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Peripheral nerve lengthening as a regenerative strategy

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Neural Regeneration Research 2014年第16期9卷 1498-1501页

作者： Kenneth m.Vaz justin m.brown Sameer B.Shah Department of Orthopaedic Surgery University of CaliforniaSan Diego La Jolla CA USA Department of Neurosurgery University of CaliforniaSan Diego La Jolla CA USA Departments of Orthopaedic Surgery and Bioengineering University of CaliforniaSan Diego La Jolla CA USA

Peripheral nerve injury impairs motor, sensory, and autonomic function, incurring substantial financial costs and diminished quality of life. For large nerve gaps, proximal lesions, or chronic nerve injury, the prognosis for recovery is particularly poor, even with autografts, the current gold standard for treating small to moderate nerve gaps. In vivo elongation of intact proximal stumps towards the injured distal stumps of severed peripheral nerves may offer a promising new strategy to treat nerve injury. This review describes several nerve lengthening strategies, including a novel internal fixator device that enables rapid and distal reconnection of proximal and distal nerve stumps.

关键词： peripheral nerve nerve regeneration nerve injury nerve transfer mechanical loading biomedical device

Unraveling the potential of acute intermittent hypoxia as a strategy for inducing robust repair in multiple sclerosis

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Neural Regeneration Research 2024年第11期19卷 2339-2340页

作者： Valerie m.K.Verge Nataliya Tokarska justin m.Naniong Department of Anatomy Physiology and PharmacologyUniversity of SaskatchewanSaskatoonSKCanada Cameco mS Neuroscience Research Center University of SaskatchewanSaskatoonSKCanada

multiple sclerosis(mS)is a debilitating inflammatory disease of the central nervous system characterized by immune-mediated segmental demyelination and variable degrees of axonal and neuronal degeneration that contribute to *** efficient and effective repair programs following demyelination is a major goal and challenge in *** mS therapies focus largely on modulating the immune aspects of the disease contributing to *** this alleviates some symptoms and mitigates damage,it does not tackle the fundamental challenge of effective remyelination,which few mS patients experience,especially in the progressive phase of the disease.

关键词： sclerosis degeneration damage

Uplifting the complexity of analysis for probabilistic security of electricity supply assessments using artificial neural networks

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Energy and AI 2024年第3期17卷 313-326页

作者： justin münch Jan Priesmann marius Reich marius Tillmanns Aaron Praktiknjo mario Adam University of Applied Sciences Duesseldorf Centre of Innovative Energy SystemsMuensterstr.15640476 DuesseldorfGermany RWTH Aachen University E.ON Energy Research CenterChair for Energy System Economics(FCN-ESE)Mathieustrasse 1052074 AachenGermany

The energy sector faces rapid decarbonisation and decision-makers demand reliable assessments of the security of electricity supply. For this, detailed simulation models with a high temporal and technological resolution are required. When confronted with increasing weather-dependent renewable energy generation, probabilistic simulation models have proven. The significant computational costs of calculating a scenario, however, limit the complexity of further analysis. Advances in code optimization as well as the use of computing clusters still lead to runtimes of up to eight hours per scenario. However ongoing research highlights that tailor-made approximations are potentially the key factor in further reducing computing time. Consequently, current research aims to provide a method for the rapid prediction of widely varying scenarios. In this work artificial neural networks (ANN) are trained and compared to approximate the system behavior of the probabilistic simulation model. To do so, information needs to be sampled from the probabilistic simulation in an efficient way. Because only a limited space in the whole design space of the 16 independent variables is of interest, a classification is developed. Finally it required only around 35 min to create the regression models, including sampling the design space, simulating the training data and training the ANNs. The resulting ANNs are able to predict all scenarios within the validity range of the regression model with a coefficient of determination of over 0.9998 for independent test data (1.051.200 data points). They need only a few milliseconds to predict one scenario, enabling in-depth analysis in a brief period of time.

关键词： Security of electricity supply Probabilistic simulation metamodeling Artificial neural networks Regression

Evaluation of a hepatic biomarker of nutritional imbalance in juvenile red drum(Sciaenops ocellatus) fed 60% soybean meal-based diets using NmR-based metabolomics

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Animal Nutrition 2024年第1期16卷 45-61页

作者： Fabio Casu Aaron m.Watson justin Yost T.Gibson Gaylord Daniel W.Bearden michael R.Denson marine Resources Research Institute South Carolina Department of Natural Resources Bozeman Fish Technology Center United States Fish and Wildlife Service marine Biochemical Sciences Group Chemical Sciences Division National Institute of Standards and Technology Hollings Marine Laboratory

A 12-week feeding trial with juvenile red drum(Sciaenops ocellatus) fed high-soybean meal(SBm) diets was conducted to investigate a putative biomarker of nutritional imbalance, N-formimino-L-glutamate(FIGLU). Three fishmeal-free, 60% SBm pelleted diets(named B12, Fol, and met, respectively) were tested to evaluate the effects on growth performance and tissue metabolite profiles of supplementation of vitamin B12(0.012 mg/kg), folate(10 mg/kg), methionine(1 g/kg) respectively, above basal supplementation levels. A fourth SBm-based diet(named B12/Fol/met) was formulated with a combination of B12, folate, and methionine to attain the above-mentioned target concentrations. A fifth 60% SBm diet(named FWS) with methionine supplementation(1 g/kg above basal supplementation levels), enriched with taurine, lysine and threonine as well as minerals, was also tested. This diet contained formulation targets and additives which have allowed for replacing fishmeal with plant proteins in rainbow trout feeds. Control diets included a fishmeal-based diet(named Fm), an unsupplemented basal 60% SBm diet(named SBm60), and a “natural” diet(named N) made up of equal parts of fish(cigar minnows), squid and shrimp as a positive reference for growth performance. Formulated feeds contained approximately 37% total crude protein, approximately 14% total crude lipid and were energetically balanced. Standard growth performance metrics were measured, and tissues(liver, muscle) were collected at week 12 to evaluate diet-induced metabolic changes using nuclear magnetic resonance(NmR)-based *** results show that the FWS diet outperformed all other SBm diets and the Fm diet under all performance metrics(Pm diets and the Fm diet. Fish fed the FWS diet and the met diet showed lower hepatic levels of FIGLU compared with the other SBm-based diets(Pmong the different supplementatio

关键词： Aquaculture metabolomics Nuclear magnetic resonance Red drum Soybean meal N-Formimino-L-glutamate

Feeding behavior and hormoligosis associated with imidacloprid resistance in Asian citrus psyllid,Diaphorina citri

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Insect Science 2024年第4期31卷 1211-1221页

作者： Xue Dong Chen justin George Lauren m.Diepenbrock Hunter Gossett Guoping Liu Jawwad A.Qureshi Lukasz L.Stelinski Entomology and Nematology Department University of FloridaCitrus Research and Education CenterLake AlfredFloridaUSA Southern Insect management Research Unit USDA-ARSStonevilleMississippiUSA Entomology and Nematology Department University of FloridaSouthwest Florida Research and Education CenterImmokaleeFloridaUSA

Imidacloprid is a neonicotinoid insecticide used for managing the Asian citrus psyllid,Diaphorina citri Kuwayama,which serves as vector of phytopathogens causing citrus ***,development of resistance to neonicotinoids among populations of *** has coincided with occasional control failures in the *** objectives of this research were to(1)survey current levels of imidacloprid resistance in Florida citrus;(2)compare feeding behavior between imidacloprid-resistant and susceptible *** using electrical penetration graph recordings,and(3)investigate the possible amplification of insecticide hormoligosis associated with *** surveys confirmed that the susceptibility of *** populations to imidacloprid has decreased in commercial Florida citrus groves compared with a laboratory-susceptible *** 12 generations of selection,resistance to imidacloprid increased by 438 fold compared with the susceptible ***-susceptible *** feeding on citrus exhibited significantly more bouts associated with intercellular pathway(C),phloem penetration(D),phloem salivation(E1),and nonprobing(Np)activities than imidacloprid-resistant ***,there were no differences observed in the frequency or duration of phloem ingestion or xylem feeding between susceptible and resistant *** was no statistical difference in fecundity between resistant and susceptible ***,the fecundity of imidacloprid-susceptible female *** treated with a sublethal concentration of imidacloprid(LC_(25))increased significantly compared with controls,while such hormoligosis was less pronounced among imidacloprid-resistant *** results suggest that imidacloprid-resistant psyllids may cease feeding sooner than susceptible counterparts following sublethal exposure to this insecticide,indicative of a behavioral resistance mechanism.

关键词： artificial selection electrical penetration graph feeding behavior hormoligosis insecticide resistance sublethal exposure

Experiment and simulation to determine the optimum orientation of building-integrated photovoltaic on tropical building façades considering annual daylight performance and energy yield

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Energy and Built Environment 2024年第3期5卷 414-425页

作者： Rizki A.mangkuto Dhian Nur Aziz T.Tresna Ikhwan m.Hermawan justin Pradipta Nurul Jamala Beta Paramita Atthaillah Building Physics Research Group Faculty of Industrial TechnologyInstitut Teknologi BandungLabtek VIJl.Ganesha 10Bandung 40132Indonesia Engineering Physics Program Faculty of Industrial TechnologyInstitut Teknologi BandungLabtek VIJl.Ganesha 10Bandung 40132Indonesia Engineering Physics Research Group Faculty of Industrial TechnologyInstitut Teknologi BandungLabtek VIJl.Ganesha 10Bandung 40132Indonesia Department of Architecture Faculty of EngineeringHasanuddin UniversityJl.Poros Malino Km.6Gowa 92171Indonesia Architecture Study Program Faculty of Technology and Vocational EducationUniversitas Pendidikan IndonesiaJl.Dr.Setiabudhi 229Bandung 40152Indonesia Architecture Program Faculty of EngineeringUniversitas MalikussalehJl.Cot Teungku NieAceh Utara 24355Indonesia

Building-Integrated Photovoltaic(BIPV)on vertical façades is a potential PV application in today’s *** performance of BIPV on façades is significantly influenced by the façade *** tropical cities,the optimum façade orientation,in terms of maximum energy yield and daylight performance,cannot be simply determined,due to relatively symmetrical sun path throughout the *** study therefore aims to determine the optimum orientation for BIPV on tropical building faç*** achieve the objective,experiment,modelling,and computational simulation are conducted to evaluate the BIPV energy yield and to predict the indoor daylight performance in a scale-model building with a 105Wp monocrystalline silicon PV,facing each cardinal orienta-tion in Bandung,*** South orientation yields practically zero ASE_(1000,250),providing the best annual daylight performance,and yielding the most desirable value in four out of five daylight *** greatest annual energy yield is at the North orientation,providing 179-186 kWh(95%prediction interval)per year,but with larger uncertainty compared to that at the South,due to direct sunlight *** on three different objective functions,the South orientation is considered optimum for placing the BIPV panel on the prototype façade in the location.

关键词： Building-integrated photovoltaic Orientation Daylight metric Energy yield Tropical building façade

Optical measurements of dissolved organic matter as proxies for COD_(mn)and BOD_(5)in plateau lakes

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Environmental Science and Ecotechnology 2024年第3期19卷 132-138页

作者： Xuan Yang Yongqiang Zhou Xiaoying Yang Yunlin Zhang Robert G.m.Spencer justin D.Brookes Erik Jeppesen Hucai Zhang Qichao Zhou Institute for Ecological Research and Pollution Control of Plateau Lakes School of Ecology and Environmental SciencesYunnan UniversityKunming650500China Institute of International River and Eco-security Yunnan UniversityKunming650500China Zhejiang College of Security Technology Wenzhou325016China Taihu Laboratory for Lake Ecosystem Research State Key Laboratory of Lake Science and EnvironmentNanjing Institute of Geography and LimnologyChinese Academy of SciencesNanjing210008China Department of Earth Ocean and Atmospheric ScienceFlorida State UniversityTallahassee32306United States Water Research Centre School of Biological ScienceThe University of AdelaideAdelaide5005Australia Department of Ecoscience Aarhus UniversityAarhus8000Denmark Sino-Danish Centre for Education and Research Chinese Academy of SciencesBeijing100101China Limnology Laboratory Department of Biological Sciences and Centre for Ecosystem Research and ImplementationMiddle East Technical UniversityAnkara06800Turkey Institute of marine Sciences Middle East Technical UniversityErdemliMersin33731Turkey Yunnan Key Laboratory of Pollution Process and management of Plateau Lake-Watershed Yunnan Research Academy of Eco-environmental SciencesKunming650034China

The presence of organic matter in lakes profoundly impacts drinking water supplies,yet treatment processes involving coagulants and disinfectants can yield carcinogenic disinfection *** assessments of organic matter,such as chemical oxygen demand(COD_(mn))and biochemical oxygen demand(BOD_(5)),are often ***,optical measurements of dissolved organic matter(DOm)offer a rapid and reliable means of obtaining organic matter composition *** we employed DOm optical measurements in conjunction with parallel factor analysis to scrutinize COD_(mn)and BOD_(5)*** was performed using an independent dataset encompassing six lakes on the Yungui Plateau from 2014 to 2016(n=256).Leveraging multiple linear regressions(mLRs)applied to DOm absorbance at 254 nm(a254)and fluorescence components C1-C5,we successfully traced COD_(mn)and BOD_(5)variations across the entire plateau(68 lakes,n=271,R^(2)>0.8,Pm optical indices yielded superior estimates(higher R^(2))of COD_(mn)and BOD_(5)during the rainy season compared to the dry season and demonstrated increased accuracy(R^(2)>0.9)in mesotrophic lakes compared to oligotrophic and eutrophic *** study underscores the utility of mLR-based DOm indices for inferring COD_(mn)and BOD_(5)variability in plateau lakes and highlights the potential of integrating in situ and remote sensing platforms for water pollution early warning.

关键词： Dissolved organic matter Chemical oxygen demand Biochemical oxygen demand Water quality Yungui plateau lakes

Cognitive function among military veterans with STEm occupations

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military medical Research 2024年第2期11卷 308-310页

作者： justin T.mcDaniel Kevin N.Hascup Erin R.Hascup Ugochukwu G.Ezigbo Amanda m.Weidhuner Harvey Henson David L.Albright Dale and Deborah Smith Center for Alzheimer's Research and trEatment(CARE) Southern Illinois University School of MedicineSpringfieldIL 62794USA STEm Education Research Center Southern Illinois UniversityCarbondaleIL 62901USA Department of Political Science The University of AlabamaTuscaloosaAL 35487USA

Dear Editor,There is limited research on the relationship between science,technology,engineering,and mathematics(STEm)occupational history and cognitive function in later life,especially among military veterans,who may be at greater risk for later-life cognitive *** study examines a nationally representative sample of military veterans to address this gap in knowledge.

关键词： Alzheimer's disease Veterans Science technology engineering and mathematics(STEm) Animal fluency test Dementia

A Rare Case of Aortic Valve Endocarditis and Acute meningitis Due to Haemophilus influenzae

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Case Reports in Clinical medicine 2024年第6期13卷 207-211页

作者： Zachary m. Visinoni justin D. Tse Christopher F. Pease Department of Graduate medical Education Internal medicine Residency Sutter Roseville Medical Center Roseville USA Sutter medical Group Roseville USA

HACEK organisms represent a rare but important group of causative pathogens in endocarditis. These bacteria have historically been associated with culture-negative endocarditis;however, modern laboratory techniques have made this less common. In this case, we present a 74-year-old man who presented with acute onset altered mentation, fever, and sepsis. He was ultimately found to have Haemophilus influenzae meningitis, cerebral empyema, aortic valve endocarditis, psoas myositis, and L2 - L3 diskitis with osteomyelitis. Although HACEK organisms are commonly found in the oropharynx and upper respiratory tract in humans, our patient did not report recent preceding dental or ENT procedures. H. influenzae is responsible for approximately 0.16% of all cases of bacterial endocarditis, representing a very limited subset. Although generally considered low virulent pathogens, this case demonstrates the unusual extent of infection from a HACEK organism, H. influenzae, causing aortic valve endocarditis as well as atypical non-cardiac sequelae, including acute meningitis.

关键词： HACEK Haemophilus influenzae Aortic Valve Endocarditis Bacterial meningitis Cerebral Empyema