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Acta Pharmaceutica Sinica B 2024年第1期14卷 421-432页

作者： Dexiu Yan Jemma Arakelyan Teng Wan Ritvik Raina Tsz Ki Chan Dohyun Ahn Vladimir Kushnarev Tsz Kiu Cheung Ho Ching Chan Inseo choi Pui Yi Ho Feijun Hu Yujeong Kim Hill Lam Lau Ying Lo Law Chi Seng Leung Chun Yin Tong kai Kap Wong Wing Lam Yim Nikolay S.Karnaukhov Richard Y.C.Kong Maria V.Babak Yudai Matsuda Department of Chemistry City University of Hong KongHong Kong SARChina iGEM Team“VarieCure” City University of Hong KongHong Kong SARChina Department of Biomedical Engineering City University of Hong KongHong Kong SARChina Moscow Clinical Research Center Named After A.S.Loginov Moscow 111123Russian Federation

A biosynthetic gene cluster for the bioactive fungal sesterterpenoids variecolin(1)and variecolactone(2)was identified in Aspergillus aculeatus ATCC *** production of 1 and 2 was achieved in Aspergillus oryzae by expressing the sesterterpene synthase VrcA and the cytochrome P450 ***,the replacement of VrcB with homologous P450s from other fungal terpenoid pathways yielded three new variecolin analogues(5-7).Analysis of the compounds’anticancer activity in vitro and in vivo revealed that although 5 and 1 had comparable activities,5 was associated with significantly reduced toxic side effects in cancer-bearing mice,indicating its potentially broader therapeutic *** study describes the first tests of variecolin and its analogues in animals and demonstrates the utility of synthetic biology for creating molecules with improved biological activities.

关键词： Animal studies Anticancer properties Biosynthesis Natural products Sesterterpenoids Synthetic biology Terpene synthases Variecolin

*** rescue in retinitis pigmentosa by the treatment of Lycium barbarum(Random Clinical Trial)

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Annals of Eye Science 2017年第1期 356-356页

作者： Henry Chan Hang-I Lam Kwok-Fai So Raymond Chuen-Chung Chang Shiu-Ming Lai Chi-Wai Do Iris F.F.Benzie Chin-Pan Leung kai-yip choi Man-Pan Chin Zhe-Chuang Li Wing-Yan Yu Laboratory of Experimental Optometry(Neuroscience) School of OptometryThe Hong Kong Polytechnic UniversityHong Kong SARChina Guangdong-Hongkong-Macao(GHM)Institute of CNS Regeneration Jinan UniversityGuangzhouChina School of Biomedical Sciences The University of Hong KongHong Kong SARChina Department of Ophthalmology The University of Hong KongHong Kong SARChina Laboratory of Experimental Optometry(Biophysic) School of OptometryThe Hong Kong Polytechnic UniversityHong Kong SARChina Department of Health Technology and Informatics The Hong Kong Polytechnic UniversityHong Kong SARChina Private practice Chinese medical doctor

Retinitis pigmentosa(RP)is a group of heredofamilial retinal diseases which is characterized by night blindness and progressive visual field *** study aims to study the treatment effect of Lycium barbarum(LB)on retinal functions and structure of RP *** study is a double-masked randomized controlled *** subjects received scheduled eye examination including visual acuity(VA),Humphrey field analysis(HFA),ganzfeld flash electroretinogram(ffERG)and optical coherence tomography(OCT).The suitable subjects were randomly allocated to either LB-treatment or placebo groups with the supply of LB or placebo for 12 *** were total 41 RP subjects(22 in LB group and 19 in placebo group)completed the 12 months *** compliance rates for LB and placebo groups were 89.8%±12.5%and 85.3%±7.7%*** compared with placebo group,there were no deteriorations of both high and low contrast VA in LB group(P<0.01).In addition,certain improvements of scotopic rod response and photopic cone response of ffERG were obtained in LB group(P<0.05).In the OCT measurement,an obvious thinning of macular thickness was observed in placebo group but not found in LB group(P<0.05).However,there were no changes found in the sensitivity of central visual field between two *** results confirm that the 12-month LB treatment for RP patients had neuroprotective effect on retina and is believed to delay or minimize the deterioration of visual function in RP.

关键词： Retinitis pigmentosa(RP) Lycium barbarum(LB) neuroprotection cone retina

Efficient organic-inorganic hybrid cathode interfacial layer enabled by polymeric dopant and its application in large-area polymer solar cells

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Science China Chemistry 2019年第1期62卷 67-73页

作者： Sheng Dong kai Zhang Xiang Liu Qingwu Yin Hin-Lap yip Fei Huang Yong Cao Institute of Polymer Optoelectronic Materials and Devices State Key Laboratory of Luminescent Materials and DevicesSouth China University of Technology

An organic-inorganic hybrid cathode interfacial layer(CIL) was developed by doping ZnO with the naphthalene-diimide based derivative NDI-PFNBr. It was found the resulting organic-inorganic hybrid CIL showed apparently improved conductivity and could act as an effective cathode interlayer to modify indium tin oxide(ITO) transparent electrodes. As a result, by employing the blend of PTB7-Th:PC71BM as the photoactive layer, the inverted polymer solar cells(PSCs) exhibited a remarkable enhancement of power conversion efficiency(PCE) from 8.52% for the control device to 10.04% for the device fabricated with the hybrid CIL. Moreover, all device parameters were simultaneously improved by using this hybrid CIL. The improved open-circuit voltage(VOC) was attributed to the reduced work function of the ITO cathode, whereas the enhancements in fill factor(FF) and short-circuit current density(JSC) were assigned to the increased conductivity and more effective charge extraction and collection at interface. Encouragingly, when the thickness of the hybrid CIL was increased to 80 nm, the resulting device could still keep a PCE of 8.81%, exhibiting less thickness dependence. Considering these advantages, 16 and 93 cm2large-area PSCs modules were successfully fabricated from the hybrid CIL by using doctor-blade coating techniques and yielded a remarkable PCE of8.05% and 4.49%, respectively. These results indicated that the hybrid CIL could be a promising candidate to serve as the cathode interlayer for high-performance large-area inverted PSCs.

关键词： hybrid cathode interfacial layer large-area module doctor-blade coating polymer solar cells

Prognostic factors of survival and a new scoring system for liver resection of colorectal liver metastasis

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World Journal of Hepatology 2022年第1期14卷 209-223页

作者： kai-Chi Cheng Ada Sze-Man yip Department of Surgery Kwong Wah HospitalHong KongChina

BACKGROUND Hepatic resection has become the preferred treatment of choice for colorectal liver metastasis(CLM)*** To identify the prognostic factors and to formulate a new scoring system for management of *** Clinicopathologic and long-term survival data were analyzed to identify the significant predictors of survival by univariate and multivariate analyses with the Cox model.A clinical score was constructed based on the analysis *** Three factors of worse overall survival were identified in the multivariate *** were number of liver metastases≥5,size of the largest liver lesion≥4 cm,and the presence of nodal metastasis from the primary *** three factors were chosen as criteria for a clinical risk score for overall *** clinical score highly correlated with median overall survival and 5-year survival(P=0.002).CONCLUSION Priority over surgical resection should be given to the lowest score groups,and alternative oncological treatment should be considered in patients with the highest score.

关键词： Colorectal cancer Liver metastasis Liver resection Long-term outcome Overall survival Disease-free survival Prognosis Score

Spectral Properties and Photochromic Characteristics of Spiropyran Dyes

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Chemical Research in Chinese Universities 2006年第4期22卷 505-509页

作者： SHEN kai-hua HAN Jian-guo ZHANG Gang choi Dong-hoon The State Key Laboratory of Fine Chemicals Dalian University of Technology Dalian 116012 P. R. China The Key Laboratory of Cellulose and Lignocellulosics Chemistry Guangzhou Institute of Chemistry Chinese Academy of Sciences Guangzhou 510650 P. R. China Polymer and Fiber Material Engineering Kyunghee University Kyong Kido 449-701 Korea

A bis-benzospiropyran（BBSP） and nitro-substituted indoline spirobenzopyrans（SBP） were prepared by following a simple procedure. The reaction mechanism of synthesizing bis-benzospiropyran is discussed. A comparative analysis of the spectral and photochromic properties between SBP and BBSP was carried out with the aid of a PMMA film. The results indicate that chemical structures and UV irradiation played an important role in the spectral and photochromic properties of SBP and BBSP, which would readily affect λmax of the colored forms and the reversibility. The IR spectra and ^1H NMR spectra of these compounds are used to interpret the photochromic phenomena under different UV irradiation and determine the configurations of SBP and BBSP.

关键词： Photochromism Spiropyran UV radiation Protonation

Traditional Chinese medicine poisoning in the emergency departments in Hong Kong: Trend, clinical presentation and predictors for poor outcome

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World Journal of Emergency Medicine 2021年第2期12卷 143-150页

作者： Rex Pui Kin Lam Eric Ho Yin Lau Wai Lam yip Joe kai Shing Leung Matthew Sik Hon Tsui Emergency Medicine Unit Li Ka Shing Faculty of Medicinethe University of Hong KongHong KongChina Accident and Emergency Department Queen Mary HospitalHong KongChina Accident and Emergency Department Pamela Youde Nethersole Eastern HospitalHong KongChina School of Public Health Li Ka Shing Faculty of Medicinethe University of Hong KongHong KongChina

Dear editor,Traditional Chinese medicine (TCM) is popular in many countries,especially in the Chinese population.^([1,2]) In Hong Kong,it has been estimated that around 15%of the population consumed Chinese medicine products/herbs in the preceding *** reasons for consumption include regulating bodily functions,curing disease,and building up health.

关键词： has editor curing

Efficacy and safety of tadalafil taken as needed for the treatment of erectile dysfunction in Asian men： results of an integrated analysis

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Asian Journal of Andrology 2009年第4期11卷 423-433页

作者： Ying-Lu Guo Vijay P Viswanathan Han-Sun Chiang Hyung Ki choi Andrew Wai Chun yip Wei Shen Vladimir Kopernicky Andrology Center Peking University First Hospital Peking University Beo＇ing 100009 China M. V. Hospital for Diabetes and Diabetes Research Centre Chennai 600013 India School of Medicine Fu Jen Catholic University Taipei 24205 Taiwan China Department of Urology Yongdong Severance Hospital Seoul 135720 Korea Department of Surgery Kwong Wah Hospital Hong Kong China Lilly USA LLC Indianapolis IN 46285 USA

We evaluated the efficacy and safety of as-needed tadalafil in a diverse clinical population （with varying patient demographics, disease severity, and comorbid medical conditions） of Asian men with erectile dysfunction （ED）. An integrated analysis of five double-blind, placebo-controlled trials （N = 1 046） was performed. Patients were randomly assigned to receive 10 mg tadalafil （N = 185）, 20 mg tadalafil （N = 510）, or placebo （N = 351）. Efficacy assessments included the International Index of Erectile Function （IIEF）, Sexual Encounter Profile （SEP） diary and Global Assessment Question （GAQ）. Patients receiving 10 mg or 20 mg tadalafil showed significant improvement from baseline-to-end point on the Erectile Function domain of the International Index of Erectile Function （IIEF-EF） domain score in all clinical sub-populations analyzed, compared with patients receiving placebo （P 〈 0.001）. The 10-mg and 20-mg tadalafil groups showed a mean success rate of 64.1% and 70.5% for sexual intercourse attempts （SEP3, successful intercourse）, respectively, compared with 33.4% in the placebo group （P 〈 0.001）, and 85.5% and 85.4% reported improved erections at end point GAQ, respectively, versus 43.5% in the placebo group （P 〈 0.001）. Tadalafil was well tolerated across all groups studied. Headache and back pain were the most frequently reported adverse events. Overall, tadalafil was effective and well tolerated across a diverse clinical spectrum of Asian men with ED.

关键词： Asia comorbidity erectile dysfunction phosphodiesterase inhibitors tadalafil

Mean sea surface heights of the South and East China Seas from ocean circulation model and geodetic leveling

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Chinese Science Bulletin 2002年第4期47卷 326-329页

作者： FANG Guohong WEI Zexun FANG Yue WANG kai choi Byungho Institute of Oceanology Chinese Academy of SciencesQingdao 266071China Department of Oceanography Texas A&M UniversityCollege StationTX 77843-3146USA Department of Civil Engineering Sungkyunkwan UniversitySuwon440-746Korea

The mean sea surface heights (sea surface topography) of the South China, East China, Yellow and Bohai Seas are derived from an ocean general circulation model and surface air pressure. The circulation model covers the global oceans, with fine grid (1/6°)? covering the East Asian marginal seas and coarse grid (3°) covering the rest part of the global oceans. The result shows that the China 1985 Na-tional Altitude Datum is 24.7 cm above the mean sea surface height of the world oceans. The mean sea surface in the coastal ocean adjacent to China is higher in the south than in the north. Intercomparison of the model results with the geodetic leveling measurements at 28 coastal tidal stations shows a standard deviation of 4.8 cm and a fitting coefficient of 95.3%. After correction through linear regression, the standard deviation is reduced to 4.5 cm. This indicates that the accuracy of model results is sufficient for practical application. Based on the model results, the mean sea surface heights for the

关键词： mean sea surface height ocean circulation model land leveling South China Sea East China Sea Yellow Sea Bohai Sea.

Ultrasonic Plasma Engineering Toward Facile Synthesis of Single-Atom M-N4/N-Doped Carbon(M=Fe,Co) as Superior Oxygen Electrocatalyst in Rechargeable Zinc-Air Batteries

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Nano-Micro Letters 2021年第4期13卷 76-95页

作者： kai Chen Seonghee Kim Minyeong Je Heechae choi Zhicong Shi Nikola Vladimir Kwang Ho Kim Oi Lun Li Department of Materials Science and Engineering Pusan National University30 Jangjeon‑dongGeumjeong‑guBusan 609‑735Republic of Korea Theoretical Materials and Chemistry Group Institute of Inorganic ChemistryUniversity of CologneGreinstr.650939 CologneGermany School of Materials and Energy Guangdong University of TechnologyGuangzhou 510006People’s Republic of China Faculty of Mechanical Engineering and Naval Architecture University of ZagrebIvana Lucica 510002 ZagrebCroatia Global Frontier R&D Center for Hybrid Interface Materials 30 Jangjeon‑dongGeumjeong‑guBusan 46241Republic of Korea

As bifunctional oxygen evolution/reduction electrocatalysts,transition-metal-based single-atom-doped nitrogen-carbon(NC)matrices are promising successors of the corresponding noblemetal-based catalysts,offering the advantages of ultrahigh atom utilization effciency and surface active ***,the fabrication of such matrices(e.g.,well-dispersed single-atom-doped M-N4/NCs)often requires numerous steps and tedious ***,ultrasonic plasma engineering allows direct carbonization in a precursor solution containing metal phthalocyanine and *** combining with the dispersion effect of ultrasonic waves,we successfully fabricated uniform single-atom M-N4(M=Fe,Co)carbon catalysts with a production rate as high as 10 mg *** Co-N4/NC presented a bifunctional potential drop ofΔE=0.79 V,outperforming the benchmark Pt/C-Ru/C catalyst(ΔE=0.88 V)at the same catalyst *** calculations revealed that Co-N4 was the major active site with superior O2 adsorption-desorption *** a practical Zn-air battery test,the air electrode coated with Co-N4/NC exhibited a specific capacity(762.8 mAh g(-1))and power density(101.62 mW cm^(-2)),exceeding those of Pt/C-Ru/C(700.8 mAh g^(-1) and 89.16 mW cm^(-2),respectively)at the same catalyst ***,for Co-N4/NC,the potential difference increased from 1.16 to 1.47 V after 100 charge-discharge *** proposed innovative and scalable strategy was concluded to be well suited for the fabrication of single-atom-doped carbons as promising bifunctional oxygen evolution/reduction electrocatalysts for metal-air batteries.

关键词： Single-atom-doped M-N4/NC catalyst Plasma engineering ORR/OER bifunctional activity DFT calculation Rechargeable Zn-air battery

Information needs of older people with heart failure： listening to their own voice

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Journal of Geriatric Cardiology 2016年第5期13卷 435-438页

作者： Ming-Ming YU Sek Ying Chair Carmen WH Chan kai Chow choi School of Nursing Peking Union Medical College Beijing China Nethersole School of Nursing The Chinese University of Hong Kong Hong Kong China

According to a large-scale census in 2000, there were approximately 4,000,000 patients with heart failure （HF） aged between 35 and 74 years in China. Patient education shows its importance and essentiality in controlling the disease by improving the self-care abilities of patients,t21 However, a shortened period of hospitalization compromises the effectiveness and efficacy of the education. It is therefore suggested that the information needs of patients with HF should be simultaneously addressed to make education more appropriate and tailored.

关键词： Education Heart failure Information needs Qualitative study