Variable <i>β</i>-globin haplotypes in Saudi <i>β</i>thalassemia population

作     者：Jameela Shinwari Tahani Alshehri Asma I. Tahir Abdullah Al Jefri Abdulkareem AlMomen Dana Bakheet Mohammad AlAnazi Arjumand Warsy Nada Al Tassan 

作者机构：Biochemistry Department College of Science King Saud University Riyadh KSA Department of Genetics Research Centre King Faisal Specialist Hospital & Research Centre Riyadh KSA Hematology Department King Khalid University Hospital King Saud University Riyadh KSA Pediatric Hematology/Oncology Department King Faisal Specialist Hospital & Research Centre Riyadh KSA 

出 版 物：《Open Journal of Genetics》 (遗传学期刊（英文）)

年 卷 期：2013年第3卷第3期

页      面：171-173页

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：SNPs Haplotype Linkage Disequilibrium Restriction Sites 

摘      要：Twenty two haplotypes were generated from a pool of 60 unrelated Saudi β thalassemia major patients using previously described restriction sites in the β globin gene. Linkage disequilibrium analysis of the polymorphic sites was also conducted, a few identified haplotypes were novel while the remainder was previously reported, haplotype1222212 was the most frequent haplotype in the study group and a strong linkage disequilibrium between two polymorphic restriction sites in these β thalassemia patients was uncovered.