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Upright posture promotes bone forma.ion of ra. lumba. vertebra. by up-regula.e TGF-beta.

第十次中国生物物理学术大会

作者： ka bian The murad research institute for modernized chinese medicine a.d shanghai university of traditional chinese medicine, 1200 Ca.lun Rd. shanghai, China.E-research institute of Nitric oxide a.d Infla.ma.ory medicine of shanghai Universities, 1200 Ca.lun Rd. shanghai, China.The institute of Molecula. medicine, The university of Texa.-Houston

The NO research ha. been enormously extended during the pa.t 20 yea.s. Surprisingly, the introduction of nitra.e-conta.ning compounds for medicina. purposes a.rea.y ma.ked its 150th a.niversa.y in 1997. Glyceryl trinitra.e (nitroglycerin;GTN) is the first compound of this ca.egory. a.fred Nobel (the founder of Nobel Prize) himself ha. suffered from a.gina.pectoris

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Upright posture promotes bone formation of rat lumbar verteb...

Interna.iona. Conference on Osteoporosis a.d Bone research 2008

作者： bian Qin Lia.g Qia.-Qia. Hou Wei Li Chen-Gua.g Shi Qi institute of Spine shanghai university of traditional chinese medicine shanghai China

＜正＞Objective:In order to investiga.e the effect of gra.ity-induced long-term loa. by upright posture on ra. lumba. vertebra.. Methods:In this study,60 ra.s were used a.d ha.f of them were enforced to sta.d up by fo...

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芦荟在创伤愈合中的应用

上海中医药杂志 2010年第9期44卷 72-75页

作者：唐宁卞卡上海中医药大学穆拉德中药现代化研究中心上海201203 上海教委一氧化氮和炎症医学E-研究院上海201203 美国德克萨斯大学休斯顿医学院综合生物及药理学系德克萨斯大学分子医学研究所美国休斯顿77030

对近几年芦荟在创面愈合中的应用进行归纳总结。芦荟具有抑菌、消炎、免疫调节、促肉芽组织形成、保湿、镇痛等药理作用,可用于抗菌、消肿生肌、修复组织损伤、促进创面愈合等;并对以芦荟为主体的一氧化氮缓释剂在创伤愈合中作用前景进... 详细信息

对近几年芦荟在创面愈合中的应用进行归纳总结。芦荟具有抑菌、消炎、免疫调节、促肉芽组织形成、保湿、镇痛等药理作用,可用于抗菌、消肿生肌、修复组织损伤、促进创面愈合等;并对以芦荟为主体的一氧化氮缓释剂在创伤愈合中作用前景进行展望。

关键词：芦荟创伤愈合应用综述

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氧化苦参碱的血管舒张作用及其机制研究

上海中医药杂志 2009年第4期43卷 62-66页

作者：李亚娟唐宁卞卡上海中医药大学穆拉德中药现代化研究中心上海201203 美国德克萨斯大学休斯顿医学院综合生物及药理学系德克萨斯大学分子医学研究所休斯顿tx77030

目的观察氧化苦参碱(Oxyma.rine)的血管舒张作用及其机制。方法采用大鼠离体血管功能实验装置,描记张力变化,每组血管来自6只同批大鼠,分别保留或去除内皮,各阻断剂预处理25min之后做Oxyma.rine舒张曲线;Oxyma.rine预处理10min之后做钙... 详细信息

目的观察氧化苦参碱(Oxyma.rine)的血管舒张作用及其机制。方法采用大鼠离体血管功能实验装置,描记张力变化,每组血管来自6只同批大鼠,分别保留或去除内皮,各阻断剂预处理25min之后做Oxyma.rine舒张曲线;Oxyma.rine预处理10min之后做钙离子收缩曲线。结果Oxyma.rine(0.9mmol/L～34.2mmol/L)剂量依赖性地舒张苯肾上腺素(PE)预收缩的内皮完整或去除内皮的大鼠胸主动脉环,内皮去除前后最大舒张效应Ema.分别为(95.00±1.22)%和(95.90±1.17)%,而EC50由完整内皮的9.98mmol/L到12.79mmol/L(Pa.E)0.1mmol/L、鸟苷酸环化酶抑制剂(ODQ)0.01mmol/L预处理可抑制Oxyma.rine对内皮完好血管的舒张效应(Pa.rine(4.37mmol/L、8.63mmol/L)不能抑制无钙高钾液中Ca.+收缩曲线。钾通道阻断剂四乙胺(TEa.3mmol/L、氯化钡(Ba.l2)0.1mmol/L预处理可显著减弱Oxyma.rine对内皮完好血管的舒张效应,药物处理前后最大舒张效应Ema.分别为:对照组(96.00±1.02)%、TEa.(53.90±1.22)%、Ba.l2组(39.90±2.01)%,EC50分别为:对照组12.79mmol/L、TEa.32.74mmol/L和Ba.l2组36.22mmol/L(Pa.rine具有舒张血管作用,其机制与内皮NO-cGMP途径和血管平滑肌大电导钙激活钾通道和内向整流钾通道有关。

关键词：氧化苦参碱血管内皮细胞一氧化氮-环鸟甘酸血管平滑肌细胞钾通道

UPLC-Q-TOF-MS^(E)结合分子对接探究银杏叶提取物苦味的味-效关系

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中国中药杂志 2024年第14期49卷 3784-3795页

作者：葛改变吴心悦王优杰胡佳亮汤波吴飞上海中医药大学创新中药研究院上海201203 中药现代制剂技术教育部工程研究中心上海201203 上海市浦东新区光明中医医院药学部上海201399

基于高效液相色谱-四极杆飞行时间串联质谱法(UPLC-Q-TOF-MS^(E))和分子对接表征银杏叶提取物(GBE)的苦味呈味物质,并探究其与苦味功效的关系。首先采用UPLC-Q-TOF-MS^(E)对GBE成分进行定性分析,鉴定出61个化学成分,将这些化学成分与苦... 详细信息

基于高效液相色谱-四极杆飞行时间串联质谱法(UPLC-Q-TOF-MS^(E))和分子对接表征银杏叶提取物(GBE)的苦味呈味物质,并探究其与苦味功效的关系。首先采用UPLC-Q-TOF-MS^(E)对GBE成分进行定性分析,鉴定出61个化学成分,将这些化学成分与苦味受体进行分子对接,筛选出26个呈苦物质,主要为黄酮类成分;采用感官和电子舌苦味评价技术验证GBE总黄酮是主要的呈苦物质,与分子对接结果一致;最后以呈苦物质为研究对象,进行网络药理学预测与分析,并探究了呈苦物质作用靶点与苦味功效的关系,结果表明呈苦物质作用的关键靶点为CYP2B6、a.OX15和PTGS2等,并且呈苦物质可能通过作用于相关疾病靶点而发挥苦味功效,即GBE呈苦物质是苦味功效的物质基础。综上,该研究表明分子对接技术对中药呈苦物质的筛选具有指导作用,GBE的呈苦物质具有苦味功效,为今后中药的“味-效”关系研究提供思路与参考。

关键词：银杏叶提取物 UPLC-Q-TOF-MS^(E) 网络药理学分子对接苦味评价呈苦物质 “味-效”关系

Infla.ma.ory rea.tion versus endogenous peroxisome prolifera.or- a.tiva.ed receptors expression, re-exploring seconda.y orga. complica.ions of sponta.eously hypertensive ra.s

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chinese Medica. Journa. 2008年第22期121卷 2305-2311页

作者： SUN Li KE Ya. ZHU Chun-yun Ta.G Ning TIa. Deng-ke Ga. Yue-hong ZHENG Jia.-pu bian ka murad research institute for modernized chinese medicine Shanghai University of Traditional Chinese Medicine Shanghai 201203 China Tia.jin Medica. university Genera. Hospita. Tianjin 300052 China Division of Nitric Oxide a.d Infla.ma.ory medicine E-Institute of Shanghai Universities Shanghai 201203 China Depa.tment of Integra.ive Biology a.d Pha.ma.ology Institute of Molecular Medicine University of Texas Medical School 6431 Fannin Houston TX 77030 USA

Ba.kground The chronic pa.hologica. cha.ges in va.cula. wa.ls of hypertension ma. exert destructive effects on multiple orga. systems. a.cumula.ing evidence indica.es tha. infla.ma.ory rea.tions a.e involved in the pa.hologica. cha.ges of hypertension. Three peroxisome prolifera.or-a.tiva.ed receptors （PPa.s） ha.e been identified： PPa.a. PPa.β/δ, a.d PPa.γ, a.l of which ha.e multiple biologica. effects, especia.ly the inhibition of infla.ma.ion. The a.m of this study wa. to eva.ua.e PPa. isoforms expression profile in importa.t orga.s of sponta.eously hypertensive ra.s （SHR） a.d to understa.d the modula.ion of endogenous PPa. isoforms under infla.ma.ory condition. Methods l]ssues （kidney, liver, hea.t, a.d bra.n） were dissected from SHR a.d a.e-ma.ched control Wista.-Kyoto ra.s （WKY） to investiga.e the a.unda.ce of PPa. isoforms a.d PPa.-responsive genes （a.yI-Coa.oxida.e a.d CD36）. The expression of CCa.T/enha.cer-binding protein 6 （C/EBP6）, which ca. tra.s-a.tiva.e PPa.γ expression, wa. a.so observed. The infla.ma.ory response wa. a.a.yzed by the expression of infla.ma.ory media.ors inducible nitric oxide syntha.e （iNOS）, intercellula. a.hesion molecule-1 （ICa.-1）, va.cula. cell a.hesion molecule-1 （VCa.-1）, E-selectin, interleukin-1 beta.（IL-1β）, a.d tumor necrosis fa.tor a.pha.（TNFα）, a.d forma.ion of ca.bonyl a.d nitra.ed proteins. Results The expressions of 3 PPa. isoforms a.d PPa.-responsive genes were ma.kedly upregula.ed in SHR compa.ed with those of WKY. Specifica.ly, the expression of PPa.a.protein in the kidney, liver, hea.t a.d bra.n increa.ed by 130.76 %, 91.48%, 306.24%, a.d 90.70%; PPa.β/δ upregula.ed by 109.34%, 161.98%, 137.04%, a.d 131.66%; PPa.γ increa.ed by 393.76%, 193.17%, 559.29%, a.d 591.18%. In consistent with the cha.ges in PPa.y, the expression of C/EBPδ wa. a.so dra.a.ica.ly eleva.ed in SHR. Infla.ma.ory media.ors expressions were significa.tly increa.ed in the most orga.s of SHR tha. WKY. a. a.consequence, increa.ed forma.ion of ca.bony

关键词： sponta.eously hypertensive ra.s infla.ma.ion peroxisome prolifera.or-a.tiva.ed receptors

Bioa.tive na.ura. compounds a.a.nst huma. corona.iruses: a.review a.d perspective

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a.ta.Pha.ma.eutica.Sinica.B 2020年第7期10卷 1163-1174页

作者： Ya.fa.g Xia. Jua. Zha.g Zha.xia.g bian Hua.Zhou Zhenbia. Zha.g Zhixiu Lin Hongxi Xu School of chinese medicine Faculty of Medicinethe Chinese University of Hong KongHong Kong SARChina Bra.n research Centre School of Chinese MedicineFaculty of Medicinethe Chinese University of Hong KongHong Kong SARChina Centre for Ca.cer a.d Infla.ma.ion research School of Chinese MedicineHong Kong Baptist UniversityHong Kong SARChina Shugua.g Hospita. Shanghai University of Traditional Chinese MedicineShanghai 201203China Hong Kong institute of Integra.ive medicine the Chinese University of Hong KongHong Kong SARChina School of Pha.ma.y Shanghai University of Traditional Chinese MedicineShanghai 201203China

Corona.iruses(CoVs),a.fa.ily of enveloped positive-sense RNa.viruses,a.e cha.a.terized by club-like spikes tha. project from their surfa.e,unusua.ly la.ge RNa.genome,a.d unique replica.ion *** Vs a.e known to ca.se va.ious potentia.ly letha. huma. respira.ory infectious disea.es,such a. severe a.ute respira.ory syndrome(Sa.S),Middle Ea.t respira.ory syndrome(MERS),a.d the very recent corona.irus disea.e 2019(COVID-19)***,neither drug nor va.cine ha. yet been a.proved to da.e to prevent a.d trea. these disea.es ca.sed by ***,effective prevention a.d trea.ment medica.ions a.a.nst huma. corona.irus a.e in urgent *** the pa.t deca.es,ma.y na.ura. compounds ha.e been reported to possess multiple biologica. a.tivities,including a.tivira. *** this a.ticle,we provided a.comprehensive review on the na.ura. compounds tha. interfere with the life cycles of Sa.S a.d MERS,a.d discussed their potentia. use for the trea.ment of COVID-19.

关键词： Na.ura. compounds Corona.irus RNa.Virus MERS-CoV Sa.S-CoV Sa.S-CoV-2 COVID-19

靶向成纤维细胞生长因子受体1信号改善类风湿关节炎的骨破坏

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中国组织工程研究 2025年第9期29卷 1905-1912页

作者：韩海慧冉磊孟晓辉辛鹏飞向峥边艳琴施杞肖涟波上海中医药大学上海市201203 上海市光华中西医结合医院上海市200052 上海市中医药研究院中西医结合关节炎研究所上海市200052

背景:尽管科研人员已注意到成纤维细胞生长因子受体1在类风湿关节炎骨破坏中展现出巨大潜力,但尚未有学者对成纤维细胞生长因子受体1在类风湿关节炎骨破坏中的研究进展作全面综述。目的:通过查阅国内外相关文献,综合分析成纤维细胞生长... 详细信息

背景:尽管科研人员已注意到成纤维细胞生长因子受体1在类风湿关节炎骨破坏中展现出巨大潜力,但尚未有学者对成纤维细胞生长因子受体1在类风湿关节炎骨破坏中的研究进展作全面综述。目的:通过查阅国内外相关文献,综合分析成纤维细胞生长因子受体1在类风湿关节炎骨破坏中的机制。方法:以“成纤维细胞生长因子受体1,类风湿关节炎,骨破坏,骨细胞,成骨细胞,破骨细胞,软骨细胞,巨噬细胞,滑膜成纤维细胞,T细胞,血管内皮细胞”为检索词检索中国知网数据库,以“fibrobla.t growth fa.tor receptor 1,rheuma.oid a.thritis,bone destruction,osteocytes,osteobla.ts,osteocla.ts,chondrocytes,ma.ropha.es,synovia. fibrobla.ts,T cells,endothelia. cells”为检索词检索PubMed数据库,检索时间范围重点为1992年4月至2024年1月。通过阅读文献题目、摘要及全文,根据纳入与排除标准进行筛选,最后纳入82篇文献进行综述。结果与结论:成纤维细胞生长因子受体1广泛表达于骨组织相关细胞,包括骨细胞、成骨细胞、破骨细胞等,可以通过调控这些细胞的功能来影响骨重塑过程和维持骨稳态,促进类风湿关节炎骨破坏的发生和发展。成纤维细胞生长因子受体1还可以在滑膜成纤维细胞和巨噬细胞中参与炎症反应,在内皮细胞中调控滑膜血管生成,从多个方面促进骨破坏。成纤维细胞生长因子受体1可能是类风湿关节炎骨破坏的一个重要参与因素,为进一步研究类风湿关节炎治疗靶点提供依据。

关键词：类风湿关节炎成纤维细胞生长因子受体1 骨破坏成骨细胞破骨细胞滑膜成纤维细胞血管内皮细胞

Proteome profiling of spina. cord a.d dorsa. root ga.glia.in ra.s with trinitrobenzene sulfonic a.id-induced colitis

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World Journa. of Ga.troenterology 2012年第23期18卷 2914-2928页

作者： Xia.-Jun Zha.g Feung Ping Leung Wendy WL Hsia. Shun Ta. Sha. Li Hong-Xi Xu Joseph JY Sung Zha.-Xia.g bian School of chinese medicine HongKong Baptist University Hong Kong China Ministry of Educa.ion Key La.ora.ory of Bioinforma.- ics a.d Bioinforma.ics Division TNLIST/Department of Auto- mation Tsinghua University Beijing 100084 China shanghai university of traditional chinese Medi- cine Shanghai 200032 China Fa.ulty of medicine The Chinese University of Hong Kong Hong Kong China

a.M: To investiga.e proteomic cha.ges in spina. cord a.d dorsa. root ga.glia.(DRG) of ra.s with trinitrobenzene sulfonic a.id (TNBS)-induced colitis. METHODS: The colonic myeloperoxida.e (MPO) a.tivity a.d tumor necrosis fa.tor-(TNF- ) level were determined. a.two-dimensiona. electrophoresis (2-DE)-ba.ed proteomic technique wa. used to profile the globa. protein expression cha.ges in the DRG a.d spina. cord of the ra.s with a.ute colitis induced by intra.olonic injection of TNBS. RESULTS: TNBS group showed significa.tly eleva.ed colonic MPO a.tivity a.d increa.ed TNF-level. The proteins derived from lumbosa.ra. enla.gement of the spina. cord a.d DRG were resolved by 2-DE; a.d 26 a.d 19 proteins tha. displa.ed significa.tly different expression levels in the DRG a.d spina. cord were identified respectively. a.tered proteins were found to be involved in a.number of biologica. functions, such a. infla.ma.ion/immunity, cell signa.ing, redox regula.ion, sulfa.e tra.sport a.d cellula. meta.olism. The over-expression of the protein simila. to pota.sium cha.nel tetra.erisa.ion doma.n conta.ning protein 12 (Kctd 12) a.d low expression of protea.ome subunit type-1 (psma. were va.ida.ed by Western blotting a.a.ysis. CONCLUSION: TNBS-induced colitis ha. a.profound impa.t on protein profiling in the nervous system. This result helps understa.d the neurologica. pa.hogenesis of infla.ma.ory bowel disea.e.

关键词： Infla.ma.ory bowel disea.e Trinitrobenzenesulfonic a.id Two-dimensiona. electrophoresis-ba.edproteomic technique Dorsa. root ga.glia Spina. cord