy required to maintain the wild type complexes, in addition, the mutant structures were loose compared to rigid wild type structures, such structural changes may impair the molecular function of the PIK3R5 and hence affect the AKT pathway.

关键词： PIK3R5 Missense Mutation Protein Modelling Protein-Protein Docking PIK3CG Gβγ

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The acute lymphoblastic leukemia among Afghan children, Indira Gandhi Children’s Hospital

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Clinical Research Communications 2022年第3期5卷 38-41页

作者： Mohamad Haroon Noori Nasser Ahmad shinwari Ahmad Mujtaba Barekzai Department of Hematology Spinghar Institute of Higher EducationKabul CampusAfghanistan Department of Pediatric Andhra Gandhi Government Hospital Department of Biotechnology and Microbial Technology Spinghar Institute of Higher EducationKabul CampusAfghanistan Research Director Spinghar Institute of Higher EducationKabul CampusAfghanistan Department of Public Health Spinghar Institute of Higher EducationKabul CampusAfghanistan Technical Manager of Food Safety providing quality and quantity inspection services for UN-WFPKICAfghanistan

Objective:Almost all leukemia patients died,fortunately now with the advancement of medicine and science and with the advent of treatment Chemotherapy,Radiotherapy,and Surgical treatment 75%of patients with leukemia who need treatment for up to 5 years,live longer than patients with leukemia who do not receive *** the one side,in our country,Afghanistan the number of incidents has increased recently,and on the other side,we do not have data at the national ***,the child health hospital administration considered the necessary and left me to research this case in the last 6 months of ***:This is an observational descriptive study,which observed 10,293 patients that come to the pediatric internal which 300 patients who indicate leukemia,and 200 patients with acute lymphoblastic leukemia(ALL),who were admitted to the oncology service of Andhra Gandhi Child Health Hospital in 2018 the study took ***:Based on the age we detect less than one year’s 10(5%)patients,1-10 years old 150(75%)patients,and more than 10 years old 40(20%)*** on sex,boys were 120(60%)patients and girls 80(40%)*** on clinical findings,anemia 155(77.5%)patients,fever 130(65%)patients,bleeding 90(45%)patients,spleen thickness 88(44%)patients,liver thickness 73(36.6%)patients,lymph nodes thickness 70(35.55%)patients,great pains 66(33%)patients and nervous system disorders 38(19%)***:We can say with great conviction that 200 patients out of 10,293 had acute lymphoblastic *** studies with prospective nature are required to confirm this observation.

关键词： acute lymphoblastic leukemia Afghan children Indira Gandhi Children’s Hospital

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Antibacterial activity of honey in north-west Pakistan against select human pathogens

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Journal of Traditional Chinese Medicine 2014年第1期34卷 86-89页

作者： Ali Talha Khalil Imran Khan Yusra Ali Khan Zabta Khan shinwari Kafeel Ahmad Jangrez Khan Department of Biotechnology Quaid-i-Azam University Centre of Biotechnology and Microbiology University of Peshawar Department of Biochemistry Quaid-i-Azam University

OBJECTIVE:To investigate the antimicrobial activity of commercially available honey and raw honey samples in Khyber Pakhtunkhwa,Pakistan,against pathogenic bacterial ***:Well diffusion assays were performed to screen pure and diluted honey samples for antibacterial activity against six Gram-negative and six Gram-positive bacterial *** of inhibition were measured and compared with 10 mg ***:When honey samples were diluted to20%-70%,the honey samples showed no activity to mild antibacterial *** highest antibacterial activity was recorded when 90%and pure undiluted honey samples were tested and compared with a control Gentamycin disc(10 mg).CONCLUSION:Commercially processed honey and raw honey samples from north-west of Pakistan possess good antimicrobial potential.

关键词： Anti-bacterial agents Disk diffusion an-timicrobial tests Honey

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Variable β-globin haplotypes in Saudi βthalassemia population

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Open Journal of Genetics 2013年第3期3卷 171-173页

作者： Jameela shinwari Tahani Alshehri Asma I. Tahir Abdullah Al Jefri Abdulkareem AlMomen Dana Bakheet Mohammad AlAnazi Arjumand Warsy Nada Al Tassan Biochemistry Department College of Science King Saud University Riyadh KSA Department of Genetics Research Centre King Faisal Specialist Hospital & Research Centre Riyadh KSA Hematology Department King Khalid University Hospital King Saud University Riyadh KSA Pediatric Hematology/Oncology Department King Faisal Specialist Hospital & Research Centre Riyadh KSA

Twenty two haplotypes were generated from a pool of 60 unrelated Saudi β thalassemia major patients using previously described restriction sites in the β globin gene. Linkage disequilibrium analysis of the polymorphic sites was also conducted, a few identified haplotypes were novel while the remainder was previously reported, haplotype1222212 was the most frequent haplotype in the study group and a strong linkage disequilibrium between two polymorphic restriction sites in these β thalassemia patients was uncovered.

关键词： SNPs Haplotype Linkage Disequilibrium Restriction Sites

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