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Continuous segregation of binary heterogeneous solids in a fast-fluidized bed

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Particuology 2017年第6期15卷 101-107页

作者： M. Prasad Babu P.S.T. Sai k. krishnaiah Department of Chemical Engineering Indian Institute of Technology Madras Chennai 600 036 India

Continuous segregation of binary heterogeneous solids （different density mixtures） is carried out in a gas-solid fluidized bed to study the effects of gas velocity, solids feed rate, feed composition and density difference of solids on the separation factor （recovery of flotsam at top outlet） and the quality of the product （purity of flotsam at top outlet） in a continuous fast-fluidized bed. The holdup of the bed material is obtained in each experimental run. It is observed that the separation factor decreases with increase in solids feed rate or density difference of solids, and increases with gas velocity or proportion of flotsam in the feed. The quality of the product decreases with increase in gas velocity or solids flow rate, and increases with feed composition or density difference of solids. The experimental results show that the separation factor and the quality of the product are more sensitive to gas velocity than to other operating parameters, Empirical correlations for predicting the separation factor and quality of the product are proposed based on the Richards model for individual flotsam mass fraction in the feed, and the predictions agree satisfactorily with the present exlgerimental data,

关键词： Fast-fluidized bed Gas-solid Continuous segregation Heterogeneous solids Solids holdup

Some hydrodynamic aspects of 3-phase inverse fluidized bed

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China Particuology 2007年第5期5卷 351-356页

作者： k.ishna S.V.S.R. Bandaru D.V.S. Murthy k. krishnaiah Department of Chemical Engineering Indian Institute of Technology Madras

Hydrodynamics of 3-phase inverse fluidized bed is studied experimentally using low density particles for different liquid and gas velocities. The hydrodynamic characteristics studied include pressure drop, minimum liquid and gas fluidization velocities and phase holdups. The minimum liquid fluidization velocity determined using the bed pressure gradient, decreases with increase in gas velocity. The axial profiles of phase holdups shows that the liquid holdup increases along the bed height, whereas the solid holdup decreases down the bed. However, the gas holdup is almost uniform in the bed.

关键词： Inverse fluidization Inverse fluidized bed Hydrodynamics Phase holdup Axial holdup

Intrumer:A Multi Module Distributed Explainable IDS/IPS for Securing Cloud Environment

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Computers, Materials & Continua 2025年第1期82卷 579-607页

作者： Nazreen Banu A S.k.B.Sangeetha Department of Computer Science and Engineering SRM Institute of Science and TechnologyVadapalani CampusChennai600026Tamil NaduIndia

The increasing use of cloud-based devices has reached the critical point of cybersecurity and unwanted network.*** environments pose significant challenges in maintaining privacy and *** approaches,such as IDS,have been developed to tack.e these ***,most conventional Intrusion Detection System(IDS)models struggle with unseen cyberattack. and complex high-dimensional *** fact,this paper introduces the idea of a novel distributed explainable and heterogeneous transformer-based intrusion detection system,named INTRUMER,which offers balanced accuracy,reliability,and security in cloud settings bymultiplemoduleswork.ng together within *** traffic captured from cloud devices is first passed to the TC&TM module in which the Falcon Optimization Algorithm optimizes the feature selection process,and Naie Bayes algorithm performs the classification of *** selected features are classified further and are forwarded to the Heterogeneous Attention Transformer(HAT)*** this module,the contextual interactions of the network.traffic are tak.n into account to classify them as normal or malicious *** classified results are further analyzed by the Explainable Prevention Module(XPM)to ensure trustworthiness by providing interpretable *** the explanations fromthe classifier,emergency alarms are transmitted to nearby IDSmodules,servers,and underlying cloud devices for the enhancement of preventive *** experiments on benchmark.IDS datasets CICIDS 2017,Honeypots,and NSL-k.D were conducted to demonstrate the efficiency of the INTRUMER model in detecting network.trafficwith high accuracy for different *** outperforms state-of-the-art approaches,obtaining better performance metrics:98.7%accuracy,97.5%precision,96.3%recall,and 97.8%*** results validate the robustness and effectiveness of INTRUMER in securing diverse cloud environments against sophisticated cyber threats.

关键词： Cloud computing intrusion detection system transformers and explainable artificial intelligence(XAI)

Effects of P301L-TAU on post-translational modifications of microtubules in human iPSC-derived cortical neurons and TAU transgenic mice

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Neural Regeneration Research 2025年第8期20卷 2348-2360页

作者： Mohamed Aghyad Al k.bbani Christoph k.hler Hans Zempel Institute of Human Genetics Faculty of Medicine and University Hospital CologneUniversity of CologneCologneGermany Center for Molecular Medicine Cologne(CMMC) University of CologneCologneGermany Center Anatomy Department ⅡMedical FacultyUniversity of CologneCologneGermany

TAU is a microtubule-associated protein that promotes microtubule assembly and stability in the *** is missorted and aggregated in an array of diseases k.own as *** are essential for neuronal function and regulated via a complex set of post-translational modifications,changes of which affect microtubule stability and dynamics,microtubule interaction with other proteins and cellular structures,and mediate recruitment of microtubule-severing *** impairment of microtubule dynamics causes neuronal dysfunction,we hypothesize cognitive impairment in human disease to be impacted by impairment of microtubule *** therefore aimed to study the effects of a disease-causing mutation of TAU(P301L)on the levels and localization of microtubule post-translational modifications indicative of microtubule stability and dynamics,to assess whether P301L-TAU causes stability-changing modifications to *** investigate TAU localization,phosphorylation,and effects on tubulin post-translational modifications,we expressed wild-type or P301L-TAU in human MAPT-k. induced pluripotent stem cell-derived neurons(i Neurons)and studied TAU in neurons in the hippocampus of mice transgenic for human P301L-TAU(p R5 mice).Human neurons expressing the longest TAU isoform(2N4R)with the P301L mutation showed increased TAU phosphorylation at the AT8,but not the p-Ser-262 epitope,and increased polyglutamylation and acetylation of microtubules compared with endogenous TAU-expressing neurons.P301L-TAU showed pronounced somatodendritic presence,but also successful axonal enrichment and a similar axodendritic distribution comparable to exogenously expressed 2N4R-wildtype-TAU.P301L-TAU-expressing hippocampal neurons in transgenic mice showed prominent missorting and tauopathy-typical AT8-phosphorylation of TAU and increased polyglutamylation,but reduced acetylation,of microtubules compared with non-transgenic *** sum,P301L-TAU results in changes in micr

关键词： human induced pluripotent stem cell microtubules P301L pR5 mice TAU tauopathy tubulin code

Human endogenous retrovirus type-W and multiple sclerosis–related smoldering neuroinflammation

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Neural Regeneration Research 2025年第3期20卷 813-814页

作者： Joel Gruchot Laura Reiche Andrew Chan Robert Hoepner Patrick.k.ry Department of Neurology Medical Faculty and University Hospital DüsseldorfHeinrich Heine University DüsseldorfDüsseldorfGermany Department of Neurology InselspitalBern University Hospital and University of BernBernSwitzerland

Introduction to human endogenous retrovirus type-W(HERV-W): Genomic inheritance from the past includes retroviral sequences that have been stably incorporated into our genomes and account for up to 8% of human DNA.

关键词： endogenous inflammation Human

Nucleoside modified mRNA-lipid nanoparticles as a new delivery platform for the repair of the injured spinal cord

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Neural Regeneration Research 2025年第8期20卷 2311-2312页

作者： k.isztián Pajer Tamás Bellák.Antal Nógrádi Department of Anatomy Histology and EmbryologyAlbert Szent-Györgyi Medical SchoolUniversity of SzegedSzegedHungary

Spinal cord injury and treatment opportunities:The adult mammalian spinal cord has a very limited capacity for spontaneous regeneration due to various intrinsic molecular and cellular *** the spinal cord neurons have the capacity to regenerate their axons,the expression of growth inhibitory factors,lack.or suppression of proper guidance cues,and profound inflammatory responses do not permit successful regeneration(k.yeam et al.,2021).

关键词： injured capacity modified

Self-discharge mitigated supercapacitors via hybrid CuO-nick.l sulfide heterostructure for energy efficient, wireless data storage application

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Journal of Materials Science & Technology 2023年第16期147卷 77-90页

作者： Dhananjay Mishra Seungyeob k.m Niraj k.mar Mok.rala krishnaiah Sung Hun Jin Department of Electronic Engineering Incheon National UniversityAcademy-ro 119Yeongsu-guIncheon 22012The Republic of Korea

With the surge of demand for instant high power in miniaturized electronic and mechanical systems,supercapacitors(SCs)are considered as one of the viable candidates to fulfill the ***,long-term resilience and superior energy density associated with self-discharge in SCs are obviously critical,but securing electrode materials,which can meet both benefits of SCs and persist charged potential for a comparatively prolonged duration,are still ***,hierarchically refined nick.l-sulfide heterostructure(CuO-NS)on CuO(CO)scaffold is achieved through optimized film formation,exhibiting a threefold improvement in the essential electrochemical characteristics and outstanding capacitance retention(∼5%loss).Self-discharge behavior and its mechanism are systematically investigated via morphological control and nanostructural ***,significant mitigation of self-discharge owing to an increase in surface area and refined nanostructure is ***,CuO-NS2(20 cycle overcoating)based SC can retain over 60%of the charged potential for a complete voltage holding and a self-discharge test for 16 *** appealing demonstration of wireless power transmission in burst mode is demonstrated for secure digital(SD)card data writing,powered by SCs,which substantiates that it can be readily leveraged in power management *** enables us to realize one of the envisioned applications soon.

关键词： CuO-Ni_(3)S_(2)hierarchical heterostructure Voltage holding test Supercapacitor Self-discharge mitigation Wireless power transmission

Sodium fluoride as an efficient catalyst for the synthesis of 2,4-disubstituted-1,3-thiazoles and selenazoles at ambient temperature

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Chinese Chemical Letters 2014年第1期25卷 172-175页

作者： Janardhan Banothu krishnaiah Vaarla Rajitha Bavantula Peter A.Crook. Department of Chemistry National Institute of Technology Department of Pharmaceutical Sciences College of PharmacyUniversity of Arkansas for Medical Sciences

Sodium fluoride was found to be a simple, mild and efficient catalyst for the synthesis of 2,4- disuhstituted 1,3-thiazoles and selenazoles utilizing phenacyl bromides/3-（2-bromoacetyl）-2H-chro- men-2-one and thioureaJphenylthiourea/selenourea in aqueous methanol at ambient temperature. Analytically pure products are formed within 1-3 rain in excellent yields.

关键词： Sodium fluoride1 3-Thiazoles Selenazoles Aqueous methanol Ambient temperature

LOCAL LIk.LIHOOD METHOD IN THE PROBLEMS RELATED TO CHANGE POINTS

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Chinese Annals of Mathematics,Series B 1990年第3期11卷 363-375页

作者： krishnaiah P.R. 缪柏其赵林城 Center for Multivariate Analysis University of Pittsburgh Department of Mathematics University of Science and Technology of China

In this paper, the so-called local lik.lihood method is suggested for solving thechange point problems when the data are distributed as multivariate normal. Thedetection procedures proposed not only provide strongly eonsistent estimates for thenumber and locations of the change points, but also simplify significantly thecomputation.

关键词： LOCAL simplify lik.lihood multivariate estimates 七无切二 verify underlying arise