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Mutations of t-complex testis expressed gene 5 transcripts in the testis of sterile t-haplotype mutant mouse

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Asian Journal of Andrology 2008年第2期10卷 219-226页

作者： Yibing Han Xue-Xiong Song Huai-Liang Feng Che-Kwok Cheung Po-Mui lam Chi-Chiu Wang Christophe John Haines Department of Obstetrics and Gynaecology Prince of Wales Hospital The Chinese University of Hong Kong Hong Kong China Department of Animal Sciences Laiyang Agricultural College Qingdao Shandong 266109 China Center for Human Reproduction North Shore University Hospital NYU School of Medicine Manhasset NY 11030 USA Li ka Shing Institute of Health Sciences Faculty of Medicine The Chinese University of Hong Kong Hong Kong China

Aim： To determine the possible roles of the t-complex testis expressed gene 5 （Tctex5） on sperm functions, the fulllength sequence of mRNA was studied and compared in the testis between the normal wild-type and the sterile t-haplotype mutant mice. Methods： We applied rapid amplification of cDNA ends, Northern blot and reverse transcription polymerase chain reaction to analyze the full length of Tctex5 mRNAs isolated from testes of the wild-type and the t-haplotype mice. Reverse transcription polymerase chain reaction was used to semi-quantitatively compare expression of Tctex5 transcripts in the 16 tissues and 9.5 day stage embryos in the wild-type mice. E-translation was applied to estimate the amino acid sequences. Results： One long and one short transcript of Tctex5 mRNA were discovered in mouse testis of wild-type （Tctex5^long-＋ and Tctex5^short-＋） and t-haplotype （Tctex5^long-＋ and Tctex5^short-＋） mice, respectively. Being enhanced only in the testis, Tctex5^long-＋ had 17 point mutations and one 15-bp-deletion in the exon 1 region, comparing with the Tctex5^long-＋, whereas the Tctex5^short-＋ was similar to the Tctex5^short-＋. The short isoforms of Tctex5 mRNAs in the two models encoded exactly the same peptides, but the long isoforms did not. The estimated peptide encoded by Tctex5^long-＋ had significant mutations on putative sites of phosphorylation and PP1 binding. Conclusion： We established that mutations that occur in the Tctex5 long transcript of the t-haplotype mice are important for normal sperm function, whereas the short transcript of Tctex5 might have a conserved function among different tissues. （Asian J Androl 2008 Mar; 10： 219-226）

关键词： t-complex testis expressed gene 5 transcripts testis mice

文化变迁与主体能动——读吉迪《中国北方边疆地区的史前社会》

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边疆考古研究 2013年第1期 337-341页

作者：林永昌美国哈佛大学人类学系

在文化变迁过程中,考察物质文化背后的象征符号如何被利用、改造来应付生活之需,是当下有关文化交流和跨地区贸易考古学研究中的核心。这一问题在中国北方地带,即长城地带以西以东地区的考古学文化研究中尤为突出,因为该地带处于东西亚... 详细信息

在文化变迁过程中,考察物质文化背后的象征符号如何被利用、改造来应付生活之需,是当下有关文化交流和跨地区贸易考古学研究中的核心。这一问题在中国北方地带,即长城地带以西以东地区的考古学文化研究中尤为突出,因为该地带处于东西亚交流的必经之路,人群移动与考古学文化的变动相对频繁。吉迪最近的研究《中国北方边疆地区的史前社会:公元前一千年间身份标识的形成与经济转变的考古学观察》所提出的学术目标,正好与此潮流不谋而合。该书对北方青铜器和北方地带游牧经济的形成提出了不少崭新的想法,在方法论上也有甚多独特建树,值得对以上问题关注的学者重视。该书大体由4部分组成。第一部分包括第1章和第2章,主要针对书中涉及的游牧经济和族群认同问题,梳理了相关理论。

关键词：地区随葬品随葬器物史前社会认同感文化变迁铜牌饰青铜文化考古学文化身份认同游牧经济中国中华人民共和国

A cross-sectional study on compliance with topical glaucoma medication and its associated socioeconomic burden for a Chinese population

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International Journal of Ophthalmology(English edition) 2017年第2期10卷 293-299页

作者： Man-Hin Lui Jason Chun Ho lam Yi Lee Kwong Tak Siu Wong Pak Long Cheung Sherri Shun Yan Lai Pak Lun Yuen Wai Yiu lam Ho Yan Chan Yiu Fai Wong Jimmy Shiu Ming Lai Kendrick Co Shih Li ka Shing Faculty of Medicine the University of Hong KongPokfulamHong KongChina Department of Ophthalmology Li Ka Shing Faculty of Medicinethe University of Hong KongPokfulamHongKongChina Department of Ophthalmology Queen Mary HospitalPokfulamHong KongChina

AIM： To estimate the overall drug compliance for local Chinese glaucoma patients on long-term topical ***： This was a retrospective cross-sectional ***-seven primary glaucoma patients from the subspecialty clinic of a publicly-funded tertiary care hospital in Hong Kong completed a questionnaire on compliance with topical glaucoma medication,attitude towards glaucoma and therapy and vision related quality of *** was defined as reporting missing more than or equal to 10% of the prescribed topical glaucoma medication during the 2wk immediately prior to the *** between noncompliance and demographics,attitude,disease and treatment status was *** was estimated with quality of life and direct medical cost involved with *** logistic regression on noncompliance was performed on selected ***： Compliance was calculated as 75%（95% CI： 64%-87%） among 57 subjects（mean age 69 y,female 51%）.No statistical significant relationship was established between noncompliance and any single factors or ***（P=0.048） and forgetfulness（P=0.064） were found to be marginally significant predictive factors on noncompliance in multivariable logistic *** might be related（P=0.130） to poorer self-rated vision-associated quality of *** societal cost of noncompliance was estimated to be over 2510 life-years and US$ 3.7 million ***： The compliance of Chinese glaucoma patients in Hong Kong is comparable to other parts in the world,and carries detrimental impacts on individual and societal *** and forgetfulness are two possible independent predictors for noncompliance.

关键词： glaucoma eye drop compliance quality of life

標準算法與肺算法在低劑量胸部CT圖像質量比較

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镜湖医学 2023年第1期23卷 61-62,69页

作者：楊貞勇杜芷瑩郭漢霖張志鋒澳門鏡湖醫院影像中心中國澳門

目的探討標準算法與肺算法重建技術對低劑量胸部薄層CT圖像質量的影響。方法收集2020年1月~2020年10月行胸部低劑量CT平掃的患者。應用GE Revolution 256層寬體探測器CT掃描儀,所得原始數據分別採用標準算法及肺算法進行重建,由一名資... 详细信息

目的探討標準算法與肺算法重建技術對低劑量胸部薄層CT圖像質量的影響。方法收集2020年1月~2020年10月行胸部低劑量CT平掃的患者。應用GE Revolution 256層寬體探測器CT掃描儀,所得原始數據分別採用標準算法及肺算法進行重建,由一名資深技師與兩名高年資放射科醫師共同觀察,對各個病灶(磨玻璃結節、實性結節)的顯示圖像質量進行評估比較並打分,對比分析2組病灶2種不同重建算法的顯示效果。結果102例患者進行了胸部低劑量CT檢查。其中實性結節101個,磨玻璃結節45個。以上2組病灶2種不同重建算法的顯示效果中,磨玻璃結節在兩種算法中具有顯著差異(P<0.01)。實性結節病灶未見明顯統計學差異。結論與肺算法相比較,標準算法對於磨玻璃結節的顯示有優勢,對實性結節的顯示相似。

关键词：肺算法標準算法低劑量胸部疾病電腦體層成像

LDCT肺算法與標準算法對AI肺結節檢出率比較

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镜湖医学 2023年第2期23卷 29-30,13页

作者：張志鋒楊貞勇杜芷瑩郭漢霖澳門鏡湖醫院影像中心中國澳門

目的探討AI肺算法與標準算法對肺結節的檢出率及性質判斷等方面的差異。方法收集2022年8月1日~2022年12月31日於中國澳門鏡湖醫院影像科採集的肺部CT檢查圖像,對檢出的肺部結節分別應用AI肺算法與標準算法對其分析,比較兩種算法對肺結... 详细信息

目的探討AI肺算法與標準算法對肺結節的檢出率及性質判斷等方面的差異。方法收集2022年8月1日~2022年12月31日於中國澳門鏡湖醫院影像科採集的肺部CT檢查圖像,對檢出的肺部結節分別應用AI肺算法與標準算法對其分析,比較兩種算法對肺結節的檢出率及性質判斷的影響。結果共納入了216例患者的肺部CT,發現肺内結節922個。AI系統肺算法與標準算法對肺實性結節的發現率比較沒有統計學意義(P=0.106);標準算法對肺磨玻璃結節的發現率高於肺算法,比較具有統計學意義(P=0.00)。結論肺算法與標準算法在AI系統對肺結節的檢出方面有較大影響,在實際工作中應該同時結合應用。

关键词：人工智能肺結節肺算法標準算法低劑量胸部CT

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全植入式助听器治疗中重度耳聋

中华耳鼻咽喉头颈外科杂志 2009年第10期44卷 843-847页

作者：唐志辉高晗余家燕王家昌宋家强尹怀信香港中文大学医学院耳鼻咽喉头颈外科学系

目的探讨全植入式助听器（Carina）治疗中重度和重度耳聋的安全性和效果。方法分析随访12个月以上的三例接受全植入式助听器手术的中重度至重度耳聋患者术后康复的效果。比较术前术后纯音测听和言语测听的差异，观察植入体日常使用情况... 详细信息

目的探讨全植入式助听器（Carina）治疗中重度和重度耳聋的安全性和效果。方法分析随访12个月以上的三例接受全植入式助听器手术的中重度至重度耳聋患者术后康复的效果。比较术前术后纯音测听和言语测听的差异，观察植入体日常使用情况及与传统助听器效果的比较。结果手术顺利，无并发症。术后手术侧无助听听阈（听力级，下同）平均升高8．3dB，四个频率（0．5、1、2、4kHz）纯音听阈功能性增益平均为35．4dB，言语听阈平均降低22．5dB，患者主观满意度评分明显高于传统助听器。结论全植入式助听器是治疗中重度和重度耳聋患者的有效方法，其远期疗效需要进一步观察。

关键词：听觉丧失助听器

Presence of extensive intraductal component in patients undergoing breast conservative surgery predicts presence of residual disease in subsequent completion mastectomy

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Chinese Medical Journal 2009年第8期122卷 900-905页

作者： Christopher C. E Yiu Wings T. Y. Loo C. K. lam Louis W. C. Chow UNIMED Medical Institute Comprehensive Centre for Breast Diseases Hong Kong China Clinical Trial Centre Li Ka Shing Faculty of Medicine University of Hong Kong China

Background Local recurrence remains a serious problem among patients undergoing breast conservative surgery. This study aimed at identifying risk factors for residual disease after breast conservative surgery. Methods This retrospective study was based on patients with invasive breast cancer who have received breast conservative surgery and subsequent completion mastectomy. All patients had a clear resection margin in the initial operation. We analyzed the association between the presence of residual disease during completion mastectomy and the following risk factors： T staging, young age, and presence of extensive intraductal component （EIC）, a close margin, lymphovascular permeation （LVP）, positivity of estrogen receptor, progesterone receptor, and c-erbB-2. Results Residual disease was encountered in 21 （45.7%） of 46 patients; EIC was present in 28 patients （60.9%）, of whom 17 had residual disease. Presence of EIC during breast conservation surgery was associated with a higher risk of residual disease during completion mastectomy （P=0.011）. Other variables were not statistically significant risk factors for presence of residual disease. No local recurrence was recorded in our cohort, and the disease-free survival and overall survival after completion mastectomy were similar for patients who had residual disease and those who had not. Conclusions The presence of EIC is a significant risk factor for residual disease in patients after breast conservative surgery. Our findings may suggest the indicated value of completion mastectomy in patients with EIC during initial breast conservative surgery to decrease the risk of subsequent local failure.

关键词： extensive intraductal component breast conservative surgery residual disease completion mastectomy

Analysis of inborn errors of metabolism： disease spectrum for expanded newborn screening in Hong Kong

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Chinese Medical Journal 2011年第7期124卷 983-989页

作者： Han-Chih Hencher Lee Chloe Miu Mak Ching-Wan lam Yuet-Ping Yuen, Angel On-Kei Chan Chi-Chung Shek Tak-Shing Siu Chi-Kong Lai Chor-Kwan Ching Wai-Kwan Siu Sammy Pak-lam Chen Chun-Yiu Law Morris Hok-Leung Tai Sidney Tam Albert Yan-Wo Chan Chemical Pathology Laboratory Department of Pathology Princess Margaret Hospital Hong Kong SAR China Division of Clinical Biochemistry Queen Mary Hospital Hong Kong SAR China Department of Pathology Li Ka Shing Faculty of Medicine The University of Hong Kong Hong Kong SAR China Chemical Pathology Laboratory Department of Pathology Queen Elizabeth Hospital Hong Kong SAR China

Background Data of classical inborn errors of metabolism （IEM） of amino acids, organic acids and fatty acid oxidation are largely lacking in Hong Kong, where mass spectrometry-based expanded newborn screening for IEM has not been initiated. The current study aimed to evaluate the approximate incidence, spectrum and other characteristics of classical IEM in Hong Kong, which would be important in developing an expanded newborn screening program for the local area.

关键词： biochemical genetics chemical pathology expanded newborn screening Hong Kong," inborn errorsof metabolism tandem mass spectrometry

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體動脈(腹腔幹)-肺動脈瘺手術治療1例

镜湖医学 2022年第1期22卷 64-64,69,I0002页

作者：林萬雙朱偉國李嘉亮澳門鏡湖醫院心胸血管外科中国澳门

肺部血管畸形是種罕見的病變,據一項納入15,000例連續屍檢的研究僅檢出3例肺動靜脈畸形[1]。另外3項來自Mayo診所的病例系列研究顯示,一般人群中的肺動靜脈畸形發生率同樣較低,45年間共報導了194例(即4.3例/年)[2-4]。而體動脈-肺動脈瘻... 详细信息

肺部血管畸形是種罕見的病變,據一項納入15,000例連續屍檢的研究僅檢出3例肺動靜脈畸形[1]。另外3項來自Mayo診所的病例系列研究顯示,一般人群中的肺動靜脈畸形發生率同樣較低,45年間共報導了194例(即4.3例/年)[2-4]。而體動脈-肺動脈瘻(Systemic artery-to-pulmonary artery fistula,SA-PAF)的畸形則是種更為罕見的肺部血管畸形。以下報導1例因自發性氣胸檢查發現腹腔幹動脈-右下肺動脈瘻的案例,因氣胸手術接受同期瘻管切斷手術治療。

关键词：肺部血管 artery 病例系列研究 pulmonary 治療腹腔畸形