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Aggresome-aggrephagy transition process:geting closer to the functional roles of HDAC6 and BAG3

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Neural regeneration research 2024年第6期19卷 1181-1182页

作者： Hagen körschgen Christian Behl The Autophagy Lab Institute of PathobiochemistryUniversity Medical Center of the Johannes Gutenberg University MainzMainzGermany

Misfolding of proteins as well as their aggregation is a major driver of age-related neurodegenerative ***,cells have evolved sophisticated protein quality control *** the ubiquitin-proteasome-system(UPS)and the autop... 详细信息

关键词： closer system transition

Efficient guiding and focusing of intense laser pulse using periodic thin slits

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Matter and radiation at Extremes 2024年第4期9卷 29-39页

作者： L.Xu T.W.Huang k.Jiang C.N.Wu H.Peng P.C.hen r.Li H.B.Zhuo C.T.Zhou Shenzhen key Laboratory of Ultraintense Laser and Advanced Material Technology Center for Intense Laser ApplicationTechnologyand College of Engineering PhysicsShenzhen Technology UniversityShenzhen 518118People’s Republic of China

Slits have been widely used in laser-plasma interactions as plasma optical components for generating high-harmonic light and controlling laser-driven particle ***,we propose and demonstrate that periodic thin slits can be regarded as a new breed of optical elements for efficient focusing and guiding of intense laser *** fundamental physics of intense laser interaction with thin slits is studied,and it is revealed that relativistic effects can lead to enhanced laser focusing far beyond the pure diffractive focusing *** addition,the interaction of an intense laser pulse with periodic thin slits makes it feasible to achieve multifold enhancement in both laser intensity and energy transfer efficiency compared with conventional *** results provide a novel method for manipulating ultra-intense laser pulses and should be of interest for many laser-based applications.

关键词： laser pulse intense

Existing Case of Transportation System in Turkey and Transportation Trends in Istanbul

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Journal of Traffic and Transportation Engineering 2024年第5期12卷 248-253页

作者： Mehmet Çağrı kızıltaş Vail karakale Istanbul Ticaret University Istanbul 34445Turkey Istanbul Medeniyet University Istanbul 34720Turkey

Transportation sector is one of the most important elements of a country’s economy with its highway,railway,airway and seaway modes,besides the information and communication *** sector has a pattern that affects the society continuously with its economic and social inputs that has a significant role in economies of countries in terms of being an important part of manufacturing process and effects of sizable investments on *** of more comfortable,more reliable,more safe and more punctual transport in developing economy is an arising trend worldwide and this shows an increase the importance of the transportation *** of an efficient and functional transportation system is closely related with traffic safety,intermodal integration and balanced modal *** Turkey,an important improvement has been achieved in these issues,but also some basic constitutive problems are still *** constitutional problems can be summarized as providing traffic safety,integration of innovative implementations to transportation system,enhancing of infrastructure and an effective usage of existing infrastructure.

关键词： Traffic safety modal share railways transportation system transportation policies

SArS-CoV-2 spike protein-ACE2 interaction increases carbohydrate sulfotransferases and reduces N-acetylgalactosamine-4-sulfatase by p38 MAPk

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Signal Transduction and Targeted Therapy 2024年第3期9卷 1174-1185页

作者： Sumit Bhattacharyya Joanne k.Tobacman Jesse Brown VA Medical Center and University of Illinois at Chicago ChicagoIL 60612USA

Immunostaining in lungs of patients who died with CovID-19 infection showed increased intensity and distribution of chondroitin sulfate and decline in N-acetylgalactostamine-4-sulfatase(Arylsulfatase B;ArSB).To explain these findings,human small airway epithelial cells were exposed to the SArS-CoV-2 spike protein receptor binding domain(SPrBD)and transcriptional mechanisms were ***-p38 MAPk and phospho-SMAD3 increased following exposure to the SPrBD,and their inhibition suppressed the promoter activation of the carbohydrate sulfotransferases CHST15 and CHST11,which contributed to chondroitin sulfate *** in ArSB was mediated by phospho-38 MAPk-induced N-terminal rb phosphorylation and an associated increase in rb-E2F1 binding and decline in E2F1 binding to the ArSB *** increases in chondroitin sulfotransferases were inhibited when treated with phospho-p38-MAPk inhibitors,SMAD3(SIS3)inhibitors,as well as antihistamine desloratadine and antibiotic *** the mouse model of carrageenan-induced systemic inflammation,increases in phosphop38 MAPk and expression of CHST15 and CHST11 and declines in DNA-E2F binding and ArSB expression occurred in the lung,similar to theobserved effects in this SPrBD model of COVID-19 *** accumulation of chondroitin sulfates is associated with fibrotic lung conditions and diffuse alveolar damage,increased attention to p38-MAPk inhibition may be beneficial in amelioratingCovid-19infections.

关键词： ACE2 lung inhibited

No effect of invasive tree species on aboveground biomass increments of oaks and pines in temperate forests

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Forest Ecosystems 2024年第4期11卷 401-413页

作者： Sebastian Bury Marcin k.Dyderski Institute of Dendrology Polish Academy of SciencesParkowa 562-035 KornikPoland

Prunus serotina and robinia pseudoacacia are the most widespread invasive trees in Central *** addition,according to climate models,decreased growth of many economically and ecologically important native trees will likely be observed in the *** aimed to assess the impact of these two neophytes,which differ in the biomass range and nitrogen-fixing abilities observed in Central European conditions,on the relative aboveground biomass increments of native oaks Qucrcus robur and *** and Scots pine Pinus *** aimed to increase our understanding of the relationship between facilitation and competition between woody alien species and overstory native *** established 72 circular plots(0.05 ha)in two different forest habitat types and stands varying in age in western *** chose plots with different abundances of the studied neophytes to determine how effects scaled along the quantitative invasion ***,we collected growth cores of the studied native species,and we calculated aboveground biomass increments at the tree and stand ***,we used generalized linear mixed-effects models to assess the impact of invasive species abundances on relative aboveground biomass increments of native tree *** did not find a biologically or statistically significant impact of invasive *** or *** on the relative aboveground,biomass increments of native oaks and pines along the quantitative gradient of invader biomass or on the proportion of total stand biomass accounted for by *** neophytes did not act as native tree growth stimulators but also did not compete with them for resources,which would escalate the negative impact of climate change on pines and *** neophytes should not significantly modify the carbon sequestration capacity of the native *** work combines elements of the per capita effect of invasion with research on mixed forest management.

关键词： Invasion ecology Exotic trees relative aboveground biomass increment Competition Facilitation Carbon sequestration

Process engineering of demineralisation of moderate to high ash Indian coals through NaOH‑HCl leaching and HF leaching

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International Journal of Coal Science & Technology 2024年第2期11卷 111-122页

作者： Heena Dhawan D.k.Sharma ANrF Ministry of ScienceNew DelhiIndia Department of Energy Science and Engineering Indian Institute of Technology DelhiNew Delhi 110016India

Chemical leaching of coals would be required to produce cleaner coals for some special applications where physical benefi-ciation may not be effective *** would also help in recovering Li and rare earth metals besides in the sequestration of CO_(2).About 20 Indian coals having complexly distributed moderate to high ash contents were sequentially treated with various alkali–acid such as NaOH-HCl,HF,HCl,HCl-HF,and NaOH-HCl-HF *** aimed to establish and design the best stepwise sequential process for the highest degree of demineralisation through a chemical leaching *** and process intensification studies were carried *** than 80%demineralisation of Madhaipur and Neemcha coals was observed using the best sequential treatment designed *** repeated stepwise treatment of the alkali and the acid was also studied,which was found to significantly enhance the degree of demineralisation of *** integrated process of alkali–acid leaching followed by solvent extraction(Organo-refining)and vice versa of the treated coal was also studied for producing cleaner coals.

关键词： Alkali–acid leaching Demineralisation Integrated process rare earth elements

The delivery of N-myc downstream-regulated gene 2(NDrG2)self-amplifying mrNA via modified lipid nanoparticles as a potential treatment for drug-resistant and metastatic cancers

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Medical review 2024年第3期4卷 235-238页

作者： Sandra E.reznik Amit k.Tiwari Vivek Chavda Charles r.Ashby Jr. Department of Pharmaceutical Sciences College of Pharmacy and Health SciencesSt.John’s UniversityQueensUSA Departments of Pathology and Obstetrics and Gynecology and Women’s Health Montefiore Medical Center/Albert Einstein College of MedicineBronxUSA Department of Pharmaceutical Sciences College of Pharmacy University of Arkansas for Medical Sciences Little RockUSA Department of Pharmaceutics and Pharmaceutical Technology L.M.College of Pharmacy AhmedabadIndia Department of Pharmaceutical Sciences College of Pharmacy and Health SciencesSt.John’s UniversityQueensNY 11439USA

The protein,N-myc downstream-regulated gene 2(NDrG2),a tumor suppressor,is significantly decreased or absent in many types of *** is a significant negative correlation between the levels of NDrG2 and the development and progression of cancer tumor recurrence and tumor invasion,in different *** contrast,the in vitro and in vivo overexpression of the NDrG2 protein decreases the proliferation,growth,adhesion and migration of many types of cancer *** in vitro overexpression of NDrG2 increases the efficacy of certain anticancer drugs in specific types of cancer *** hypothesize that the delivery of the mrNA of the NDrG2 protein,encapsulated by lipid nanoparticles,could represent a potential treatment of metastatic and drug-resistant *** would be accomplished using a self-amplifying mrNA that encodes the NDrG2 protein and an rNA-dependent-rNA polymerase,obtained from an in vitrotranscribed(IVT)*** IVT mrNA would be encapsulated in a lipid *** efficacy of the nanoformulation would be determined in cultured cancer cells and if the results are positive,nude mice transplanted with either drug-resistant or metastatic drug-resistant cancer cells,would be treated with the nanoformulation and monitored for efficacy and adverse *** the appropriate preclinical studies indicate this formulation is efficacious and safe,it is possible it could be evaluated in clinical trials.

关键词： N-myc downstream-regulated gene 2(NDrG2) cancer self-amplifying mrNA nanoparticle

Commentary on“Incidence of urinary incontinence following endoscopic laser enucleation of the prostate by en-bloc and non-en-bloc techniques:a multicenter,real-world experience of 5068 patients”

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Asian Journal of Andrology 2024年第3期26卷 333-334页

作者： James F Jiang Narmina k Onder Akhil k Das Department of Urology University of California Irvine Orange CA 92868 USA.

Laser enucleation of the prostate is a proven and effectivesize-independent method for the surgical management of symptomaticbenign prostatic hyperplasia(BPH)and is considered as the“goldstandard”by many *** major hurdles that stand in theway of this becoming a universally used procedure for BPH are thesteep learning curve associated with mastering the procedure andpossibility of perioperative transient *** advances inteaching methodologies have helped tackle the difficulty in learning itand increased the number of urologists utilizing the *** forthe second hurdle,transient incontinence rates postlaser enucleationof the prostate have improved with the advent of newer techniques *** et al.1 assesses the incidence of stress,urge,andmixed urinary incontinence following laser enucleation of the prostateby comparing en-bloc and non-en-bloc techniques in a multicenterseries of 5068 men with BPH.

关键词： urinary incontinence transient

Laparoscopic management of remnant gall bladder with stones: Lessons from a tertiary care centre's experience

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Laparoscopic, Endoscopic and robotic Surgery 2024年第1期7卷 27-33页

作者： Gilbert Samuel Jebakumar Jeevanandham Muthiah Loganathan Jayapal r.Santhosh kumar Siddhesh Tasgaonkar k.S.Santhosh Anand J.k.A.Jameel Sudeepta kumar Swain k.J.raghunath Prasanna kumar reddy Tirupporur Govindaswamy Balachandar Department of Surgical Gastroenterology Apollo HospitalsChennai 600006India Department of General Surgery Apollo HospitalsChennai 600006India Department of Minimal Access Surgery Apollo HospitalsChennai 600006India

Objective:Laparoscopic cholecystectomy is currently the gold standard for treating symptomatic gallstone *** its success,approximately 10%of patients may experience persistent biliary symptoms,leading to the post-cholecystectomy syndrome.A remnant gallbladder with cystic duct or bile duct stones is one of the causes of this *** objective of this study was to shed light on the clinical manifestations,evaluation,therapeutic strategies,and outcomes associated with laparoscopic management of symptomatic remnant ***:This was a retrospective study,conducted over a five-year period(January 2017 to December 2022)at Apollo Hospitals in South *** patients who underwent laparoscopic completion cholecystectomy for a remnant gall bladder were *** following data were collected:patient demographics,symptoms,preoperative investigations,intraoperative details and post operative ***:In total,36 patients were included and *** majority of patients were male(25,69.4%),with a mean age of 50.7±12.1 *** most common presentation was pain in the upper abdomen or right upper quadrant region(24,66.7%).The laparoscopic approach was attempted in all patients,with a success rate of 94.4%.Two patients required conversion to open *** fistula to the colon was observed in one *** was observed in 7 patients(19.4%),and stone clearance was successfully achieved using endoscopic retrograde cholangiopancreatography in all patients ***:Incomplete gall bladder removal either intentionally or unintentionally leaves a remnant gall bladder that is at risk for stone formation and *** who have this clinical entity with symptoms require a redo or complete cholecystectomy,a complex procedure associated with certain *** study highlights the feasibility and safety of laparoscopic completion cholecystectomy for the management of remnant gallbladder

关键词： remnant gall bladder Stump cholecystitis Subtotal cholecystectomy Laparoscopic completion cholecystectomy