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Gut commensal metabolite rhamnose promotes macrophages phagocytosis by activating SLC12A4 and protects against sepsis in mice

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Acta Pharmaceutica Sinica B 2024年第7期14卷 3068-3085页

作者： Dongping Li Rongjuan Wei Xianglong Zhang Shenhai Gong Meijuan Wan Fangzhao Wang Jiaxin Li Meiling Chen Ruofan Liu Yantong Wan Yinghao Hong Zhenhua Zeng Peng Gu Zhang Wang kutty selva Nandakumar Yong Jiang Hongwei Zhou Peng Chen Department of Pathophysiology Guangdong Provincial Key Laboratory of ProteomicsSchool of Basic Medical SciencesSouthern Medical UniversityGuangzhou 510000China Department of Critical Care Medicine Nanfang HospitalSouthern Medical UniversityGuangzhou 510000China Department of Gastroenterology Shenzhen HospitalSouthern Medical UniversityShenzhen 518000China Institute of Ecological Sciences School of Life SciencesSouth China Normal UniversityGuangzhou 510000China Department of Environmental and Biosciences School of BusinessInnovation and SustainabilityKristian IV’s vag 3Halmstad UniversityHalmstad 30004Sweden Microbiome Medicine Center Zhujiang HospitalSouthern Medical UniversityGuangzhou 510000China

Sepsis progression is significantly associated with the disruption of gut ***,the modulatory mechanisms of gut microbiota operating during sepsis are still ***,we investigated how gut commensals impact sepsis development in a pre-clinical *** ligation and puncture(CLP)surgery was used to establish polymicrobial sepsis in *** depleted of gut microbiota by an antibiotic cocktail(ABX)exhibited a significantly higher level of mortality than *** determined by metabolomics analysis,ABX treatment has depleted many metabolites,and subsequent supplementation with L-rhamnose(rhamnose,Rha),a bacterial carbohydrate metabolite,exerted profound immunomodulatory properties with a significant enhancement in macrophage phagocytosis,which in turn improved organ damage and ***,rhamnose binds directly to and activates the solute carrier family 12(potassium-chloride symporter),member 4(SLC12A4)in macrophages and promotes phagocytosis by activating the small G-proteins,Ras-related C3 botulinum toxin substrate1(Rac1)and cell division control protein 42 homolog(Cdc42).Interestingly,rhamnose has enhanced the phagocytosis capacity of macrophages from sepsis *** conclusion,by identifying SLC12A4 as the host interacting protein,we disclosed that the gut commensal metabolite rhamnose is a functional molecular that could promote the phagocytosis capacity of macrophages and protect the host against sepsis.

关键词： Gut microbiota Sepsis Rhamnose SLC12A4 GTP-Rac1 GTP-Cdc42 Macrophage Phagocytosis

Effect of Plastic Deformation on Magnetic Properties of Fe-40%Ni-2%Mn Austenitic Alloy

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Journal of Iron and Steel Research International 2007年第4期14卷 56-60页

作者： selva Büyükakka■ H Aktas S Akturk Physics Department Nigde UniversityNigde 51100NigdeTurkey Physics Department Kirikkale UniversityYahsihan 71450KirikkaleTurkey

The effects of plastic deformation on the magnetic properties of austenite structure in an Fe-40% Ni-2 % Mn alloy is investigated by using Mossbauer spectroscopy and Differential Scanning Calorimetry （DSC） techniques The morphology of the alloy has been obtained by using Scanning Electron Microscopy （SEM）. The magnetic behaviour of austenite state is ferromagnetic. After plastic deformation, a mixed magnetic structure including both paramagnet- ic and ferromagnetic states has been obtained at the room temperature. The volume fraction changes, the effective hyperfine fields of the ferromagnetic austenite phase and isomery shift values have also been determined by Mossbauer spectroscopy. The Curie point （Tc） and the Neel temperature （TN） have been investigated by means of DSC system for non-deformed and deformed Fe-Ni-Mn alloy. The plastic deformation of the alloy reduces the TN and enhances the paramagnetic character of austenitic Fe-Ni-Mn alloy.

关键词： Mossbauer spectroscopy differential scanning calorimetry (DSC) scanning electron microscopy (SEM) plastic deformation magnetically ordered material ferromagnetic austenite

Autophagy induced by STING, an unnoticed and primordial function of cGAS

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Cellular & Molecular Immunology 2019年第8期16卷 683-684页

作者： Junjie Yang Xiaoshan Tang kutty selva Nandakumar kui Cheng Guangdong Provincial key Laboratory of New Drug Screening and Guangzhou key Laboratory of Drug Research for Emerging Virus Prevention and Treatment School of Pharmaceutical SciencesSouthern Medical UniversityGuangzhou 510515China

Cyclic GMP-AMP synthase(cGAS),combined with dsDNA,produces cyclic GMP-AMP(cGAMP)to stimulate STING and activates the kinases TBk1 and Ikk to induce interferon and other cytokines,which play an important role in host *** addition to the traditional interferon inflammatory signaling pathway of cGAS,recently,Chen et al.1 discovered a new mechanism in which cGAS-cGAMP-STING activated autophagy through WIPI2 and *** is a process induced under various cellular stress conditions,such as oxygen deficit,nutrient deprivation,lack of growth factors,and infection,aiming to maintain the basic survival of cells or promote apoptosis of senescent cells.2,3 The activation of the autophagy-related(ATG)1/Unc-51-like kinase(ULk)complex is vital for autophagy *** ATG1/ULk1 complex phosphorylates or recruits its downstream proteins,contributing to autophagosome formation.3 Under the regulation of related genes,“cargo”is transferred to the lysosome and digested by various *** addition,cyclic GMP-AMP synthase(cGAS),which detects exogenous or self-damaged dsDNA in the cytoplasm after binding to dsDNA,produces cGAMP to activate the adaptor protein stimulator of interferon genes(STING),triggering the downstream pathway and secretion of interferon or other cytokines.

关键词： maintain transferred STING

Ellagic acid in strawberry(Fragaria spp.):Biological,technological,stability,and human health aspects

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Food Quality and Safety 2017年第4期1卷 227-252页

作者： selva Muthukumaran Carole Tranchant John Shi Xingqian Ye Sophia Jun Xue Department of Food Science and Post-Harvest Technology Institute of TechnologyHaramaya UniversityPost Box 138Dire DawaEthiopia School of Food Science Nutrition and Family StudiesFaculty of Health Sciences and Community ServicesUniversitéde MonctonMonctonNew Brunswick E1A 3E9Canada***Guelph Research and Development CenterAgriculture and Agri-Food Canada93 Stone Road WestGuelphOntario N1G 5C9Canada School of Biosystems Engineering and Food Science Zhejiang UniversityHangzhouChina

Ellagic acid(EA)is one of the plant phenolics associated with human health *** derives from ellagitannins found in some nuts,seeds,and fruits,especially *** are considered a functional food and nutraceutical source,mainly because of their high concentration of EA and its *** review presents the current state of knowledge regarding EA,focusing on its content in strawberry plants,stability during processing and storage of strawberry-based foods,production methods,and relevance to human *** alternatives to acid-solvent extraction,fermentation-enzymatic bioprocesses hold great promises for more eco-efficient production of EA from plant *** fruits are generally rich in EA,with large variations depending on cultivar,growth conditions and maturity at *** EA contents are also reported in strawberry achenes and leaves,and in wild *** postharvest storage,processing and subsequent storage can influence EA *** low concentration in strawberry juice and wine can be increased by incorporating pre-treated *** recognition of strawberries as functional foods is substantiated by evidence of EA biological effects,including antioxidant,antiinflammatory,antidiabetic,cardioprotective,neuroprotective,and prebiotic *** health benefits attributed to EA-rich foods are thought to involve various protective mechanisms at the cellular *** EA is converted by the intestinal microbiota to urolithins,which are better absorbed than EA and may contribute significantly to the health effects attributed to EA-rich *** on the evidence available,strawberry EA shows strong promises for functional,nutraceutical,and pharmaceutical *** research should be directed at quantifying EA in different parts of the strawberry plant and in their byproducts;optimizing EA production from byproducts;understanding the biological actions of EA-derived metabolites in vivo,inc

关键词： Strawberry plant Ellagic acid Processing Metabolism Bioacti

Studies on the seasonal variations in the proximate composition of ascidians from the Palk Bay,Southeast coast of India

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Asian Pacific Journal of Tropical Biomedicine 2012年第10期2卷 793-797页

作者： Ananthan G karthikeyan MM selva Prabhu A Raghunathan C Centre of Advanced Study in Marine Biology Faculty of Marine SciencesAnnamalai University Zoological Survey of India Andaman and NicobarRegional Station.1Horticulture RoadHaddoPort Blair744102

Objective:To investigate the seasonal fluctuations of the proximate composition of the ascidians ***:The moisture content was estimated by drying 1 g of fresh tissue at a constant temperature at 105(?)for 24 *** loss of weight was taken as moisture *** total protein was estimated using the Biuret *** total carbohydrate in dried sample was estimated spectrophotometrically following the phenol-sulphuric acid *** lipid in the dried sample tissue was gravimetrically estimated following the chloroform-methanol mixture *** content was determined gravimetrically by incinerating 1 g dried sample in muffle furnace at about 550℃for 6 h and results are expressed in ***:It was found very difficult to compare the monthly variations,as all the ten species,exhibited wide fluctuations in their proximate *** the sake of convenience,average seasonal values were calculated by summing the monthly ***:The proximate composition of the 10 commonly available ascidians showed high nutritive value and hence these groups especially solitary ascidians can be recommended for human consumption in terms of pickles,soup,curry and others after ensuring the safety of consumers.

关键词： Ascidians Biochemical composition Seasonal variations proximate composition

Periocular necrotising fasciitis after traumatic laceration and concurrent COVID-19 infection:a case report

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Annals of Eye Science 2023年第1期8卷 3-7页

作者： Terence Ang Thomas Rogerson Thilochana Nagolla Yugesh Caplash Dinesh selva The University of Adelaide AdelaideSouth AustraliaAustralia Department of Ophthalmology The Royal Adelaide HospitalAdelaideSouth AustraliaAustralia Department of Plastic and Reconstructive Surgery Royal Adelaide HospitalAdelaideSouth AustraliaAustralia

Background:Necrotising fasciitis(NF)is a rare but severe necrotising infection of the subcutaneous *** report a case of periocular NF associated with a concurrent COVID-19 infection and explore potential mechanisms of pathogenesis of COVID-19 infection and necrotising *** Description:A 33-year-old previously healthy female presented with right-sided progressive periocular swelling,erythema,pain and fever,two days after sustaining a laceration to the right superolateral brow from a clenched *** had a concurrent COVID-19 infection,detected on nasopharyngeal polymerase chain reaction swab thirteen days prior to presentation and again at *** did not have an oxygen *** was a large bulbous collection of the right upper lid with fluctuance and overlying erythema,and a communicating sinus drained frank pus from the superolateral ***-operative T2-weighted MRI demonstrated fascial hyperintensity involving the pre-septal tissues and extending to the anterior temporal *** was commenced on intravenous meropenem,clindamycin and vancomycin,and underwent early surgical *** debridement demonstrated right upper lid necrosis involving the dermal and pre-septal layers,including the orbicularis,but sparing the *** pyogenes was isolated,and she was continued on a prolonged course of intravenous *** defects were repaired with a right-sided brow adipo-fascial flap based on the supratrochlear artery,browpexy and dual full thickness skin grafts on the right upper lid and ***:NF is an acute fulminant infection rarely affecting the periocular *** represents a unique case of periocular NF associated with a concurrent COVID-19 infection.

关键词： Necrotising fasciitis(NF) periocular COVID-19 infection case report

Antiproliferative role of Indig ofera aspalathoides on 20 methylcholanthrene induced fibrosarcoma in rats

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Asian Pacific Journal of Tropical Biomedicine 2012年第12期2卷 966-974页

作者： Sivagnanam selva kumar Mudiganti Ram krishna Rao Maruthaiveeran Periyasamy Balasubramanian Department of Industrial Biotechnology Bharath University Department of Pharmacology and Environmental Toxicology Dr.A.L.M.Post graduate Institute of Basic Medical SciencesUniversity of Madras

Objective:To find out the anticancer effect of indigofera aspalathoides(***)on20-methylcholanthrene induced fibrosarcoma in ***:Fibrosarcoma was induced in Wistar strain male albino rats by ***(i.p.)administration of250 mg/kg body weight/day of aqueous extract of *** for 30 d effectively suppressed chemically induced *** such as body weight,liver and kidney weight,tumor weight,mean survival time,behavioral changes,blood glucose,blood glycogen and marker enzymes such as alanine aminotransferase(ALT),aspartate aminotransferase(AST),alkaline phosphatase(ALP),acid phosphatase(ACP)and 5'-nucleiotidase(5'-NT)in serum,liver and kidney and lipid profiles such as total cholesterel,phospholipids,free fatty acids in liver and kidney of control and experimental animals were ***:Fibrosarcoma bearing animals were ferocious and *** mean survival time was found to increase after the *** body weights were significantly decreased(Pkidney weights were significantly increased whereas the tumor weights decreased as compared to the weights in untreated fibrosarcoma bearing *** blood glucose and the liver and kidney glycogen levels were found to decrease significantly(Pker enzymes were observed in serum,liver and kidney of fibrosarcoma bearing GroupⅡanimals which were normalize after *** *** the liver and kidney of GroupⅡanimals the total cholesterol increased whereas the pbospbolipids and free fatty acid levels decreased(P<0.001)which were normalized after ***:The treatment by *** on fihrosarcoma bearing rats has improved the levels of various parameters indicating its antiproliferative and anticancer activity.

关键词： Chemoprevention Tumor weight Mean survival time Glucose Glycogen Marker enzymes

Simultaneous colorectal and parenchymal-sparing liver resection for advanced colorectal carcinoma with synchronous liver metastases:Between conventional and mini-invasive approaches

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World Journal of Gastroenterology 2020年第42期26卷 6529-6555页

作者： Emilio De Raffele Mariateresa Mirarchi Dajana Cuicchi Ferdinando Lecce Riccardo Casadei Claudio Ricci Saverio selva Francesco Minni Division of Pancreatic Surgery Department of Digestive DiseasesAzienda Ospedaliero-Universitaria di BolognaPoliclinico S.Orsola-Malpighi40138 BolognaItaly Dipartimento Strutturale Chirurgico Ospedale SS Antonio e Margherita15057 Tortona(AL)Italy Surgery of the Alimentary Tract Department of Digestive DiseasesAzienda Ospedaliero-Universitaria di BolognaPoliclinico S.Orsola-Malpighi40138 BolognaItaly Division of Pancreatic Surgery Department of Medical and Surgical Sciences(DIMEC)Alma Mater StudiorumUniversity of Bologna40138 BolognaItaly

The optimal timing of surgery in case of synchronous presentation of colorectal cancer and liver metastases is still under *** approach,with initial colorectal resection followed by liver resection(LR),or even the reverse,liver-first approach in specific situations,is traditionally *** resections,however,represent an appealing strategy,because may have perioperative risks comparable to staged resections in appropriately selected patients,while avoiding a second surgical *** patients with larger or multiple synchronous presentation of colorectal cancer and liver metastases,simultaneous major hepatectomies may determine worse perioperative outcomes,so that parenchymal-sparing LR should represent the most appropriate option whenever ***-invasive colorectal surgery has experienced rapid spread in the last decades,while laparoscopic LR has progressed much slower,and is usually reserved for limited tumours in favourable ***,mini-invasive parenchymal-sparing LR is more complex,especially for larger or multiple tumours in difficult *** remains to be established if simultaneous resections are presently feasible with mini-invasive approaches or if we need further technological advances and surgical expertise,at least for more complex *** review aims to critically analyze the current status and future perspectives of simultaneous resections,and the present role of the available miniinvasive techniques.

关键词： Synchronous colorectal liver metastases Colorectal surgery Liver surgery Simultaneous resection Parenchymal-sparing liver resection Mini-invasive surgery Intraoperative ultrasonography

Small molecule SMU-CX24 targeting toll-like receptor 3 counteracts inflammation:A novel approach to atherosclerosis therapy

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Acta Pharmaceutica Sinica B 2022年第9期12卷 3667-3681页

作者： Xiaohong Cen Baoqu Wang Yuqing Liang Yanlin Chen Yu Xiao Shaohua Du kutty selva Nandakumar Hang Yin Shuwen Liu kui Cheng Guangdong Provincial key Laboratory of New Drug Screening and State key Laboratory of Organ Failure Research School of Pharmaceutical SciencesSouthern Medical UniversityGuangzhou 510515China Department of Musculoskeletal Oncology the Third Affiliated Hospital of Southern Medical UniversityGuangzhou 510642China School of Pharmaceutical Sciences Beijing Advanced Innovation Center for Structural BiologyTsinghua-Peking Joint Center for Life SciencesTsinghua UniversityBeijing 100084China

Toll-like receptor 3(TLR3),as an important pattern recognition receptor(PRR),dominates the innate and adaptive immunity regulating many acute and chronic inflammatory *** is proved as an inflammatory disease,and inflammatory events involved in the entire process of initiation and ***,the contribution of TLR3 to atherosclerosis remains ***,we identified the clinical relevance of TLR3 upregulation and disease processes in human ***,activation of TLR3 also directly led to significant expression of atherogenic chemokines and adhesion ***,silencing TLR3 inhibited the uptake of oxLDL by macrophages and significantly reduced foam cell *** the aberrance in TLR3 functions on atherosclerosis progression,we hypothesized that TLR3 could serve as novel target for clinical atherosclerosis ***,we developed the novel ellipticine derivative SMU-CX24,which specifically inhibited TLR3(IC_(50)=18.87±2.21 nmol/L).In vivo,atherosclerotic burden was alleviated in Western diet fed ApoE^(−/−)mice in response to SMU-CX24 treatment,accompanying notable reductions in TLR3 expression and inflammation infiltration within atherosclerotic ***,for the first time,we revealed that pharmacological downregulation of TLR3 with specific inhibitor regenerated inflammatory environment to counteract atherosclerosis progression,thereby proposing a new strategy and probe for atherosclerosis therapy.

关键词： Toll-like receptor 3 Atherosclerosis Small molecule Inflammation Macrophage