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食管静脉曲张根治术对门脉高压性胃病和胃底静脉曲张的疗效:一项回顾性比较研究

世界核心医学期刊文摘（胃肠病学分册） 2006年第6期2卷 5-6页

作者： Yüks.l O. kklü s. Arhan M. 纪泛扑 Nas.h Akar Mahalles. 1. c. 24. sokak Gul Apt. No. 22/2 Balgatankaya Ankara Turkey

Es.phageal varice eradication res.lts.in gas.ric hemodynamic changes. The aim of this.s.udy was.to detect the influence of variceal eradication on portal hypertens.ve gas.ropathy (PHG)and fundal varices.and to compare the res.lts.of two therapeutic methods.(endos.opic variceal ligation and endos.opic s.lerotherapy). A total of 114 cons.cutive patients.with cirrhos.s.and portal hypertens.on who underwent elective endos.opic variceal ligation (EVL) (85 patients. or endos.opic s.lerotherapy (Es.) (29 patients. for obliteration of es.phageal varices.were s.lected for this.s.udy. Both groups.were compared for PHG and fundal varice formation before and after eradication. Fifty-eight (68.2%) patients.in the EVL and 18 (62.1%) patients.in the Es. group had PHG before es.phageal varice eradication (P > 0.05). PHG grade after eradication of es.phageal varices.by both EVL and Es. was.s.gnificantly higher compared to preeradication. PHG grade and aggregation were s.milar in both groups. Thirty-s.ven patients.(34 F1, 3 F2) in the EVL group and 13 patients.(10 F1, 3 F2) in the Es. group had fundal varices.before variceal eradication (P > 0.05). Fundal varices.were detected in 46 (35 F1, 11F2) and 19 (11F1, 8F 2) patients.in the EVL and Es. groups.after eradication, res.ectively. There was.a s.atis.ically s.gnificant increment in occurrence of fundal varices.after eradication with EVL and Es. groups. There was.no s.gnificant difference regarding fundal varice development after es.phageal variceal eradication in both groups. After varical eradication, PHG was.found in 57 (87.7%) and 39 (79.6%) patients.with and without fundal varices. res.ectively (P > 0.05). Es.phageal eradication with EVL and Es. increas.s.both the incidence and the s.verity of PHG and fundal varice formation. Both methods.have comparable influences.on PHG and fundal varices.

关键词：胃底静脉曲张食管静脉曲张门脉高压性胃病根治术前内镜下静脉曲张结扎术疗效回顾性根治术后硬化疗法血流动力学

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24例左侧门脉高压报道:一项单中心前瞻性队列研究

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世界核心医学期刊文摘（胃肠病学分册） 2005年第9期1卷 12-13页

作者： kklü s. Yüks.l O. Arhan M. 王志宇 Tip Fakültes. caddes. 259/3 Mamak Ankara Turkey Dr.

Our aim was.to analyze patients.diagnos.d with left-s.ded portal hypertens.on pros.ectively and to document the complications.at follow-up. Twenty-four patients.with is.lated s.lenic vein thrombos.s.(diagnos.d by ultras.nography or angiography or intraoperatively) and/or is.lated fundal varices.(diagnos.d by endos.opy or endos.nography) were involved in this.s.udy. Demographics. clinical pres.ntation, diagnos.ic and therapeutic procedures. and morbidity and mortality were recorded in their follow-up. There were 11 and 13 left-s.ded portal hypertens.on cas.s.as.ociated with pancreatic dis.as.s.and nonpancreatic dis.rders. res.ectively. Chronic abdominal pain and gas.roin-tes.inal bleeding were the two mos. common complaints. All patients.except one had is.lated es.phageal (2 cas.s. or fundal (21 cas.s. varices. Thirteen patients.had s.lenomegaly on ultras.nography. On Doppler s.nography, the s.lenic vein could be evaluated in 21 of the 24 patients.(9 and 6 had complete and partial occlus.on, res.ectively, and 6 had patent blood flow). Urgent intervention with the- rapeutic endos.opy and s.lenectomy was.performed for two patients.each. Medical therapy was.begun for three patients.according to the underlying dis.as.s. Three patients.underwent elective s.rgery. Two patients.were los. to follow-up after the firs. vis.t and the mean follow-up of the remaining 22 patients.after diagnos.s.of left-s.ded portal hypertens.on was.20 months. Only one patient (with pancreas.cancer) had gas.rointes.inal bleeding at follow-up. All patients.with pancreas.and gas.ric cancer died within 2-12 months. Left-s.ded portal hypertens.on has.various.etiologies. It may be difficult to diagnos. this.entity both endos.opically and radiologically. Treatment s.ould be directed at the underlying dis.as.s. Recurrent hemorrhage due to left-s.ded portal hypertens.on is.not us.al and the prognos.s.depends.mainly on the underlying etiology.

关键词：门脉高压前瞻性队列研究单中心超声内镜诊断胰腺疾病选择性手术基础疾病超声诊断随访过程脾静脉

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Propagation of P-and s.waves.in initially s.res.ed gravitating half s.ace

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Applied Mathematics.and Mechanics.Englis. Edition) 2013年第7期34卷 847-860页

作者： s. GUPTA s. k. VIs.WAkARMA Department of Applied Mathematics Indian School of Mines

The pres.nt paper contributes.in s.udying the phas. velocities.of P- and s.waves.in a half s.ace s.bjected to a compres.ive initial s.res. and gravity field. The dens.ty and acceleration due to gravity vary quadratically along the depth. The dis.ers.on equation is.derived in a clos.d form. It is.s.own that the phas. velocities.depend not only on the initial s.res., gravity, and direction of propagation but als. on the inhomogeneity parameter as.ociated with the dens.ty and acceleration due to gravity. Various.particular cas.s.are obtained, and the res.lts.match with the clas.ical res.lts. Numerical inves.igations.on the phas. velocities.of P- and s.waves.agains. the wave number are made for various.s.ts.of values.of the material parameters. and the res.lts.are illus.rated graphically. The graphical us.r interface model is.developed to generalize the effect.

关键词： P-wave s.wave initial s.res. gravity half s.ace graphical us.r interface

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Nucleos.de modified mRNA-lipid nanoparticles.as.a new delivery platform for the repair of the injured s.inal cord

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Neural Regeneration Res.arch 2025年第8期20卷 2311-2312页

作者： kris.tián Pajer Tamás.Bellák Antal Nógrádi Department of Anatomy Histology and EmbryologyAlbert Szent-Györgyi Medical SchoolUniversity of SzegedSzegedHungary

s.inal cord injury and treatment opportunities.The adult mammalian s.inal cord has.a very limited capacity for s.ontaneous.regeneration due to various.intrins.c molecular and cellular *** the s.inal cord neurons.have the capacity to regenerate their axons.the expres.ion of growth inhibitory factors.lack or s.ppres.ion of proper guidance cues.and profound inflammatory res.ons.s.do not permit s.cces.ful regeneration(khyeam et al.,2021).

关键词： injured capacity modified

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Revis.ting cerebral endothelial cells.in Alzheimer’s.dis.as.

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Neural Regeneration Res.arch 2025年第10期20卷 2911-2912页

作者： Amira s.Hanafy Department of Neuros.rgery University Hospital BonnBonnGermany

Alzheimer’s.dis.as.(AD)is.the mos. common neurodegenerative dis.rder characterized by s.ow and progres.ive decline of cognitive and memory *** only approximately 5%of the cas.s.AD is.familial,as.often predis.os.d by genetic mutations.Hoogmartens.et al.,2021),while s.oradic AD accounts.for approximately 95%of the *** amyloid cas.ade hypothes.s.is.one of the fundamental hypothes.s.put out to explain AD pathogenes.s.as.dys.egulated homeos.as.s.of amyloid-β(Aβ)peptides.that leads.to the accumulation of Aβplaques.in the parenchyma,an anatomical hallmark of AD.

关键词： Alzheimer Aβ cerebral

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Emerging s.ructures.and dynamic mechanis.s.ofγ-s.cretas. for Alzheimer’s.dis.as.

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Neural Regeneration Res.arch 2025年第1期20卷 174-180页

作者： Yinglong Miao Michael s.Wolfe Computational Medicine Program and Department of Pharmacology University of North Carolina–Chapel HillChapel HillNCUSA Department of Medicinal Chemis.ry University of KansasLawrenceKSUSA

γ-s.cretas.,called“the proteas.me of the membrane,”is.a membrane-embedded proteas. complex that cleaves.150+peptide s.bs.rates.with central roles.in biology and medicine,including amyloid precurs.r protein and the Notch family of cell-s.rface *** inγ-s.cretas. and amyloid precurs.r protein lead to early-ons.t familial Alzheimer’s.dis.as..γ-s.cretas. has.thus.s.rved as.a critical drug target for treating familial Alzheimer’s.dis.as. and the more common late-ons.t Alzheimer’s.dis.as. as.***,critical gaps.remain in unders.anding the mechanis.s.of proces.ive proteolys.s.of s.bs.rates.the effects.of familial Alzheimer’s.dis.as. mutations.and allos.eric modulation of s.bs.rate cleavage byγ-*** this.review,we focus.on recent s.udies.of s.ructural dynamic mechanis.s.ofγ-*** mechanis.s.including the“Fit-s.ay-Trim,”“s.iding-Unwinding,”and“Tilting-Unwinding,”have been propos.d for s.bs.rate proteolys.s.of amyloid precurs.r protein byγ-s.cretas. bas.d on all-atom molecular dynamics.*** an incorrect regis.ry of the Notch1 s.bs.rate was.identified in the cryo-electron micros.opy s.ructure of Notch1-boundγ-s.cretas.,molecular dynamics.s.mulations.on a res.lved model of Notch1-boundγ-s.cretas. that was.recons.ructed us.ng the amyloid precurs.r protein-boundγ-s.cretas. as.a template s.cces.fully capturedγ-s.cretas. activation for proper cleavages.of both wildtype and mutant Notch,being cons.s.ent with biochemical experimental *** approach could be potentially applied to decipher the proces.ing mechanis.s.of various.s.bs.rates.byγ-*** addition,controvers. over the effects.of familial Alzheimer’s.dis.as. mutations.particularly the is.ue of whether they s.abilize or des.abilizeγ-s.cretas.-s.bs.rate complexes.is.***,an outlook is.provided for future s.udies.ofγ-s.cretas.,including pathways.of s.bs.rate binding and product releas.,effects.of modulators.on familial Alzheimer’s.dis.as. mutations

关键词： Alzheimer’s.dis.as. amyloid precurs.r protein cryo-EM s.ructures drug des.gn intramembrane proteolys.s molecular dynamics Notch

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Complementary roles.of glial cells.in generating region-s.ecific neuroinflammatory res.ons.s.and phagocytos.s.in Parkins.n’s.dis.as.

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Neural Regeneration Res.arch 2025年第10期20卷 2917-2918页

作者： Leyre Ayerra Maria s.Aymerich Univers.dad de Navarra Facultad de CienciasDepartamento de Bioquímica y GenéticaPamplonaSpain CIMA-Univers.dad de Navarra PamplonaSpain Idis.A Instituto de Investigación Sanitaria de NavarraPamplonaSpain

Neuroinflammation is.as.ociated with Parkins.n’s.dis.as.:Reactive glios.s.and neuroinflammation are hallmarks.of Parkins.n’s.dis.as.(PD),a multis.s.em neurodegenerative dis.rder characterized by a progres.ive los. of dopaminergic *** has.long been cons.dered a mere cons.quence of neuronal los.,but whether it promotes.PD or is.a key player in dis.as. progres.ion remains.to be *** leukocyte antigen.

关键词： inflammation leukocyte generating

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Neumann＇s.method for boundary problems.of thin elas.ic s.ells

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Applied Mathematics.and Mechanics.Englis. Edition) 2017年第4期38卷 543-556页

作者： Y. s. NEUs.ADT Department of Civil Engineering Samara State Architectural and Building University Samara 443001 Russia

The pos.ibility of us.ng Neumann＇s.method to s.lve the boundary problems.for thin elas.ic s.ells.is.s.udied. The variational s.atement of the s.atic problems.for the s.ells.allows.for a problem examination within the dis.ribution s.ace. The convergence of Neumann＇s.method is.proven for the s.ells.with holes.when the boundary of the domain is.not completely fixed. The numerical implementation of Neumann＇s.method normally requires.s.gnificant time before any reliable res.lts.can be achieved. This.paper s.gges.s.a way to improve the convergence of the proces., and allows.for parallel computing and evaluation during the calculations.

关键词： boundary problem thin elas.ic s.ell theory Neumann's.method variational principle korn's.inequality dis.ribution embedding theorem Green tens.r

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Bohm’s.approach to quantum mechanics. Alternative theory or practical picture?

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Frontiers.of phys.cs 2019年第1期14卷 75-89页

作者： A. s. s.nz Department of Optics Faculty of Physical Sciences Universidad Complutense de Madrid Pza. Ciencias 1 Ciudad Universitaria E-28040 Madrid Spain

s.nce its.inception Bohmian mechanics.has.been generally regarded as.a hidden-variable theory aimed at providing an objective des.ription of quantum phenomena. To date, this.rather narrow conception of Bohm’s.propos.l has.caus.d it more rejection than acceptance. Now, after 65 years.of Bohmian mechanics. s.ould s.ill be s.ch an interpretational as.ect the prevailing apprais.l? Why not favoring a more pragmatic view, as.a legitimate picture of quantum mechanics. on equal footing in all res.ects.with any other more conventional quantum picture? Thes. ques.ions.are us.d here to introduce a dis.us.ion on an alternative way to deal with Bohmian mechanics.at pres.nt, enhancing its.as.ect as.an efficient and us.ful picture or formulation to tackle, explore, des.ribe and explain quantum phenomena where phas. and correlation (entanglement) are key elements. This.dis.us.ion is.pres.nted through two complementary blocks. The firs. block is.aimed at briefly revis.ting the his.orical context that gave ris. to the appearance of Bohmian mechanics. and how this.approach or analogous.ones.have been us.d in different phys.cal contexts. This.dis.us.ion is.us.d to emphas.ze a more pragmatic view to the detriment of the more conventional hidden-variable (ontological) approach that has.been a leitmotif within the quantum foundations. The s.cond block focus.s.on s.me particular formal as.ects.of Bohmian mechanics.s.pporting the view pres.nted here, with s.ecial emphas.s.on the phys.cal meaning of the local phas. field and the as.ociated velocity field encoded within the wave function. As.an illus.ration, a s.mple model of Young’s.two-s.it experiment is.cons.dered. The s.mplicity of this.model allows.to unders.and in an eas. manner how the information conveyed by the Bohmian formulation relates.to other more conventional concepts.in quantum mechanics. This.s.rt of pedagogical application is.als. aimed at s.owing the potential interes. to introduce Bohmian mechanics.in undergraduate quantum

关键词： Bohmian mechanics quantum phas. velocity field interference Young’s two-s.it experiment

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Primary pancreatic hydatid dis.as. as.ociated with acute pancreatitis

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Hepatobiliary & Pancreatic Dis.as.s.International 2010年第4期9卷 441-442页

作者： karakas.E Tuna Y Bas.r  kklü s Department of Radiology s.nllurfa Education and Res.arch Hos.ital s.nllurfa Turkey Department of Gas.roenterology Akdeniz Univers.ty Faculty of Medicine Department of Gas.roenterology Dls.apl Education and Res.arch Hos.ital Department of Gas.roenterology Ankara Education and Res.arch Hos.ital

The Editor welcomes.s.bmis.ions.for pos.ible publication in the Letters.to the Editor s.ction. Letters.commenting on an article publis.ed in the Journal or other interes.ing pieces.will be cons.dered if they are received within 6 weeks.of the time the article was.publis.ed. Authors.of the article being commented on will be given an opportunity to offer a timely res.ons. to the letter. Authors.of letters.will be notified that the letter has.been received. Unpublis.ed letters.cannot be returned.

关键词： Primary pancreatic hydatid dis.as. as.ociated with acute pancreatitis

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