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Subpopulations of regulatory T cells are associated with subclinical atherosclerotic plaques,levels of LDL,and cardiorespiratory fitness in the elderly

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Journal of Sport and Health Science 2024年第3期13卷 288-296,I0002页

作者： Tim Böttrich Pascal Bauer Vincent Gröβer Magdalena Huber Hartmann Raifer Torsten Frech Svenja Nolte Theresa Dombrowski Franz Cemic Natascha Sommer Robert Ringseis k.aus eder karsten krüger Christopher Weyh Department of Exercise Physiology and Sports Therapy Institute of Sports ScienceJustus-Liebig-UniversityGiessen 35394Germany Department of Cardiology and Angiology Justus-Liebig-University GiessenGiessen 35392Germany Institute for Systems Immunology Center for Tumor und ImmunologyMarburg 35032Germany TH Mittelhessen Department of Computer ScienceUniversity of Applied Sciences GiessenGiessen 35390Germany Department of Internal Medicine Universities of Giessen and Marburg Lung Center(UGMLC)Member of the German Center for Lung Research(DZL)Giessen 35394Germany Excellence Cluster Cardio-Pulmonary Institute(CPI) Justus-Liebig UniversityGiessen 35394Germany Institute of Animal Nutrition and Nutrition Physiology Justus-Liebig-University GiessenGiessen 35390Germany

Background:Atherosclerosis forms the pathological basis for the development of cardiovascular *** pathological processes initially develop without clinically relevant symptoms,the identification of early markers in the subclinical stage plays an important role for initiating early *** is evidence that regulatory T cells(Tregs)are involved in the development of ***,the present study aimed to identify and investigate associations with Tregs and their subsets in a cohort of healthy elderly individuals with and without subclinical atherosclerotic plaques(SAP).In addition,various lifestyle and risk factors,such as cardiorespiratory fitness,were investigated as associated ***:A cross-sectional study was performed in 79 participants(male:n=50;age=63.6±3.7 years;body mass index=24.9±3.1 kg/m2;mean±SD)who had no previous diagnosis of chronic disease and were not taking *** of the carotids to identify SAP,cardiovascular function measurement for vascular assessment and a cardiorespiratory fitness test to determine peak oxygen uptake were ***,tests were conducted to assess blood lipids and determine glucose *** of Tregs and their subtypes(resting(rTregs)and effector/memory(mTregs))was performed by 8-chanel flow *** were categorized according to atherosclerotic plaque *** and logistic regression models were used to analyze associations between ***:SAP was detected in a total of 29 *** participants with plaque were older(64.8±3.6 years vs.62.9±3.5 years)and had higher peripheral systolic blood pressure(133.8±14.7 mmHg vs.125.8±10.9 mmHg).The participants with SAP were characterized by a lower percentage of rTregs(28.8%±10.7%vs.34.6%±10.7%)and a higher percentage of mTregs(40.3%±14.7%vs.30.0%±11.9%).Multiple logistic regression identified age(odds ratio(OR)=1.20(95%confidence interval(95%CI):1.011.42))and

关键词： Cardiorespiratory fitness Elderly Regulatory T cells Subclinical atherosclerosis

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工业自动化生产动力电池

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现代制造 2024年第S1期 46-46,48,49页

作者： Thomas eder 不详

尽管当前困难重重,但一些代工厂却生意兴隆。因为他们已经实现了数字化和自动化生产,并且是在没有增加企业员工数量的情况下提高了企业的生产能力。有些代工厂甚至实现了批量化大生产。一些小型企业也在推动生产数字化和自动化的进程,... 详细信息

尽管当前困难重重,但一些代工厂却生意兴隆。因为他们已经实现了数字化和自动化生产,并且是在没有增加企业员工数量的情况下提高了企业的生产能力。有些代工厂甚至实现了批量化大生产。一些小型企业也在推动生产数字化和自动化的进程,因为它们所承受的技术工人缺乏和竞争的压力尤为严重。田园诗般的土地为这些企业提供了犹如一家人般的亲情、和谐的工作环境和多种多样的工作岗位。

关键词：小型企业员工数量工作岗位自动化生产批量化动力电池代工厂数字化

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持续25年的服务

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现代制造 2024年第S1期 55-56页

作者： Thomas eder 不详

在物流行业的广阔天地中,伍尔特工业服务公司独树一帜,以其无与伦比的能力著称——即在“精准时刻,将精确数量的理想产品送达指定位置”。历经25年的稳健前行与卓越发展,该公司已傲然屹立于欧洲小型工业零件供应领域的巅峰,成为行业内... 详细信息

在物流行业的广阔天地中,伍尔特工业服务公司独树一帜,以其无与伦比的能力著称——即在“精准时刻,将精确数量的理想产品送达指定位置”。历经25年的稳健前行与卓越发展,该公司已傲然屹立于欧洲小型工业零件供应领域的巅峰,成为行业内的领航标杆。总部地址位于巴登-符藤堡州künzelsau市的伍尔特工业服务有限公司是一家从事紧固件和组装技术的家族企业。1999年1月13日,在千禧之交的前一年,伍尔特工业服务有限责任公司(Würth Industrie Service Gmb H&***)分拆出来,成为伍尔特集团的子公司。

关键词：家族企业服务公司总部地址物流行业组装技术傲然屹立紧固件指定位置

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Adsorption of yttrium(Y^(3+)) and concentration of rare earth elements from phosphogypsum using chitin and chitin aerogel

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Journal of Rare Earths 2024年第4期42卷 775-782页

作者： Glaydson S.dos Reis Diana Pinto Sabrina F.Lütke eder C.Lima Luis F.O.Silva Irineu A.S.De Brum Guilherme L.Dotto Department of Forest Biomaterials and Technology Biomass Technology Centre Swedish University of Agricultural SciencesUmeaE13Swedn Universidad De La Costa Calle 58#55-66080002BarranquillaAtlanticoColombia Research Group on Adsorptive and Catalytic Process Engineering(ENGEPAC) Federal University of Santa MariaAv.Roraima100079705900Santa MariaRSBrazil Institute of Chemistry Federal University of Rio Grande do Sul90040060Porto AlegreBrazil

Chitin powder and chitin-aerogel were prepared from shrimp wastes and used to uptake Y^(3+)from aqueous solutions and concentrate this rare earth element from phosphogypsum(PG).Chitin aerogel displays a specific surface area of 945 m^(2)/g,while chitin powder is 3.6 m^(2)/g,which largely influences its adsorption *** the adsorption in synthetic solutions,the effect of pH on Y^(3+)removal is strong for chitin powder *** contrast,no big pH influence was detected for chitin *** interactions and chelation can highlight the proposed mechanism of Y^(3+)on chitin adsorbents for the powder and ***,in addition to these interactions,pore filling/pore diffusion is the main mechanism of Y^(3+)removal in the chitin *** aerogel is efficient in concentrating 8 times the Y^(3+)from PG,a very complex *** complex chitin aerogel-Y^(3+)can be a secondary source of rare earth elements for other applications.

关键词： Rare earths Sustainable material Chitin powder Chitin porous aerogel Yttrium adsorption and recovery

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Fibroblast growth factor 21 in dairy cows:current knowledge and potential relevance

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Journal of Animal Science and Biotechnology 2022年第2期13卷 303-315页

作者： k.aus eder Denise k.Gessner Robert Ringseis Institute of Animal Nutrition and Nutrition Physiology Justus-Liebig-University GiessenHeinrich-Buff-Ring 26-3235392 GiessenGermany

Fibroblast growth factor 21(FGF21)has been identified as an important regulator of carbohydrate and lipid metabolism,which plays an important role for metabolic regulation,particularly under conditions of energy deprivation or stress *** cows are subjected to a negative energy balance and various kinds of stress particularly during the periparturient phase and during early *** has been shown that the plasma concentration of FGF21 in dairy cows is dramatically increased at parturition and remains high during the first weeks of *** finding suggests that FGF21 might exert similar functions in dairy cows than in other species,such as mice or ***,the role of FGF21 in dairy cows has been less investigated so *** a brief summary of the previous findings about the function of FGF21 in humans and mice,the present review aims to present the current state of knowledge about the role of FGF21 in dairy *** first part of the review deals with the tissue localization of FGF21 and with conditions leading to an upregulation of FGF21 expression in the liver of dairy *** the second part,the influence of nutrition on FGF21 expression and the role of FGF21 for metabolic diseases in dairy cows is *** the third part,findings of exogenous FGF21 application on metabolism in dairy cows are ***,the potential relevance of FGF21 in dairy cows is *** is concluded that FGF21 might be of great importance for metabolic adaptation to negative energy balance and stress conditions in dairy ***,further studies are needed for a better understanding of the functions of FGF21 in dairy cows.

关键词： Dairy cow Energy deprivation Fibroblast growth factor 21 Metabolic adaptation Stress

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Heat stress in pigs and broilers:role of gut dysbiosis in the impairment of the gut-liver axis and restoration of these effects by probiotics,prebiotics and synbiotics

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Journal of Animal Science and Biotechnology 2023年第2期14卷 465-480页

作者： Robert Ringseis k.aus eder Institute of Animal Nutrition and Nutrition Physiology Justus-Liebig-University GiessenHeinrich‑Buff‑Ring 26‑3235392 GiessenGermany

Heat stress is one of the most challenging stressors for animal production due to high economic losses resulting from impaired animal’s productivity,health and *** the fact that all farm animal species are susceptible to heat stress,birds and pigs are particularly sensitive to heat stress due to either lacking or non-functional sweat ***-vincing evidence in the literature exists that gut dysbiosis,a term used to describe a perturbation of commensal gut microbiota,develops in broilers and pigs under heat *** to the protective role of commensal bacteria for the gut barrier,gut dysbiosis causes a disruption of the gut barrier leading to endotoxemia,which contributes to the typical characteristics of heat stressed broilers and growing and growing-finishing pigs,such as reduced feed intake,decreased growth and reduced lean carcass weight.A substantial number of studies have shown that feeding of probiotics,prebiotics and synbiotics is an efficacious strategy to protect broilers from heat stress-induced gut barrier disruption through altering the gut microbiota and promoting all decisive structural,biochemical,and immunologi-cal elements of the intestinal *** most of the available studies in heat stressed broilers,the alterations of gut microbiota and improvements of gut barrier function induced by feeding of either probiotics,prebiotics or synbiot-ics were accompanied by an improved productivity,health and/or welfare when compared to non-supplemented broilers exposed to heat *** findings indicate that the restoration of gut homeostasis and function is a key target for dietary interventions aiming to provide at least partial protection of broilers from the detrimental impact of heat stress *** the fact that the number of studies dealing with the same feeding strategy in heat stressed pigs is limited,the available few studies suggest that feeding of probiotics might also be a suitable approach to enhance productivi

关键词： Broilers Commensal bacteria Gut dysbiosis Heat stress Pigs Prebiotics Probiotics Synbiotics

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Interpreting Morphologically Homogeneous(Paleo-)Populations as Ecological Species Enables Comparison of Living and Fossil Organism Groups,Exemplified by Nummulitid Foraminifera

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Journal of Earth Science 2022年第6期33卷 1362-1377页

作者： Johann Hohenegger Ana Ivis Torres-Silva Wolfgang eder Institute for Paleontology University of Vienna1090ViennaAustria

Morphologically homogeneous groups,either living populations or fossil paleo-populations,must be regarded as ecological species,independent of their molecular genetic resemblance in living *** is always expressed during development by structure genes initiated from a network of regulator genes acting at different times and intensities,additionally being subjected to epigenetic ***,homogeneous populations influenced by the environment represent species better than the reproduction(biological species)or molecular-genetic approach using ancestral sequences like *** and fossil representatives of nummulitid foraminifera were chosen to demonstrate complete reconstruction of morphology using metrical growth-invariant and growth-independent *** these characters,6 models were established to define ecological species in living and fossil ***,a distinction between evolutionary and environmental effects in fossil forms was possible using discriminant analysis showing characters that are responsible for differentiating between evolutionary and environmental trends.

关键词： ecological species growth-invariant metrical characters morphology homogeneity nummulitids

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Shock index and its variants as predictors of mortality in severe traumatic brain injury

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World Journal of Critical Care Medicine 2024年第1期13卷 40-48页

作者： Randhall B Carteri Mateus Padilha Silvaine Sasso de Quadros eder kroeff Cardoso Mateus Grellert Department of Nutrition Centro Universitário CESUCAPorto Alegre 94935-630Brazil Department of Analysis and Systems Development Centro Universitário CESUCAPorto Alegre 94935-630Brazil Department of Nutrition Hospital Pronto Socorro de Porto AlegrePorto Alegre 90040-192Rio Grande do SulBrazil Department of Physiotherapy Hospital Pronto Socorro de Porto AlegrePorto Alegre 90040-192Rio Grande do SulBrazil Institute of Informatics Federal University of Rio Grande do Sul(UFRGS)Porto Alegre 91501-970Rio Grande do SulBrazil

BACkGROUND The increase in severe traumatic brain injury(sTBI)incidence is a worldwide phenomenon,resulting in a heavy disease burden in the public health systems,specifically in emerging *** shock index(SI)is a physiological parameter that indicates cardiovascular status and has been used as a tool to assess the presence and severity of shock,which is increased in *** the high mortality of sTBI,scrutinizing the predictive potential of SI and its variants is *** To describe the predictive potential of SI and its variants in *** This study included 71 patients(61 men and 10 women)divided into two groups:Survival(S;n=49)and Non-survival(NS;n=22).The responses of blood pressure and heart rate(HR)were collected at admission and 48 h after *** SI,reverse SI(rSI),rSI multiplied by the Glasgow Coma Score(rSIG),and Age multiplied SI(AgeSI)were *** comparisons included Shapiro-Wilk tests,and independent samples *** predictive analysis,logistic regression,receiver operator curves(ROC)curves,and area under the curve(AUC)measurements were *** No significant differences between groups were identified for SI,rSI,or *** AgeSI was significantly higher in NS patients at 48 h following admission(S:26.32±14.2,and NS:37.27±17.8;P=0.016).Both the logistic regression and the AUC following ROC curve analysis showed that only AgeSI at 48 h was capable of predicting sTBI *** Although an altered balance between HR and blood pressure can provide insights into the adequacy of oxygen delivery to tissues and the overall cardiac function,only the AgeSI was a viable outcome-predictive tool in sTBI,warranting future research in different cohorts.

关键词： Head trauma Critical patient Neuro-cardio axis Predictive tool Clinical practice

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Estimation of radiation-induced health hazards from a“dirty bomb”attack with radiocesium under different assault and rescue conditions

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Military Medical Research 2022年第1期9卷 106-125页

作者： Alexis Rump Stefan eder Cornelius Hermann Andreas Lamkowski Patrick Ostheim Michael Abend Matthias Port Bundeswehr Institute of Radiobiology Neuherberg Str.1180937 MunichGermany

In the case of a terrorist attack by a“dirty bomb”,blast injuries,external irradiation and the incorporation of radioactivity are to be *** from information about the radiological attack scenario with cesium-137 in the *** Scenario Planning Guide,we estimated the radiological doses *** calculations were performed for a smaller plume size and a detonation in a *** conditions as described in the ***,the committed effective dose amounted to a maximum of 848 mSv,even for very unfavorable *** bone marrow equivalent doses are insufcient to induce acute radiation sickness(ARS).In the case of a smaller plume size,the ARS threshold may be exceeded in some *** a subway bombing,doses are much higher and the occurrence of ARS should be *** health hazards from a dirty bomb attack will depend on the location and the explosive *** derived Haddon matrix indicates that preparing for such an event includes education of all the medical staff about radiation effects,the time lines of radiation damages and the treatment *** determinants of the outcome include rapid evacuation even from difficult locations,the availability of a specific triage tool to rapidly identify victims at risk for ARS,the availability of an antidote stockpile and dedicated hospital beds to treat seriously irradiated victims.

关键词： Medical NRBC protection Terrorism Radiological emergency Dirty bomb Combined injuries Triage Acute radiation sickness Radionuclide incorporation

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Layered double hydroxide(LDH)-based materials:A mini-review on strategies to improve the performance for photocatalytic water splitting

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Journal of Energy Chemistry 2022年第1期31卷 406-431,I0011页

作者： Hanane Boumeriame Eliana S.Da Silva Alexey S.Cherevan Tarik Chafik Joaquim L.Faria Dominik eder Laboratory of Separation and Reaction Engineering-Laboratory of Catalysis and Materials(LSRE-LCM) Faculdade de EngenhariaUniversidade do PortoRua Dr Roberto Frias s/n4200-465 PortoPortugal Institute of Materials Chemistry Technische Universicat Wien(TU Wien)Getreidemarkt 9Vienna 1060Austria Laboratory of Chemical Engineering and Valorization of Resources(LGCVR-UAE/L01FST).Faculte des Sciences et Techniques Universite Abdelmalek EssaadiTangierMorocco

The high energy demand we currently face in society and the subsequent large consumption of fossil fuels cause its depletion and increase the pollution *** quest for the production of clean energy from renewable and sustainable sources remains *** conversion of solar energy into hydrogen via the water-splitting process,assisted by pho tores pons ive semiconductor catalysts,is one of the most promising *** progress has been made on water splitting in the past few years and a variety of photocatalysts active not only under ultra-violet(UV) light but especially with the visible part of the electromagnetic spectrum have been *** double hydroxides(LDH)-based materials have emerged as a promising class of nanomaterials for solar energy applications owing to their unique layered structure,compositional flexibility,tunable bandgaps,ease of synthesis and low manufacturing *** review covers the most recent research dedicated to LDH materials for photocatalytic water-splitting applications and encompasses a range of synthetic strategies and post-modifications used to enhance their ***,we provide a thorough discussion of the experimental conditions crucial to obtaining improved photoactivity and highlight the impact of some specific parameters,namely,catalysts loading,cocatalysts,sacrificial agents,and irradiation *** review provides the necessary tools to select the election technique for adequately enhancing the photoactivity of LDH and modified LDH-based materials and concludes with a critical summary that outlines further research directions.

关键词： Layered double hydroxides Water splitting Photocatalysis Hydrogen generation Oxygen evolution Nanomaterials

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