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Efficacy of Vaccine Protection Against COVID-19 Virus Infection in Patients with Chronic Liver Diseases

Journal of Clinical and Translational Hepatology 2023年第3期11卷 718-735页

作者： Carmen ka Man cheung Kimmy Wan Tung Law Alvin Wing Hin Law Man Fai Law Rita Ho Sunny Hei Wong Department of Medicine and Therapeutics Prince of Wales HospitalHong KongChina West Island School Hong KongChina Department of Medicine North District HospitalHong KongChina Institute of Digestive Disease and Department of Medicine and Therapeutics State Key Laboratory of Digestive DiseaseLi Ka Shing Institute of Health SciencesThe Chinese University of Hong KongHong KongChinaLee Kong Chian School of MedicineNanyang Technological UniversitySingapore

The outbreak of coronavirus disease 2019 (COVID-19) has resulted in significant morbidity and mortality worldwide. Vaccination against coronavirus disease 2019 is a use-ful weapon to combat the virus. Patients with chronic liver diseases (CLDs), including compensated or decompensated liver cirrhosis and noncirrhotic diseases, have a decreased immunologic response to coronavirus disease 2019 vaccines. At the same time, they have increased mortality if infected. Current data show a reduction in mortality when patients with chronic liver diseases are vaccinated. A suboptimal vac-cine response has been observed in liver transplant recipi-ents, especially those receiving immunosuppressive therapy, so an early booster dose is recommended to achieve a better protective effect. Currently, there are no clinical data com-paring the protective efficacy of different vaccines in patients with chronic liver diseases. Patient preference, availability of the vaccine in the country or area, and adverse effect profiles are factors to consider when choosing a vaccine. There have been reports of immune-mediated hepatitis after coronavi-rus disease 2019 vaccination, and clinicians should be aware of that potential side effect. Most patients who developed hepatitis after vaccination responded well to treatment with prednisolone, but an alternative type of vaccine should be considered for subsequent booster doses. Further prospec-tive studies are required to investigate the duration of immu-nity and protection against different viral variants in patients with chronic liver diseases or liver transplant recipients, as well as the effect of heterologous vaccination.

关键词： COVID-19 SARS-CoV-2 Chronic liver disease Liver transplanta-tion Vaccine mRNA.

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幽门螺杆菌治疗后长期使用质子泵抑制剂与胃癌发生的风险:以人群为基础的研究

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英国医学杂志中文版 2019年第7期22卷 422-422页

作者： ka shing cheung Esther W Chan Angel Y S Wong Lijia Chen lan C K Wong Wai Keung Leung 彭浩(译) 不详应急总医院普外肿瘤科

目的质子泵抑制剂(PPIs)与胃萎缩恶化相关,尤其是在幽门螺杆菌(HP)感染者中。我们确定了在接受抗HP治疗的HP感染者中,PPIs使用与胃癌(GC)之间的相关性。设计本研究以中国香港全区健康资料库为基础。我们首先确认出自2003至2012年间接受... 详细信息

目的质子泵抑制剂(PPIs)与胃萎缩恶化相关,尤其是在幽门螺杆菌(HP)感染者中。我们确定了在接受抗HP治疗的HP感染者中,PPIs使用与胃癌(GC)之间的相关性。设计本研究以中国香港全区健康资料库为基础。我们首先确认出自2003至2012年间接受过以克拉霉素为基础的三联疗法门诊处方的成年人。排除标准:使用该处方治疗失败的患者,HP治疗后12个月内确诊为GC的患者,以及治疗后发生胃溃疡者。GC排除前的6个月内开始PPIs或H2受体阻滞剂(H2RA)治疗,以避免原始偏倚。通过C。x比例风险模型的倾向分数调整,评估GC发生风险与质子泵抑制剂二者之间的关系。H2RA作为阴性对照暴露。结果共63 397名合格受试者入选,在平均7.6年的随访时间中,有153(0.24%)名发生GC。PPIs使用与GC发生风险增高相关[危害比(HR)2.44,95%可信区间(C/)1.42-4.20],而H2RA无相关性(“R 0.72,95%CI 0.48-1.07)0GC发生的风险随PPIs使用时间的延长而增高(PPIs使用时间/年22年和年的GC发生风险分别为:HR 5.04.95%CI 1.23-20.61;6.65,1.62-27.26和8.34,95%CI 2.02-34.41)。PPIs使用相比非PPIs使用,调整的绝对风险差为每10000人年超过4.29 GC(95%C/1.25-9.54)。结论即使在HP根除治疗后,长期使用质子泵抑制剂仍与GC的发生风险增加相关。

关键词： Cox比例风险模型质子泵抑制剂治疗失败幽门螺杆菌胃癌发生 H2受体阻滞剂人群 HP根除治疗

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Command and Control Cities in Global Space-economy Before and after 2008 Geo-economic Transition

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Chinese Geographical Science 2012年第3期22卷 334-342页

作者： Ernest ka shing LEE Simon Xiaobin ZHAO Yang XIE International Center for China Development Studies & Department of Geography Faculty of Social Sciences the University of Hong Kong Hong Kong China Department for Rural Economic Development Research Center of the State Council Beijing 100010 China

The global economic downturn caused primarily by the US sub-prime mortgage crisis in 2007 engendered revenue loss of the multinational *** studies have yet to depict the detrimental impacts on city's command and control functions induced by the sub-prime mortgage crisis together with its residual wave of global economic recession on the global spatial *** and previous studies have produced an 'instant history' of the global spatial economy before the global economic downturn undermines the global economy in late ***,the waxes and wanes of major cities' command and control functions on the global economic arena before and after the outbreak of financial crisis and its associated geo-economic transitions are still poorly *** paper attempts to contribute a new set of customized data to update and fill in the gap in the literature with the investigation of the command and control functions of cities around the world from 2005 to *** attentions are paid to the time-space relationship of the geo-economic transition that can capture the recent historical images of the command and control situation of different cities in the world.

关键词：控制功能经济空间地缘经济大城市指挥经济转型经济衰退全球经济

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The Saturation Characteristics of Glucose Transport in Bovine Retinal Pigment Epithelium

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眼科学报 1998年第3期14卷 126-129页

作者： Chi Ho To Kin Kwok cheung shing Hon Chiu Hon Ming Lai ka Shun Lung Laboratory of Ocular Physiology and Biochemistry Department of Optometry and Radiography The Hong Kong Polytechnic University Hung Hom Kawloon Hong KongLaboratory of Ocular Physiology and Biochemistry Department of Optometry and Radiography The Hong Kong Polytechnic University Hung Hom Kawloon Hong KongLaboratory of Ocular Physiology and Biochemistry Department of Optometry and Radiography The Hong Kong Polytechnic University Hung Hom Kawloon Hong KongLaboratory of Ocular Physiology and Biochemistry Department of Optometry and Radiography The Hong Kong Polytechnic University Hung Hom Kawloon Hong KongLaboratory of Ocular Physiology and Biochemistry Department of Optometry and Radiography The Hong Kong Polytechnic University Hung Hom Kawloon Hong Kong

Purpose: To study the saturation characteristics of the glucose transport across the bovine retinal pigment epithelium(RPE).Methods :The bovine RPE preparations were munted with a modified Ussing chamber. The L-[3H]-glucose and 3-0-methyl-D-[14C]-glucose fluxes across the RPE from the choroid to retina were studied at different glucose ***: The glucose transport was found to be stereospecific, with 3-0-methyl-D-glucose (MDG) being transported about three times faster than L-glucose. The glucose transport showed typical saturation characteristics in Michaelis-Menten fashion. The Vmax and the Km of corrected MDG were 2452 nmol cm-2h-1 and 30.8 mM respectively. It was shown that the glucose transport system was saturated at 61.6 *** : The saturation characteristics of the corrected MDG flux suggested that the capacity of glucose transport through the bovine RPE is immense. Eye Science 1998; 14: 726 -729.

关键词：视网膜色素上皮细胞葡萄糖运输饱和动力学

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Drugging IGF-1R in cancer: New insights and emerging opportunities

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Genes & Diseases 2023年第1期10卷 199-211页

作者： Panpan Wang Victor CY.Mak Lydia WT.cheung School of Biomedical Sciences Li Ka Shing Faculty of MedicineThe University of Hong KongHong Kong SARChina

The insulin-like growth factor(IGF)axis plays important roles in cancer development and *** type 1 IGF receptor(IGF-1R)is a key member in the IGF axis and has long been recognized for its oncogenic role in multiple cancer *** we review the occurrence of IGF-1R aberrations and activation mechanisms in cancers,which justify the development of anti-IGF-1R *** describe the therapeutic agents available for IGF-1R inhibition,with focuses on the recent or ongoing pre-clinical and clinical *** include antisense oligonucleotide,tyrosine kinase inhibitors and monoclonal antibodies which may be conjugated with cytotoxic ***,simultaneous targeting of IGF-1R and several other oncogenic vulnerabilities has shown early promise,highlighting the potential benefits of combination ***,we discuss the challenges in targeting IGF-1R so far and new concepts to improve therapeutic efficacy such as blockage of the nuclear translocationofIGF-1R.

关键词： Cancer IGF-1R Targeted therapy Metastasis Combination therapy

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与一个学习计划造一个电子公事包中央途径

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Journal of Zhejiang University-Science C(Computers and Electronics) 2012年第1期13卷 37-47页

作者： Lam-for KWOK ka-shing CHAN Department of Computer Science City University of Hong Kong

一个公事包在个人生长过程记录成就。一个个人发展电子公事包在计划其发展路径并且在其自己的学习之上思考帮助一个个人。在这件物品，我们建议一条途径到构造一个个人发展公事包。一个抽象信息模型被介绍支持如此的一个公事包。信息模... 详细信息

一个公事包在个人生长过程记录成就。一个个人发展电子公事包在计划其发展路径并且在其自己的学习之上思考帮助一个个人。在这件物品，我们建议一条途径到构造一个个人发展公事包。一个抽象信息模型被介绍支持如此的一个公事包。信息模型被建议基于在之上并且根据 IMS 标准。这条途径的使用通过一个原型电子公事包系统被说明。如此的一个公事包的用法情形和限制也被讨论。

关键词：电子公事包教育技术系统终生的学习

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Brain delivering RNA-based therapeutic strategies by targeting mTOR pathway for axon regeneration after central nervous system injury

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Neural Regeneration Research 2022年第10期17卷 2157-2165页

作者： Ming-Xi Li Jing-Wen Weng Eric S.Ho shing Fung Chow Chi Kwan Tsang Clinical Neuroscience Institute The First Affiliated Hospital of Jinan UniversityGuangzhouGuangdong ProvinceChina Department of Pharmacology and Pharmacy Li Ka Shing Faculty of MedicineUniversity of Hong KongHong Kong Special Administrative RegionChina Department of Biology and Department of Computer Science Lafayette CollegeEastonPAUSA

Injuries to the central nervous system(CNS)such as stroke,brain,and spinal cord trauma often result in permanent disabilities because adult CNS neurons only exhibit limited axon *** brain has a surprising intrinsic capability of recovering itself after ***,the hostile extrinsic microenvironment significantly hinders axon *** advances have indicated that the inactivation of intrinsic regenerative pathways plays a pivotal role in the failure of most adult CNS neuronal ***,substantial evidence has convincingly demonstrated that the mechanistic target of rapamycin(mTOR)signaling is one of the most crucial intrinsic regenerative pathways that drive axonal regeneration and sprouting in various CNS *** this review,we will discuss the recent findings and highlight the critical roles of mTOR pathway in axon regeneration in different types of CNS ***,we will demonstrate that the reactivation of this regenerative pathway can be achieved by blocking the key mTOR signaling components such as phosphatase and tensin homolog(PTEN).Given that multiple mTOR signaling components are endogenous inhibitory factors of this pathway,we will discuss the promising potential of RNA-based therapeutics which are particularly suitable for this purpose,and the fact that they have attracted substantial attention recently after the success of coronavirus disease 2019 *** specifically tackle the blood-brain barrier issue,we will review the current technology to deliver these RNA therapeutics into the brain with a focus on nanoparticle *** will propose the clinical application of these RNA-mediated therapies in combination with the brain-targeted drug delivery approach against mTOR signaling components as an effective and feasible therapeutic strategy aiming to enhance axonal regeneration for functional recovery after CNS injury.

关键词： axon sprouting axon regeneration brain targeted drug delivery CNS injury ischemic stroke mTOR nanoparticle neural circuit reconstruction PTEN RNA-based therapeutics

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A machine learning model for colorectal liver metastasis post-hepatectomy prognostications

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Hepatobiliary Surgery and Nutrition 2023年第4期12卷 495-506,I0007-I0016页

作者： Cynthia Sin Nga Lam Alina Ashok Bharwani Evelyn Hui Yi Chan Vernice Hui Yan Chan Howard Lai Ho Au Margaret kay Ho Shireen Rashed Bernard Ming Hong Kwong Wentao Fang ka Wing Ma Chung Mau Lo Tan To cheung Li ka shing Faculty of Medicine The University of Hong KongHong Kong SARChina Department of Surgery Li Ka Shing Faculty of MedicineThe University of Hong KongHong Kong SARChina

Background:Currently,surgical resection is the mainstay for colorectal liver metastases(CRLM)management and the only potentially curative treatment *** tools can support patient selection for surgical resection to maximize therapeutic *** study aimed to develop a survival prediction model using machine learning based on a multicenter patient sample in Hong ***:Patients who underwent hepatectomy for CRLM between 1 January 2009 and 31 December 2018 in four hospitals in Hong Kong were included in the *** analysis was performed using Cox proportional hazards(CPH).A stepwise selection on Cox multivariable models with Least Absolute Shrinkage and Selection Operator(LASSO)regression was applied to a multiply-imputed dataset to build a prediction *** model was validated in the validation set,and its performance was compared with that of Fong Clinical Risk Score(CRS)using concordance ***:A total of 572 patients were included with a median follow-up of 3.6 *** full models for overall survival(OS)and recurrence-free survival(RFS)consist of the same 8 established and novel variables,namely colorectal cancer nodal stage,CRLM neoadjuvant treatment,Charlson Comorbidity Score,pre-hepatectomy bilirubin and carcinoembryonic antigen(CEA)levels,CRLM largest tumor diameter,extrahepatic metastasis detected on positron emission-tomography(PET)-scan as well as KRAS *** CRLM Machine-learning Algorithm Prognostication model(CMAP)demonstrated better ability to predict OS(C-index=0.651),compared with the Fong CRS for 1-year(C-index=0.571)and 5-year OS(C-index=0.574).It also achieved a C-index of 0.651 for ***:We present a promising machine learning algorithm to individualize prognostications for patients following resection of CRLM with good discriminative ability.

关键词： Machine-learning colorectal liver metastasis(CRLM) prognostic model survival analysis hepatectomy outcome

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Diagnostic accuracy of Focused Abdominal Sonography for Trauma in blunt abdominal trauma patients in a trauma centre of Hong Kong

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Chinese Journal of Traumatology 2012年第5期15卷 273-278页

作者： cheung Kent Shek Wong Hay Tai Leung Ling Pong Tsang Tat Chi Leung Gilberto ka Kit Department of Accident and Emergency Queen Mary Hospital 102 Pokfulam Road Pokfulam Hong Kong China Department of Surgery Li Ka Shing Faculty of Medicine University of Hong Kong Hong Kong China

为损伤的 ObjectiveFocused 腹的 Sonography (快) 广泛地为 intraperitoneal 的察觉被使用在受不了钝腹的损伤(蝙蝠) 的病人的免费液体。针对在指明的损伤 *** 估计这调查的诊断精确性的这研究是在在香港在一个损伤中心看见的 6 年时... 详细信息

为损伤的 ObjectiveFocused 腹的 Sonography (快) 广泛地为 intraperitoneal 的察觉被使用在受不了钝腹的损伤(蝙蝠) 的病人的免费液体。针对在指明的损伤 *** 估计这调查的诊断精确性的这研究是在在香港在一个损伤中心看见的 6 年时期上的蝙蝠病人的回顾的研究。快调查结果与剖腹术，腹的计算断层摄影术或尸体调查结果相比，它为 intraperi-toneal 的存在用作标准答案免费液体。没快有的病人或确定的测试执行了，有先存在的腹液体，在复活死了或有快调查结果的 imcomplete 文档的标准答案被排除。性能当敏感，特性，预兆的值(PV ) ，可能性的比率(LR ) 和 *** 在 302 个病人被执行，他们中的 153 个在这分析被包括，快被表示。敏感，特性，积极 PV，否定 PV，积极 LR，否定 LR 和精确性为快分别地 50.0% ， 97.3% ， 87.0% ， 84.6% ， 18.8， 0.5 和 85.0% 。快被发现在不太严重地受伤的病人和在更严重地受伤的 *** 特定的更多更敏感是在对蝙蝠病人的起始的评价的可靠调查。诊断价值能被损害的严厉快影响，职员训练被需要进一步提高它的有效使用。

关键词：诊断准确性闭合性创伤患者腹部损伤香港超音波

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Experience of living donor liver transplantation for hepatocellular carcinoma in the University of Hong Kong Hospital

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Hepatoma Research 2022年第1期8卷 90-105页

作者： Janice Hoi Man Mok ka Wing Ma Kenneth Siu Ho Chok Li ka shing Faculty of Medicine The University of Hong KongHong KongChina Department of Surgery The University of Hong KongHong KongChina

Aim:To describe the current practise of living donor liver transplantation(LDLT)for hepatocellular carcinoma(HCC),including the patient selection criteria,surgical techniques,management of small-for-size syndrome,postoperative complications,and the results of our units,in the Liver Transplant Centre of Queen Mary Hospital,Hong Kong,one of the high-volume centres for LDLT in ***:Our centre practises careful selection for HCC patients using the University of California,San Francisco(UCSF)criteria,supplemented by alpha-fetoprotein level and the model for end-stage liver disease *** flexibility is offered to enthusiastic donors and recipients in LDLT while balancing the risks and *** pioneered in using the extended right lobe graft and the novel hepatic venoplasty technique,which lessen the risk of hyperperfusion and small-for-size syndrome with improved overall recipient *** were collected prospectively and presented as the mean values and ranges,or the number of patients in proportion of total patient ***:Of our patients,74.9% met the UCSF criteria,and 64.5% met the Milan criteria.A 5-year overall and disease-free survival rate of 78.9% and 76.3% were ***:LDLT is an ideal treatment for HCC in Hong Kong with regard to the critical organ shortage and high demand for *** current surgical techniques and post-transplant surveillance contribute to the positive outcome.

关键词： Living donor liver transplantation hepatocellular carcinoma high volume centre LDLT HCC

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