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Neural Regeneration Research 2025年第3期20卷 671-681页

作者： Angelid Pabon Jagannatham Naidu Bhupana Ching-On wong Department of Biological Sciences Rutgers UniversityNewarkNJUSA

Cells undergo metabolic reprogramming to adapt to changes in nutrient availability, cellular activity, and transitions in cell states. The balance between glycolysis and mitochondrial respiration is crucial for energy production, and metabolic reprogramming stipulates a shift in such balance to optimize both bioenergetic efficiency and anabolic requirements. Failure in switching bioenergetic dependence can lead to maladaptation and pathogenesis. While cellular degradation is known to recycle precursor molecules for anabolism, its potential role in regulating energy production remains less explored. The bioenergetic switch between glycolysis and mitochondrial respiration involves transcription factors and organelle homeostasis, which are both regulated by the cellular degradation pathways. A growing body of studies has demonstrated that both stem cells and differentiated cells exhibit bioenergetic switch upon perturbations of autophagic activity or endolysosomal processes. Here, we highlighted the current understanding of the interplay between degradation processes, specifically autophagy and endolysosomes, transcription factors, endolysosomal signaling, and mitochondrial homeostasis in shaping cellular bioenergetics. This review aims to summarize the relationship between degradation processes and bioenergetics, providing a foundation for future research to unveil deeper mechanistic insights into bioenergetic regulation.

关键词： autophagy bioenergetics endolysosome energy production glycolysis metabolic reprogramming mitochondria

Advances in Graphene‑Based Electrode for Triboelectric Nanogenerator

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Nano-Micro Letters 2025年第1期17卷 378-403页

作者： Bin Xie Yuanhui Guo Yun Chen Hao Zhang Jiawei Xiao Maoxiang Hou Huilong Liu Li Ma Xin Chen Chingping wong State key Laboratory of Precision Electronic Manufacturing Technology and Equipment Guangdong University of TechnologyGuangzhou 510006People’s Republic of China School of Electromechanical Engineering Guangdong University of TechnologyGuangzhou 510006People’s Republic of China School of Materials Science and Engineering Georgia Institute of TechnologyAtlantaGA 30332USA

With the continuous development of wearable electronics,wireless sensor networks and other micro-electronic devices,there is an increasingly urgent need for miniature,flexible and efficient nanopower generation *** nanogenerator(TENG)technology can convert small mechanical energy into electricity,which is expected to address this *** the core component of TENG,the choice of electrode materials significantly affects its *** metal electrode materials often suffer from problems such as durability,which limits the further application of ***,as a novel electrode material,shows excellent prospects for application in TENG owing to its unique structure and excellent electrical *** review systematically summarizes the recent research progress and application prospects of TENGs based on graphene *** precision processing methods of graphene electrodes are introduced,and the applications of graphene electrode-based TENGs in various scenarios as well as the enhancement of graphene electrodes for TENG performance are *** addition,the future development of graphene electrode-based TENGs is also prospectively discussed,aiming to promote the continuous advancement of graphene electrode-based TENGs.

关键词： Triboelectric nanogenerator Precision processing Graphene electrode Self-powered sensor

Nanoimprint lithography-assisted block copolymer self-assembly for hyperfine fabrication of magnetic patterns based on L10-FePt nanoparticles

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Science China Chemistry 2025年

作者： Jie Zhang Yi Chen Guijun Li Zelin Sun Zhengong Meng Wai-Yeung wong Department of Applied Biology and Chemical Technology and Research Institute for Smart Energy The Hong Kong Polytechnic University The Hong kong Polytechnic University Shenzhen Research Institute Division of Integrative Systems and Design and Department of Electronic and Computer Engineering The Hong Kong University of Science and Technology School of Flexible Electronics (Future Technology) and Institute of Advanced Materials (IAM) Nanjing Tech University

L10-FePt-type bit-patterned media has provided a promising alternative for ultrahigh-density magnetic recording systems in the current digital era, but rapid fabrication of magnetic patterns with hyperfine bit islands is still challenging, especially with the target for miniaturization and scalable production simultaneously. Herein, Fe,Pt-containing block copolymers were utilized as single-source precursors for solution-processable patterning and subsequent generation of the demanding magnetic FePt dots by in situ pyrolysis. High-throughput nanoimprint lithography was initially employed to fabricate the predefined bit cells precisely,and then the intrinsic self-assembly of phase-separated block copolymers further drove the formation of accurate bit *** from the synergistic effect of top-down lithographic approach and bottom-up self-assembly, the customizable patterns could be achieved for large-scale mass production in targeted areas, but high-density isolated dots could also be accurately aligned along the patterned features after subsequent self-assembly. This reliable strategy would provide a good avenue to precisely construct ultrahigh-density magnetic data storage devices.

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Polarization Fatigue in Ferroelectric Thin Films

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Chinese Physics Letters 2002年第4期19卷 566-568页

作者：王忆 k.H.wong 等 StructureResearchLaboratory&DepartmentofAstronomyandAppliedPhysics UniversityofScienceandTechnologyofChinaHefei230026 DepartmentofAppliedPhysics TheHongKongPolytechnicUniversi

The fatigue problem in ferroelectric thin films is investigated based on the switched charge per unit area versus switching cycles. The temperature, dielectric permittivity, voltage bias, frequency and defect valence dependent switching polarization properties are calculated quantitatively with an extended Dawber-Scott model. The results are in agreement with the recent experiments.

关键词： Ferroelectric thin films

The Weakly Potency of Certain HNN Extensions of Nilpotent Groups

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Algebra Colloquium 2014年第4期21卷 689-696页

作者： k.B. wong P.C. wong Institute of Mathematical Sciences University of Malaya 50603 Kuala Lumpur Malaysia

In this paper we give a characterization for certain HNN extensions oi suogroup separable groups with normal associated subgroups to be weakly potent. We then apply our result to show that certain HNN extensions of fi... 详细信息

关键词： weakly potent HNN extensions subgroup separable finitely generated nilpo-tent groups

SCHEDULING TWO GROUPS OF JOBS WITH INCOMPLETE INFORMATION

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Systems Science and Systems Engineering 2003年第1期12卷 73-81页

作者： GuochuanZHANG XiaoqiangCAI C.k.wong DepartmentofMathematics ZhejiangUniversityHangzhou30027P.R.China DepartmentofSystemsEngineeringandEngineeringManagement TheChineseUniversityofHongKongShatinN.T.HongKong DepartmentofComputerScienceandEngineering TheChineseUniversityofHangKongShatinN.T.HongKong

In real world situations, most scheduling problems occur neither as complete off-line nor as complete on-line models. Most likely, a problem arises as an on-line model with some partial information. In this article, we consider such a model. We study the scheduling problem P(n1,n2), where two groups of jobs are to be scheduled. The first job group is available beforehand. As soon as all jobs in the first group are assigned, the second job group appears. The objective is to minimize the longest job completion time (makespan). We show a lower bound of 3/2 even for very special cases. Best possible algorithms are presented for a number of cases. Furthermore, a heuristic is proposed for the general case. The main contribution of this paper is to discuss the impact of the quantity of available information in designing an on-line algorithm. It is interesting to note that the absence of even a little bit information may significantly affect the performance of an algorithm.

关键词： Machine scheduling worst-case analysis on-line algorithm

STRUCTURE AND SURFACE STUDIES OF Mg_xZn_(1-x)O FILMS GROWN BY PULSED LASER DEPOSITION

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Acta Metallurgica Sinica(English Letters) 2005年第3期18卷 237-241页

作者： L.Zhuang k.H.wong DepartmentofAppliedPhysics TheHongKongPolytechnicUniversityKowloonHongKongChina

The structural and surface properties of high-quality epitaxial cubic MgxZn1-xO films deposited by pulsed laser deposition (PLD) were studied by X-ray diffracti on and atomic force microscopy respectively. For films of about 500nm thick, sca ns over a 30μm × 30μm area revealed a surface roughness Ra of about 100nm. Th is relatively large surface roughness is primarily attributed to the particulate and outgrowth during the PLD process. A good epitaxial growth on LaAlO3 (LAO ) (100) substrates, however has been obtained for composition x = 0.9, 0.7 and 0 .5 with the heteroepitaxial relationship of (100)■∥(100)LAO (out-of-plane) and (011)■∥(010)LAO (in-plane). These structural qualities suggest that cubic Mgx Zn1-xO alloys films have good potential in a variety of optoelectronic device ap plications.

关键词： pulsed laser deposition thin film XRD MgxZn1-xO

Fundamental Groups of Graphs of Cyclic Subgroup Separable and Weakly Potent Groups

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Algebra Colloquium 2021年第1期28卷 119-130页

作者： M.S.M.Asri k.B.wong P.C.wong Institute of Mathematical Sciences Faculty of ScienceUniversity of Malaya50603 Kuala LumpurMalaysia

We give a characterization of the cyclic subgroup separability and weak potency of the fundamental group of a graph of polycyclic-by-finite groups and free-by-finite groups amalgamating edge subgroups of the form×D,w... 详细信息

关键词： HNN extensions fundamental groups of graphs of groups weakly potent residually finite

Femtosecond Degenerate Four-Wave-Mixing in ZnO Microcrystallite Thin Films

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Chinese Physics Letters 1999年第6期16卷 418-419页

作者： ZHANG Wei-li WANG Qing-yue CHAI Lu XING Qi-rong k.S.wong H.Wang Z.k.Tang G.k.L.wong R.Jain Ultrafast Laser Laboratory School of Precision Instruments&Optoelectronics Engineeringand Optoelectronic Information Science and Technology LaboratoryTianjin UniversityTianjin 300072 School of Science Tianjin UniversityTianjin 300072 Department of Physics Hong Kong University of Science and TechnologyClear Water BayKowloonHong Kong Center for High Technology Materials University of New Mexico1313 Goddard SEAlbuquerqueNM 87106USA

Transient third-order optical nonlinearityχ^(3)of ZnO microcrystallite thin films is measured at various temperatures by using femtosecond degenerate ***-temperature excitonic enhancement of is *** magnitude ofχ^(3)ranges between 10^(-4)to 10^(-6)esu from 4.2k to room *** measuredχ^(3)response time ranging from 200 to 300 fs ultrafast for temperature down to 4.2k.

关键词： temperature. crystallite nonlinearity

Effects of 2,3,7,8-TCDD and benzo[a]pyrene on modulating vitellogenin expression in primary culture of crucian carp (Carassius auratus) hepatocytes

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Chinese Science Bulletin 2004年第22期49卷 2372-2378页

作者： LIANGYong C.k.C.wong XUYing M.H.wong StatekeyLaboratoryofFreshwaterEcologyandBiotechnology InstituteofHydrobiologyChineseAcademyofSciencesWuhan430072China//GraduateSchoolofChineseAcademyofSciencesBeijing100039China DepartmentofBiology HongKongBaptistUniversityKowloonTongHongKong StatekeyLaboratoryofFreshwaterEcologyandBiotechnology InstituteofHydrobiologyChineseAcademyofSciencesWuhan430072China

Vitellogenin (Vtg) is the precursor of yolk protein. Its expression and secretion are estrogen-regulated and are crucial for oocyte maturation. An in vitro xenoestro- gen screening model was established by measuring Vtg in- duction in cultured primary hepatocytes from crucian carp. Vtg production was detected by biotin-avidin sandwich ELISA method while Vtg and cytochrome P4501A1 (CYP1A1) mRNA induction were measured by semi- quan- titative PCR-primer dropping technique. Vtg and Vtg mRNA were dose-dependently induced by diethylstilbestrol (DES, 0.2—200 ng/mL) in hepatocytes of crucian carp. Co-treatment of the DES-induced hepatocytes with either 2,3,7,8-TCDD (TCDD, 0.1—4 pg/mL) or benzo[a]pyrene (B[a]P, 5—1000 ng/mL) resulted in a reduction of Vtg pro- duction and an increment of CYP1A1 mRNA expression both in a dose dependent manner, indicating the anti-estro- genic effects of the compounds. However, at lower tested concentrations, TCDD (0.1, 0.2 pg/mL), B[a]P (5 ng/mL) seemed to have a potentiating effect on Vtg expression and secretion, although by their own these compounds had no observable estrogenic effect on Vtg induction. Tamoxifen (a selective estrogen receptor modulators, 1 nmol/L—1 μmol/L), and β-naphtho-flavone (β-NF, an aryl hydrocarbon receptor inducing compounds, 2.5—1000 ng/mL) also were employed to study the possible interactions in DES-induced Vtg ex- pression. In co-treatment of the DES-induced hepatocytes with β-NF or tamoxifen, the decrease in Vtg production did parallel induction of CYP1A1 for β-NF, but tamoxifen inhib- ited Vtg induction did not parallel induced CYP1A1 expres- sion in all test concentrations. On the contrary, it was found that in co-treatment of the TCDD-induced hepatocytes with DES, TCDD induced CYP1A1 mRNA production was inhib- ited by DES also. These results implicated a possible cross talk between estrogen receptor- and aryl hydrocarbon re- ceptor-mediated pathways in the hepatocytes.

关键词： 2,3,7,8-TCDD 苯并[a]芘卵黄蛋白原鲫鱼鲤鱼肝细胞 CYP1A1 卵黄蛋白质异种雌激素