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Journal of Integrative Medicine 2022年第4期20卷 288-291页

作者： Theocharis Koufakis kalliopi kotsa Nikolaos Papanas Division of Endocrinology and Metabolism and Diabetes Centre First Department of Internal MedicineMedical SchoolAristotle University of ThessalonikiAHEPA University Hospital54636 ThessalonikiGreece Diabetes Centre Second Department of Internal MedicineDemocritus University of Thrace68100 AlexandroupolisGreece

Theoretically, a new diagnosis of type 2 diabetes mellitus(T2DM) requires a dramatic change in an individual’s way of life. Weight loss and physical activity can lead to remission of diabetes, which has been associated with a lower risk of developing complications. Today, the importance of a healthy lifestyle is further highlighted by data showing that obesity and diabetes increase the risk of severe complications from coronavirus disease 2019. However, remission rarely occurs in reality, probably due to the inability of people with T2DM to adhere to the intensive lifestyle interventions that are necessary. The complexity of contributing factors may explain why making these changes is so challenging and underscore the fact that there is no magical solution for T2DM. Instead, hard work from both patients and health care providers is needed for the conversion to be achieved. This article calls for more research on the underlying reasons why adhering to a healthy way of life is so difficult for people with diabetes and obesity. Clearly defining these barriers would facilitate the planning of effective policies to promote the adoption of appropriate lifestyle changes early in the course of the disease.

关键词： Type 2 diabetes Remission Exercise Diet Lifestyle change

Pharmacologic adjunctive to insulin therapies in type 1 diabetes:The journey has just begun

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World Journal of Diabetes 2019年第4期10卷 234-240页

作者： Spyridon N Karras Theocharis Koufakis Pantelis Zebekakis kalliopi kotsa Division of Endocrinology and Metabolism and Diabetes Center First Department of Internal MedicineMedical School Aristotle University of Thessaloniki AHEPA University Hospital

Treatment of type 1 diabetes(T1 D) is currently based exclusively on insulin replacement therapy. However, there is a need for better glycemic control, lower hypoglycemia rates, more effective weight management, and further reduction of cardiovascular risk in people with T1 D. In this context, agents from the pharmaceutical quiver of type 2 diabetes are being tested in clinical trials, as adjunctive to insulin therapies for T1 D patients. Despite the limited amount of relevant evidence and the inter-class variability, it can be said that these agents have a role in optimizing metabolic control, assisting weight management and reducing glycemic variability in people with T1 D. Specific safety issues, including the increased risk of hypoglycemia and diabetic ketoacidosis, as well as the effects of these treatments on major cardiovascular outcomes should be further assessed by future studies, before these therapeutic choices become widely available for T1 D management.

关键词： Type 1 diabetes Insulin Adjunctive therapies Cardiovascular risk

The sugar-free paradox:cardiometabolic consequences of erythritol

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Signal Transduction and Targeted Therapy 2023年第7期8卷 3200-3202页

作者： kalliopi Pafili Michael Roden Department of Endocrinology and Diabetology Medical Faculty and University Hospital DüsseldorfHeinrich-Heine-University Düsseldorf40225 DüsseldorfGermany German Center for Diabetes Research Partner Düsseldorf85764 München-NeuherbergGermany Institute for Clinical Diabetology German Diabetes CenterLeibniz Center for Diabetes Research at Heinrich-Heine-University Düsseldorf40225 DüsseldorfGermany

In a recent study published in Nature Medicine,Witkowski and colleagues applied untargeted metabolomics studies in 1157 people at high risk for cardiovascular disease,comprising 22%with diabetes mellitus,followed by q... 详细信息

关键词： cardiovascular targeted Medicine

Solid extraintestinal malignancies in patients with inflammatory bowel disease

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World Journal of Gastrointestinal Oncology 2021年第12期13卷 1956-1980页

作者： Anastasia Mala kalliopi Foteinogiannopoulou Ioannis E Koutroubakis University Hospital of Heraklion Heraklion 71110CreteGreece Department of Gastroenterology University Hospital of HeraklionHeraklion 71110CreteGreece

Malignancies constitute the second cause of death in patients with inflammatory bowel diseases(IBD),after cardiovascular *** it has been postulated that IBD patients are at greater risk of colorectal cancer compared to the general population,lately there has been evidence supporting that this risk is diminishing over time as a result of better surveillance,while the incidence of extraintestinal cancers(EICs)is *** could be attributed either to systemic inflammation caused by IBD or to long-lasting immunosuppression due to IBD *** seems that the overall risk of EICs is higher for Crohn’s disease patients and it is mainly driven by skin cancers,and liver-biliary cancers in patients with IBD and primary sclerosing *** aims of this review were first to evaluate the prevalence,characteristics,and risk factors of EICs in patients with IBD and second to raise awareness regarding a proper surveillance program resulting in early diagnosis,better prognosis and survival,especially in the era of new IBD treatments that are on the way.

关键词： Extraintestinal malignancies Crohn’s disease Ulcerative colitis Thiopurines Anti-tumor necrosis factor

Analysis of residual crosslinking agent content in UV cross-linked poly(ethylene oxide) hydrogels for dermatological application by gas chromatography

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Journal of Pharmaceutical Analysis 2016年第5期6卷 307-312页

作者： Rachel Shet Hui Wong Mark Ashton kalliopi Dodou Department of Pharmacy Health and Wellbeing Faculty of Applied Sciences University of Sunderland Science Complex

Acrylates have been widely used in the synthesis of pharmaceutical polymers. The quantitation of residual acrylate monomers is vital as they are strong irritants and allergens, but after polymerization, are relatively inert, causing no irritation and allergies. Poly(ethylene oxide)(PEO) hydrogels were prepared using pentaerythritol tetra-acrylate(PETRA) as UV crosslinking agent. A simple, accurate, and robust quantitation method was developed based on gas chromatographic techniques(GC), which is suitable for routine analysis of residual PETRA monomers in these hydrogels. Unreacted PETRA was initially identified using gas chromatography–mass spectrometry(GC–MS). The quantitation of analyte was performed and validated using gas chromatography equipped with a flame ionization detector(GC–FID). A linear relationship was obtained over the range of 0.0002%–0.0450%(m/m) with a correlation coefficient(r2)greater than 0.99. The recovery( 4 90%), intra-day precision(%RSD o 0.67), inter-day precision(%RSD o2.5%), and robustness(%RSD o1.62%) of the method were within the acceptable values. The limit of detection(LOD) and limit of quantitation(LOQ) were 0.0001%(m/m) and 0.0002%(m/m), *** assay provides a simple and quick way of screening for residual acrylate monomer in hydrogels.

关键词： Poly(ethylene oxide) (PEO) Residual monomer HydrogelGas chromatography–mass spectrometry (GC–MS) Gas chromatography–flame ionization detection (GC–FID)

Effects of seed moisture content, stratification and sowing date on the germination of Corylus avellana seeds

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Journal of Forestry Research 2020年第3期31卷 743-749页

作者： Elias Pipinis Athanasios Stampoulidis Elias Milios Kyriaki Kitikidou Sofia Akritidou Stavroula Theodoridou kalliopi Radoglou School of Forestry and Natural Environment Aristotle University of Thessaloniki54124 ThessalonikiGreece Department of Forestry and Management of the Environment and Natural Resources Democritus University of ThracePandazidou 19368200 OrestiadaGreece 67133 Dioikitirio XanthiPrefecture of XanthiGreece

For Corylus avellana, pericarp permeability,seed desiccation tolerance, and the effect of warm and cold moist stratification combinations on germination and of outdoor sowing date on dormancy breaking and seedling emergence were investigated. Seeds with(intact fruit nut)and without the pericarp were subjected to an imbibition test, and water uptake was measured. After nuts had been stored for 5 months at 3–5℃, seeds and desiccated seeds were cold-stratified at 3–5 ℃(for 0, 1, 2 or 3 months),then tested for germination. Nuts were warm-stratified at 20–25℃(for 0, 1 or 2 months), then cold-stratified(for 0,1, 2 or 3 months) and tested for seed germination. The nuts were sown outdoors on three dates in the same year of their collection: 15 September(immediately after collection), 2 November, and 17 December, and emerged seedlings were counted the following spring. The pericarp was not a barrier to water uptake by the seed;however, the seeds imbibed water faster and had more mass when the pericarp was removed. Seeds tolerated desiccation;germinationpercentage was not reduced when seed moisture content was reduced to 8.71%. Germination of seeds without the pericarp(regardless of the moisture content) was the highest when the seeds were cold-stratified for 2 *** seeds with the pericarp were tested for germination,2 months of warm stratification before a 2-month cold stratification maximized seed germination. For outdoor sowing of nuts, sowing date affected percentage of seedling emergence the following spring;early autumn sowing(immediately after collection) resulted in the best emergence.

关键词： Corylus avellana Desiccation tolerance Dormancy Pericarp Water uptake

Autoimmune hepatitis,one disease with many faces:Etiopathogenetic,clinico-laboratory and histological characteristics

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World Journal of Gastroenterology 2015年第1期21卷 60-83页

作者： Nikolaos K Gatselis kalliopi Zachou George K Koukoulis George N Dalekos Department of Medicine and Research Laboratory of Internal Medicine School of MedicineUniversity of Thessaly41110 LarissaGreece Department of Pathology School of MedicineUniversity of Thessaly41110 LarissaGreece

Autoimmune hepatitis(AIH) is an unresolving progressive liver disease of unknown etiology characterized byhypergammaglobulinemia,autoantibodies detection and interface *** to the absence of specific diagnostic markers and the large heterogeneity of its clinical,laboratory and histological features,AIH diagnosis may be potentially ***,in this in-depth review we summarize the substantial progress on etiopathogenesis,clinical,serological and histological phenotypes of *** has a global distribution affecting any age,both sexes and all ethnic *** manifestations vary from asymptomatic to severe or rarely fulminant *** with selective elevation of IgG is found in most *** attack is perpetuated,possibly via molecular mimicry,and favored by the impaired control of T-regulatory ***(interface hepatitis,emperipolesis and hepatic rosette formation) and autoantibodies detection although not pathognomonic,are still the hallmark for a timely *** remains a major diagnostic *** should be considered in every case in the absence of viral,metabolic,genetic and toxic etiology of chronic or acute *** personnel,hepato-pathologists and clinicians need to become more familiar with disease expressions and the interpretation of liver histology and autoimmune serology to derive maximum benefit for the patient.

关键词： Autoimmune hepatitis Liver autoimmunity Liver-rela

COVID-19 and the cardiovascular system-current knowledge and future perspectives

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World Journal of Clinical Cases 2022年第27期10卷 9602-9610页

作者： Dimitrios G Chatzis kalliopi Magounaki Ioannis Pantazopoulos Sonu Menachem Maimonides Bhaskar Medical School European University CyprusNicosia 2404Cyprus Department of Internal Medicine KAT General HospitalAthens 14561Greece Department of Emergency Medicine Faculty of MedicineUniversity of ThessalyLarissa 41500Greece NSW Brain Clot Bank NSW Health PathologySydneyNSW 2170Australia Department of Neurology and Neurophysiology Liverpool Hospital and South Western Sydney Local Health DistrictSydneyNSW 2170Australia

The current coronavirus disease 2019(COVID-19) pandemic has had devastating impact on populations around the *** high mortality rates in patients with COVID-19 has been attributed to the influence of severe acute respiratory syndrome coronavirus-2(SARS-CoV-2),its causative viral agent,on several physiological systems in human body,including the respiratory,cardiovascular,and neurological *** is emerging evidence on propensity of this virus to attack cardiovascular ***,various pathophysiological mechanisms by which SARS-CoV-2 interacts with cardiovascular system and leads to high morbidity and mortality,including cardiovascular complications,are poorly *** mini review aims to provide an update on the current knowledge and perspectives on areas of future research.

关键词： COVID-19 Angiotensin-converting enzyme 2 receptors Cardiovascular manifestations Therapies

Individualization of chronic hepatitis C treatment according to the host characteristics

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World Journal of Gastroenterology 2014年第11期20卷 2839-2853页

作者： Nikolaos K Gatselis kalliopi Zachou Asterios Saitis Maria Samara George N Dalekos Department of Medicine and Research Laboratory of Internal Medicine School of MedicineUniversity of Thessaly41110 LarissaGreece Department of Pathology School of MedicineUniversity of Thessaly41110 LarissaGreece

Hepatitis C virus(HCV)infection is a global health problem that affects more than 170 million people *** is a major cause of cirrhosis and hepatocellular carcinoma,making the virus the most common cause of liver failure and *** standardof-care treatment for chronic hepatitis C(CHC)has been changed during the last decade and direct acting antiviral drugs have already been ***,understanding of the pathogenesis of CHC has evolved rapidly during the last years and now several host factors are known to affect the natural history and response to *** genome-wide association studies have shown the important role of interleukin-28B and inosine triphosphatase in HCV *** present review article attempts to summarize the current knowledge on the role of host factors towards individualization of HCV treatment.

关键词： Chronic hepatitis C Hepatitis C virus host factors Interleukin 28B Inosine triphosphatase Single nucleotide polymorphism

Preliminary results of Preserflo Microshunt versus Preserflo Microshunt and Ologen implantation

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Eye and Vision 2021年第1期8卷 324-337页

作者： Iraklis Vastardis Sofia Fili Georgios Perdikakis kalliopi Kontopoulou Miltos Balidis Zisis Gatzioufas Markus Kohlhaas Department of Ophthalmology St.Johannes Academic Hospital DortmundDortmundGermany Ophthalmica Eye Institute ThessalonikiGreece Department of Ophthalmology University Hospital BaselBaselSwitzerland

Purpose:To report preliminary 6-month results on the use of the Preserflo Microshunt implant with and without Ologen in 50 pseudophakic eyes with moderate to advanced primary open-angle glaucoma(POAG).Methods:Fifty pseudophakic eyes underwent ab externo Preserflo Microshunt *** was gathered retrospectively and two groups were then created,group A with application of MMC 0.2 mg/ml and group B with MMC 0.2 mg/ml and Ologen collagen matrix(OCM)*** success was regarded as the percentage of eyes achieving:a)5≤intraocular pressure(IOP)≤13 mmHg,b)5≤IOP≤16 mmHg,and c)5≤IOP≤21 mmHg without additional medication or surgery and qualified success was regarded as the percentage of eyes achieving a)IOP≤13 mmHg,b)IOP≤16 mmHg,and c)IOP≤21 mmHg with or without *** was performed using a log-rank Kaplan-Meier test.A scatterplot analysis presented the treatment effect data of all eyes with a minimum of 20%IOP reduction per *** was defined as requiring additional surgery,IOP greater than 21 mmHg with or without medication and failure to reach 20%IOP ***:Mean postoperative IOP was significantly lower in both *** decreased by 49.06%in group A and by 53.01%in group B at 6 months(P0.05).Cumulative IOP results per case were not statistically different in group A compared with group *** revision surgery in group A(4%failure rate)and three in group B(12%failure rate)were ***:Both groups showed equal results in terms of cumulative and mean IOP reduction,medication reduction as well as in absolute and qualified success *** significant difference was found in any parameters tested between Preserflo Microshunt with MMC 0.2 mg/ml and with or without OCM implantation at 6 ***-term follow-up is required to fu

关键词： Micro invasive glaucoma surgery Ab externo surgery Refractory POAG SIBS polymer Mitomycin C