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铜导体CFETR氦冷固态包层及屏蔽中子学设计与分析

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核聚变与等离子体物理 2018年第1期38卷 48-54页

作者：赵奉超冯开明曹启祥栗再新张国书核工业西南物理研究院成都610041

根据铜导体CFETR设计要求,对铜导体CFETR固态包层和屏蔽进行了中子学设计与分析,提出了套管结构的氦冷固态包层设计方案。包层设计和屏蔽分析结果表明,基于套管的氦冷固态包层的氚增殖比(TBR)达到了1.25,满足铜导体CFTER氚自持设计要求... 详细信息

根据铜导体CFETR设计要求,对铜导体CFETR固态包层和屏蔽进行了中子学设计与分析,提出了套管结构的氦冷固态包层设计方案。包层设计和屏蔽分析结果表明,基于套管的氦冷固态包层的氚增殖比(TBR)达到了1.25,满足铜导体CFTER氚自持设计要求;环向场线圈绝缘层在堆寿期内不会出现显著的辐射感应电导率(RIC)与辐射引起的电气性能退化(RIED)效应。

关键词：铜导体CFETR 氦冷固态包层中子学 MCNP程序屏蔽分析

Meningeal lymphatic vessel crosstalk with central nervous system immune cells in aging and neurodegenerative diseases

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Neural Regeneration Research 2025年第3期20卷 763-778页

作者： Minghuang Gao Xinyue Wang Shijie Su Weicheng Feng Yaona Lai Kongli Huang Dandan cao qi Wang Science and Technology Innovation Center Guangzhou University of Chinese MedicineGuangzhouGuangdong ProvinceChina Institute of Clinical Pharmacology Guangzhou University of Chinese MedicineGuangzhouGuangdong ProvinceChina The Sixth Affiliated Hospital Sun Yat-sen UniversityGuangzhouGuangdong ProvinceChina

Meningeal lymphatic vessels form a relationship between the nervous system and periphery, which is relevant in both health and disease. Meningeal lymphatic vessels not only play a key role in the drainage of brain metabolites but also contribute to antigen delivery and immune cell activation. The advent of novel genomic technologies has enabled rapid progress in the characterization of myeloid and lymphoid cells and their interactions with meningeal lymphatic vessels within the central nervous system. In this review, we provide an overview of the multifaceted roles of meningeal lymphatic vessels within the context of the central nervous system immune network, highlighting recent discoveries on the immunological niche provided by meningeal lymphatic vessels. Furthermore, we delve into the mechanisms of crosstalk between meningeal lymphatic vessels and immune cells in the central nervous system under both homeostatic conditions and neurodegenerative diseases, discussing how these interactions shape the pathological outcomes. Regulation of meningeal lymphatic vessel function and structure can influence lymphatic drainage, cerebrospinal fluid-borne immune modulators, and immune cell populations in aging and neurodegenerative disorders, thereby playing a key role in shaping meningeal and brain parenchyma immunity.

关键词： central nervous system meningeal lymphatic vessels immunity myeloid cells lymphatic cells neurodegenerative disease

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机器人奇异形位分析及协调控制方法

上海交通大学学报 2002年第8期36卷 1138-1142页

作者：刘成良张凯曹其新付庄殷跃红上海交通大学机械与动力工程学院上海200030

把 6R机器人奇异形位分为边界奇异、内部奇异、结构边界奇异和腕部奇异 ,分析了这些奇异形位的形成条件 ,并对每一种奇异进行了计算机仿真 .在深入分析奇异边界构成的基础上 ,给出了内部奇异直观的计算机图形仿真结果 ,克服了以往笼统... 详细信息

把 6R机器人奇异形位分为边界奇异、内部奇异、结构边界奇异和腕部奇异 ,分析了这些奇异形位的形成条件 ,并对每一种奇异进行了计算机仿真 .在深入分析奇异边界构成的基础上 ,给出了内部奇异直观的计算机图形仿真结果 ,克服了以往笼统而欠实用描述方法的不足 .通过分析 J-1( J为 Jacobian矩阵 )

关键词：控制方法机器人奇异形位协调控制计算机仿真边界奇异内部奇异腕部奇异

Multilevel analysis of the central-peripheral-target organ pathway:contributing to recovery after peripheral nerve injury

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Neural Regeneration Research 2025年第10期20卷 2807-2822页

作者： Xizi Song Ruixin Li Xiaolei Chu qi Li Ruihua Li qingwen Li kai-Yu Tong Xiaosong Gu Dong Ming Academy of Medical Engineering and Translational Medicine Tianjin UniversityTianjinChina Haihe Laboratory of Brain-Machine Interface and Human-Machine Fusion TianjinChina Department of Rehabilitation Tianjin University Tianjin HospitalTianjinChina Department of Hand Microsurgery Tianjin University Tianjin HospitalTianjinChina School of Exercise and Health Tianjin University of SportTianjinChina Department of Biomedical Engineering the Chinese University of Hong KongHong Kong Special Administrative RegionChina

Peripheral nerve injury is a common neurological condition that often leads to severe functional limitations and *** on the pathogenesis of peripheral nerve injury has focused on pathological changes at individual injury sites,neglecting multilevel pathological analysis of the overall nervous system and target *** has led to restrictions on current therapeutic *** this paper,we first summarize the potential mechanisms of peripheral nerve injury from a holistic perspective,covering the central nervous system,peripheral nervous system,and target *** peripheral nerve injury,the cortical plasticity of the brain is altered due to damage to and regeneration of peripheral nerves;changes such as neuronal apoptosis and axonal demyelination occur in the spinal *** nerve will undergo axonal regeneration,activation of Schwann cells,inflammatory response,and vascular system regeneration at the injury *** damage to target organs can occur,including skeletal muscle atrophy and sensory receptor *** then provide a brief review of the research advances in therapeutic approaches to peripheral nerve *** main current treatments are conducted passively and include physical factor rehabilitation,pharmacological treatments,cell-based therapies,and physical ***,most treatments only partially address the problem and cannot complete the systematic recovery of the entire central nervous system-peripheral nervous system-target organ ***,we should further explore multilevel treatment options that produce effective,long-lasting results,perhaps requiring a combination of passive(traditional)and active(novel)treatment methods to stimulate rehabilitation at the central-peripheral-target organ levels to achieve better functional recovery.

关键词： central nervous system central peripheral target organ multilevel pathological analysis nerve regeneration peripheral nerve injury peripheral nervous system target organs therapeutic approach

Role of the globus pallidus in motor and non-motor symptoms of Parkinson's disease

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Neural Regeneration Research 2025年第6期20卷 1628-1643页

作者： Yimiao Jiang Zengxin qi Huixian Zhu Kangli Shen Ruiqi Liu Chenxin Fang Weiwei Lou Yifan Jiang Wangrui Yuan Xin cao Liang Chen qianxing Zhuang Department of Physiology School of MedicineNantong UniversityNantongJiangsu ProvinceChina Department of Neurosurgery Huashan HospitalShanghai Medical CollegeFudan UniversityShanghaiChina National Center for Neurological Disorders ShanghaiChina Shanghai Key Laboratory of Brain Function Restoration and Neural Regeneration ShanghaiChina State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science Institute of Brain ScienceFudan UniversityShanghaiChina

The globus pallidus plays a pivotal role in the basal ganglia circuit. Parkinson's disease is characterized by degeneration of dopamine-producing cells in the substantia nigra, which leads to dopamine deficiency in the brain that subsequently manifests as various motor and non-motor symptoms. This review aims to summarize the involvement of the globus pallidus in both motor and non-motor manifestations of Parkinson's disease. The firing activities of parvalbumin neurons in the medial globus pallidus, including both the firing rate and pattern, exhibit strong correlations with the bradykinesia and rigidity associated with Parkinson's disease. Increased beta oscillations, which are highly correlated with bradykinesia and rigidity, are regulated by the lateral globus pallidus. Furthermore,bradykinesia and rigidity are strongly linked to the loss of dopaminergic projections within the cortical-basal ganglia-thalamocortical loop. Resting tremors are attributed to the transmission of pathological signals from the basal ganglia through the motor cortex to the cerebellum-ventral intermediate nucleus circuit. The cortico–striato–pallidal loop is responsible for mediating pallidi-associated sleep disorders. Medication and deep brain stimulation are the primary therapeutic strategies addressing the globus pallidus in Parkinson's disease. Medication is the primary treatment for motor symptoms in the early stages of Parkinson's disease, while deep brain stimulation has been clinically proven to be effective in alleviating symptoms in patients with advanced Parkinson's disease,particularly for the movement disorders caused by levodopa. Deep brain stimulation targeting the globus pallidus internus can improve motor function in patients with tremordominant and non-tremor-dominant Parkinson's disease, while deep brain stimulation targeting the globus pallidus externus can alter the temporal pattern of neural activity throughout the basal ganglia–thalamus network. Therefore, the comp

关键词： anxiety basal ganglia bradykinesia deep brain stimulation depression globus pallidus externus globus pallidus internus lateral globus pallidus medial globus pallidus neural circuit Parkinson's disease

Electrocatalytic cleavage of a lignin β-O-4 model compound and coupling with nitrogen-containing aromatics using Prussian blue analogue-derived nickel–cobalt spinel

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Journal of Energy Chemistry 2025年第1期100卷 628-636页

作者： Yi qi Xueying Chen Bowen Liu Xuliang Lin Xueqing qiu Yanlin qin Guangdong Provincial Key Laboratory of Plant Resources Biorefinery School of Chemical Engineering and Light Industry Guangdong University of Technology Guangdong Provincial Laboratory of Chemistry and Fine Chemical Engineering Jieyang Center Guangdong Basic Research Center of Excellence for Ecological Security and Green Development Guangdong University of Technology

Electrochemical conversion of lignin for the production of high-value heterocyclic aromatic compounds has great *** demonstrate the targeted synthesis and cation modulation of NiCo2O4spinel nanoboxes,synthesized via cation exchange and calcination *** catalysts exhibit excellent efficacy in the electrocatalytic conversion of lignin model compounds,specifically 2-phenoxy-1-phenylethanol,into nitrogen-containing aromatics,achieving high conversion rates and *** catalysts were synthesized via a cation exchange and calcination oxidation process,using Prussian blue nanocubes as *** porous architecture and polymetallic composition of the NiCo2O4spinel demonstrated superior performance in electrocatalytic oxidative coupling,achieving a 99.2 wt%conversion rate of the 2-phenoxy-1-phenylethanol with selectivities of 37.5 wt%for quinoline derivatives and 31.5 wt%for *** innovations include the development of a sustainable one-pot synthesis method for quinoline derivatives,the elucidation of a multistage reaction pathway involving cao bond cleavage,hydroxyaldol condensation,and CAN bond formation,and a deeper mechanistic understanding derived from DFT *** work establishes a new strategy for lignin valorization,offering a sustainable route to produce high-value nitrogen-containing aromatics from renewable biomass under mild conditions,without the need for additional reagents.

关键词： Spinel Biomass valorization Electrocatalysis Lignin oxidation Coupling

Seepage simulation of high concrete-faced rockfill dams based on generalized equivalent continuum model

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Water Science and Engineering 2018年第3期11卷 250-257页

作者： Shou-kai Chen qi-dong He Ji-gang cao School of Water Conservancy North China University of Water Resources and Electric PowerZhengzhou 450045China Henan Key Laboratory of Water Environment Simulation and Treatment North China University of Water Resources and Electric PowerZhengzhou 450045China Academician Workstation of Water Environment Governance and Ecological Restoration Zhengzhou 450002China Collaborative Innovation Center of Water Resources Efficient Utilization and Protection Engineering North China University of Water Resources and Electric PowerZhengzhou 450045China

This research focused on the three-dimensional(3 D) seepage field simulation of a high concrete-faced rockfill dam(CFRD) under complex hydraulic conditions. A generalized equivalent continuum model of fractured rock mass was used for equivalent continuous seepage field analysis based on the improved node virtual flow method. Using a high CFRD as an example, the generalized equivalent continuum range was determined, and a finite element model was established based on the terrain and geological conditions, as well as structural face characteristics of the dam area. The equivalent seepage coefficients of different material zones or positions in the dam foundation were calculated with the Snow model or inverse analysis. Then, the 3 D seepage field in the dam area was calculated under the normal water storage conditions, and the corresponding water head distribution, seepage flow, seepage gradient, and seepage characteristics in the dam area were analyzed. The results show that the generalized equivalent continuum model can effectively simulate overall seepage patterns of the CFRD under complex hydraulic conditions and provide a reference for seepage analysis of similar CFRDs.

关键词： Concrete-faced rockfill dam(CFRD) Generalized equivalent continuum model Node virtual flow method Fractured rock mass Seepage field Seepage coefficient

Artificial intelligence on diabetic retinopathy diagnosis: an automatic classification method based on grey level co-occurrence matrix and naive Bayesian model

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International Journal of Ophthalmology(English edition) 2019年第7期12卷 1158-1162页

作者： kai cao Jie Xu Wei-qi Zhao Beijing Institute of Ophthalmology Beijing Tongren Hospital of Capital Medical University

AIM: To develop an automatic tool on screening diabetic retinopathy(DR) from diabetic ***: We extracted textures from eye fundus images of each diabetes subject using grey level co-occurrence matrix method and trained a Bayesian model based on these textures. The receiver operating characteristic(ROC) curve was used to estimate the sensitivity and specificity of the Bayesian ***: A total of 1000 eyes fundus images from diabetic patients in which 298 eyes were diagnosed as DR by two ophthalmologists. The Bayesian model was trained using four extracted textures including contrast, entropy, angular second moment and correlation using a training dataset. The Bayesian model achieved a sensitivity of 0.949 and a specificity of 0.928 in the validation dataset. The area under the ROC curve was 0.938, and the 10-fold cross validation method showed that the average accuracy rate is 93.5%.CONCLUSION: Textures extracted by grey level cooccurrence can be useful information for DR diagnosis, and a trained Bayesian model based on these textures can be an effective tool for DR screening among diabetic patients.

关键词： grey level co-occurrence matrix Bayesian textures artificial intelligence receiver operating characteristiccurve diabetic retinopathy

Full 2D Hydrodynamic Modelling of Rainfall-induced Flash Floods

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Journal of Mountain Science 2015年第5期12卷 1203-1218页

作者： HUANG Wei cao Zhi-xian qi Wen-jun Gareth PENDER ZHAO kai State Key Laboratory of Water Resources and Hydropower Engineering Science Wuhan University Changjiang Waterway Planning Design and Research Institute Office of Shanxi Provincial Flood Defense and Drought Relief Headquarters Institute for Infrastructure and Environment Heriot-Watt University Shanxi Provincial Hydrographic and Water Resources Survey Bureau

Mountain catchments are prone to flash flooding due to heavy rainfall. Enhanced understanding of the generation and evolution processes of flash floods is essential for effective flood risk management. However, traditional distributed hydrological models based on kinematic and diffusion wave approximations ignore certain physical mechanisms of flash floods and thus bear excessive uncertainty. Here a hydrodynamic model is presented for flash floods based on the full two-dimensional shallow water equations incorporating rainfall and infiltration. Laboratory experiments of overland flows were modelled to illustrate the capability of the model. Then the model was applied to resolve two observed flash floods of distinct magnitudes in the Lengkou catchment in Shanxi Province, China. The present model is shown to be able to reproduce the flood flows fairly well compared to the observed data. The spatial distribution of rainfall is shown to be crucial for the modelling of flash floods. Sensitivity analyses of the model parameters reveal that the stage and discharge hydrographs are more sensitive to the Manning roughness and initial water content in the catchment than to the Green-Ampt head. Most notably, as the flash flood augments due to heavier rainfall, the modelling results agree with observed data better, which clearly characterizes the paramount role of rainfall in dictating the floods. From practical perspectives, the proposed model is more appropriate for modelling large flash floods.

关键词： Flash flood Full hydrodynamic model Spatial distribution Rainfall