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A functional tacrolimus-releasing nerve wrap for enhancing nerve regeneration following surgical nerve repair

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Neural Regeneration Research 2025年第1期20卷 291-304页

作者： Simeon C.Daeschler katelyn J.W.So konstantin Feinberg Marina Manoraj Jenny Cheung Jennifer Zhang kaveh Mirmoeini JPaul Santerre Tessa Gordon Gregory HBorschel Sickkids Research Institute Neuroscience and Mental Health ProgramTorontoONCanada Institute of Biomaterials and Biomedical Engineering University of TorontoTorontoONCanada Indiana University School of Medicine IndianapolisINUSA Division of Plastic and Reconstructive Surgery the Hospital for Sick ChildrenTorontoONCanada Translational Biology and Engineering Program Ted Rogers Centre for Heart ResearchInstitute of Biomedical EngineeringFaculty of DentistryUniversity of TorontoTorontoONCanada

Axonal regeneration following surgical nerve repair is slow and often incomplete,resulting in poor functional recovery which sometimes contributes to lifelong ***,there are no FDA-approved therapies available to promote nerve *** accelerates axonal regeneration,but systemic side effects presently outweigh its potential benefits for peripheral nerve *** authors describe herein a biodegradable polyurethane-based drug delivery system for the sustained local release of tacrolimus at the nerve repair site,with suitable properties for scalable production and clinical application,aiming to promote nerve regeneration and functional recovery with minimal systemic drug *** is encapsulated into co-axially electrospun polycarbonate-urethane nanofibers to generate an implantable nerve wrap that releases therapeutic doses of bioactive tacrolimus over 31 *** and drug loading are adjustable for applications in small and large caliber nerves,and the wrap degrades within 120 days into biocompatible *** released from the nerve wrap promotes axon elongation in vitro and accelerates nerve regeneration and functional recovery in preclinical nerve repair models while off-target systemic drug exposure is reduced by 80%compared with systemic *** its surgical suitability and preclinical efficacy and safety,this system may provide a readily translatable approach to support axonal regeneration and recovery in patients undergoing nerve surgery.

关键词： biodegradable local drug delivery nerve injury nerve regeneration nerve wrap tacrolimus

Topology optimization of shear wall structures under seismic loading

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Earthquake Engineering and Engineering Vibration 2020年第1期19卷 105-116页

作者： Pooya Zakian Ali kaveh Department of Civil Engineering Faculty of EngineeringArak UniversityArak 38156-8-8349Iran Centre of Excellence for Fundamental Studies in Structural Engineering Iran University of Science and TechnologyNarmakTehran-16Iran

A topology optimization formulation is developed to find the stiffest structure with desirable material distribution subjected to seismic loads. Finite element models of the structures are generated and the optimality criteria method is modified using a simple penalty approach and introducing fictitious strain energy to simultaneously consider both material volume and displacement constraints. Different types of shear walls with/without opening are investigated. Additionally, the effects of shear wall-frame interaction for single and coupled shear walls are studied. Gravity and seismic loads are applied to the shear walls so that the definitions provide a practical approach for locating the critical parts of these structures. The results suggest new viewpoints for architectural and structural engineering for placement of openings.

关键词： topology optimization seismic loads shear wall minimum compliance multiple constraints fi nite element analysis

Mechanical characterization of Mg-B4C nanocomposite fabricated at different strain rates

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International Journal of Minerals,Metallurgy and Materials 2020年第2期27卷 252-263页

作者： Gholam Hossein Majzoobi kaveh Rahmani Mechanical Engineering Department Bu-Ali Sina University

Magnesium has wide application in *** main purpose of this investigation was to improve the properties of magnesium by reinforcing it using B4C *** reinforced nanocomposites were fabricated using a powder compaction technique for 0,1.5vol%,3vol%,5vol%,and 10vol% of *** compaction was conducted using a split Hopkinson bar(SHB),drop hammer(DH),and Instron to reach different compaction loading *** compressive stress–strain curves of the samples were captured from quasi-static and dynamic tests carried out using an Instron and split Hopkinson pressure bar,*** revealed that,to achieve the highest improvement in ultimate strength,the contents of B4C were 1.5vol%,3vol%,and 3vol% for Instron,DH,and SHB,*** results also indicated that the effect of compaction type on the quasi-static strength of the samples was not as significant,although its effect on the dynamic strength of the samples was *** improvement in ultimate strength obtained from the quasi-static stress–strain curves of the samples(compared to pure Mg)varied from 9.9% for DH to 24% for *** dynamic strength of the samples was improved(with respect to pure Mg)by 73%,116%,and 141%for the specimens compacted by Instron,DH,and SHB,*** improvement in strength was believed to be due to strengthening mechanisms,friction,adiabatic heating,and shock waves.

关键词： powder compaction B4C magnesium strain rate ultimate strength sintering

Real-Time Detection of Cracks on Concrete Bridge Decks Using Deep Learning in the Frequency Domain

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Engineering 2021年第12期7卷 1786-1796页

作者： Qianyun Zhang kaveh Barri Saeed k.Babanajad Amir H.Alavi Department of Civil and Environmental Engineering University of PittsburghPittsburghPA 15261USA Wiss JanneyElstner Associates Inc.NorthbrookIL 60062USA Department of Computer Science and Information Engineering Asia UniversityTaichungTaiwan 41354China

This paper presents a vision-based crack detection approach for concrete bridge decks using an integrated one-dimensional convolutional neural network(1D-CNN)and long short-term memory(LSTM)method in the image frequency *** so-called 1D-CNN-LSTM algorithm is trained using thousands of images of cracked and non-cracked concrete bridge *** order to improve the training efficiency,images are first transformed into the frequency domain during a preprocessing *** algorithm is then calibrated using the flattened frequency *** is used to improve the performance of the developed network for long sequence *** accuracy of the developed model is 99.05%,98.9%,and 99.25%,respectively,for training,validation,and testing *** implementation framework is further developed for future application of the trained model for large-scale *** proposed 1D-CNN-LSTM method exhibits superior performance in comparison with existing deep learning methods in terms of accuracy and computation *** fast implementation of the 1D-CNN-LSTM algorithm makes it a promising tool for real-time crack detection.

关键词： Crack detection Concrete bridge deck Deep learning Real-time

Flood risk on arid alluvial fans:a case study in the Joghatay Mountains,Northeast Iran

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Journal of Mountain Science 2023年第5期20卷 1183-1200页

作者： kaveh GHAHRAMAN Balázs NAGY Department of Physical Geography Eotvos Loránd UniversityPázmány Péter stny.1/CH-1117 BudapestHungary

Among the common hazards related to alluvial fans,flooding is one of the most ***,in populated alluvial fans,not only the natural processes are effective in floods,but the artificial structures and modifications can change the behavior of flooding and its potential *** study aims to indicate the flood-prone landforms in a set of populated alluvial fans in an arid region and investigate the role of anthropogenic activities in controlling/exacerbating flooding in alluvial *** achieve this goal,15 Ground Range Detected in High resolution(GRDH)SAR Sentinel-1 images,covering a total of 24 alluvial fans,were ***-processing and post-processing steps were applied to all images to identify flood-prone sections of the studied alluvial *** results showed that feeder channels,spreading sites,and wide interfluves are the most flood-prone landforms of alluvial *** terms of anthropogenic modifications to mitigate flooding,a rampart system is distributed in the study *** are levee like structures formed from the fan *** aim to mitigate flood hazard on residential areas,infrastructures,and agricultural lands of the study *** show that the rampart system can reduce the danger of floods,but it cannot be considered a long-term ***,a comprehensive flood protection system distributed throughout the whole alluvial fan system is *** also reveal that in regions where flood monitoring is challenging,SAR images can be used as a freely available data set to monitor and identify flooding hotspots.

关键词： Alluvial fan Flood Anthropogenic activities Rampart Sentineli SAR

Spherical Tropical Geometry:a Survey of Recent Developments

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Acta Mathematica Sinica,English Series 2018年第3期34卷 454-465页

作者： kiumars kaveh Christopher MANON Department of Mathematics University of PittsburghPittsburghPAUSA Department of Mathematics Univcrsity of KentuckyLexingtonKYUSA

This is a survey of some recent results on spherical tropical geometry.

关键词： Tropical geometry reductive group action spherical variety Grbner theory

Green,mild and efficient bromination of aromatic compounds by HBr promoted by trans-3,5-dihydroperoxy-3,5-dimethyl-1,2-dioxolane in water as a solvent

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Chinese Chemical Letters 2012年第4期23卷 387-390页

作者： kaveh khosravi Samira kazemi Department of Chemistry Faculty of ScienceUniversity of Arak Department of Chemistry Shahr-e-Rey branchIslamic Azad University

A combination of HBr and trans-3,5-dihydroperoxy-3,5-dimethyl-1,2-dioxolane as anew and powerful oxidant was found effective for facile brotnination of different aromatic compounds at room temperature in water as a green *** reaction conditions,high selectivity and yield,high reaction rate and non-toxicity are some of the major advantages of this synthetic protocol.

关键词： Trans-3 5-dihydroperoxy-3 5-dimethyl-1 2-dioxolane HBr Bromination Anilines Phenoles

Superfunctional high-entropy alloys and ceramics by severe plastic deformation

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Rare Metals 2023年第10期42卷 3246-3268页

作者： Parisa Edalati Masayoshi Fuji kaveh Edalati Department of Life Science and Applied Chemistry Nagoya Institute of TechnologyTajimi507-0071Japan Advanced Ceramics Research Center Nagoya Institute of TechnologyTajimi507-0071Japan WPI International Institute for Carbon-Neutral Energy Research(WPI-I2CNER) Kyushu UniversityFukuoka819-0395Japan Mitsui Chemicals Inc.—Carbon Neutral Research Center(MCI-CNRC)Kyushu UniversityFukuoka819-0395Japan

High-entropy alloys and ceramics containing at least five principal elements have recently received high attention for various mechanical and functional *** application of severe plastic deformation(SPD),particularly the high-pressure torsion method,combined with the CALPHAD(calculation of phase diagram) and first-principles calculations resulted in the development of numerous superfunctional high-entropy materials with superior properties compared to the normal functions of engineering *** article reviews the recent advances in the application of SPD to developing superfunctional high-entropy *** superfunctional properties include(ⅰ) ultrahigh hardness levels comparable to the hardness of ceramics in high-entropy alloys,(ⅱ) high yield strength and good hydrogen embrittlement resistance in high-entropy alloys;(ⅲ) high strength,low elastic modulus,and high biocompatibility in high-entropy alloys,(ⅳ) fast and reversible hydrogen storage in high-entropy hydrides,(ⅴ) photovoltaic performance and photocurrent generation on high-entropy semiconductors,(ⅵ) photocatalytic oxygen and hydrogen production from water splitting on high-entropy oxides and oxynitrides,and(ⅶ)CO_(2) photoreduction on high-entropy *** findings introduce SPD as not only a processing tool to improve the properties of existing high-entropy materials but also as a synthesis tool to produce novel high-entropy materials with superior properties compared with conventional engineering materials.

关键词： Multi-principal element alloys(MPEAs) High-entropy alloys(HEAs) High-entropy ceramics(HECs) High-entropy oxides(HEOs) Ultrafine-grained(UFG)microstructure High-pressure torsion(HPT)

Silica gel supported AlCl_3 catalyzed Friedel-Crafts acylation of aromatic compounds

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Chinese Chemical Letters 2010年第12期21卷 1395-1398页

作者： kaveh Parvanak Boroujeni Department of Chemistry Shahrekord UniversityShahrekord(115)Iran

Silica gel supported aluminium trichloride（SiO2-AlCl3） has been shown to be a mild,efficient,and chemoseiective heterogeneous Lewis acid catalyst for the acylation of aromatic compounds with acid *** catalyst can be... 详细信息

关键词： Acylation ketones Aluminium trichloride Silica gel