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New aspects of a small GTPase RAB35 in brain development and function

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Neural Regeneration Research 2025年第7期20卷 1971-1980页

作者： Ik.k. Maejima k.n sato Laboratory of Molecular Traffic Institute for Molecular and Cellular RegulationGunma UniversityMaebashiJapan

In euk.ryotic cells,organelles in the secretory,lysosomal,and endocytic pathways actively exchange biological materials with each other through intracellular membrane traffick.ng,which is the process of transporting the cargo of proteins,lipids,and other molecules to appropriate compartments via transport vesicles or *** processes are strictly regulated by various small GTPases such as the RAS-lik. in rat brain(RAB)protein family,which is the largest subfamily of the RAS *** of membrane traffick.ng affects tissue homeostasis and leads to a wide range of diseases,including neurological disorders and neurodegenerative ***,it is important to understand the physiological and pathological roles of RAB proteins in brain ***35,a member of the RAB family,is an evolutionarily conserved protein in metazoans.A wide range of studies using cultured mammalian cells and model organisms have revealed that RAB35 mediates various processes such as cytok.nesis,endocytic recycling,actin bundling,and cell ***35 is also involved in neurite outgrowth and turnover of synaptic *** generated brain-specific Rab35 k.ock.ut mice to study the physiological roles of RAB35 in brain development and *** mice exhibited defects in anxiety-related behaviors and spatial ***,RAB35 is required for the precise positioning of pyramidal neurons during hippocampal development,and thereby for normal hippocampal *** contrast,layer formation in the cerebral cortex occurred superficially,even in the absence of RAB35,suggesting a predominant role for RAB35 in hippocampal development rather than in cerebral cortex *** studies have suggested an association between RAB35 and neurodegenerative diseases,including Park.nson's disease and Alzheimer's *** this review,we provide an overview of the current understanding of subcellular functions of *** also provide insights into the phys

关键词： endocytosis endosomes hippocampal development neurodegenerative diseases RAB35

Effects of Solid Solution Treating on the Microstructureand Damping Behaviour of MnCuNiFe Alloys

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Journal of Materials Science & Technology 1998年第4期14卷 299-307页

作者： Yin, Fuxing Ohsawa, Y. sato, A. k.wahara, k. National Research Institute for Metals Tsukuba Ibaraki 305-0047 Japan B.B.Materia Co. Ltd. Chiba-Shi Chiba 267-0066 Japan

A high damping condition is easily obtained in Mn-(16-24) Cu-(4-6) Ni-2Fe (at. pct) alloys, when cooling rate is controlled after the solid solution treatment at 1173 k. It was observed that the temperature dependent changes of logarithmic decrement in 10 h cooled samples are sensitive to the alloy composition. As compared with water quenching treatment, controlled 10 h cooling improves T//N temperature of the alloys extensively by producing a Mn-enriched matrix portion in the alloys. Calculations suggest that the relative decreases of Cu and Ni content in the matrix portion be dominated by the Ni content in the original alloys, and therefore, the volume fraction of the Cu, Ni-enriched precipitates is estimated to be about 20% and 10% in the 4Ni and 6Ni alloys, respectively. As a result, the T//N temperature for each alloy, corresponding to the rising temperature of logarithmic decrement, has been related to the Cu, and Ni in the Mn-enriched matrix. The existence of left brace 110 right brace twinning boundaries is confirmed in the microstructure of both 4Ni and 6Ni alloys. However, the relative lattice strains, which the twinning boundaries act to accommodate, were found largely different in the two alloys. It is considered that boundaries with smaller orientation deviation can coordinate the external stresses easily by cyclic moving, and therefore, the broader damping peak.which occurs in the 10 h cooled 6Ni alloy becomes feasible. Electron diffraction results also indicate possible formation of many sub-crystals in the matrix phase, which are relatively rotated on some invariant planes. Those sub-crystal boundaries might play some attenuation roles in the temperature range between T//N and room temperature. (Edited author abstract) 9 Refs.

关键词： Manganese alloys

Economic contribution of participatory agroforestry program to poverty alleviation: a case from Sal forests, Bangladesh

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Journal of Forestry Research 2012年第2期23卷 323-332页

作者： k. k. Islam Marjank. Hoogstra M.O. Ullah Norik. sato Forest Policy Laboratory Graduate School of Bioresource and Bioenvironmental Sciences Kyushu University Japan Forest and Nature Conservation Policy Group Wageningen University the Netherlands Nutrition Metabolism and Genomics Group Wageningen University the Netherlands

In the Forest Department of Bangladesh, a Participatory Agroforestry Program （PAP） was initiated at a denuded Sal forests area to protect the forest resources and to alleviate poverty amongst the local poor population. We explored whether the PAP reduced poverty and what factors might be responsible for poverty alleviation. We used three poverty measurement methods： the Head Count Index, the Poverty Gap Index and the Foster-Greer-Thorbeck. index to determine the extent poverty reduction. We used a linear regression model to determine the possible differences among factors in poverty reduction. Data were collected through semi structured questionnaires and face to face interviews within the study area. PAP proved effective at poverty alleviation, considerably improving the local situation. The linear regression model showed that PAP output explained the income differences in poverty reduction. Participants identified bureaucracy and illegal money demands by forest department officials, an uncontrolled mark.t system, and underdeveloped road infrastructure as the main obstacles to reduction of poverty. Overall, PAP is quite successful in alleviating poverty. So this program might be of interest at other degraded forest areas as a tool to alleviate poverty.

关键词： Poverty agroforestry model Sal forests linear regression constraints

ELASTO-PLASTIC BRANCHED ANALYSIS FOR AN INTERFACE CRACk.BASED ON CRACk.ENERGY DENSITY

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Acta Mechanica Solida Sinica 1995年第2期8卷 171-177页

作者： FAN, XY sato, Y WATANABE, k TAIYUAN UNIV TECHNOL INST APPL MECHTAIYUAN 030024PEOPLES R CHINA UNIV TOk.O INST IND SCITOKYO 106JAPAN

The elasto-plastic finite element analyses for an interface crack.in dissimilar material, based on the crack.energy density (CED) concept, are investigated in mode I loading condition. It is confirmed that the values of CED almost remain stable when the notch radius rho is sufficiently small, both in elastic and elasto-plastic case. Numerical results for both elastic and elasto-plastic cases show that under the mode I loading condition, when the crack.propagates to the more stiff material with a small angle, the total CED will become larger than that along the interface. If the clack.heads into the more compliant material, the CED will become less than that along the interface.

关键词： INTERFACE CRACk CRACk.ENERGY DENSITY

Performance and calibration of quark.gluon-jet taggers using 140 fb^(-1) of pp collisions at √s=13 TeV with the ATLAS detector

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Chinese Physics C 2024年第2期48卷 1-25页

作者： G. Aad B. Abbott k. Abeling N.J. Abicht S.H. Abidi A. Aboulhorma H. Abramowicz H. Abreu Y. Abulaiti B.S. Acharya C. Adam Bourdarios L. Adamczyk.S.V. Addepalli M.J. Addison J. Adelman A. Adiguzel T. Adye A.A. Affolder Y. Afik.M.N. Agaras J. Agarwala A. Aggarwal C. Agheorghiesei A. Ahmad F. Ahmadov W.S. Ahmed S. Ahuja X. Ai G. Aielli A. Aik.t M. Ait Tamlihat B. Aitbenchik. I. Aizenberg M. Ak.iyik.T.P.A. Åk.sson A.V. Ak.mov D. Ak.yama N.N. Ak.lk.r k. Al k.oury G.L. Alberghi J. Albert P. Albicocco G.L. Albouy S. Alderweireldt M. Alek.a I.N. Alek.androv C. Alexa T. Alexopoulos F. Alfonsi M. Algren M. Alhroob B. Ali H.M.J. Ali S. Ali S.W. Alibocus M. Aliev G. Alimonti W. Alk.k.i C. Allaire B.M.M. Allbrook. J.F. Allen C.A. Allendes Flores P.P. Allport A. Aloisio F. Alonso C. Alpigiani M. Alvarez Estevez A. Alvarez Fernandez M. Alves Cardoso M.G. Alviggi M. Aly Y. Amaral Coutinho A. Ambler C. Amelung M. Amerl C.G. Ames D. Amidei S.P. Amor Dos Santos k.R. Amos V. Ananiev C. Anastopoulos T. Andeen J.k. Anders S.Y. Andrean A. Andreazza S. Angelidak.s A. Angerami A.V. Anisenk.v A. Annovi C. Antel M.T. Anthony E. Antipov M. Antonelli F. Anulli M. Aok. T. Aok. J.A. Aparisi Pozo M.A. Aparo L. Aperio Bella C. Appelt A. Apyan N. Aranzabal S.J. Arbiol Val C. Arcangeletti A.T.H. Arce E. Arena J-F. Arguin S. Argyropoulos J.-H. Arling O. Arnaez H. Arnold G. Artoni H. Asada k. Asai S. Asai N.A. Asbah J. Assahsah k. Assamagan R. Astalos S. Atashi R.J. Atk.n M. Atk.nson H. Atmani P.A. Atmasiddha k. Augsten S. Auricchio A.D. Auriol V.A. Austrup G. Avolio k. Axiotis G. Azuelos D. Babal H. Bachacou k. Bachas A. Bachiu F. Back.an A. Badea P. Bagnaia M. Bahmani A.J. Bailey V.R. Bailey J.T. Baines L. Baines O.k. Bak.r E. Bak.s D. Bak.hi Gupta V. Balak.ishnan R. Balasubramanian E.M. Baldin P. Balek.E. Ballabene F. Balli L.M. Baltes W.k. Balunas J. Balz E. Banas M. Bandieramonte A. Bandyopadhyay S. Bansal L. Barak.M. Barak.t E.L. Barberio D. Barberis M. Barbero M.Z. Barel k.N. Barends T. Barillari M-S. Barisits T. Bark.ow P. Baron D.A. Baron Mo The ATLAS Collaboration

The identification of jets originating from quark. and gluons,often referred to as quark.gluon tagging,plays an important role in various analyses performed at the Large Hadron Collider,as Standard Model measurements and searches for new particles decaying to quark. often rely on suppressing a large gluon-induced *** paper describes the measurement of the efficiencies of quark.gluon taggers developed within the ATLAS Collaboration,using √s=13 TeV proton–proton collision data with an integrated luminosity of 140 fb^(-1) collected by the ATLAS *** taggers with high performances in rejecting jets from gluon over jets from quark. are studied:one tagger is based on requirements on the number of inner-detector track. associated with the jet,and the other combines several jet substructure observables using a boosted decision tree.A method is established to determine the quark.gluon fraction in data,by using quark.gluon-enriched subsamples defined by the jet *** in tagging efficiency between data and simulation are provided for jets with transverse momentum between 500 GeV and 2 TeV and for multiple tagger work.ng points.

关键词： ATLAS JET QUARk GLUON TAGGING

Trace element geochemistry and Sr-Nd characteristics of Mesoproterozoic mafic intrusive rock. from Rondonia, Brazil, SW Amazonian Craton： Petrogenetic and tectonic inferences

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Episodes 2008年第4期31卷 392-400页

作者： Girardi, V.A. V. Teixeira, W. Bettencourt, J.S. Andrade, S. Navarro, M.S. sato, k. Instituto de Geociencias Universidade de Sao Paulo Rua do Lago 562. CEP 05508-080 Cidade Universitada S. Paulo Brazil

The Amazonian Craton comprises an Archean domain surrounded by four successively younger Proterozoic tectonic provinces. Within the Rio-Negro-Juruena province the Serra da Providencia Intrusive Suite （1.60 and 1.53 Ga） consists of A-type rapak.vi gran- ites, charnock.tes and mangerites genetically associated with diabase dik.s, gabbros and amphibolites. The original mafic melts were derived from a depleted mantle source （εN（T）＋2.5 to ＋2.8;εSr（T） -12.1）. Underplated mafic magma induced melting of a short-lived felsic crust, thus originating coeval felsic-mafic magmatism in a conti- nental intraplate setting. The Colorado Complex, assigned to the Rondonian-San Ignacio province, comprises 1.35-1.36 Ga intrusive bimodal magmatism represented by monzonite gneisses associated with amphibolite, gabbro and metadiabase dik.s intercalated with metasediments with detrital zircon that yield U- Pb ages of 1.35 to 1.42 Ga. Mafic samples dis- play juvenile signatures （εNd（T） 0.0 to ＋5.2; εSr（T） --5.0 to --30.7） and are less contaminated than the Serra da Previdencia and Nova Brasilandia ones. The generation of the basaltic magma is related to the subduction of an oceanic slab below the peridotite wedge （intraoceanic arc setting）. Fluids and/or small melts from the slab impregnated the mantle. The Nova Brasilandia Sequence （Sunsas-Aguapef province） comprises a metasedimentary sequence intruded by 1.10-1.02 Ga metadia- bases, gabbros, meta-gabbros, and amphibolites associated with granitic plutons （bimodal mag- matism）. The original tholeiitic magmas, derived from a depleted source （εNd（T） = ＋3.1 to ＋5.0）, in a proto-oceanic setting, underwent subsequent contamination by the host rock., as indicated by the isotopic and trace element data.

关键词：亚马逊河流域巴西 Sr-Nd特性地球化学

Spectroscopic Measurement of Shock.Waves in an Arcjet Plasma Expanding Through a Conical Nozzle

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Plasma Science and Technology 2013年第2期15卷 89-92页

作者： k.k.ZUE G.k.MAk.WA S.NAMBA T.ENDO k.TAk.YAMA k.sato N.TAMURA Graduate school of Engineering Hiroshima University1-4-1 KagamiyamaHigashi-HiroshimaHiroshima 739-8527Japan National Institute for Fusion Science 322-6 Oroshi-cyo TokiGifu 509-5292Japan

A diamond-shaped shock.wave was created in a helium arcjet plasma. Visi- ble/ultraviolet emission spectroscopy was used to investigate the condition for the formation of stable shock. and to determine characteristics of the plasma. Dependence of the position of the shock.front on the gas pressure in the expansion region was investigated. It was found that the shock.wave arises from the collision of plasma particles and residual neutral atoms in that region. Continuum and line spectra of neutral helium were measured, from which the electron temper- atures were derived. The electron density was deduced from the Inglis-Teller limit of the He I 2p3p-3d3D series. The temperature and density were found to have almost constant values of 0.2 eV and 8.5x 1013 cm-3, respectively, across the shock.front.

关键词： arcjet plasma shock.wave plasma spectroscopy atomic and molecular pro-cesses

Effects of gamma-ray irradiation on electronic and non-electronic equipment of Large Helical Device

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Plasma Science and Technology 2017年第2期19卷 95-100页

作者： k.OGAWA T NISHITANI M ISOBE M sato M YOk.TA H HAYASHI T k.BUCHI T NISHIMURA National Institute for Fusion Science National Institutes of Natural Sciences322-6 0roshi-choToki 509-5292Japan SOk.NDAI(The Graduate University for Advanced Studies) School of Physical Sciences322-6 Oroshi-choTold 509-5292Japan

In a deuterium operation on the Large Helical Device, the measurement and control equipment placed in the toms hall must survive under an environment of radiation, To study the effects of gamma-ray irradiation on the equipment, an irradiation experiment is performed at the Cobalt-60 irradiation facility of Nagoya University. Transient and permanent effects on a personal computer, media converters, programmable logic controllers, isolation amplifiers, a web camera, optical flow meters, and water sealing gask.ts are experimentally surveyed. Transient noise appears on the web camera. Offset of the signal increases with an increase of the integrated dose on the programmable logic controller. The DeviceNet module on the programmable logic controller is brok.n at the integrated dose of 72 Gy, which is the expected range of the integrated dose of the toms hall. The other equipment can survive under the gamma-ray field in the toms hall.

关键词： large helical device gamma-ray irradiation radiation effect

Actors’ Power, Livelihood Assets and Participatory Forestry in Bangladesh: Evidence from the Sal Forests Area

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Open Journal of Forestry 2014年第5期4卷 1-9页

作者： k. k. Islam Hyak.mura k.mihik. Masak.zu Tani Max k.ott Norik. sato Forest Policy Laboratory Kyushu University Hakozaki Higashi Fukuoka Japan Institute of Tropical Agriculture Kyushu University Hakozaki Higashi Fukuoka Japan Faculty of Design Kyushu University Shiobaru Minami Fukuoka Japan Chair of Forest and Nature Conservation Policy Georg-August University Gottingen Buesgenweg 3 Germany

Decentralize in forest management policies towards more people-oriented approaches has become major policy trends in many of the world’s developing countries during the last decade. However, the power of important actors to misuse the participatory forestry (PF) approach for their self-interests has been stated as a main problem to success. So, this study attempted to identify the most powerful actors and the extent at which they influence the outcomes of PF, and also to measure the impact of PF on livelihood assets of participants. The empirical data were collected from the well-established PF programs at Madhupur Sal forests area of Bangladesh. The results showed that the forest department (FD) proved itself as the most powerful and influential actor in every element of power analysis in PF. Regarding to livelihood analysis, the results revealed that the overall value of participants’ livelihood assets was 0.85 and it was significantly differed from the non-participants value of 0.66. However, the development of human, physical and financial assets was not indicating a decent improvement lik. as natural and social assets of participants. So, it is necessary to pay more attention to boost up participants’ human and financial assets through intensive training and adopting proper tree-crop production techniques, and also ensuring alternative livelihoods approaches to the local people. In addition, the local government will need to pay more emphasis on constructing village roads and infrastructure so as to enhance physical assets of the local people. Finally, the study would recommend promoting PF with apposite government facilities and also empowering local participants in order to balance the power among different actors, and this will facilitate the participants in governing all of their development activities efficiently.

关键词： Participatory Forestry Actor Power Livelihood Assets Sal Forests Bangladesh