检索结果-南通市图书馆

Modular next generation fast-neutron detector for portal monitoring

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Nuclear Science and Techniques 2022年第1期33卷 140-148页

作者： e.Aboud S.Ahn G.V.Rogachev V.e.johnson J.Bishop G.Christian e.koshchiy C.e.Parker D.P.Scriven Cyclotron Institute Texas A&M UniversityCollege StationTX 77843USA Department of Physics and Astronomy Texas A&M UniversityCollege StationTX 77843USA Department of Statistics Texas A&M UniversityCollege StationTX 77843USA

Nuclear nonproliferation is of critical importance for global *** fissile materials including highly enriched uranium and weapons-grade plutonium are especially important to *** interrogation techniques may result in much better sensitivity but are difficult with conventional portal monitors that rely on detecting thermal ***,most conventional portal monitoring systems rely on ^(3)He,which has a finite and continually decreasing *** designing a highly segmented array of organic scintillators,we posit that we can accurately and quickly identify fissile materials,including weapons-grade plutonium and highly enriched uranium,being *** propose a new design for a fast-neutron detector that overcomes the limitations of the current generation of portal ***6 simulations have been performed in conjunction with the UMPBT statistical model to determine the sensitivity limitations of the proposed *** suggest that the proposed detector may be 10 times more efficient than current-generation thermal neutron detectors and may be able to positively identify a 81 mg 235U source in as little as 192 seconds utilizing active interrogation techniques.

关键词： Fast-neutron detection Portal monitoring Nonproliferation

exploring kidney biopsy findings in congenital heart diseases:Insights beyond cyanotic nephropathy

在线全文

学校读者我要写书评

暂无评论

World Journal of Nephrology 2024年第1期13卷 25-32页

作者： Jose Daniel Juarez-Villa Iván Zepeda-Quiroz Sebastián Toledo-Ramírez Victor Hugo Gomez-johnson Francisco Pérez-Allende Brian Ricardo Garibay-Vega Francisco e Rodríguez Castellanos Bernardo Moguel-González edgar Garcia-Cruz Salvador Lopez-Gil Department of Nephrology Instituto Nacional de Cardiología Ignacio ChavezMexico City 14080Mexico Congenital Heart Disease Instituto Nacional de Cardiología Ignacio ChavezMexico City 14080Mexico

BACkGROUND The association between congenital heart disease and chronic kidney disease is well *** mechanisms of kidney damage associated with congenital heart disease have been *** etiology of kidneydisease has commonly been considered to be secondary to focal segmental glomerulosclerosis(FSGS),however,this has only been demonstrated in case reports and not in observational or clinical *** To identify baseline and clinical characteristics,as well as the findings in kidney biopsies of patients with congenital heart disease in our *** This is a retrospective observational study conducted at the Nephrology Depart-ment of the National Institute of Cardiology“Ignacio Chávez”.All patients over 16 years old who underwent percutaneous kidney biopsy from January 2000 to January 2023 with congenital heart disease were included in the *** Ten patients with congenital heart disease and kidney biopsy were *** average age was 29.00 years±15.87 years with pre-biopsy proteinuria of 6193 mg/24 h±6165 mg/24 *** most common congenital heart disease was Fallot’s tetralogy with 2 cases(20%)and ventricular septal defect with 2(20%)*** the 10 cases,one case of IgA nephropathy and one case of membranoproliferative glomerulonephritis associated with immune complexes were found,receiving specific treatment after histopathological diagnosis,delaying the initiation of kidney replacement *** remaining 8 cases(80%),one case of FSGS with perihilar variety was found,while the other 7 cases were non-specific *** Determining the cause of chronic kidney disease can help in delaying the need for kidney replacement *** 2 out of 10 patients in our study,interventions were performed,and initiation of kidney replacement therapy was *** studies are needed to determine the usefulness of kidney biopsy in patients with congenital heart disease.

关键词： Renal biopsy Congenital heart disease Chronic kidney disease Focal segmental glomerulosclerosis

Targeting proliferation and survival pathways in head and neck cancer for therapeutic benefit

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Cancer 2012年第7期31卷 319-326页

作者： Daniel e. johnson Departments of Medicine and Pharmacology & Chemical Biology University of Pittsburgh Cancer InstitutePittsburgh Pennsylvania 15213 USA

Head and neck squamous cell carcinomas (HNSCC) are common human malignancies with poor clinical outcomes. The 5-year survival rates for patients with advanced stage HNSCC have not changed appreciably in the past few decades, underscoring a dire need for improved therapeutic options. Recent studies have elucidated a key signaling axis, the eGFR-STAT3-Bcl-XL signaling axis, that is aberrantly activated in a majority of HNSCC and contributes to the proliferation and survival of malignant cells. Considerable effort is being placed on developing highly specific inhibitors of different components of this pathway. This review highlights the progress that is being made towards achieving potent inhibition of the eGFR-STAT3-Bcl-XL signaling axis in HNSCC and the promising therapeutic strategies that are currently under development for this disease.

关键词：治疗效果头颈部癌症存活增殖鳞状细胞癌头部恶性肿瘤

Social-ecological correlates of fundamental movement skills in young children

在线全文

学校读者我要写书评

暂无评论

Journal of Sport and Health Science 2019年第2期8卷 122-129页

作者： Nan Zeng Susan L.johnson Richard e.Boles Laura L.Bellows Department of Food Science and Human Nutrition Colorado State University Department of Pediatrics University of Colorado Anschutz Medical Campus

Purpose: To identify the social-ecological correlates associated with fundamental movement skills at the child, family, and environment levels in young ***: Preschool children from 4 Colorado Head Start/preschool centers were recruited from 2010 to 2012. Two hundred twenty-eight children(128 girls; age = 56.08 § 4.09 months; body mass index(BMI) z-score = 0.53 § 1.12(mean § SD); 42.1% Hispanic/Latino) and 159 families were included in the final analysis. Children's perceived competence and fundamental movement skills were assessed via the Pictorial Scale of Perceived Competence and Social Acceptance and the Bruininks-Oseretsky Test of Motor Proficiency, 2 nd edition. Data on the number of children in the family, parent age, BMI, education, employment status, family income, perception of child coordination, and home physical activity environment were collected via a questionnaire. Linear regressions adjusted for child BMI, age, sex, and school site were performed at each ***: Child perceived cognitive competence was positively associated with locomotor skills(p = 0.04; adjusted R2= 0.035) and object-control skills(p = 0.003; adjusted R2= 0.083) at the child level. Parent education, BMI, and perception of child coordination were positively associated with locomotor skills and explained 8.8% of variance, but only parent education was significant(p = 0.04) at the family level. In addition, physical environment was positively associated with locomotor skills(p = 0.02) and explained 5.5% of variance at the environment ***: Social-ecological correlates associated with young children's fundamental movement skills are multidimensional and differ according to skill category at the child, family, and environment levels.

关键词： Activity environment Fundamental movement skills Parent education Perceived cognitive competence Preschool children

Hybridization and the species problem in conservation

在线全文

学校读者我要写书评

暂无评论

Current Zoology 2015年第1期61卷 206-216页

作者： Benjamin M. FITZPATRICk Maureen e. RYAN Jarrett R. johnson Joel CORUSH evin T. CARTeR ecology and evolutionary Biology University of Tennessee Knoxville TN 37996 USA School of environmental and Forest Sciences University of Washington Seattle WA 98195 USA Biology Department Western Kentucky University Bowling Green KY 42101 USA

Most biologists recognize the ＂species phenomenon＂ as a real pattern in nature： Biodiversity is characterized by dis- continuities between recognizable groups classified as species. Many conservation laws focus on preventing species extinction. However, species are not fixed. Discontinuities evolve gradually and sometimes disappear. exactly how to define particular spe- cies is not always obvious. Hybridization between taxonomic species reminds us that species classification is not a perfect repre- sentation of nature. Classification is a model that is very useful, but not adequate in all cases. Conservationists often confront questions about how to apply species-based laws when hybridization confounds classification. Development of sophisticated techniques and nuanced interpretation of data in the basic study of species and speciation has exposed the need for deeper educa- tion in genetics and evolution for applied conservationists and decision makers. Here we offer a brief perspective on hybridiza- tion and the species problem in conservation. Our intended audience is conservation practitioners and decision-makers more than geneticists and evolutionary biologists. We wish to emphasize that the goals and premises of legislative classification are not identical to those of scientific classification. Sometimes legal classification is required when the best available science indicates that discrete classification is not an adequate model for the case. establishing legal status and level of protection for hybrids and hybrid populations means choosing from a range of scientifically valid alternatives. Although we should not abandon species-based approaches to conservation, we must recognize their limitations and work to clarify the roles of science and values in ethical and legal decisions [Current Zoology 61 （1）： 206-216, 2015].

关键词： Hybridization Hybrid zone Conservation Genetics Policy Classification Delimitation

Prograde and retrograde growth of monazite in migmatites:An example from the Nagercoil Block,southern India

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Geoscience Frontiers 2015年第3期6卷 373-387页

作者： Tim e.johnson Chris Clark Richard J.M.Taylor M.Santosh Alan S.Collins Department of Applied Geology The Institute for Geoscience Research(TIGeR)Curtin University School of the earth Sciences and Resources China University of Geosciences(Beijing) Tectonics Resources and Exploration(TRaX)Department of Earth SciencesUniversity of Adelaide

Data from a migmatised metapelite raft enclosed within charnockite provide quantitative constraints on the pressure-temperature-time （P-T-t） evolution of the Nagercoil Block at the southernmost tip of peninsular India. An inferred peak metamorphic assemblage of garnet, k-feldspar, sillimanite, plagioclase, magnetite, ilmenite, spinel and melt is consistent with peak metamorphic pressures of 6-8 kbar and temperatures in excess of 900 ℃. Subsequent growth of cordierite and biotite record high-temperature retrograde decompression to around 5 kbar and 800 ℃. SHRIMP U-Pb dating of magmatic zircon cores suggests that the sedimentary protoliths were in part derived from felsic igneous rocks with Palae- oproterozoic crystallisation ages. New growth of metamorphic zircon on the rims of detrital grains constrains the onset of melt crystallisation, and the minimum age of the metamorphic peak, to around 560 Ma. The data suggest two stages of monazite growth. The first generation of Ree-enriched monazite grew during partial melting along the prograde path at around 570 Ma via the incongruent breakdown of apatite. Relatively Ree-depleted rims, which have a pronounced negative europium anomaly, grew during melt crystallisation along the retrograde path at around 535 Ma. Our data show the rocks remained at suprasolidus temperatures for at least 35 million years and probably much longer, supporting a long-lived high-grade metamorphic history. The metamorphic conditions, timing and duration of the implied clockwise P-T-t path are similar to that previously established for other regions in peninsular India during the ediacaran to Cambrian assembly of that part of the Gondwanan supercontinent.

关键词： Monazire Migmatite Zircon Geochronology Phase equilibria modelling Gondwana

Recurrent cyclops lesion after primary anterior cruciate ligament reconstruction using bone tendon bone allograft:A case report

在线全文

学校读者我要写书评

暂无评论

World Journal of Orthopedics 2023年第11期14卷 836-842页

作者： Grayson kelmer Andrea H johnson Justin J Turcotte Daniel e Redziniak Orthopedic Research Anne Arundel Medical CenterAnnapolisMD 21401United States Medical School Campbell University School of Osteopathic MedicineLillingtonNC 27546United States Orthopedic Surgery Anne Arundel Medical CenterAnnapolisMD 21401United States

BACkGROUND Cyclops lesions are a known complication of anterior cruciate ligament(ACL)reconstruction,with symptomatic cyclops syndrome occurring in up to 11%of *** cyclops lesions have been rarely documented;this case study documents the successful treatment of a recurrent cyclops *** SUMMARY A 28-year-old female presented following a non-contact injury to the right *** and clinical exam revealed an ACL tear,and arthroscopic reconstruction was *** years later a cyclops lesion was discovered and removed via arthroscopic *** months postoperatively,the patient presented with pain,stiffness,and difficulty achieving terminal extension.A smaller recurrent cyclops lesion was diagnosed,and a repeat synovectomy was *** patient recovered *** To the best of our knowledge,this is the first documented case of recurrent cyclops lesion after bone-patellar tendon-bone allograft ACL reconstruction presenting as cyclops syndrome.

关键词： Anterior cruciate ligament Cyclops lesion Cyclops syndrome knee arthroscopy Anterior cruciate ligament reconstruction Case report

Intraspecific variation in precipitation responses of a widespread C_(4) grass depends on site water limitation

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Plant ecology 2017年第2期10卷 310-321页

作者： Michael J.Aspinwall Philip A.Fay Christine V.Hawkes David B.Lowry Albina khasanova Jason Bonnette Briana k.Whitaker Nicholas johnson Thomas e.Juenger Hawkesbury Institute for the environment Western Sydney UniversityHawkesbury CampusLocked Bag 1797PenrithNew South Wales 2751Australia USDA-ARS Grassland Soil and Water Research Laboratory 808 East Blackland RdTempleTX 76502USA Department of Integrative Biology University of Texas at Austin1 University StationAustinTX 78712USA Department of Plant Biology Michigan State University612 Wilson RoadEast LansingMI 48824USA

Aims Variation in precipitation strongly influences plant growth,species distributions and genetic *** variation in pheno-typic plasticity,the ability of a genotype to alter its growth,morphol-ogy or physiology in response to the environment,could influence species responses to changing precipitation and climate *** this,the patterns and mechanisms of intraspecific varia-tion in plasticity to variable precipitation,and the degree to which genotype responses to precipitation are influenced by variation in edaphic conditions,remain poorly ***,we determined whether genotypes of a widespread C_(4) grass(Panicum virgatum L.,switchgrass)varied in aboveground productivity in response to changes in precipitation,and if site edaphic conditions modified genotype aboveground productivity responses to *** also determined if genotype productivity responses to precipitation are related to plasticity in underlying growth and phenological *** Nine *** genotypes originating from an aridity gradient were grown under four treatments spanning the 10th to the 90th percentiles of annual precipitation at two sites in central Texas:one site with deep,fine-textured soils and another site with shallow,coarse-textured *** measured volumetric soil water content(VWC),aboveground net primary productivity(ANPP),tiller pro-duction(tiller number),average tiller mass,canopy height,leaf area index(LAi)and flowering time on all plants at both sites and examined genotype responses to changes in *** Findings Across precipitation treatments,VWC was 39%lower and more variable at the site with shallow,coarse-textured soils compared to the site with deep,fine-textured *** averaged across genotypes and precipita-tion treatments was also 103%higher at the site with deep,fine-textured soils relative to the site with shallow,coarse-textured soils,indicating substantial differences in site water limitation.W

关键词： climate change Panicum virgatum phenology phenotypic plasticity precipitation

Reappraising the P-T evolution of the Rogaland-Vest Agder Sector,southwestern Norway

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Geoscience Frontiers 2017年第1期8卷 1-14页

作者： eleanore Blereau Tim e.johnson Chris Clark Richard J.M.Taylor Peter D.kinny Martin Hand Department of Applied Geology The Institute for Geoscience Research(TIGeR)Curtin University Centre for Tectonics Resources and Exploration(TRaX)School of Earth and Environmental SciencesUniversity of Adelaide

The Rogaland-Vest Agder Sector of southwestern Norway comprises high-grade metamorphic rocks intruded by voluminous plutonic bodies that include the ~1000 km^2 Rogaland Igneous Complex（RIC）.New petrographic observations and thermodynamic phase equilibria modelling of three metapelitic samples collected at various distances（30 km,10 km and ~ 10 m） from one of the main bodies of RIC anorthosite were undertaken to assess two alternative P-T-t models for the metamorphic evolution of the *** results are consistent with a revised two-phase *** metamorphism followed a clockwise P-T path reaching peak conditions of ~ 850-950 ℃ and ~7-8 kbar at ~1035 Ma followed by high-temperature decompression to ~5 kbar at ~950 Ma,and resulted in extensive anatexis and melt loss to produce highly residual *** emplacement of the RIC at ~930 Ma caused regional-scale contact metamorphism that affected country rocks 10 km or more from their contact with the *** thermal overprint is expressed in the sample proximal to the anorthosite by replacement of sillimanite by coarse intergrowths of cordierite plus spinel and growth of a second generation of garnet,and in the intermediate（10 km） sample by replacement of sapphirine by coarse intergrowths of cordierite,spinel and *** formation of late biotite in the intermediate sample may suggest the rocks retained small quantities of melt produced by regional metamorphism and remained at temperatures above the solidus for up to 100 *** results are more consistent with an accretionary rather than a collisional model for the Sveconorwegian Orogen.

关键词： UHTPhase equilibria modellingRogaland Igneous ComplexTHeRMOCALCSveconorwegian Orogen