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SARS-CoV-2 spike protein-ACe2 interaction increases carbohydrate sulfotransferases and reduces N-acetylgalactosamine-4-sulfatase by p38 MAPk

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Signal Transduction and Targeted Therapy 2024年第3期9卷 1174-1185页

作者： Sumit Bhattacharyya Joanne k.Tobacman Jesse Brown VA Medical Center and University of Illinois at Chicago ChicagoIL 60612USA

Immunostaining in lungs of patients who died with CovID-19 infection showed increased intensity and distribution of chondroitin sulfate and decline in N-acetylgalactostamine-4-sulfatase(Arylsulfatase B;ARSB).To explain these findings,human small airway epithelial cells were exposed to the SARS-CoV-2 spike protein receptor binding domain(SPRBD)and transcriptional mechanisms were ***-p38 MAPk and phospho-SMAD3 increased following exposure to the SPRBD,and their inhibition suppressed the promoter activation of the carbohydrate sulfotransferases CHST15 and CHST11,which contributed to chondroitin sulfate *** in ARSB was mediated by phospho-38 MAPk-induced N-terminal Rb phosphorylation and an associated increase in Rb-e2F1 binding and decline in e2F1 binding to the ARSB *** increases in chondroitin sulfotransferases were inhibited when treated with phospho-p38-MAPk inhibitors,SMAD3(SIS3)inhibitors,as well as antihistamine desloratadine and antibiotic *** the mouse model of carrageenan-induced systemic inflammation,increases in phosphop38 MAPk and expression of CHST15 and CHST11 and declines in DNA-e2F binding and ARSB expression occurred in the lung,similar to theobserved effects in this SPRBD model of COVID-19 *** accumulation of chondroitin sulfates is associated with fibrotic lung conditions and diffuse alveolar damage,increased attention to p38-MAPk inhibition may be beneficial in amelioratingCovid-19infections.

关键词： ACe2 lung inhibited

No effect of invasive tree species on aboveground biomass increments of oaks and pines in temperate forests

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Forest ecosystems 2024年第4期11卷 401-413页

作者： Sebastian Bury Marcin k.Dyderski Institute of Dendrology Polish Academy of SciencesParkowa 562-035 KornikPoland

Prunus serotina and Robinia pseudoacacia are the most widespread invasive trees in Central *** addition,according to climate models,decreased growth of many economically and ecologically important native trees will likely be observed in the *** aimed to assess the impact of these two neophytes,which differ in the biomass range and nitrogen-fixing abilities observed in Central european conditions,on the relative aboveground biomass increments of native oaks Qucrcus robur and *** and Scots pine Pinus *** aimed to increase our understanding of the relationship between facilitation and competition between woody alien species and overstory native *** established 72 circular plots(0.05 ha)in two different forest habitat types and stands varying in age in western *** chose plots with different abundances of the studied neophytes to determine how effects scaled along the quantitative invasion ***,we collected growth cores of the studied native species,and we calculated aboveground biomass increments at the tree and stand ***,we used generalized linear mixed-effects models to assess the impact of invasive species abundances on relative aboveground biomass increments of native tree *** did not find a biologically or statistically significant impact of invasive *** or *** on the relative aboveground,biomass increments of native oaks and pines along the quantitative gradient of invader biomass or on the proportion of total stand biomass accounted for by *** neophytes did not act as native tree growth stimulators but also did not compete with them for resources,which would escalate the negative impact of climate change on pines and *** neophytes should not significantly modify the carbon sequestration capacity of the native *** work combines elements of the per capita effect of invasion with research on mixed forest management.

关键词： Invasion ecology exotic trees Relative aboveground biomass increment Competition Facilitation Carbon sequestration

Process engineering of demineralisation of moderate to high ash Indian coals through NaOH‑HCl leaching and HF leaching

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International Journal of Coal Science & Technology 2024年第2期11卷 111-122页

作者： Heena Dhawan D.k.Sharma ANRF Ministry of ScienceNew DelhiIndia Department of energy Science and engineering Indian Institute of Technology DelhiNew Delhi 110016India

Chemical leaching of coals would be required to produce cleaner coals for some special applications where physical benefi-ciation may not be effective *** would also help in recovering Li and rare earth metals besides in the sequestration of CO_(2).About 20 Indian coals having complexly distributed moderate to high ash contents were sequentially treated with various alkali–acid such as NaOH-HCl,HF,HCl,HCl-HF,and NaOH-HCl-HF *** aimed to establish and design the best stepwise sequential process for the highest degree of demineralisation through a chemical leaching *** and process intensification studies were carried *** than 80%demineralisation of Madhaipur and Neemcha coals was observed using the best sequential treatment designed *** repeated stepwise treatment of the alkali and the acid was also studied,which was found to significantly enhance the degree of demineralisation of *** integrated process of alkali–acid leaching followed by solvent extraction(Organo-refining)and vice versa of the treated coal was also studied for producing cleaner coals.

关键词： Alkali–acid leaching Demineralisation Integrated process Rare earth elements

Self-Triggered Set Stabilization of Boolean Control Networks and Its Applications

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Ieee/CAA Journal of Automatica Sinica 2024年第7期11卷 1631-1642页

作者： Rong Zhao Jun-e Feng Dawei Zhang the School of Mathematics Shandong UniversityShandong UniversityJinan 250100China

Set stabilization is one of the essential problems in engineering systems, and self-triggered control(STC) can save the storage space for interactive information, and can be successfully applied in networked control systems with limited communication resources. In this study, the set stabilization problem and STC design of Boolean control networks are investigated via the semi-tensor product technique. On the one hand, the largest control invariant subset is calculated in terms of the strongly connected components of the state transition graph, by which a graph-theoretical condition for set stabilization is derived. On the other hand, a characteristic function is exploited to determine the triggering mechanism and feasible controls. Based on this, the minimum-time and minimum-triggering open-loop, state-feedback and output-feedback STCs for set stabilization are designed,respectively. As classic applications of self-triggered set stabilization, self-triggered synchronization, self-triggered output tracking and self-triggered output regulation are discussed as well. Additionally, several practical examples are given to illustrate the effectiveness of theoretical results.

关键词： Boolean control networks(BCNs) output regulation self-triggered control semi-tensor product of matrices set stabilization synchronization

Nonlinear wave dispersion in monoatomic chains with lumped and distributed masses:discrete and continuum models

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Applied Mathematics and Mechanics(english edition) 2024年第4期45卷 633-648页

作者： e.GHAVANLOO S.eL-BORGI School of Mechanical engineering Shiraz UniversityShiraz 71963-16548Iran Mechanical engineering Program Texas A&M University at QatarDoha 23874Qatar

The main objective of this paper is to investigate the influence of inertia of nonlinear springs on the dispersion behavior of discrete monoatomic chains with lumped and distributed *** developed model can represent the wave propagation problem in a non-homogeneous material consisting of heavy inclusions embedded in a *** inclusions are idealized by lumped masses,and the matrix between adjacent inclusions is modeled by a nonlinear spring with distributed ***,the model is capable of depicting the wave propagation in bi-material bars,wherein the first material is represented by a rigid particle and the second one is represented by a nonlinear spring with distributed *** discrete model of the nonlinear monoatomic chain with lumped and distributed masses is first considered,and a closed-form expression of the dispersion relation is obtained by the second-order Lindstedt-Poincare method(LPM).Next,a continuum model for the nonlinear monoatomic chain is derived directly from its discrete lattice model by a suitable continualization *** subsequent use of the second-order method of multiple scales(MMS)facilitates the derivation of the corresponding nonlinear dispersion relation in a closed *** novelties of the present study consist of(i)considering the inertia of nonlinear springs on the dispersion behavior of the discrete mass-spring chains;(ii)developing the second-order LPM for the wave propagation in the discrete chains;and(iii)deriving a continuum model for the nonlinear monoatomic chains with lumped and distributed ***,a parametric study is conducted to examine the effects of the design parameters and the distributed spring mass on the nonlinear dispersion relations and phase velocities obtained from both the discrete and continuum *** parameters include the ratio of the spring mass to the lumped mass,the nonlinear stiffness coefficient of the spring,and the wave amplitude.

关键词： nonlinear mass-spring chain discrete model continuum model LindstedtPoincare method(LPM) method of multiple scales(MMS) dispersion phase velocity

Annual variation of adult survival of a south-temperate House Wren population in Argentina

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Avian Research 2024年第2期15卷 229-237页

作者： Gustavo J.Fernandez Mariana e.Carro Paulo e.Llambías Grupo de Investigacion en ecofisiología de Fauna Silvestre INIBIOMA-CONICETAsentamiento Universitario San Martín de los Andes(AUSMA)Universidad Nacional Del ComahuePasaje de la Paz 235(8370)San Martín de los AndesNeuquenArgentina Grupo de Investigacion de Biología de Aves IADIZA CCT-MendozaUniversidad Nacional de CuyoAvenida RuizLeal s/n Parque General San Martin5500MendozaArgentina

Identifying factors affecting the survival of individuals is essential for understanding the evolution of life-history traits and population *** numerous studies on this subject in north-temperate environments,there is a lack of equivalent studies at similar latitudes in the ***,we used a 14-year dataset of capture,banding,and resighting to estimate the annual variation in the apparent adult survival probability of a south-temperate population of House Wrens(Troglodytes aedon bonariae).We evaluated temporal variation in sur-vival and the effect of environmental(climatic)and demographic variables(adult abundance,total number of fledglings produced during each breeding season)on survival *** found that the probability of adult survival decreased as the abundance of breeding adults *** density-dependent effect could be related to the resident lifestyle of southern House Wrens,which could determine an intense competition for territories and resources that ultimately would affect their survival.

关键词： Annual variation CJS Density-dependence Survival Troglodytes aedon bonariae

Commentary on“Incidence of urinary incontinence following endoscopic laser enucleation of the prostate by en-bloc and non-en-bloc techniques:a multicenter,real-world experience of 5068 patients”

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Asian Journal of Andrology 2024年第3期26卷 333-334页

作者： James F Jiang Narmina k Onder Akhil k Das Department of Urology University of California Irvine Orange CA 92868 USA.

Laser enucleation of the prostate is a proven and effectivesize-independent method for the surgical management of symptomaticbenign prostatic hyperplasia(BPH)and is considered as the“goldstandard”by many *** major hurdles that stand in theway of this becoming a universally used procedure for BPH are thesteep learning curve associated with mastering the procedure andpossibility of perioperative transient *** advances inteaching methodologies have helped tackle the difficulty in learning itand increased the number of urologists utilizing the *** forthe second hurdle,transient incontinence rates postlaser enucleationof the prostate have improved with the advent of newer techniques *** et al.1 assesses the incidence of stress,urge,andmixed urinary incontinence following laser enucleation of the prostateby comparing en-bloc and non-en-bloc techniques in a multicenterseries of 5068 men with BPH.

关键词： urinary incontinence transient

Beyond p-y method:A review of artificial intelligence approaches for predicting lateral capacity of drilled shafts in clayey soils

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Journal of Rock Mechanics and Geotechnical engineering 2024年第9期16卷 3812-3840页

作者： M.e.Al-Atroush A.e.Aboelela ezz el-Din Hemdan Civil and environmental engineering Program Engineering Management DepartmentCollege of EngineeringPrince Sultan UniversityRiyadhSaudi Arabia Department of Structural engineering Faculty of EngineeringAin Shams UniversityCairoEgypt Structure and Materials Research Lab Prince Sultan UniversityRiyadhSaudi Arabia Computer Science and engineering Department Faculty of Electronic EngineeringMenoufia UniversityMenoufiaEgypt

In 2023,pivotal advancements in artificial intelligence(AI)have significantly *** that in mind,traditional methodologies,notably the p-y approach,have struggled to accurately model the complex,nonlinear soil-structure interactions of laterally loaded large-diameter drilled *** study undertakes a rigorous evaluation of machine learning(ML)and deep learning(DL)techniques,offering a comprehensive review of their application in addressing this geotechnical challenge.A thorough review and comparative analysis have been carried out to investigate various AI models such as artificial neural networks(ANNs),relevance vector machines(RVMs),and least squares support vector machines(LSSVMs).It was found that despite ML approaches outperforming classic methods in predicting the lateral behavior of piles,their‘black box'nature and reliance only on a data-driven approach made their results showcase statistical robustness rather than clear geotechnical insights,a fact underscored by the mathematical equations derived from these ***,the research identified a gap in the availability of drilled shaft datasets,limiting the extendibility of current findings to large-diameter *** extensive dataset,compiled from a series of lateral loading tests on free-head drilled shaft with varying properties and geometries,was introduced to bridge this *** paper concluded with a direction for future research,proposes the integration of physics-informed neural networks(PINNs),combining data-driven models with fundamental geotechnical principles to improve both the interpretability and predictive accuracy of AI applications in geotechnical engineering,marking a novel contribution to the field.

关键词： Laterally loaded drilled shaft load transfer and failure mechanisms Physics-informed neural networks(PINNs) P-y curves Artificial intelligence(AI) Dataset

Liquid superlubricity of lubricants containing hydroxyl groups and their aqueous solution under rolling/sliding conditions

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Friction 2024年第1期12卷 164-173页

作者： Tomáš POLÁČek Petr ŠPeRkA Ivan kŘUPkA Faculty of Mechanical engineering Brno University of TechnologyBrno 61669Czech Republic

Macroscale rolling/sliding conditions are in the superlubricity,a little-studied topic so *** purpose of this paper is to examine the formation of elastohydrodynamic lubrication(eHL)films by water-based lubricants(glycerol and polyethylene glycol(PeG)),providing superlubricous *** were carried out on an optical ball-on-disc tribometer under rolling/sliding *** film thickness was measured by the thin film colorimetric interferometry,and the viscosity of liquids was measured by rotational and high-pressure falling body *** results show that tribochemical reactions are not the mandatory reason for friction to reach the superlubricity level when using the water-based *** studied liquids themselves are almost *** the addition of water,the signs of shear thinning behavior disappear even *** conditions for this type of lubricant can be predicted using the known Hamrock–Dowson *** anomaly in the thickness of the lubricants was observed as an abrupt change at certain *** more PeG there is in the lubricant,the higher the thickness at the beginning of the jump.

关键词： macroscale superlubricity super low traction water-based lubricants elastohydrodynamic lubrication(eHL) film thickness