检索结果-南通市图书馆

Neural Regeneration Research 2025年第10期20卷 2921-2922页

作者： ori Bar Avi Eran Perlson Department of Physiology and Pharmacology Faculty of Medical&Health ScienceTel-Aviv UniversityTel-AvivIsrael Sagol School of Neuroscience Tel-Aviv UniversityTel-AvivIsrael

Neurons are highly polarized cells with axons reaching over a meter long in adult *** survive and maintain their proper function,neurons depend on specific mechanisms that regulate spatiotemporal signaling and metabolic events,which need to be carried out at the right place,time,and *** mechanisms include axonal transport,local synthesis,and liquid-liquid phase *** and malfunctions in these processes are correlated to neurodegenerative diseases such as amyotrophic lateral sclerosis(ALS).

关键词： synthesis local aggregation

A hardening load transfer function for rock bolts and its calibration using distributed fiber optic sensing

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Journal of Rock Mechanics and Geotechnical Engineering 2023年第11期15卷 2816-2830页

作者： Assaf klar ori Nissim Itai Elkayam Faculty of Civil and Environmental Engineering Technion-Israel Institute of TechnologyHaifa32000Israel

Confinement of rock bolts by the surrounding rock formation has long been recognized as a positive contributor to the pull-out behavior,yet only a few experimental works and analytical models have been reported,most of which are based on the global rock bolt response evaluated in pull-out *** paper presents a laboratory experimental setup aiming to capture the rock formation effect,while using distributed fiber optic sensing to quantify the effect of the confinement and the reinforcement pull-out behavior on a more local *** is shown that the behavior along the sample itself varies,with certain points exhibiting stress drops with crack *** edge effects related to the kinematic freedom of the grout to dilate are also ***,it was found that the mid-level response is quite similar to the average response along the *** ability to characterize the variation of the response along the sample is one of the many advantages high-resolution fiber optic sensing allows in such *** paper also offers a plasticity-based hardening load transfer function,representing a"slice"of the *** paper describes in detail the development of the model and the calibration/determination of its *** suggested model captures well the coupled behavior in which the pull-out process leads to an increase in the confining stress due to dilative behavior.

关键词： Rock bolts Distributed fiber optic sensing Pull-out tests Load transfer function Hardening model

Regulating dual-use research:Lessons from Israel and the United States

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Biosafety and Biosecurity 2019年第2期1卷 80-85页

作者： ori Lev Department of Public Policy and Administration Sapir Academic CollegeIsrael

Over the past 20 years,and with greater urgency since the H5N1 papers controversy(2012),dual-use research of concern(DURC)has been extensively debated by the scientific community,regulators,and the public at *** have raised the need to regulate DURC;however,despite the urgency of this issue,to date,only two countries have implemented specific regulations,United States and Israel(notably,China is in the final stages of creating a set of DURC-related regulations).In this paper,I have compared these policies as case studies that may benefit other ***,the present study aimed to critically compare the DURC policies of the US and Israel and determine whether their different approaches provide a rigorous framework for the regulation of DURC.I have shown that in some aspects,they have adopted similar approaches;for example,allowing local committees to play a role in assessing the ***,they differ in certain important aspects;for instance,the US policies have laid out a mechanism through which academic institutions and the government decide jointly on how to address risky studies,while the Israeli law places the authority solely in government *** aim in comparing the policies is twofold;first,to reveal the weaknesses and strengths of each policy,thereby aiding their improvement,and second,to provide those that are considering developing policies in this field an overview of what the current approaches look like,thereby enabling them to articulate their own approach while taking into account the experience gained by the US and Israel.

关键词： Antimicrobial resistance Extended spectrum beta lactamase(ESBL) Urinary tract infections(UTIs) Gram negative bacteria(GNB)

Toll-like receptor 4 involvement in hepatic ischemia/reperfusion injury in mice

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Hepatobiliary & Pancreatic Diseases International 2004年第2期3卷 250-253页

作者： ori Rotstein Department of General Surgery Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 430022 China

BACkGROUND: Toll-like receptor 4 (TLR4) is involved in innate immunity by recognizing endotoxin resulting in a burst of inflammatory cascade. We investigated the relation between activation of TLR4 and liver injury in partial hepa- tic ischemia/reperfusion (I/R) injury in mice. METHODS: TLR4-deficient mice ( C3H/Hej) and wild type mice (WT, C3H/Heouj) were used in the model of I/R injury. Partial hepatic ischemia was produced by oc- clusion of inflow to the median and left lobes for 45 mi- nutes. Blood was drawn at 1 and 3 hours after reperfusion. The blood was analyzed for aspartate aminotransferase (AST) and tumor necrosis factor alpha (TNF-α). TNF-α mRNA expression and myeloperoxidase (MPO) level in the ischemic lobes were examined by northern blot and myeloperoxidase assay respectively. RESULTS: AST levels were significantly decreased in TLR4- deficient mice compared with WT mice at both time points (WT: 1215.5 ±174. 03, 2958. 17 ± 186. 81 IU/L at 1 and 3 hours respectively vs TLR4def: 661.83±106.09, 1145.17± 132.43 IU/L at 1 and 3 hours, mean ± SD, 6 mice/group, (=-6.65 and -5.57, P <0.001). Consistent with the role of TNF-α in hepatic I/R, serum TNF-α was decreased in TLR4 deficient mice at 3 hours after reperfusion compared with WT (152.39±43.3 vs 249.12 ± 51.89, n=6, t=-3.13, P<0.05). MPO level in the ischemic lobes in TLR4 defi- cient mice at 3 hours after reperfusion was significantly low- er than that in WT mice (0.059±0.004 vs 0.173±0.025, n=6, F=33.49, P<0.001). This difference appears to be mediated at the gene level since TLR4 deficient mice had decreased TNF-α mRNA expression at 1 hour after reperfu- sion compared with WT mice (80.3±28.8 vs 189.4±24.6, t=-3.25, P<0.05). CONCLUSIONS: Compared with WT mice, TLR4-defi- cient mice appear to have a mild I/R injury. Regulation of TNF-a at mRNA level seems to have a critical effect. These suggest TLR4 be involved in the mechanism of he-patic I/R injury in mice.

关键词： liver ischemia/reperfusion injury toll-like receptor endotoxin

多壁纳米碳管对磷酸铁锂正极材料热稳定性及表面形貌的影响(英文)

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

新型炭材料 2013年第1期28卷 1-7页

作者： Mária Filkusová Andrea Fedorková Renáta oriňáková Andrej oriňák Zuzana Nováková Lenka Skantárová Department of Physical and Theoretical Chemistry Faculty of Science Comenius University Mlynská|Dolina SK-842 15 Bratislava 4 Slovak Republic Department of Physical Chemistry Faculty of Science P.J. afárik University Moyzesova 11 SK-04154 Koice Slovak Republic Department of Electrical and Electronic Technology Faculty of Electrical Engineering and Communication Brno University of Technology Czech Republic Department of Analytical Chemistry Faculty of Science Comenius University Mlynská|Dolina SK-842 15 Bratislava 4 Slovak Republic

合成了一种新型的LiFePO4/多壁纳米碳管(MWCNTs)复合正极材料。通过MWCNTs和PPy-PEG粘结剂有机地在LiFePO4颗粒间构成三维网络导电结构,并借助SEM、TGA和高分辨裂解气相色谱,研究了LiFePO4-MWCNT正极材料的表面形貌和热稳定性。结果表明... 详细信息

合成了一种新型的LiFePO4/多壁纳米碳管(MWCNTs)复合正极材料。通过MWCNTs和PPy-PEG粘结剂有机地在LiFePO4颗粒间构成三维网络导电结构,并借助SEM、TGA和高分辨裂解气相色谱,研究了LiFePO4-MWCNT正极材料的表面形貌和热稳定性。结果表明,500℃下该材料的热分解程度非常小,说明MWCNTs和PPy-PEG的复合是提高LiFePO4正极材料的热稳定性和改善表面形貌的有效途径。

关键词：多壁纳米碳管多吡咯磷酸铁锂锂离子电池

Early respiratory complications after liver transplantation

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2013年第48期19卷 9271-9281页

作者： Paolo Feltracco Cristiana Carollo Stefania Barbieri Tommaso Pettenuzzo Carlo ori Department of Medicine Anesthesia and Intensive Care Unit Padova University Hospital35128 Padova Italy

The poor clinical conditions associated with end-stage cirrhosis,pre-existing pulmonary abnormalities,and high comorbidity rates in patients with high Model for End-Stage Liver Disease scores are all well-recognized factors that increase the risk of pulmonary complications after orthotopic liver transplantation(OLT)*** intraoperative and postoperative events,such as fluid overload,massive transfusion of blood products,hemodynamic instability,unexpected coagulation abnormalities,renal dysfunction,and serious adverse effects of reperfusion syndrome,are other factors that predispose an individual to postoperative respiratory *** advances in surgical techniques and anesthesiological management,the lung may still suffer throughout the perioperative period from various types of injury and ventilatory impairment,with different clinical *** complications after OLT can be classified as infectious or *** effusion,atelectasis,pulmonary edema,respiratory distress syndrome,and pneumonia may contribute considerably to early morbidity and mortality in liver transplant *** is of paramount importance to accurately identify lung disorders because infectious pulmonary complications warrant speedy and aggressive treatment to prevent diffuse lung injury and the risk of evolution into multisystem organ *** review discusses the most common perioperative factors that predispose an individual to postoperative pulmonary complications and these complications’early clinical manifestations after OLT and influence on patient outcome.

关键词： Respiratory complications Postoperative respiratory failure Liver transplantation Postoperative edema Post-transplant pneumonia

The combined role of visual and olfactory cues in foraging by Cataglyphis ants in laboratory mazes

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Current Zoology 2023年第4期69卷 401-408页

作者： Tomer Gilad ori Bahar Malak Hasan Adi Bar Aziz Subach Inon Scharf School of Zoology George S Wise Faculty of Life SciencesTel Aviv University69978 Tel AvivIsrael

Foragers use several senses to locate food,and many animals rely on vision and *** is beneficial not to rely on a single sense,which might fail under certain *** examined the contribution of vision and smell to foraging and maze exploration under laboratory conditions using Cataglyphis desert ants as a *** intensity,measured as the number of workers entering the maze and arriving at the target as well as target arrival time,were greater when food,blue light,or both were offered or presented in contrast to a *** trained to forage for a combined food and light cue elevated their foraging intensity with ***,foraging intensity was not higher when using both cues simultaneously than in either one of the two *** training,we split between the two cues and moved either the food or the blue light to the opposite maze *** manipulation impaired foraging success by either leading to fewer workers arriving at the target cell(when the light stayed and the food was moved)or to more workers arriving at the opposite target cell,empty of food(when the food stayed and the light was moved).This result indicates that ant workers use both senses when foraging for food and readily associate light with food.

关键词： binary-tree maze desert ants diet choice foraging sensual modality spatial learning

Li, Huaiyin, Reinventing Modern China： Imagination and Authenticity in Chinese Historical Writing

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Frontiers of History in China 2014年第1期9卷 153-156页

作者： ori Sela Tel Aviv University

Li Huaiyin＇s new book deals with the dialectic and competing processes ofwriting the history of ＂modem China＂ in China during the past century. Li presents the writing of history as a literary genre that has produced multiple narratives in different periods, narratives that corresponded to or were instigated by particular socio-political （especially political） circumstances of the protagonists of his story. In general, Li depicts these narratives as ＂romantic,＂＂optimistic,＂ or ＂pessimistic,＂ based on two major conflicting paradigms （or ＂grand narratives＂--Li often uses ＂narrative＂ and ＂paradigm＂ interchangeably）：＂modernization＂ and ＂revolutionary.＂

关键词：

Ultrafast photonic PCR

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Light(Science & Applications) 2015年第1期4卷 267-273页

作者： Jun Ho Son Byungrae Cho SoonGweon Hong Sang Hun Lee ori Hoxha Amanda J Haack Luke P Lee Department of Bioengineering University of CaliforniaBerkeleyCA 94720USA Berkeley Sensor and Actuator Center University of CaliforniaBerkeleyCA 94720USA Department of Electrical Engineering and Computer Sciences University of CaliforniaBerkeleyCA 94720USA Biophysics Graduate Program University of CaliforniaBerkeleyCA 94720USA

Nucleic acid amplification and quantification via polymerase chain reaction(PCR)is one of the most sensitive and powerful tools for clinical laboratories,precision medicine,personalized medicine,agricultural science,forensic science and environmental *** multiplex PCR,characterized by low power consumption,compact size and simple operation,is ideal for timely diagnosis at the point-of-care(POC).Although several fast/ultrafast PCR methods have been proposed,the use of a simple and robust PCR thermal cycler remains challenging for POC ***,we present an ultrafast photonic PCR method using plasmonic photothermal light-to-heat conversion via photon–electron–phonon *** demonstrate an efficient photonic heat converter using a thin gold(Au)film due to its plasmon-assisted high optical absorption(approximately 65%at 450 nm,the peak wavelength of heat source light-emitting diodes(LEDs)).The plasmon-excited Au film is capable of rapidly heating the surrounding solution to over 150℃ within 3 *** this method,ultrafast thermal cycling(30 cycles;heating and cooling rate of 12.7960.93℃ s^(-1) and 6.660.29℃ s^(-1),respectively)from 55℃(temperature of annealing)to 95℃(temperature of denaturation)is accomplished within 5 *** photonic PCR thermal cycles,we demonstrate here successful nucleic acid(λ-DNA)*** simple,robust and low cost approach to ultrafast PCR using an efficient photonic-based heating procedure could be generally integrated into a variety of devices or procedures,including on-chip thermal lysis and heating for isothermal amplifications.

关键词： genomics light-emitting diodes(LEDs) molecular diagnostics personalized medicine plasmonics point-of-care(POC)diagnostics polymerase chain reaction(PCR)

Blood loss,predictors of bleeding,transfusion practice and strategies of blood cell salvaging during liver transplantation

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Hepatology 2013年第1期5卷 1-15页

作者： Feltracco Paolo Brezzi Marialuisa Barbieri Stefania Galligioni Helmut Milevoj Moira Carollo Cristiana ori Carlo Department of Medicine UO Anesthesia and Intensive Care University Hospital of PadovaVia Cesare Battisti25635128 PadovaItaly

Blood loss during liver transplantation (OLTx) is a common consequence of pre-existing abnormalities of the hemostatic system,portal hypertension with multiple collateral vessels,portal vein thrombosis,previous abdominal surgery,splenomegaly,and poor "functional" recovery of the new *** intrinsic coagulopathic features of end stage cirrhosis along with surgical technical difficulties make transfusion-free liver transplantation a major challenge,and,despite the improvements in understanding of intraoperative coagulation profiles and strategies to control blood loss,the requirements for blood or blood products remains *** impact of blood transfusion has been shown to be significant and independent of other well-known predictors of *** effects on immunomodulation and an increased risk of postoperative complications and mortality have been repeatedly *** hemodilution,the extensive utilization of thromboelastogram and the use of autotransfusion devices are among the commonly adopted procedures to limit the amount of blood *** use of intraoperative blood salvage and autologous blood transfusion should still be considered an important method to reduce the need for allogenic blood and the associated *** this article we report on the common preoperative and intraoperative factors contributing to blood loss,intraoperative transfusion practices,anesthesiologic and surgical strategies to prevent blood loss,and on intraoperative blood salvaging techniques and autologous blood *** though the advances in surgical technique and anesthetic management,as well as a better understanding of the risk factors,have resulted in a steady decrease in intraoperative bleeding,most patients still bleed *** transfusion therapy is still a critical feature during OLTx and various studies have shown a large variability in the use of blood products among different centers and even among indi

关键词： Transplantation surgery Liver dysfunction Liver transplant Intraoperative bleeding Intraoperative transfusion Autotransfusion Autologous transfusions Transfusion requirements Blood salvage Cell salvage