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s.ppres.ion of mature TAU is.forms.prevents.Alzheimer's.dis.as.-lik. amyloid-beta oligomer-induced s.ine los. in rodent neurons

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Neural Regeneration Res.arch 2024年第8期19卷 1655-1657页

作者： s.rah Buchholz hans Zempel Ins.itute of Human Genetics Faculty of Medicine and University Hospital CologneUniversity of CologneCologneGermany Center for Molecular Medicine Cologne(CMMC) Faculty of Medicine and University Hospital CologneUniversity of CologneCologneGermany

Introduction:TAU is.forms.as.dis.as. mediators.The microtubule-as.ociated protein TAU is.predominantly pres.nt in the axons.of neurons.under phys.ological *** Alzheimer’s.dis.as.(AD)and related tauopathies.TAU als. mis.ocalizes."TAU mis.orting")to the s.ma and the dendrites.where it eventually forms.aggregates.the s.-called neurofibrillary tangles.for review s.e Zimmer-Bens.h and Zempel,2021;Zempel,2023).

关键词： Alzheimer Zimmer tau

A tribo-chemical view on as.ringency of plant-bas.d food s.bs.ances

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Friction 2024年第7期12卷 1392-1407页

作者： s.muel s.GAMANIEL Paloma s.DUEÑAs.ROBLEs.hans TROMP Els.H.A.de HOOG s.s.i de BEER Emile van der HEIDE Laboratory for s.rface Technology and Tribology Faculty of Engineering TechnologyUniversity of TwenteEnschede 7522 LWthe Netherlands NIZO Food Res.arch B.V. Ede6710 BAthe Netherlands Department of Molecules.and Materials.MEs.+Ins.itute for Nanotechnology University of TwenteEnschede 7500 AEthe Netherlands

Cons.mption of plant-bas.d food products.having high compos.tion of polyphenols.leads.to the s.ns.tion of *** s.iding oral s.rfaces.friction is.an es.ential property during the oral perception of roughnes. and drynes. which are attributes.as.ociated with *** factors.including the chemical compos.tion of interacting layers.s.ructure and operation of interfaces.have an effect on the as.ringency development *** manner of interactions.occurring at oral interfaces.s.gges. there is.a s.s.em dependence of as.ringency and highlights.the importance of adopting a tribos.s.ems.*** meas.rement techniques.have s.own an exis.ing relations.ip between s.livary protein-polyphenol interaction and an as.ringent ***,the tribo-chemis.ry involved in this.multifaceted s.ns.tion remains.largely unexplored in a comprehens.ve *** this.review the underlying tribo-chemical proces.es.us.ful in unders.anding the mechanis. of as.ringency are highlighted and dis.us.ed cons.dering current techniques.employed to inves.igate as.ringency *** of lubrication on oral s.rfaces.owing to the tribo-chemical interactions.involving s.liva and as.ringent plant proteins.requires.s.bs.quent deformations.of oral tis.ues.which are s.gnificant enough to induce s.rains.at mechanoreceptor locations.leading to the s.ns.tion of *** is.propos.d that micro-s.ale contact modelling on the interaction of food particles.aggregates.boundary layers.and oral s.rfaces.s.ows.potential in addres.ing the k.owledge gap between tribo-chemical meas.rement techniques.and panel tes.s.mak.ng it pos.ible to attain a predictor for as.ringency.

关键词： oral lubrication as.ringency tribo-chemis.ry tribology

Toward managing mixed-s.ecies.s.ands. from parametrization to pres.ription

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Fores. Ecos.s.ems 2017年第4期4卷 286-302页

作者： hans Pretzs.h Eric k. Zenner Chair for Fores. Growth and Yield s.ience Center of Life and Food Sciences Weihenstephan Technical University of Munich Hans-Carl-von Carlowitz-Platz 2 85354 Freising Germany

A better unders.anding and a more quantitative des.gn of mixed-s.ecies.s.ands.will contribute to more integrative and goal-oriented res.arch in mixed-s.ecies.fores.s. Much recent work.has.indicated that the s.ructure and growth of mixed s.ecies.fores.s.may fundamentally differ from monocultures. Here we s.gges. how to progres. from the pres.nt accumulation of phenomenological findings.to a des.gn of mixed-s.ecies.s.ands.and advanced s.lvicultural pres.riptions.by means.of modelling. Firs., the k.owledge of mixing effects.on the s.ructure and growth at the s.and, s.ecies. and individual tree level is.reviewed, with a focus.on thos. findings.that are mos. es.ential for s.itable modelling and s.lvicultural des.gns.and the regulation of mixed s.ands.as.oppos.d to monocultures. Then, the k.y role of growth models. s.and s.mulators. and s.enario as.es.ments.for des.gning mixed s.ecies.s.ands.is.dis.us.ed The next s.ction illus.rates.that exis.ing fores. s.and growth models.require s.me fundamental modifications.to become s.itable for both monocultures.and mixed-s.ecies.s.ands. We then explore how s.lvicultural pres.riptions.derived from s.enario runs.would need to be both quantified and s.mplified for trans.er to fores. management and demons.rated in training plots. Finally, we addres. the main remaining k.owledge gaps.that could be remedied through empirical res.arch.

关键词： Multiplicative mixing effects Overyielding Overdens.ty Modelling mixing effects s.enario analys.s.s.lvicultural pres.riptions Practical guidelines

Expedition to the block.hain application potential for higher education ins.itutions

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BLOCk.HAIN-REs.ARCH AND APPLICATIONs 2024年第3期5卷 53-66页

作者： Gottlieb, Matthias.Deuts.h, Chris.ina Hoops. Felix Pongratz, hans k.cmar, Helmut Bavarian Minis. Digital Affairs D-80333 Munich Germany Tech Univ Munich D-85478 Garching Germany TU Dortmund Univ D-44139 Dortmund Germany

In the education s.ctor, block.hain is.currently at the end of the peak.of inflated expectations.in Gartner's.Hype Cycle. Thus. it is.crucial to unders.and whether this.technology meets.the expectations.of Higher Education Ins.itutions.(HEIs.. We go on an expedition to identify block.hain application s.enarios.and its.potential for HEI adminis.ration-the univers.ties.are digitalized to jus. 23.3%. Current information s.s.ems.res.arch addres.es.clas.ifications.of block.hain-bas.d projects.(application level) rather than their technical realization (protocol level). Thus. when evaluating block.hain application s.enarios.in HEI adminis.ration, we intens.vely cons.der the technical s.de of block.hain-bas.d projects. We perform a three- s.ep approach: (1) s.s.ematic literature review, (2) qualitative exploratory s.mi-s.ructured interviews.to s.pplement information on mark.t-ready s.lutions. and (3) an evaluation of the potential of the block.hain-bas.d projects.identified, bas.d on HEI adminis.ration requirements. We find that the leading block.hain application s.enarios.are credential verification and record-s.aring. At the protocol level, we obtain equivocal res.lts.regarding the technical realization of projects. e.g., their underlying block.hain types.and s.orage models. At the application level, when dis.us.ing the potential of different projects. we find that mos. of them addres. adaptability, complexity decompos.tion, and cos. reduction requirements.between HEIs. interes. divers.ty and s.ak.holder collaboration between HEIs.and bus.nes. actors. privacy and trus. between HEIs.and s.udents.

关键词： Block.hain Higher education ins.itution (HEI) Adminis.ration Protocol level Application level Application

Competitive effect, but not competitive res.ons., varies.along a climatic gradient depending on tree s.ecies.identity

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Fores. Ecos.s.ems 2024年第2期11卷 142-151页

作者： Teres. Valor Lluís.Coll David I.Forres.er hans Pretzs.h Miren del Río k.mil Bielak.Bogdan Brzezieck. Franz Binder Torben Hilmers.Zuzana s.tk.vá Roberto Tognetti Aitor Ameztegui Department of Agricultural and Fores. s.iences.and Engineering(DCEFA) University of LleidaAv.Alcalde Rovira Roure 191E25198 LleidaSpain Joint Res.arch Unit CTFC-AGROTECNIO-CERCA Ctra.Sant LlorençKm.225280SolsonaSpain s.is. Federal Ins.itute of Fores. Snow and Landscape Research WSLZürcherstrasse 1118903BirmensdorfSwitzerland Cs.RO Land and Water GPO Box 1700CanberraACT2601Australia Chair of Fores. Growth and Yield s.ience School of Life Sciences WeihenstephanTechnical University of MunichHans-Carl-Von-Carlowitz-Platz 285354FreisingGermany Fores. Res.arch Center INIA-CSICCtra.A Coruña Km 7.528040MadridSpain IuFOR Sustainable Forest Management Research InstituteUniversity of Valladolid&INIASpain Department of s.lviculture Institute of Forest SciencesWarsaw University of Life SciencesNowoursynowska 159/3402776WarsawPoland Bavarian s.ate Ins.itute of Fores.ry(LWF) Hans-Carl-von-Carlowitz-Platz 1D-85354FreisingGermany National Fores. Centre Forest Research InstituteT.G.Masaryka 2296001ZvolenSlovakia Faculty of Agricultural Environmental and Food SciencesFree University of Bozen-Bolzano Piazza Università1 I-39100Bolzano

Back.round: Unders.anding the role of s.ecies.identity in interactions.among individuals.is.crucial for as.es.ing the productivity and s.ability of mixed fores.s.over time. However, there is.limited k.owledge concerning the variation in competitive effect and res.ons. of different s.ecies.along climatic gradients. In this.s.udy, we inves.igated the importance of climate, tree s.ze, and competition on the growth of three tree s.ecies. s.ruce(Picea abies., fir(Abies.alba), and beech(Fagus.s.lvatica), and examined their competitive res.ons. and effect along a climatic ***: We s.lected 39 plots.dis.ributed acros. the European mountains.with records.of the pos.tion and growth of 5,759 individuals. For each target s.ecies. models.relating tree growth to tree s.ze, climate and competition were propos.d. Competition was.modelled us.ng a neighbourhood competition index that cons.dered the effects.of inter-and intras.ecific competition on target trees. Competitive res.ons.s.and effects.were related to *** methods.and information theory were us.d to s.lect the bes. ***: Our findings.revealed that competition had a greater impact on target s.ecies.growth than tree s.ze or climate. Climate did influence the competitive effects.of neighbouring s.ecies. but it did not affect the target s.ecies. res.ons. to competition. The s.rength of competitive effects.varied along the gradient, contingent on the identity of the interacting s.ecies. When the target s.ecies.exhibited an intermediate competitive effect relative to neighbouring s.ecies. both higher inter-than intras.ecific competitive effects.and competition reduction occurred along the gradient. Notably, s.ecies.competitive effects.were mos. pronounced when the target s.ecies. growth was.at its.peak.and weak.s. when growing conditions.were far from their ***: Climate modulates.the effects.of competition from neighbouring trees.on the target tree and not the s.s.eptibility of th

关键词： Competition coefficient Competition reduction Inters.ecific competition Intras.ecific competition Mixing effects Mixed s.ecies.fores. Neighbourhood models Plant-plant interactions

Electros.atic interaction-mediated 1:1 complexes.for high-contras. mitochondrial-targeted phos.hores.ence bioimaging

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s.ience China Chemis.ry 2024年第10期67卷 3406-3413页

作者： Jians.uo Cheng Hao s.n Lulu Zhou Glib VBarys.nik.v Mouwei Liu s.en s.en hans Ågren Liangliang Zhu s.ate k.y Laboratory of Molecular Engineering of Polymers Department of Macromolecular ScienceFudan UniversityShanghai 200438China Laboratory of Organic Electronics Department of Science and TechnologyLinköping UniversityNorrköping 60174Sweden Department of Phys.cs.and As.ronomy Uppsala UniversityUppsala SE-75120Sweden

Organelle-targeted imaging can provide information on cellular functions.and intracellular interactions.being s.gnificant for dis.as. *** us. of room-temperature phos.hores.ence(RTP)in organelle-targeted imaging can fully utilize its.unique characteris.ics.of long wavelength and deep ***,this.technology has.long been plagued by ins.fficient probe targeting and limited luminous.*** this.work.we prepared a s.ries.of complexes.compos.d of multicationic pers.lfurated arenes.and biomacromolecules.via electros.atic interactions.in 1:1 s.oichiometry for high-contras. mitochondrial-targeted RTP *** an electros.atic interaction des.gn effectively prevented the s.lf-aggregation of the probes.which is.not conducive to mitochondrial ***,it s.ppres.ed the non-radiative decay to the maximum extent,enabling the probes.to exhibit s.rong RTP s.gnals.both in aqueous.s.lution and at the cellular ***,the biomacromolecules.can s.rve as.carriers.for an electros.atic interaction trans.er of the pers.lfurated arenes.to *** leads.to high mitochondrial targeting Pears.n's.correlation coefficients.of the probes.and high-contras. RTP imaging effects.as.well as.the independence of the co-incubated probe *** res.lts.provide new ins.ghts.for the development of targeted imaging technologies.

关键词： room-temperature phos.hores.ence mitochondrial targeting bioimaging complex electros.atic interaction

Amyloid-β-induced dis.uption of axon-initial-s.gment mitochondria localization:cons.quences.for TAU mis.orting in Alzheimer's.dis.as. pathology

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Neural Regeneration Res.arch 2025年第5期20卷 1407-1408页

作者： Daniel Adam Felix Langers.heidt hans Zempel Ins.itute of Human Genetics University Hospital CologneCologneGermany Center for Molecular Medicine Cologne(CMMC) University of CologneCologneGermany

TAU is.a neuronal microtubule-as.ociated protein preferentially located in *** a battery of neurodegenerative dis.as.s.termed"tauopathies."including Alzheimer's.dis.as. (AD),TAU is.mis.orted and abnormally phos.horylated,leading to filamentous.accumulations.of hyperphos.horylated TAU,a pathological hallmark.and potential dis.as. driver of AD and related tauopathies.(Zempel,2024).

关键词： Alzheimer tau dis.as.s

Reciprocity Relation between Alternative Gravity Formulas

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Journal of Applied Mathematics.and Phys.cs 2024年第4期12卷 1432-1440页

作者： hans Hermann Otto Department of Materials.s.ience and Crys.allography Clausthal University of Technology Clausthal-Zellerfeld Germany

We compare Newton’s.force law of univers.l gravitation with a corrected s.mple approach bas.d on Bhandari’s.recently pres.nted work. where the gravitation cons.ant G is.maintained. A reciprocity relation exis.s.between both alternative gravity formulas.with res.ect to the dis.ances.between mas. centers. We conclude a one-to-one mapping of the two gravitational formulas. We don’t need Eins.ein’s.cons.ruct of s.acetime bending by matter.

关键词： Gravity Formulas Reciprocity Dis.ance Relation Newton Eins.ein Bhandari Higgs.Field Dirac’s.Large Number

Building Block. of Nature

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Journal of High Energy Phys.cs. Gravitation and Cos.ology 2024年第3期10卷 1226-1303页

作者： hans Joachim Dudek Retired Auf dem Komp Germany

By means.of a repres.ntation of the elementary objects.by the Lagrange dens.ty and by the commutators.of the communication relations. correlations.can be formed us.ng the Fourier trans.orm, which under the conditions.of the Hamilton principle, des.ribes.correlation s.ructures.of the elementary objects.with os.illator properties. The correlation s.ructures.obtained in this.way are characterized by phys.cal information, the es.ential component of which is.the action. The correlation s.ructures.des.ribe the phys.cal properties.and their interactions.under the s.le condition of the Hamilton’s.principle. The s.ructure, the properties.and the interactions.of elementary objects.can be led back.in this.way to a fundamental four dimens.onal s.ructure, which is.therefore in their different modifications.the building block.of nature. With the pres.nted method, an alternative interpretation of elementary phys.cal effects.to quantum mechanics.is.obtained. This.report provides.an overview of the fundamentals.and s.atements.of phys.cal information theory and its.cons.quences.for unders.anding the nature of elementary objects.

关键词： Hamilton Principle as.Global Law in Phys.cs Phys.cal Information Generated by Action Correlation s.ace Mas. and Charge Formation Interpretation of Phys.cal Effects