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Intrumer:A Multi Module Distributed Explainable IDS/IPS for Securing Cloud Environment

Computers, Materials & Continua 2025年第1期82卷 579-607页

作者： Nazreen Banu A S.k.B.Sangeetha Department of Computer Science and Engineering SRM Institute of Science and TechnologyVadapalani CampusChennai600026Tamil NaduIndia

The increasing use of cloud-based devices has reached the critical point of cybersecurity and unwanted network *** environments pose significant challenges in maintaining privacy and *** approaches,such as IDS,have been developed to tackle these ***,most conventional Intrusion Detection System(IDS)models struggle with unseen cyberattacks and complex high-dimensional *** fact,this paper introduces the idea of a novel distributed explainable and heterogeneous transformer-based intrusion detection system,named INTRUMER,which offers balanced accuracy,reliability,and security in cloud settings bymultiplemodulesworking together within *** traffic captured from cloud devices is first passed to the TC&TM module in which the Falcon Optimization Algorithm optimizes the feature selection process,and Naie Bayes algorithm performs the classification of *** selected features are classified further and are forwarded to the Heterogeneous Attention Transformer(HAT)*** this module,the contextual interactions of the network traffic are taken into account to classify them as normal or malicious *** classified results are further analyzed by the Explainable Prevention Module(XPM)to ensure trustworthiness by providing interpretable *** the explanations fromthe classifier,emergency alarms are transmitted to nearby IDSmodules,servers,and underlying cloud devices for the enhancement of preventive *** experiments on benchmark IDS datasets CICIDS 2017,Honeypots,and NSL-kDD were conducted to demonstrate the efficiency of the INTRUMER model in detecting network trafficwith high accuracy for different *** outperforms state-of-the-art approaches,obtaining better performance metrics:98.7%accuracy,97.5%precision,96.3%recall,and 97.8%*** results validate the robustness and effectiveness of INTRUMER in securing diverse cloud environments against sophisticated cyber threats.

关键词： Cloud computing intrusion detection system transformers and explainable artificial intelligence(XAI)

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Effects of P301L-TAU on post-translational modifications of microtubules in human iPSC-derived cortical neurons and TAU transgenic mice

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Neural Regeneration Research 2025年第8期20卷 2348-2360页

作者： Mohamed Aghyad Al kabbani Christoph köhler Hans Zempel Institute of Human Genetics Faculty of Medicine and University Hospital CologneUniversity of CologneCologneGermany Center for Molecular Medicine Cologne(CMMC) University of CologneCologneGermany Center Anatomy Department ⅡMedical FacultyUniversity of CologneCologneGermany

TAU is a microtubule-associated protein that promotes microtubule assembly and stability in the *** is missorted and aggregated in an array of diseases known as *** are essential for neuronal function and regulated via a complex set of post-translational modifications,changes of which affect microtubule stability and dynamics,microtubule interaction with other proteins and cellular structures,and mediate recruitment of microtubule-severing *** impairment of microtubule dynamics causes neuronal dysfunction,we hypothesize cognitive impairment in human disease to be impacted by impairment of microtubule *** therefore aimed to study the effects of a disease-causing mutation of TAU(P301L)on the levels and localization of microtubule post-translational modifications indicative of microtubule stability and dynamics,to assess whether P301L-TAU causes stability-changing modifications to *** investigate TAU localization,phosphorylation,and effects on tubulin post-translational modifications,we expressed wild-type or P301L-TAU in human MAPT-kO induced pluripotent stem cell-derived neurons(i Neurons)and studied TAU in neurons in the hippocampus of mice transgenic for human P301L-TAU(p R5 mice).Human neurons expressing the longest TAU isoform(2N4R)with the P301L mutation showed increased TAU phosphorylation at the AT8,but not the p-Ser-262 epitope,and increased polyglutamylation and acetylation of microtubules compared with endogenous TAU-expressing neurons.P301L-TAU showed pronounced somatodendritic presence,but also successful axonal enrichment and a similar axodendritic distribution comparable to exogenously expressed 2N4R-wildtype-TAU.P301L-TAU-expressing hippocampal neurons in transgenic mice showed prominent missorting and tauopathy-typical AT8-phosphorylation of TAU and increased polyglutamylation,but reduced acetylation,of microtubules compared with non-transgenic *** sum,P301L-TAU results in changes in micr

关键词： human induced pluripotent stem cell microtubules P301L pR5 mice TAU tauopathy tubulin code

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CFD-based analysis of urban haze-fog dispersion—A preliminary study

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Building Simulation 2021年第2期14卷 365-375页

作者： Yu Zhang Yong Yu k.C.S.kwok Feng Yan School of Medicine Tsinghua UniversityBeijingChina School of Aerospace Engineering Beijing Institute of TechnologyBeijingChina Faculty of Engineering School of Civil EngineeringThe University of SydneySydneyNew South WalesAustralia First Hospital of Tsinghua University BeijingChina

This paper proposes a computational fluid dynamics(CFD)model,along with dimensionless quantitative assessment standard—air pollution residual time(APRT)for the evaluation of local haze-fog(HF)dispersion in a built environment.A low APRT value ensures good ventilation.A building group model that comprises high-rise business building,mid-rise office buildings,low-mid-rise residential buildings(at the center of the building group),a mid-rise recreational center,and a local road(open terrain),was scaled down(1:100)to simulate the HF dispersion *** orientation of the building group was numerically modified to generate a wind incidence normal to the high-rise building,mid-rise buildings,recreational center,and *** results showed that the orientation of the building group largely determines the *** most favorable orientation can reduce APRT by more than 50%.Our results strongly suggested that in order to reduce the consequential negative effect of air pollution,future urban designs should undergo a comprehensive ventilation assessment to ensure a low APRT value.

关键词： air pollution residual time urban environment high-rise building wind direction computational fluid dynamics

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Strategies in boosting photosensitization for biomedical applications

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Science China Chemistry 2022年第4期65卷 647-649页

作者： Ming Chen Ryan T.k.kwok Youhong Tang Dan Ding College of Chemistry and Materials Science Jinan UniversityGuangzhou 510632China Frontiers Science Center for Cell Responses State Key Laboratory of Medicinal Chemical BiologyKey Laboratory of Bioactive MaterialsMinistry of EducationCollege of Life SciencesNankai UniversityTianjin 300071China Department of Nephrology Huai’an Hospital Affiliated to Xuzhou Medical College and Huai’an Second HospitalHuai’an 223002China Department of Chemistry The Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and ReconstructionInstitute for Advanced StudyDepartment of Chemical and Biological EngineeringThe Hong Kong University of Science and TechnologyHong KongChina Australia-China Joint Centre for Personal Health Technologies Medical Device Research InstituteCollege of Science and EngineeringFlinders UniversitySouth Australia 5042Australia Guangdong Provincial key Laboratory of Luminescence from Molecular Aggregates South China University of TechnologyGuangzhou 510640China

Photodynamic therapy(PDT)has emerged as an effective treatment method for its few adverse effects,little invasiveness,short treatment time and low cost[1,2].The rapid development of PDT has dramatically boosted its mu... 详细信息

关键词： treatment boosting immunotherapy

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Human endogenous retrovirus type-w and multiple sclerosis–related smoldering neuroinflammation

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Neural Regeneration Research 2025年第3期20卷 813-814页

作者： Joel Gruchot Laura Reiche Andrew Chan Robert Hoepner Patrick küry Department of Neurology Medical Faculty and University Hospital DüsseldorfHeinrich Heine University DüsseldorfDüsseldorfGermany Department of Neurology InselspitalBern University Hospital and University of BernBernSwitzerland

Introduction to human endogenous retrovirus type-w(HERV-w): Genomic inheritance from the past includes retroviral sequences that have been stably incorporated into our genomes and account for up to 8% of human DNA.

关键词： endogenous inflammation Human

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Nucleoside modified mRNA-lipid nanoparticles as a new delivery platform for the repair of the injured spinal cord

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Neural Regeneration Research 2025年第8期20卷 2311-2312页

作者： krisztián Pajer Tamás Bellák Antal Nógrádi Department of Anatomy Histology and EmbryologyAlbert Szent-Györgyi Medical SchoolUniversity of SzegedSzegedHungary

Spinal cord injury and treatment opportunities:The adult mammalian spinal cord has a very limited capacity for spontaneous regeneration due to various intrinsic molecular and cellular *** the spinal cord neurons have the capacity to regenerate their axons,the expression of growth inhibitory factors,lack or suppression of proper guidance cues,and profound inflammatory responses do not permit successful regeneration(khyeam et al.,2021).

关键词： injured capacity modified

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Organics in the solar system

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Research in Astronomy and Astrophysics 2019年第4期19卷 1-6页

作者： Sun kwok Laboratory for Space Research The University of Hong Kong Department of Earth Oceanand Atmospheric SciencesUniversity of British ColumbiaVancouver

Complex organics are now commonly found in meteorites, comets, asteroids, planetary satellites and interplanetary dust particles. The chemical composition and possible origin of these organics are presented. Specifically, we discuss the possible link between Solar System organics and the complex organics synthesized during the late stages of stellar evolution. Implications of extraterrestrial organics on the origin of life on Earth and the possibility of existence of primordial organics on Earth are also discussed.

关键词： meteorites organics stellar evolution origin of life

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Laser Surface Modification of Lean-alloyed Austenitic Stainless Steel for Corrosion Resistance

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腐蚀与防护 2012年第S1期33卷 55-61页

作者： Chan w k kwok C T Chan M C Lo k H University of Macao Av.Padre Tomás Pereira Taipa Macao China

In order to reduce the cost of the austenitic stainless steels(ASSs),the expensive austenite former(nickel) is often substituted by ***,manganese is generally seen to have a detrimental effect on the corrosion *** the present study,the feasibility of laser surface modification of a lean-alloyed ASS(FeCrMn) for enhancing pitting corrosion resistance was *** surface modification of FeCrMn was successfully achieved by a 2.3 kw high power diode laser(HPDL).Cyclic polarization tests for FeCrMn after laser surface modification in 3.5% NaCl solution at 25 ℃ were performed by using a *** pitting resistance of the laser-modified specimens was found to be significantly improved as reflected by the noble shift in pitting *** could be attributed to redistribution of manganese sulphide leading to a more homogenous and refined *** corrosion resistance of the laser-treated FeCrMn followed by subsequent citric acid passivation was found to be further improved as reflected by the noble shift in pitting potential to 0.18 V.

关键词： laser surface melting HPDL lean-alloyed austenite stainless steel pitting corrosion citric acid passivation

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Risk of stroke after acute myocardial infarction among Chinese

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Chinese Medical Journal 2001年第2期114卷 98-99页

作者： Ping-wingNG wai-kwongCHAN Patrick kwok-Leung k wAN Department of Medicine and Geriatrics United Christian Hospital Hong Kong China

Following an acute myocardial infarction (AMI), patients have an increased risk of stroke. Estimates of risk are mainly derived from AMI treatment trials or secondary prevention studies. The reported incidence of stroke in Caucasians in the early phase after AMI ranged from 0.5% to 2.5%.1-3 Similar assessment of risk in the Chinese population is lacking. As thrombolytic therapy becomes standard treatment for AMI, there is concern that there may be an increase in haemorrhagic stroke complicating AMI treatment, especially since haemorrhagic stroke is more common in Asian populations.

关键词： Aged Cerebrovascular Accident China Female Humans Male Myocardial Infarction Risk Factors

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A GENERALIZATION OF BOYD’S INTERPOLATION THEOREM

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Acta Mathematica Scientia 2021年第4期41卷 1263-1274页

作者： kwok-Pun HO Department of Mathematics and Information Technology the Education University of Hong KongHong KongChina

Boyd^interpolation theorem for quasilinear operators is generalized in this paper,which gives a generalization for both the Marcinkiewicz interpolation theorem and Boyd^interpolation *** using this new interpolation theorem,we study the spherical fractional maximal functions and the fractional maximal commutators on rearrangement-invariant quasi-Banach function *** particular,we obtain the mapping properties of the spherical fractional maximal functions and the fractional maximal commutators on generalized Lorentz spaces.

关键词： Interpolation of operator quasilinear operator rearrangement-invariant function space spherical fractional maximal function fractional maximal commutator generalized Lorentz space

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