Bioactive natural compounds against human coronaviruses: a review and perspective

作     者：Yanfang Xian Juan Zhang Zhaoxiang Bian Hua Zhou Zhenbiao Zhang Zhixiu Lin Hongxi Xu Yanfang Xian;Juan Zhang;Zhaoxiang Bian;Hua Zhou;Zhenbiao Zhang;Zhixiu Lin;Hongxi Xu

作者机构：School of Chinese MedicineFaculty of Medicinethe Chinese University of Hong KongHong Kong SARChina Brain Research CentreSchool of Chinese MedicineFaculty of Medicinethe Chinese University of Hong KongHong Kong SARChina Centre for Cancer and Inflammation ResearchSchool of Chinese MedicineHong Kong Baptist UniversityHong Kong SARChina Shuguang HospitalShanghai University of Traditional Chinese MedicineShanghai 201203China Hong Kong Institute of Integrative Medicinethe Chinese University of Hong KongHong Kong SARChina School of PharmacyShanghai University of Traditional Chinese MedicineShanghai 201203China 

出 版 物：《Acta Pharmaceutica Sinica B》 (药学学报（英文版）)

年 卷 期：2020年第10卷第7期

页      面：1163-1174页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 100705[医学-微生物与生化药学] 1001[医学-基础医学(可授医学、理学学位)] 100103[医学-病原生物学] 10[医学] 

主　　题：Natural compounds Coronavirus RNA-Virus MERS-CoV SARS-CoV SARS-CoV-2 COVID-19 

摘      要：Coronaviruses(CoVs),a family of enveloped positive-sense RNA viruses,are characterized by club-like spikes that project from their surface,unusually large RNA genome,and unique replication *** Vs are known to cause various potentially lethal human respiratory infectious diseases,such as severe acute respiratory syndrome(SARS),Middle East respiratory syndrome(MERS),and the very recent coronavirus disease 2019(COVID-19)***,neither drug nor vaccine has yet been approved to date to prevent and treat these diseases caused by ***,effective prevention and treatment medications against human coronavirus are in urgent *** the past decades,many natural compounds have been reported to possess multiple biological activities,including antiviral *** this article,we provided a comprehensive review on the natural compounds that interfere with the life cycles of SARS and MERS,and discussed their potential use for the treatment of COVID-19.