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模拟人血脂谱的载脂蛋白B和胆固醇酯转运蛋白双转基因鼠磷脂转运蛋白缺乏可增强高密度脂蛋白抗动脉粥样硬化作用

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中国动脉硬化杂志 2009年第7期17卷 605-605页

作者：秦树存王家富 M kashyap V k.manna A Tall X Jiang 泰山医学院山东省泰安市271016 美国加州大学美国纽约州立大学

血脂异常为动脉粥样硬化(As)的主要危险因素之一,磷脂转运蛋白(P1胛)在血脂代谢中发挥重要作用,尤其可影响高密度脂蛋白(HDL)的代谢。我们的前期研究发现PLTP缺乏可抑制公认的三个As模型鼠的主动脉宽块形成,其作用机制与减少富有载脂蛋... 详细信息

血脂异常为动脉粥样硬化(As)的主要危险因素之一,磷脂转运蛋白(P1胛)在血脂代谢中发挥重要作用,尤其可影响高密度脂蛋白(HDL)的代谢。我们的前期研究发现PLTP缺乏可抑制公认的三个As模型鼠的主动脉宽块形成,其作用机制与减少富有载脂蛋白B的脂蛋白颗粒的合成与分泌,并增强脂蛋白的抗氧化能力等有关。新近的实验发现PLIP缺陷鼠HDL的抗炎作用增强,但因为使用的小鼠模型天生缺乏参与人脂蛋白代谢的重要成分胆固醇酯转运蛋白(CETP),[第一段]

关键词：脂蛋白表型磷脂转运蛋白高密度脂蛋白动脉粥样硬化

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烟酸用于治疗,防止和逆转脂肪肝疾病的研究

乙醛醋酸化工 2016年第9期 55-页

作者： kashyap Motil

烟酸防止和/或逆转实验的肝状的脂肪分解的发展,甘油三酯在肝脏和人体血浆沉积,总胆固醇在肝脏和人体血浆沉积,并在发生脂肪肝疾病或NAFLDD风险中抑制人体中肝脂肪的过氧化反应和氧化压力。在培养的人的肝细胞中,抑制了乙醇-诱导的脂肪... 详细信息

烟酸防止和/或逆转实验的肝状的脂肪分解的发展,甘油三酯在肝脏和人体血浆沉积,总胆固醇在肝脏和人体血浆沉积,并在发生脂肪肝疾病或NAFLDD风险中抑制人体中肝脂肪的过氧化反应和氧化压力。在培养的人的肝细胞中,抑制了乙醇-诱导的脂肪累积。US2013303548(A1)

关键词：脂肪肝肝疾病疾病人体血浆烟酸尼克酸

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Treatments and limitations for methicillin-resistant Staphylococcus aureus: A review of current literature

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World Journal of Clinical Infectious Diseases 2019年第1期9卷 1-10页

作者： Rahul kashyap Aditya Shah Taru Dutt Patrick.M Wieruszewsk. Jaishid Ahdal Rishi Jain Department of Anesthesiology and Perioperative Medicine Mayo ClinicRochesterMN 55902United States Department of Infectious Diseases Mayo ClinicRochesterMN 55902United States Neurology Research Mayo ClinicRochesterMN 55902United States Department of Pharmacy Critical Care MedicineMayo ClinicRochesterMN 55902United States Work.ardt Limited Bandra EastMumbaiMaharashtra 400051India

Methicillin-resistant Staphylococcus aureus(MRSA)has remained a major threat to healthcare;in both hospital and community settings over the past five *** the current use of antibiotics for a variety of infections,including MRSA,emerging resistance is a major *** available treatments have restrictions limiting their *** issues include,but are not limited to,side effects,cross-resistance,lack.of understanding of pharmacok.netics and clinical pharmacodynamics,gradual increment in minimal inhibitory concentration over the period(MIC creep)and ineffectiveness in dealing with bacterial *** availability of various therapeutic options for MRSA,the clinical cure rates remain low with high morbidity and *** these challenges with existing treatments,there is a need for development of novel agents for *** with prompt infection control strategies and strict implementation of antibiotic stewardship,cautious use of newer anti-MRSA agents will be of utmost *** article reviews the treatments and limitations of MRSA management and highlights the future path.

关键词： Methicillin resistant Methicillin-resistant Staphylococcus aureus Antibiotics Monotherapy

Brainstem glioma progression in juvenile and adult rats

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中国神经肿瘤杂志 2009年第3期7卷 203-203页

作者： Liu Q Liu R kashyap MV Agarwal R Shi X Wang CC Yang SH Department of Pharmacology and Neuroscience University of North Texas Health Science Center Fort Worth Texas 76107 USA

OBJECT: Brainstem gliomas are common in children and have the worst prognosis of any brain tumor in this age group. On the other hand, brainstem gliomas are rare in adults, and the authors of some clinical studies have suggested that this lesion behaves dif ferently in adults than in children. In the present study, the authors test an orthotopic C6 brainstem glioma model in juvenile and adult rats, and investigate the biological behavior of this lesion in the 2 age groups. METHODS: The C6 glioma cells were stereotacti eally implanted into the pons of juvenile or adult male rats. Neurological presentation and survival time were recorded.

关键词：脑干胶质瘤儿童临床分析治疗方法病症

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茄子的生物技术

国外作物育种 2004年第1期23卷 60-60页

作者： V．kashyap 谢国禄

茄子(Solanum melongena L．)是栽培在世界不同热带和温带地区的一种重要的蔬菜作物。茄子的栽培种以及野生种中存在广泛的遗传多样性；茄子栽培品种对很多种昆虫和病原体以及各种非生物胁迫环境都是敏感的。相反，大多数野生种对已知... 详细信息

茄子(Solanum melongena L．)是栽培在世界不同热带和温带地区的一种重要的蔬菜作物。茄子的栽培种以及野生种中存在广泛的遗传多样性；茄子栽培品种对很多种昆虫和病原体以及各种非生物胁迫环境都是敏感的。相反，大多数野生种对已知的几乎全部昆虫和茄子的病原体都有抗性，因而是茄子作物改良时希望性状的来源。

关键词：茄子生物技术野生种转基因器官形成体细胞胚形成花药培养原生质体培养

功能异常高密度脂蛋白构成成分改变的分子病理学及其干预靶点的研究

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中国病理生理杂志 2012年第11期 2007-2007页

作者：秦树存宋国华于杨宗传龙姚树桐司艳红桑慧 JIANG Xian-cheng Moti L.kashyap Vaijinath S.k.MANNA 山东省高校动脉粥样硬化重点实验室泰山医学院动脉粥样硬化研究所纽约州立大学下城医学中心加州大学尔湾分校VA医学中心

代谢综合征、糖尿病、肥胖等血脂异常人群中的血浆高密度脂蛋白(high-density lipoprotein,HDL)的抗动脉粥样硬化特性普遍减弱或丧失,提示临床观察HDL的抗动脉粥样硬化功能不仅需要检查其血浆含量还需要评估其质量。因此功能异常HDL生... 详细信息

代谢综合征、糖尿病、肥胖等血脂异常人群中的血浆高密度脂蛋白(high-density lipoprotein,HDL)的抗动脉粥样硬化特性普遍减弱或丧失,提示临床观察HDL的抗动脉粥样硬化功能不仅需要检查其血浆含量还需要评估其质量。因此功能异常HDL生物学特性改变的临床评价、分子病理学和干预靶点的研究已成为近10年来脂蛋白领域新的研究热点和难点之一。本

关键词：功能异常分子病理学高密度脂蛋白靶点

Critical care practice in India:Results of the intensive care unit need assessment survey(ININ2018)

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World Journal of Critical Care Medicine 2020年第2期9卷 31-42页

作者： Rahul kashyap k.rtivardhan Vashistha Chetan Saini Taru Dutt Dileep Raman Vik.s Bansal Harpreet Singh Geeta Bhandari Nagarajan Ramak.ishnan Harshit Seth Divya Sharma Premk.mar Seshadri Mradul k.mar Daga Mohan Gurjar Yash Javeri Salim Surani Joseph Varon 无 Department of Anesthesiology and Perioperative Medicine Mayo ClinicRochesterMN 55905United States Department of Infectious Disease Mayo ClinicRochesterMN 55905United States Department of Internal Medicine Allegheny General HospitalPittsburghPA 15212United States Department of Radiology Mayo ClinicRochesterMN 55905United States Department of Medicine Jacobi Medical Center/Albert Einstein College of MedicineBronxNY 14061United States Department of Neurology Mayo ClinicRochesterMN 55905United States and Department of PsychiatryHennepin County Medical CenterMinneapolisMN 55415United States Department of Medicine Cloud Physician HealthcareBangalore 560038India Department of Critical Care Medicine Mayo ClinicRochesterMN 55905United States Department of Internal Medicine Maulana Azad Medical College&Associated HospitalsNew DelhiDelhi 110002India Department of Anesthesiology Government Medical CollegeHaldwaniNainital 263129India Department of Critical Care Medicine Apollo HospitalsChennai 600006India Department of Hospitalist Medicine Allegany ClinicAllegany Health NetworkPittsburghPA 15222United States Premk.mar Seshadri Department of MedicineMAAGF HealthcareChennai 600024India Department of Internal Medicine and Center for Occupational and Environment Health Maulana Azad Medical CollegeNew DelhiDelhi 110002India Department of Critical Care Medicine Sanjay Gandhi Postgraduate Institute of Medical SciencesLucknow 226014India Department of Critical Care Medicine Regency Super Speciality HospitalLucknow 208005India Nayati Healthcare New DelhiDelhi 110065India Department of Pulmonary and Critical Care Medicine Texas A&M UniversityCollege StationTX 77843United States Department of Critical Care United Memorial Medical CenterHoustonTX 77091United States ININ-2018 Investigators Team

BACk.ROUND A diverse country lik. India may have variable intensive care units(ICUs)practices at state and city *** To gain insight into clinical services and processes of care in ICUs in India,this would help plan for potential educational and quality improvement *** The Indian ICU needs assessment research group of diverse-sk.lled individuals was formed.A pan-India survey"Indian National ICU Needs"assessment(ININ 2018-I)was designed on google forms and deployed from July 23rd-August 25th,*** survey was sent to select distribution lists of ICU providers from all 29 states and 7 union territories(UTs).In addition to emails and phone calls,social medial applications-WhatsApp™,Facebook.and Link.dIn™were used to remind and motivate *** completing and submitting the survey,providers gave their consent for research *** study was deemed eligible for category-2 Institutional Review Board exempt *** There were total 134 adult/adult-pediatrics ICU responses from 24(83%out of 29)states,and two(28%out of 7)UTs in 61 *** had median(IQR)16(10-25)beds and most,were mixed medical-surgical,111(83%),with 108(81%)being adult-only *** responders were young,median(IQR),38(32-44)years age and majority,n=108(81%)were *** consultants were,n=101(75%).A total of 77(57%)reported to have 24 h in-house intensivist.A total of 68(51%)ICUs reported to have either 2:1 or 2≥:1 patient:nurse *** than 80%of the ICUs were open,and mixed *** followed regularly by the ICUs included sepsis care,ventilator-associated pneumonia(83%each);nutrition(82%),deep vein thrombosis prophylaxis(87%),stress ulcer prophylaxis(88%)and glycemic control(92%).Digital infrastructure was found to be poor,with only 46%of the ICUs reporting high-speed internet *** In this large,national,semi-structured,need-assessment survey,the need for improved manpower including;in-house intensivists,and decreasing

关键词： Intensive care unit Critical care India Survey Intensive care unit survey Intensive care unit needs

Association of latitude and altitude with adverse outcomes in patients with COVID-19: The VIRUS registry

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World Journal of Critical Care Medicine 2022年第2期11卷 102-111页

作者： Aysun Tek.n Shahraz Qamar Romil Singh Vik.s Bansal Mayank.Sharma Allison M LeMahieu Andrew C Hanson Phillip J Schulte Marija Bogojevic Neha Deo Simon Zec Diana J Valencia Morales k.therine A Belden Smith F Heavner Margit k.ufman Sreek.nth Cheruk. Valerie C Danesh Valerie M Banner-Goodspeed Catherine A St Hill Amy B Christie Syed A k.an Lynn Retford k.ren Boman Vishak.a k.umar John C O'Horo Juan Pablo Domecq Allan J Walk.y Ognjen Gajic Rahul kashyap Salim Surani TheSociety of Critical Care Medicine(SCCM)Discovery Viral Infection and Respiratory Illness Universal Study(VIRUS):COVID-Registry Investigator Group Department of Anesthesiology Mayo ClinicRochesterMN 55905United States Post-baccalaureate Research Education Program Mayo Clinic College of Medicine and ScienceRochesterMN 55905United States Division of Pulmonary and Critical Care Medicine Department of Internal MedicineMayo ClinicRochesterMN 55905United States Division of Clinical Trials and Biostatistics Department of Quantitative Health SciencesMayo ClinicRochesterMN 55905United States Alix School of Medicine Mayo ClinicRochesterMN 55905United States Division of Infectious Diseases Thomas Jefferson University HospitalPhiladelphiaPA 19107United States Prisma Health GreenvilleSC 29605United States Englewood Health EnglewoodNJ 07631United States Divisions of Cardiothoracic Anesthesiology and Critical Care Medicine Department of Anesthesiology and Pain ManagementUT Southwestern Medical CenterDallasTX 75390United States Center for Applied Health Research Baylor Scott and White HealthDallasTX 75246United States Department of Anesthesiology Critical Care and Pain MedicineBeth Israel Deaconess Medical CenterBostonMA 02215United States Allina Health MinneapolisMN 55407United States Department of Critical Care Atrium Health NavicentMaconGA 31201United States Division of Critical Care Medicine Mayo Clinic Health SystemMankatoMN 56001United States Society of Critical Care Medicine Mount ProspectIL 60056United States Division of Infectious Diseases Mayo ClinicRochesterMN 55905United States Division of Nephrology and Hypertension Department of Internal MedicineMayo ClinicRochesterMN 55905United States Pulmonary Center Division of PulmonaryAllergyCritical Care and Sleep MedicineDepartment of MedicineEvans Center of Implementation and Improvement SciencesBoston University School of MedicineBostonMA 02118United States Department of Pulmonary and Critical Care Medicine Texas A&M UniversityBryanTX 77807United States 不详

BACk.ROUND The coronavirus disease 2019(COVID-19)course may be affected by environmental *** studies previously suggested a link.between climatological factors and COVID-19 fatality ***,individual-level impact of these factors has not been thoroughly evaluated *** To study the association of climatological factors related to patient location with unfavorable outcomes in *** In this observational analysis of the Society of Critical Care Medicine Discovery Viral Infection and Respiratory Illness Universal Study:COVID-19 Registry cohort,the latitudes and altitudes of hospitals were examined as a covariate for mortality within 28 d of admission and the length of hospital *** for baseline parameters and admission date,multivariable regression modeling was *** estimating equations were used to fit the *** Twenty-two thousand one hundred eight patients from over 20 countries were *** median age was 62(interquartile range:49-74)years,and 54%of the included patients were *** median age increased with increasing latitude as well as the frequency of ***,the percentage of comorbidities was lower in elevated *** within 28 d of hospital admission was found to be 25%.The median hospital-free days among all included patients was 20 *** the significant linear relationship between mortality and hospital-free days(adjusted odds ratio(aOR)=1.39(1.04,1.86),P=0.025 for mortality within 28 d of admission;aOR=-1.47(-2.60,-0.33),P=0.011 for hospital-free days),suggesting that adverse patient outcomes were more common in locations further away from the Equator;the results were no longer significant when adjusted for baseline differences(aOR=1.32(1.00,1.74),P=0.051 for 28-day mortality;aOR=-1.07(-2.13,-0.01),P=0.050 for hospital-free days).When we look.d at the altitude’s effect,we discovered that it demonstrated a non-linear association with mortality wi

关键词： 28 d mortality Altitude COVID-19 Hospital-free days Latitude Outcomes

Influence of quenching medium on the dendrite morphology,hardness, and tribological behaviour of cast Cu-Ni-Sn spinodal alloy for defence application

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