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Engineering neuroregenerative microenvironment via aligned hydrogel-assisted magnetic stimulation for complete spinal cord injury repair

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Engineered Regeneration 2024年第2期5卷 139-152页

作者： Chun-Yi yang Zhe Meng Zhijun He Pengchao Ma Zhaohui Hou Kunkoo Kim Jingsong Lu kaiyuan yang Guihuai Wang Xiumei Wang State Key Laboratory of New Ceramics and Fine Processing Key Laboratory of Advanced Materials of Ministry of EducationSchool of Materials Science and EngineeringTsinghua UniversityBeijing 100084China Department of Neurosurgery Beijing Tsinghua Changgung HospitalSchool of Clinical MedicineTsinghua UniversityBeijing102218China

Utilizing biomaterials in tissue engineering has shown considerable promise for tissue regeneration,particularly through delivering multimodel cell-regulatory signals,including the material-related signals and extrinsic *** this research,we developed a magnetic-responsive aligned nanofiber fibrin hydrogel(MAFG),integrating the structured alignment of nanofibers and the pliability of fibrin hydrogel with an external magnetic *** design aimed to enhance the regenerative response in spinal cord injury treatment.A medium-strength magnetic field,aligned with the spinal cord,was applied to aid motor function recovery in rats with spinal cord *** use of MAFG in this context not only intensified the effect of the magnetic field but also encouraged the activation and differentiation of native neural stem ***,this method effectively steered macrophage polarization towards a beneficial M2 phenotype,addressing immune dysregulation at the injury *** parallel application of magnetic field stimulation through MAFG in a spinal cord injury model contributed to the concurrent promotion of neurogenesis,angiogenesis,and immunomodulation,resulting in marked improvement in motor function in *** investigation underscores the therapeutic potential of magnetic field stimulation and highlights how aligning this stimulation with the spinal cord can significantly enhance the regenerative milieu at the injury site.

关键词： Angiogenesis Neurogenesis Immunomodulation Magnetic-responsive hydrogel Magnetic stimulation

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深度学习光学合成孔径共相闭环实验研究

中国激光 2024年第13期51卷 288-296页

作者：马霞飞杨开元马浩统杨虎谢宗良中国科学院光电技术研究所光场调控科学技术全国重点实验室四川成都610209 中国科学院光束控制重点实验室四川成都610209 中国科学院大学北京100049 电子科技大学自动化工程学院四川成都610209

光学合成孔径是研制大口径望远镜的有效技术途径。合成孔径光电望远镜实际分辨率能达到衍射极限的关键在于实时检测并校正各子孔径之间的平移误差。通过构建轻量化MobileNet卷积神经网络拟合宽波段点扩展函数和平移误差的非线性映射关系... 详细信息

光学合成孔径是研制大口径望远镜的有效技术途径。合成孔径光电望远镜实际分辨率能达到衍射极限的关键在于实时检测并校正各子孔径之间的平移误差。通过构建轻量化MobileNet卷积神经网络拟合宽波段点扩展函数和平移误差的非线性映射关系,并基于该网络完成了三孔径共相闭环实验。对三孔径合成孔径系统时序施加平移误差,采集相应宽波段点扩展函数,利用点扩展函数-平移误差数据训练轻量化MobileNet网络至收敛。在闭环校正阶段,将训练好的模型部署到嵌入式计算平台中,根据预测输出控制压电反射镜进行误差校正。共相闭环结果表明,该方法每次检测耗时3 ms,具有较好实时性,且能够在±6λ_(0)(λ_(0)=600 nm)的检测范围内,实现26.2 nm的检测精度。通过深度学习共相闭环实验,验证了深度学习方法作为工程级共相解决方案的可行性。

关键词：成像系统卷积神经网络平移误差光学合成孔径共相闭环

导演克里斯托弗·诺兰《星际穿越》中的时间叙事技法探析

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艺术科技 2024年第2期37卷 143-145页

作者：杨凯源扬州大学新闻与传媒学院江苏扬州225000

目的:文章深入探讨英国导演克里斯托弗·诺兰在其杰作《星际穿越》中如何利用时间叙事技法来提升故事的情感深度。诺兰的电影以独特的时间处理手法而闻名,文章探析他在这部电影中对时间叙事的具体应用及其效果。方法:细致分析电影文本,... 详细信息

目的:文章深入探讨英国导演克里斯托弗·诺兰在其杰作《星际穿越》中如何利用时间叙事技法来提升故事的情感深度。诺兰的电影以独特的时间处理手法而闻名,文章探析他在这部电影中对时间叙事的具体应用及其效果。方法:细致分析电影文本,结合叙事理论和电影学相关概念,研究《星际穿越》中的叙事结构、时间跳跃、视觉呈现、音响效果等元素。特别关注非线性叙事和时间扭曲这两个叙事策略,以及它们如何与电影中展示的科学理论和人物情感相互作用。结果:研究表明,《星际穿越》通过创新运用非线性叙事和时间概念,在观众心中构建了非传统的时间感知。影片中的时间叙事技法不仅使情节变得复杂,而且通过时间和空间的相对性,凸显了人物的情感冲突,使观众在理解角色心理和故事发展的同时,展开了一次关于时间本质的哲学思考。结论:《星际穿越》中的时间叙事技法展现了诺兰在电影叙事上的创新和大胆尝试。这部电影不仅仅是一部科幻作品,还探讨了时间的相对性、人类的感知限制、情感与存在的深层次联系。诺兰通过这部作品邀请观众深入多维的时间结构,提供了一种全新的、互动的观影模式,丰富了观众的观影体验。希望文章的分析可以进一步证明诺兰如何通过对时间叙事技法的运用,赋予电影独特的艺术魅力,并在全球范围内产生深远影响。

关键词：克里斯托弗·诺兰《星际穿越》非线性叙事时间概念

基坑位移监测与ABAQUS有限元综合评估研究

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绿色建造与智能建筑 2024年第9期 51-55页

作者：杨凯源中铁建设集团南方工程有限公司广州511400

基坑工程作为现代建筑施工中常见的一种地下开挖工程,其安全性和稳定性的评估对于保障工程质量和人员安全至关重要。本文通过基坑位移监测数据与ABAQUS有限元分析的综合评估,提出了一种基于ABAQUS的基坑位移监测模拟方法。模拟结果表明... 详细信息

基坑工程作为现代建筑施工中常见的一种地下开挖工程,其安全性和稳定性的评估对于保障工程质量和人员安全至关重要。本文通过基坑位移监测数据与ABAQUS有限元分析的综合评估,提出了一种基于ABAQUS的基坑位移监测模拟方法。模拟结果表明,支护前期的土体位移受钻孔影响集中于桩体孔径附近,支护后期桩周土体位移受导墙支撑而变小,最大位移产生于导墙边角处。通过将实测位移数据与有限元分析结果进行比较,验证了该监测方法的可靠性。该研究有望为优化基坑施工方案,降低深基坑施工风险提供技术支持。

关键词：基坑工程位移监测 ABAQUS有限元计算综合评估

Leachate Lithium Characteristics of Loess-paleosol Sequences on the Chinese Loess Plateau and their Paleoclimatic Significance

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Acta Geologica Sinica(English Edition) 2023年第6期97卷 1814-1824页

作者： JIA Peng FU Chaofeng HE Maoyong LIU Junfeng LIU Na LI Yulong yang kaiyuan School of Earth Science and Resources Chang’an UniversityXi’an 710054China State Key Laboratory of Loess and Quaternary Geology Institute of Earth EnvironmentChinese Academy of SciencesXi’an 710061China Department of Geological Engineering Qinghai UniversityXining 810016China Key Laboratory of Comprehensive and Highly Efficient Utilization of Salt Lake Resources Qinghai Institute of Salt LakesChinese Academy of SciencesXining 810008China School of Water and Environment Chang’an UniversityXi’an 710054China

The geochemical components of the leachate from loess-paleosol deposits can provide information about climaterelated post-depositional *** example,leachate lithium([Li]_(leachate))is a potential paleoclimate proxy because lithium is a typical lithophile element that is readily adsorbed by clay minerals during weathering and pedogenesis,and thus stratigraphic variations in[Li]leachatecan reflect these *** investigated the[Li]leachatevalues of two loess-paleosols profiles(the Luochuan and Weinan sections),on a north-south climatic gradient on the Chinese Loess *** paleoclimate information was provided by measurements of magnetic susceptibility,grain size,Rb/Sr ratios,and clay mineral *** the last glacial-interglacial period,[Li]leachateincreased from 0.39 to 1.97μg/g at Luochuan and from 0.67 to 2.45μg/g at Weinan,mainly due to increasing *** on these results we developed a conceptual model to explain the variations in[Li]leachate,Li^(+)within loess layers is mainly derived from dust input and the decomposition of primary minerals,influenced by the East Asian winter monsoon,while in paleosol layers Li is mainly derived from clay mineral adsorption during pedogenic processes,influenced by the East Asian summer monsoon.

关键词： leachate lithium concentration loess-paleosol sequences last glacial-interglacial cycle paleoclimate record

3D bio-printed living nerve-like fibers refine the ecological niche for long-distance spinal cord injury regeneration

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Bioactive Materials 2023年第7期25卷 160-175页

作者： Jia yang kaiyuan yang Weitao Man Jingchuan Zheng Zheng Cao Chun-Yi yang Kunkoo Kim Shuhui yang Zhaohui Hou Guihuai Wang Xiumei Wang State Key Laboratory of New Ceramics and Fine Processing Key Laboratory of Advanced MaterialsSchool of Materials Science and EngineeringTsinghua UniversityBeijing100084China Department of Neurosurgery Beijing Tsinghua Changgung HospitalSchool of Clinical MedicineTsinghua UniversityBeijing102218China School of Materials Science and Engineering Zhejiang-Mauritius Joint Research Center for BiomaterialsTissue Engineering Zhejiang Sci-Tech UniversityHangzhou310018China

3D bioprinting holds great promise toward fabricating biomimetic living constructs in a bottom-up assembly *** date,various emergences of living constructs have been bioprinted for in vitro applications,while the conspicuous potential serving for in vivo implantable therapies in spinal cord injury(SCI)has been relatively ***,living nerve-like fibers are prepared via extrusion-based 3D bioprinting for SCI *** living nerve-like fibers are comprised of neural stem cells(NSCs)embedded within a designed hydrogel that mimics the extracellular matrix(ECM),assembled into a highly spatial ordered architecture,similar to densely arranged bundles of the nerve *** pro-neurogenesis ability of these living nerve-like fibers is tested in a 4 mm-long complete transected SCI rat *** shows that living nerve-like fibers refine the ecological niche of the defect site by immune modulation,angiogenesis,neurogenesis,neural relay formations,and neural circuit remodeling,leading to outstanding functional reconstruction,revealing an evolution process of this living construct after *** effective strategy,based on biomimetic living constructs,opens a new perspective on SCI therapies.

关键词： Neural stem cells Hydrogels 3D bioprinting Living constructs Spinal cord injury

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极端数据辅助的RSSE-PSP盲分离算法

信息工程大学学报 2024年第4期25卷 384-390页

作者：李钟书李天昀李放邱钊洋杨开元信息工程大学河南郑州450001

针对逐幸存路径处理(PSP)算法在处理成对载波多址(PCMA)信号盲分离问题时复杂度过高的问题,提出一种基于极端数据辅助的减状态序列估计逐幸存路径处理(RSSE-PSP)盲分离算法。该算法基于PCMA信号中存在部分极端数据,按照单路源信号的参... 详细信息

针对逐幸存路径处理(PSP)算法在处理成对载波多址(PCMA)信号盲分离问题时复杂度过高的问题,提出一种基于极端数据辅助的减状态序列估计逐幸存路径处理(RSSE-PSP)盲分离算法。该算法基于PCMA信号中存在部分极端数据,按照单路源信号的参数估计结果去除频偏、相偏后能够凸显出极端数据,充分利用这部分极端数据,可以直接解调出源信号相应位置的传输符号,继而在PSP算法进行序列估计的过程中减少需要遍历的状态数,有效降低了PSP算法的复杂度,同时避免了极端符号位置的误码。仿真实验表明,在较高信噪比条件下,RSSE-PSP算法在分离复杂度和分离性能方面均优于传统的PSP算法。

关键词：成对载波多址信号盲分离减状态序列估计逐幸存路径处理极端数据

N‑Cadherin‑Functionalized Nanofiber Hydrogel Facilitates Spinal Cord Injury Repair by Building a Favorable Niche for Neural Stem Cells

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Advanced Fiber Materials 2023年第4期5卷 1349-1366页

作者： kaiyuan yang Jia yang Weitao Man Zhe Meng Chun‑Yi yang Zheng Cao Jun Liu Kunkoo Kim Yaosai Liu Shuhui yang Yi Guo Zhijun He Chao Ma Guihuai Wang Xiumei Wang State Key Laboratory of New Ceramics and Fine Processing Key Laboratory of Advanced MaterialsSchool of Materials Science and EngineeringTsinghua UniversityBeijing 100084China Department of Neurosurgery Beijing Tsinghua Changgung HospitalSchool of Clinical MedicineTsinghua UniversityBeijing 102218China School of Materials Science and Engineering Zhejiang‑Mauritius Joint Research Center for Biomaterials and Tissue EngineeringZhejiang Sci-Tech UniversityHangzhou 310018China

The inhospitable niche at the injury site after spinal cord injury(SCI)brings several challenges to neural stem cell(NSC)therapy,such as limited NSC retention and neuronal ***-based stem cell transplantation has become a promising strategy for building a favorable niche to stem ***,an aligned fibrin nanofiber hydrogel modified with N-Cadherin-Fc(AFGN)was fabricated by electrospinning and biochemical conjugation to deliver NSCs for SCI *** AFGN hydrogel provides multimodal cues,including oriented nanofibrous topography,soft stiffness,and specific cell binding ligand,for directing NSC functions and nerve *** conjugated N-Cadherin-Fc recapitulated the homo-philic cell-cell interaction for NSCs’adhesion on AFGN and modulated cellular mechanosensing in response to AFGN for NSC *** addition,the AFGN hydrogel carrying exogenous NSCs was implanted in a rat 2 mm-long complete transected SCI model and significantly promoted the grafted NSCs retention,immunomodulation,neuronal differentiation,and in vivo integration with inherent neurons,thus finally achieved renascent neural relay formation and an encouraging locomotor functional ***,this study represents a valuable strategy for boosting NSC-based therapy in SCI regeneration by engineering an NSC-specific niche.

关键词： N-cadherin Aligned fibrin nanofiber scaffold Niche Neural stem cell Spinal cord injury

A SICHUAN FARMER IN TIBET

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China's Tibet 2010年第4期21卷 32-41页

作者： Sun kaiyuan & yang Jun

A decade ago he was a diligent laborer from Sichuan *** now,he has become a general farmer in Tibet,although his life is different from other farmers, because he has twice gone through a reincarnation.

关键词：四川省西藏劳动者农民