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Regression analysis of squeezing-induced hybrid nanofluid flow in Darcy-Forchheimer porous medium

Applied mathematics and mechanics(English Edition) 2025年第1期46卷 193-208页

作者： k.mUHAmmAD m.SARFRAZ Department of Humanities and Sciences School of Electrical Engineering and Computer Science National University of Sciences and Technology Department of mathematics Quaid-i-Azam University

This article presents a mathematical model addressing a scenario involving a hybrid nanofluid flow between two infinite parallel plates. One plate remains stationary, while the other moves downward at a squeezing velocity. The space between these plates contains a Darcy-Forchheimer porous medium. A mixture of water-based fluid with gold(Au) and silicon dioxide(Si O2) nanoparticles is formulated. In contrast to the conventional Fourier's heat flux equation, this study employs the cattaneo-christov heat flux equation. A uniform magnetic field is applied perpendicular to the flow direction, invoking magnetohydrodynamic(mHD) effects. Further, the model accounts for Joule heating, which is the heat generated when an electric current passes through the fluid. The problem is solved via NDSolve in mATHEmATIcA. Numerical and statistical analyses are conducted to provide insights into the behavior of the nanomaterials between the parallel plates with respect to the flow, energy transport, and skin *** findings of this study have potential applications in enhancing cooling systems and optimizing thermal management strategies. It is observed that the squeezing motion generates additional pressure gradients within the fluid, which enhances the flow rate but reduces the frictional drag. consequently, the fluid is pushed more vigorously between the plates, increasing the flow velocity. As the fluid experiences higher flow rates due to the increased squeezing effect, it spends less time in the region between the plates. The thermal relaxation, however, abruptly changes the temperature, leading to a decrease in the temperature fluctuations.

关键词： convective boundary condition Darcy-Forchheimer medium hybrid nanofluid Joule heating magnetohydrodynamic (mHD) numerical solution squeezing flow regression analysis O361 O175.2

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Engineered polycaprolactone–magnesium hybrid biodegradable porous scaffold for bone tissue engineering

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Progress in Natural Science:materials International 2014年第5期24卷 561-567页

作者： Hoi man Wong Paul k.chu Frankie k.L.Leung k.nneth m.c.cheung keith D.k.Luk kelvin W.k.Yeung Department of Orthopaedics and Traumatology The University of Hong Kong Shenzhen key Laboratory for Innovative Technology in Orthopaedic Trauma The University of Hong Kong Shenzhen Hospital Department of Physics and materials Science City University of Hong Kong Peking University Shenzhen Institution

In this paper, we describe the fabrication of a new biodegradable porous scaffold composed of polycaprolactone(PcL) and magnesium(mg)micro-particles. The compressive modulus of PcL porous scaffold was increased to at least 150% by incorporating 29% mg particles with the porosity of 74% using micro-cT analysis. Surprisingly, the compressive modulus of this scaffold was further increased to at least 236% when the silane-coupled mg particles were added. In terms of cell viability, the scaffold modified with mg particles significantly convinced the attachment and growth of osteoblasts as compared with the pure PcL scaffold. In addition, the hybrid scaffold was able to attract the formation of apatite layer over its surface after 7 days of immersion in normal culture medium, whereas it was not observed on the pure PcL scaffold. This in vitro result indicated the enhanced bioactivity of the modified scaffold. moreover, enhanced bone forming ability was also observed in the rat model after 3 months of implantation. Though bony in-growth was found in all the implanted scaffolds. High volume of new bone formation could be found in the mg/PcL hybrid scaffolds when compared to the pure PcL scaffold. Both pure PcL and mg/PcL hybrid scaffolds were degraded after 3 months. However, no tissue inflammation was observed. In conclusion, these promising results suggested that the incorporation of mg micro-particles into PcL porous scaffold could significantly enhance its mechanical and biological properties. This modified porous bio-scaffold may potentially apply in the surgical management of large bone defect fixation.

关键词： magnesium Polycaprolactone Biodegradability Biocompatibility mechanical properties

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Unexpectedly large energy variations from dopant interactions in ferroelectric HfO_(2) from high-throughput ab initio calculations

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npj computational materials 2018年第1期4卷 45-53页

作者： max Falkowski christopher k.nneth Robin materlik Alfred kersch munich University of Applied Sciences Lothstr.3480335 MunichGermany

Insight into the origin of process-related properties like small-scale inhomogeneities is key for material ***,we analyze DFT calculations of randomly doped HfO_(2) structures with Si,La,and VO and relate them to the kind of production *** energies of the relevant ferroelectric Pbc2_(1) phase are compared with the competing crystallographic phases under the influence of the arising local inhomogeneities in a coarse-grained *** interaction among dopants adds to the statistical effect from the random positioning of the *** anneals after atomic layer or chemical solution deposition processes,which are short compared to ceramic process tempering,the large energy variations remain because the dopants do not *** the energy difference is the criterion for the phase stability,the large variation suggests the possibility of nanoregions and diffuse phase transitions because these local doping effects may move the system over the paraelectric-ferroelectric phase boundary.

关键词： ferroelectric dopant grain

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Gradient descent decomposition of force-field motor primitives optogenetically elicited for motor mapping of the murine lumbosacral spinal cord

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Zoological Research 2023年第3期44卷 604-619页

作者： Paola Salmas Vincent c.k cheung School of Biomedical Sciences and Gerald Choa Neuroscience InstituteThe Chinese University of Hong KongHong Kong SARChina kunming Institute of Zoology-The chinese University of Hong kong(kIZ-cUHk)Joint Laboratory of Bioresources and molecular Research of common Diseases Hong Kong SARChina

Generating diverse motor behaviors critical for survival is a challenge that confronts the central nervous system(cNS)of all *** movement execution,the cNS performs complex calculations to control a large number of neuromusculoskeletal *** theory of modular motor control proposes that spinal interneurons are organized in discrete modules that can be linearly combined to generate a variety of behavioral *** modules have been previously represented as stimulus-evoked force fields(FFs)comprising isometric limb-endpoint forces across workspace ***,we ask whether FFs elicited by different stimulations indeed represent the most elementary units of motor control or are themselves the combination of a limited number of even more fundamental motor *** probe for potentially more elementary modules,we optogenetically stimulated the lumbosacral spinal cord of intact and spinalized Thy1-chR2 transgenic mice(n=21),eliciting FFs from as many single stimulation loci as possible(20-70 loci per mouse)at minimally necessary *** found that the resulting varieties of FFs defied simple categorization with just a few *** used gradient descent to further decompose the FFs into their underlying basic force fields(BFFs),whose linear combination explained FF *** mice,we identified 4-5 BFFs with partially localizable but overlapping representations along the spinal *** BFFs were structured and topographically distributed in such a way that a rostral-to-caudal traveling wave of activity across the lumbosacral spinal cord may generate a swing-to-stance gait *** BFFs may represent more rudimentary submodules that can be flexibly merged to produce a library of motor modules for building different motor behaviors.

关键词： motor mapping Optogenetics Spinal cord motor primitives Traveling wave

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Stepwise 3D-spatio-temporal magnesium cationic niche: Nanocomposite scaffold mediated microenvironment for modulating intramembranous ossification

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Bioactive materials 2021年第2期6卷 503-519页

作者： Jie Shen Bo chen Xinyun Zhai Wei Qiao Shuilin Wu Xuanyong Liu Ying Zhao changshun Ruan Haobo Pan Paul k.chu k.nneth m.c.cheung kelvin W.k.Yeung Department of Orthopaedics and Traumatology The University of Hong KongHong KongChina Shenzhen key Laboratory for Innovative Technology in Orthopaedic Trauma Department of Orthopaedics and Traumatologythe University of Hong Kong-Shenzhen HospitalShenzhenChina Shanghai Institute of Traumatology and Orthopaedics Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint DiseasesRuijin HospitalSchool of MedicineShanghai Jiaotong UniversityShanghaiChina School of materials Science and Engineering Nankai UniversityTianjinChina School of materials Science&Engineering the Key Laboratory of Advanced Ceramics and Machining Technology by the Ministry of Education of ChinaTianjin UniversityTianjinChina ministry-of-Education key Laboratory for the Green Preparation and Application of Functional materials Hubei Key Laboratory of Polymer MaterialsSchool of Materials Science&EngineeringHubei UniversityWuhanChina State key Laboratory of High Performance ceramics and Superfine microstructure Shanghai Institute of CeramicsChinese Academy of SciencesShanghaiChina cixi center of Biomaterials Surface Engineering Shanghai Institute of CeramicsChinese Academy of SciencesNingboChina center for Human Tissues and Organs Degeneration Shenzhen Institutes of Advanced TechnologyChinese Academy of SciencesShenzhenChina Department of Physics Department of Materials Science&Engineeringand Department of Biomedical EngineeringCity University of Hong KongHong KongChina

The fate of cells and subsequent bone regeneration is highly correlated with temporospatial coordination of chemical,biological,or physical cues within a local tissue *** understanding of how mammalian cells react to local tissue microenvironment is paramount important when designing next generation of biomaterials for tissue *** study aims to investigate that the regulation of magnesium cationic(mg^2+)tissue microenvironment is able to convince early-stage bone regeneration and its mechanism undergoes intramembranous *** was discovered that moderate mg^2+content niche(~4.11 mm)led to superior bone regeneration,while mg^2+-free and strong mg^2+content(~16.44 mm)discouraged cell adhesion,proliferation and osteogenic differentiation,thereby bone formation was rarely *** magnesium ions diffused into free mg zone from concentrated zone in late time point,new bone formation on free mg zone became significant through intramembranous *** study successfully demonstrates that magnesium cationic microenvironment serves as an effective biochemical cue and is able to modulate the process of bony tissue *** knowledge of how a mg^2+cationic microenvironment intertwines with cells and subsequent bone formation gained from this study may provide a new insight to develop the next generation of tissuerepairing biomaterials.

关键词： Nanocomposite magnesium ion microenvironment 3D scaffold Bone tissue regeneration

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Regulation of extracellular bioactive cations in bone tissue microenvironment induces favorable osteoimmune conditions to accelerate in situ bone regeneration

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Bioactive materials 2021年第8期6卷 2315-2330页

作者： Zhengjie Lin Danni Shen Weixiao Zhou Yufeng Zheng Tiantian kong Xuanyong Liu Shuilin Wu Paul k.chu Ying Zhao Jun Wu k.nneth m.c.cheung kelvin W.k.Yeung college of chemistry and Environmental Engineering Shenzhen UniversityShenzhen518060China Department of Orthopaedics and Traumatology The University of Hong KongHong KongChina Department of materials Science and Engineering College of EngineeringPeking UniversityBeijing100871China Shenzhen key Laboratory for Innovative Technology in Orthopaedic Trauma The University of Hong Kong Shenzhen Hospital1 Haiyuan 1st RoadFutian DistrictShenzhenChina Guangdong key Laboratory for Biomedical measurements and Ultrasound Imaging Department of Biomedical EngineeringSchool of MedicineShenzhen UniversityShenzhen518060China State key Laboratory of High Performance ceramics and Superfine microstructure Shanghai Institute of CeramicsChinese Academy of SciencesShanghai200050China School of materials Science&Engineering the Key Laboratory of Advanced Ceramics and Machining Technology by the Ministry of Education of ChinaTianjin UniversityTianjin300072China Department of Physics Department of Materials Science and EngineeringCity University of Hong KongTat Chee AvenueKowloonHong KongChina centre for Human Tissues and Organs Degeneration Shenzhen Institutes of Advanced TechnologyChinese Academy of SciencesShenzhen518055China State key Laboratory of Bioelectronics School of Biological Science and Medical EngineeringSoutheast UniversityNanjing210096China

The design of orthopedic biomaterials has gradually shifted from“immune-friendly”to“immunomodulatory,”in which the biomaterials are able to modulate the inflammatory response via macrophage polarization in a local immune microenvironment that favors osteogenesis and implant-to-bone *** the well-known effects of bioactive metallic ions on osteogenesis,how extracellular metallic ions manipulate immune cells in bone tissue microenvironments toward osteogenesis and subsequent bone formation has rarely been ***,we investigate the osteoimmunomodulatory effect of an extracellular bioactive cation(mg^(2+))in the bone tissue microenvironment using custom-made poly lactic-co-glycolic acid(PLGA)/mgO-alendronate microspheres that endow controllable release of magnesium *** results suggest that the mg^(2+)-controlled tissue microenvironment can effectively induce macrophage polarization from the m0 to m2 phenotype via the enhancement of anti-inflammatory(IL-10)and pro-osteogenic(BmP-2 and TGF-β1)cytokines *** also generates a favorable osteoimmune microenvironment that facilitates the proliferation and osteogenic differentiation of bone marrow mesenchymal stem *** in vivo results further verify that a large amount of bony tissue,with comparable bone mineral density and mechanical properties,has been generated at an early post-surgical stage in rat intramedullary bone defect *** study demonstrates that the concept of in situ immunomodulated osteogenesis can be realized in a controlled magnesium tissue microenvironment.

关键词： Bone regeneration Osteoimmunomodulatory property Osteoimmune environment macrophage polarization magnesium ions

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magnesium cationic cue enriched interfacial tissue microenvironment nurtures the osseointegration of gamma-irradiated allograft bone

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Bioactive materials 2022年第4期7卷 32-47页

作者： Wenhao Wang Jie Shen Yuan meng miaoman Ye Shaozhang Lin Qi Zhao Le Wang k.nneth m.c.cheung Shuilin Wu Yufeng Zheng Xuanyong Liu Paul k.chu kelvin W.k.Yeung Zhi-Yong Zhang Translational Research centre of Regenerative medicine and 3D Printing of Guangzhou medical University Guangdong Province Engineering Research Center for Biomedical EngineeringState Key Laboratory of Respiratory DiseaseThe Third Affiliated Hospital of Guangzhou Medical UniversityGuangzhou510150PR China Department of Orthopaedics and Traumatology The University of Hong KongHong Kong999077PR China Shenzhen key Laboratory for Innovative Technology in Orthopaedic Trauma The University of Hong Kong Shenzhen HospitalShenzhen518053PR China Department of Orthopaedic Surgery The Third Affiliated Hospital of Guangzhou Medical UniversityGuangzhou510150PR China Shenzhen key Laboratory of Spine Surgery Department of Spine SurgeryPeking University Shenzhen HospitalShenzhen518036PR China ministry of Education key Laboratory for the Green Preparation and Application of Functional materials Hubei Key Laboratory of Polymer MaterialsSchool of Materials&EngineeringHubei UniversityWuhan430062PR China ministry of Education key Laboratory for Advanced ceramics and machining Technology School of Materials Science&EngineeringTianjin UniversityTianjin300352PR China State key Laboratory for Turbulence and complex System Department of Materials Science and EngineeringCollage of EngineeringPeking UniversityBeijing100871PR China State key Laboratory of High Performance ceramics and Superfine microstructure Shanghai Institute of CeramicsChinese Academy of SciencesShanghai200050PR China Department of materials Science and Engineering City University of Hong KongHong Kong999077PR China

Regardless of the advancement of synthetic bone substitutes,allograft-derived bone substitutes still dominate in the orthopaedic circle in the treatments of bone ***,the stringent devitalization process jeopardizes their osseointegration with host bone and therefore prone to long-term ***,improving osseointegration and transplantation efficiency remains *** alteration of bone tissue microenvironment(TmE)to facilitate osseointegration has been generally ***,the concept of exerting metal ionic cue in bone TmE without compromising the mechanical properties of bone allograft is *** address this concern,an interfacial tissue microenvironment with magnesium cationc cue was tailored onto the gamma-irradiated allograft bone using a customized magnesium-plasma surface *** formation of the mg cationic cue enriched interfacial tissue microenvironment on allograft bone was verified by the scanning ion-selective electrode *** cellular activities of human TERT-immortalized mesenchymal stem cells on the mg-enriched grafts were notably *** the animal test,superior osseointegration between mg-enriched graft and host bone was found,whereas poor integration was observed in the gamma-irradiated controls at 28 days ***,the bony in-growth appeared on magnesium-enriched allograft bone was significant *** mechanism possibly correlates to the up-regulation of integrin receptors in mesenchymal stem cells under modified bone TmE that directly orchestrate the initial cell attachment and osteogenic differentiation of mesenchymal stem ***,our findings demonstrate the significance of magnesium cation modified bone allograft that can potentially translate to various orthopaedic procedures requiring bone augmentation.

关键词： Osseointegration Allograft bone Bone tissue microenvironment Bone-implant interface magnesium

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Is there an anatomical endophenotype for neurodevelopmental disorders? A review of dual disorder anatomical likelihood estimation (ALE) meta-analyses of grey matter volumes

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chinese Science Bulletin 2011年第32期56卷 3376-3381页

作者： mcALONAN Grainne m YU kevin k cHAN Raymond c k cHUA Siew E cheung charlton Department of Psychiatry the University of Hong Kong State key Laboratory for Brain and cognitive Sciences the University of Hong Kong Neuropsychology and Applied cognitive Neuroscience Laboratory Key Laboratory of Mental Health Institute of Psychology Chinese Academy of Sciences

The term "neurodevelopmental disorder" broadly encompasses conditions thought to arise early in development and includes schizophrenia, bipolar disorder and autism among others. These conditions share a number of genetic and environmental risk factors postulated to lead to common difficulties in socio-emotional processing, communication and cognitive function. The alternative position is that, while the same traits are affected across these conditions, the nature or direction in which they are modified may be distinct. mRI studies provide a rapidly expanding and rich database which we propose can be used to contribute to this debate. Anatomical likelihood estimation (ALE) is a method of meta-analysis applied to voxel-based mRI studies. We have adapted this method to explore the extent to which schizophrenia and bipolar disorder and schizophrenia and autism share a common brain structural phenotype. We will review this work here and discuss whether there is sufficient other evidence to justify a common framework for further research into the inter-relatedness of such conditions.

关键词：神经疾病似然估计审查工作解剖精神分裂症稳定质数进修

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Intrumer:A multi module Distributed Explainable IDS/IPS for Securing cloud Environment

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computers, materials & continua 2025年第1期82卷 579-607页

作者： Nazreen Banu A S.k.B.Sangeetha Department of computer Science and Engineering SRM Institute of Science and TechnologyVadapalani CampusChennai600026Tamil NaduIndia

The increasing use of cloud-based devices has reached the critical point of cybersecurity and unwanted network *** environments pose significant challenges in maintaining privacy and *** approaches,such as IDS,have been developed to tackle these ***,most conventional Intrusion Detection System(IDS)models struggle with unseen cyberattacks and complex high-dimensional *** fact,this paper introduces the idea of a novel distributed explainable and heterogeneous transformer-based intrusion detection system,named INTRUmER,which offers balanced accuracy,reliability,and security in cloud settings bymultiplemodulesworking together within *** traffic captured from cloud devices is first passed to the Tc&Tm module in which the Falcon Optimization Algorithm optimizes the feature selection process,and Naie Bayes algorithm performs the classification of *** selected features are classified further and are forwarded to the Heterogeneous Attention Transformer(HAT)*** this module,the contextual interactions of the network traffic are taken into account to classify them as normal or malicious *** classified results are further analyzed by the Explainable Prevention module(XPm)to ensure trustworthiness by providing interpretable *** the explanations fromthe classifier,emergency alarms are transmitted to nearby IDSmodules,servers,and underlying cloud devices for the enhancement of preventive *** experiments on benchmark IDS datasets cIcIDS 2017,Honeypots,and NSL-kDD were conducted to demonstrate the efficiency of the INTRUmER model in detecting network trafficwith high accuracy for different *** outperforms state-of-the-art approaches,obtaining better performance metrics:98.7%accuracy,97.5%precision,96.3%recall,and 97.8%*** results validate the robustness and effectiveness of INTRUmER in securing diverse cloud environments against sophisticated cyber threats.

关键词： cloud computing intrusion detection system transformers and explainable artificial intelligence(XAI)

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NONLINEAR ANALYSIS OF DYNAmIc STABILITY FOR LAmINATED cIRcULAR cYLINDRIcAL THIck SHELLS WITH ENDS ELASTIcALLY SUPPORTED AGAINST ROTATION

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Acta mechanica Solida Sinica 1994年第1期7卷 15-28页

作者： Y.k.cheung Y.m.Fu Department of civil and Structural Engineering University of Hong kong Hong Kong Department of Engineering mechanics Hunan University ChangshaP.R.China

Based on Timoshenko-mindlin kinematic hypotheses and Hamilton's principle,a dynamic non-linear theory for general laminated circular cylindrical shells with transverse shear deformation is developed.A multi-mode solution for periodic in- plane loads is formulated for the non-linear dynamic stability of an anti-symmetric angle-ply cylinder with its ends elastically restrained against *** resulted equations in terms of time function are solved by the incremental harmonic balance method.

关键词： Hamilton's principle dynamic stability

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