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Nonbismuth concomitant quadruple therapy for Helicobacter pylori eradication in Chinese regions: A meta-analysis of randomized controlled trials

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World Journal of Gastroenterology 2016年第23期22卷 5445-5453页

作者： Lien-Chieh Lin Tzu-Herng Hsu Kuang-Wei Huang ka-wai tam School of Medicine College of MedicineTaipei Medical University Department of Gastroenterology College of MedicineTaipei Medical University Division of General Surgery Department of SurgeryShuang Ho HospitalTaipei Medical University Department of Surgery School of MedicineCollege of MedicineTaipei Medical University Cochrane Taiwan Taipei Medical University Center for Evidence-based Health Care Shuang Ho HospitalTaipei Medical University

AIM: To evaluate the applicability of nonbismuth concomitant quadruple therapy for Helicobacter pylori(H. pylori) eradication in Chinese ***: A systematic review and meta-analysis of randomized controlled trials was performed to evaluate the efficacy of nonbismuth concomitant quadruple therapy between sequential therapy or triple therapy for H. pylori eradication in Chinese regions. The defined Chinese regions include China, Hong Kong, Taiwan, and Singapore. The primary outcome was the H. pylori eradication rate; the secondary outcome was the compliance with therapy. The Pub Med, Embase, Scopus, and Cochrane databases were searched for studies published in the period up to March 2016 with no language ***: We reviewed six randomized controlled trials and 1616 patients. In 3 trials comparing concomitant quadruple therapy with triple therapy, the H. pylori eradication rate was significantly higher for 7-d nonbismuth concomitant quadruple therapy than for 7-d triple therapy(91.2% vs 77.9%, risk ratio = 1.17, 95%CI: 1.09-1.25). In 3 trials comparing quadruple therapy with sequential therapy, the eradication rate was not significant between groups(86.9% vs 86.0%). However, higher compliance was achieved with concomitant therapy than with sequential ***: The H. pylori eradication rate was higher for nonbismuth concomitant quadruple therapy than for triple therapy. Moreover, higher compliance was achieved with nonbismuth concomitant quadruple therapy than with sequential therapy. Thus, nonbismuth concomitant quadruple therapy should be the first-line treatment in Chinese regions.

关键词： Helicobacter pylori eradication nonbismuth concomitant quadruple therapy Peptic ulcer Chinese region

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Nucleoside modified mRNA-lipid nanoparticles as a new delivery platform for the repair of the injured spinal cord

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Neural Regeneration Research 2025年第8期20卷 2311-2312页

作者： Krisztián Pajer tamás Bellák Antal Nógrádi Department of Anatomy Histology and EmbryologyAlbert Szent-Györgyi Medical SchoolUniversity of SzegedSzegedHungary

Spinal cord injury and treatment opportunities:The adult mammalian spinal cord has a very limited capacity for spontaneous regeneration due to various intrinsic molecular and cellular *** the spinal cord neurons have the capacity to regenerate their axons,the expression of growth inhibitory factors,lack or suppression of proper guidance cues,and profound inflammatory responses do not permit successful regeneration(Khyeam et al.,2021).

关键词： injured capacity modified

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Privacy-preserving explainable AI: a survey

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Science China(Information Sciences) 2025年第1期68卷 23-56页

作者： Thanh tam NGUYEN Thanh Trung HUYNH Zhao REN Thanh Toan NGUYEN Phi Le NGUYEN Hongzhi YIN Quoc Viet Hung NGUYEN School of Information and Communication Technology Griffith University School of Computer and Communication Sciences Ecole Polytechnique Federale de Lausanne Faculty of Mathematics and Computer Science University of Bremen Faculty of Information Technology HUTECH University Department of Computer Science Hanoi University of Science and Technology School of Electrical Engineering and Computer Science The University of Queensland

As the adoption of explainable AI(XAI) continues to expand, the urgency to address its privacy implications intensifies. Despite a growing corpus of research in AI privacy and explainability, there is little attention on privacy-preserving model explanations. This article presents the first thorough survey about privacy attacks on model explanations and their countermeasures. Our contribution to this field comprises a thorough analysis of research papers with a connected taxonomy that facilitates the categorization of privacy attacks and countermeasures based on the targeted explanations. This work also includes an initial investigation into the causes of privacy leaks. Finally, we discuss unresolved issues and prospective research directions uncovered in our analysis. This survey aims to be a valuable resource for the research community and offers clear insights for those new to this domain. To support ongoing research, we have established an online resource repository, which will be continuously updated with new and relevant findings.

关键词： privacy-preserving explainable AI privacy attacks privacy defences PrivEx PPXAI

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Exacerbated VEGF up-regulation accompanies diabetes-aggravated hemorrhage in mice after experimental cerebral ischemia and delayed reperfusion

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Neural Regeneration Research 2022年第7期17卷 1566-1575页

作者： Angela ka wai Lai Tsz Chung Ng Victor ka Lok Hung ka Cheung tam Chi wai Cheung Sookja Kim Chung Amy Cheuk Yin Lo Department of Ophthalmology Li Ka Shing Faculty of MedicineThe University of Hong KongHong Kong Special Administration RegionChina Department of Anesthesiology Laboratory and Clinical Research Institute for PainThe University of Hong KongHong Kong Special Administration RegionChina Macao University of Science and Technology TaipaMacao Special Administration RegionChinaSchool of Biomedical SciencesThe State Key Laboratory of Pharmaceutical BiotechnologyThe University of Hong KongHong Kong Special Administration RegionChina

Reperfusion therapy is the preferred treatment for ischemic stroke,but is hindered by its short treatment window,especially in patients with diabetes whose reperfusion after prolonged ischemia is often accompanied by exacerbated *** mechanisms underlying exacerbated hemorrhage are not fully *** study aimed to identify this mechanism by inducing prolonged 2-hour transient intraluminal middle cerebral artery occlusion in diabetic Ins2Akita/+mice to mimic patients with diabetes undergoing delayed mechanical *** results showed that at as early as 2 hours after reperfusion,Ins2Akita/+mice exhibited rapid development of neurological deficits,increased infarct and hemorrhagic transformation,together with exacerbated down-regulation of tight-junction protein ZO-1 and upregulation of blood-brain barrier-disrupting matrix metallopeptidase 2 and matrix metallopeptidase 9 when compared with normoglycemic Ins2+/+*** indicated that diabetes led to the rapid compromise of vessel integrity immediately after reperfusion,and consequently earlier death and further aggravation of hemorrhagic transformation 22 hours after *** observation was associated with earlier and stronger up-regulation of pro-angiogenic vascular endothelial growth factor(VEGF)and its downstream phospho-Erk1/2 at 2 hours after reperfusion,which was suggestive of premature angiogenesis induced by early VEGF up-regulation,resulting in rapid vessel disintegration in diabetic *** reticulum stress-related pro-apoptotic C/EBP homologous protein was overexpressed in challenged Ins2Akita/+mice,which suggests that the exacerbated VEGF up-regulation may be caused by overwhelming endoplasmic reticulum stress under diabetic *** conclusion,the results mimicked complications in patients with diabetes undergoing delayed mechanical thrombectomy,and diabetes-induced accelerated VEGF up-regulation is likely to underlie exacerbated hemorrhagic transformat

关键词： blood-brain barrier brain injury diabetes mellitus hemorrhagic transformation infarct ischemia/reperfusion injury middle cerebral artery occlusion mouse model stroke vascular endothelial growth factor

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Transcanal endoscopic assisted skull base endolymphatic sac tumor resection: A rare disease with advanced technology

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Journal of Otology 2020年第1期15卷 1-5页

作者： wai Tsz Chang ka Yue tam Hung Yao Kwan Ho Chow Michael Chi Fai Tong Department of Otorhinolaryngology Head and Neck Surgerythe Chinese University of Hong KongHong Kong Department of Pathology Princess Margaret HospitalHong Kong Department of Neurosurgery Princess Margaret HospitalHong Kong

Endolymphatic sac tumors(ELSTs) are rare, papillary adenomatous tumors that arise from the endothelium of the endolymphatic sac. We demonstrate a difficult case of endolymphatic sac tumor and how it is managed via transcanal endoscopic assisted technique, with discussion of feasibility of transcanal approach to lateral skull base tumor.

关键词： Endolymphatic sac Lateral skull base Transcanal endoscopic assisted technique Transcanal combined endoscopic microscopic approach

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Notes on M-Estimation in Exponential Signal Models

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Communications in Mathematics and Statistics 2021年第2期9卷 139-151页

作者： Shu Ding Yuehua Wu Kwok-wai tam School of Economics Hefei University of TechnologyHefeiChina Department of Mathematics and Statistics York UniversityTorontoONCanada Department of Mathematics Portland State UniversityPortlandORUSA

An M-estimation of the parameters in an undamped exponential signal model was proposed in Wu and tam(IEEE Trans Signal Process 49(2):373–380,2001),and the estimation was shown to be consistent under mild *** this paper,the limiting distributions of the M-estimators are *** is shown that they are asymptotically normally distributed under similar conditions as assumed in Wu and tam(IEEE Trans Signal Process 49(2):373–380,2001).In addition,a recursive algorithm for computing the M-estimators of frequencies is proposed,and the strong consistency of these estimators is *** Carlo simulation studies using Huber’sρfunction are also provided.

关键词： Exponential signal model M-estimation Limiting distribution Recursive algorithm Consistency

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Effects of root morphology and anatomy on cadmium uptake and translocation in rice(Oryza sativa L.)

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Journal of Environmental Sciences 2019年第1期31卷 296-306页

作者： Lu Huang wai Chin Li Nora Fung Yee tam Zhihong Ye School of Life Sciences Sun Yat-sen University Department of Science and Environmental Studies The Education University of Hong Kong State Key Laboratory in Marine Pollution and Department of Chemistry City University of Hong Kong

A clear description of the certain mechanisms of cadmium(Cd) uptake and translocation in rice(Oryza sativa L.) may help to reduce Cd accumulation in rice grain. Hydroponic experiments were carried out to determine the effects of cultivation conditions(aerated and stagnant) on the uptake, translocation and subcellular distribution of Cd in relation to the morphology and anatomy of roots in two rice genotypes with different Cd accumulations in grains. Marked differences in morphology and anatomy were observed between these two genotypes under different cultivation conditions. Genotypes with low Cd accumulation in grains tended to develop fewer root tips per root surface area, larger root porosity and more mature apoplastic barriers. The stagnant cultivation condition decreased the number of root tips per root surface area but increased root porosity and accelerated apoplastic barrier formation in root *** Cd uptake studies revealed that rice plants with fewer number of root tips per root surface area reduced root Cd uptake ability, while mature apoplastic barriers increased root Cd retention in cell walls and the symplast. Thus, the fewer number of root tips per root surface area and the earlier formation of mature apoplastic barriers led to lower Cd uptake and translocation. The results indicated that the morphology and anatomy of roots could play important roles in Cd uptake and translocation in rice, and could be influenced by both genotype and cultivation conditions. The present results would be useful in screening and planting rice plants with low Cd accumulation.

关键词： Apoplastic barriers Cadmium Rice Root morphology

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Comparison of Adult Defendants' Forensic Psychiatric Evaluation in Criminal Courts between China' Mainland and Taiwan region:From Law to Clinical Practice

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Journal of Forensic Science and Medicine 2022年第1期8卷 32-40页

作者： wai-Cheong Carl tam Department of Psychology Chung Yuan Christian UniversityTaoyuan CityTaiwanChina

The defendant’s mental capacity is often crucial in criminal procedure,and an expert witness may be requested to conduct a forensic psychiatric *** paper analyzes the law and clinical practice of adult defendants’forensic psychiatric evaluation in criminal courts between China' Mainland and Taiwan *** indicated that the law in Taiwan region explicitly mentioned more mental illness and mental capacity than the law in China' Mainland regarding forensic psychiatric *** expert witnesses,China' Mainland has established a registration and management system,but in Taiwan region,the judge decides the expert witness’s ***,clinical evaluation guidelines have been promulgated in China' Mainland,while none in Taiwan *** of the findings were discussed.

关键词： Criminal responsibility expert witness forensic assessment legal competence

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Virtual reality based multiple life skill training for intellectual disability:A multicenter randomized controlled trial

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Engineered Regeneration 2022年第2期3卷 121-130页

作者： James Chung-wai Cheung Ming Ni Andy Yiu-Chau tam Tim Tin-Chun Chan Alyssa ka-Yan Cheung Ocean Yu-Hong Tsang Chi-Bun Yip Wing-kai Lam Duo wai-Chi Wong Department of Biomedical Engineering Faculty of EngineeringThe Hong Kong Polytechnic UniversityHong Kong 999077China Research Institute for Smart Ageing The Hong Kong Polytechnic UniversityHong Kong 999077China Jockey Club Smart Ageing Hub Department of Biomedical EngineeringFaculty of EngineeringThe Hong Kong Polytechnic UniversityHong Kong 999077China Department of Orthopaedics Pudong New Area People’s Hospital Affiliated to Shanghai Jiaotong UniversityShanghai 201299China Social Service Department Yan Chai HospitalHong Kong 999077China C2 Innovations and Research Limited Hong Kong 999077China Department of Kinesiology Shenyang Sport UniversityShenyang 110102China Sports Information and External Affairs Centre Hong Kong Sports InstituteHong Kong 999077China

Life skill-based training is essential for intellectual disabled individuals to regain autonomy and social *** reality(VR)could deliver a nascent application that is more engaging and *** objective of this study was to evaluate the training effects of the VR-based multiple life skill training program on life skill perfor-mance,self-efficacy,memory,cognitive and behavioral functions via a multicenter randomized controlled trial.A total of 145 intellectual disabled participants were recruited for a randomized controlled trial with three in-tervention arms:VR(n=42);traditional(n=53);and control(n=50).The life skill tasks for the interventions included 1)grocery shopping,2)cooking,and 3)kitchen *** measures were performance scores for the three tasks,self-efficacy scale,digit span score,and Frontal Assessment Battery score,graded by blinded ***-after effects of each group were evaluated using separated Wilcoxon Signed-rank *** sig-nificantly improved cooking,cleaning performance,and memory span,while traditional training significantly improved shopping,cooking,and cleaning *** generalized estimating equation evaluated effects between groups adjusted for age,gender and intelligence quotient(IQ).VR had significantly larger improvement effects in cooking and cleaning than the control group and memory span compared to traditional training and controls *** appeared to be a significant confounder on the training *** work may consider developing artificial intelligence to customize programs depending on IQ level.

关键词： Mental retardation Intellectual development X-reality Immersive rehabilitation Metaverse

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Colonoscopy in Hong Kong Chinese children

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World Journal of Gastroenterology 2010年第9期16卷 1119-1122页

作者： Yuk Him tam Kim Hung Lee Kin wai Chan Jennifer Dart Yin Sihoe Sing Tak Cheung Jennifer wai Cheung Mou Division of Paediatric Surgery & Paediatric Urology Department of SurgeryPrince of Wales HospitalThe Chinese University of Hong Kong

AIM:To investigate the safety and diagnostic yield of colonoscopy in Chinese children in whom the procedure is not often ***:We conducted a retrospective review of all colonoscopies in consecutive children who underwent their fi rst diagnostic colonoscopy from Jan 2003 to ***:Seventy-nine children (48 boys,31 girls;mean age 9.2 ± 4.2 years) were identified and reviewed with a total of 82 colonoscopies *** caecal and ileal intubation rates were 97.6% and 75.6% *** patients (50.6%) had a positive diagnosis made in colonoscopy and that included colonic polyps (23),Crohn's disease (12),ulcerative colitis (1),and miscellaneous causes (4).80% of polyps were in the rectosigmoid *** but one were juvenile hamartomatous *** exceptionwas an adenomatous *** mean ages for children with inflammatory bowel disease (IBD) and polyps were 11.3 and 4.3 years *** was no procedure-related ***:Colonoscopy is a safe procedure in our Chinese *** increasing diagnosis of IBD in recent decades may reflect a rising incidence of the disease in our children.

关键词： Colonoscopy Children Inflammatory bowel disease Colonic polyps

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