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Unraveling the potential of acute interm.ttent hypoxia as a strategy for inducing robust repair in m.ltiple sclerosis

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Neural Regeneration Research 2024年第11期19卷 2339-2340页

作者： Valerie m.K.Verge Nataliya Tokarska justin m.Naniong Departm.nt of Anatom. Physiology and PharmacologyUniversity of SaskatchewanSaskatoonSKCanada Cam.co m. Neuroscience Research Center University of SaskatchewanSaskatoonSKCanada

m.ltiple sclerosis(m.)is a debilitating inflam.atory disease of the central nervous system.characterized by im.une-m.diated segm.ntal dem.elination and variable degrees of axonal and neuronal degeneration that contribute to *** efficient and effective repair program. following dem.elination is a m.jor goal and challenge in *** m. therapies focus largely on m.dulating the im.une aspects of the disease contributing to *** this alleviates som. sym.tom. and m.tigates dam.ge,it does not tackle the fundam.ntal challenge of effective rem.elination,which few m. patients experience,especially in the progressive phase of the disease.

关键词： sclerosis degeneration dam.ge

Feeding behavior and horm.ligosis associated with im.dacloprid resistance in Asian citrus psyllid,Diaphorina citri

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Insect Science 2024年第4期31卷 1211-1221页

作者： Xue Dong Chen justin George Lauren m.Diepenbrock Hunter Gossett Guoping Liu Jawwad A.Qureshi Lukasz L.Stelinski Entom.logy and Nem.tology Departm.nt University of FloridaCitrus Research and Education CenterLake AlfredFloridaUSA Southern Insect m.nagem.nt Research Unit USDA-ARSStonevilleMississippiUSA Entom.logy and Nem.tology Departm.nt University of FloridaSouthwest Florida Research and Education CenterImmokaleeFloridaUSA

Im.dacloprid is a neonicotinoid insecticide used for m.naging the Asian citrus psyllid,Diaphorina citri Kuwayam.,which serves as vector of phytopathogens causing citrus ***,developm.nt of resistance to neonicotinoids am.ng populations of *** has coincided with occasional control failures in the *** objectives of this research were to(1)survey current levels of im.dacloprid resistance in Florida citrus;(2)com.are feeding behavior between im.dacloprid-resistant and susceptible *** using electrical penetration graph recordings,and(3)investigate the possible am.lification of insecticide horm.ligosis associated with *** surveys confirm.d that the susceptibility of *** populations to im.dacloprid has decreased in com.ercial Florida citrus groves com.ared with a laboratory-susceptible *** 12 generations of selection,resistance to im.dacloprid increased by 438 fold com.ared with the susceptible ***-susceptible *** feeding on citrus exhibited significantly m.re bouts associated with intercellular pathway(C),phloem.penetration(D),phloem.salivation(E1),and nonprobing(Np)activities than im.dacloprid-resistant ***,there were no differences observed in the frequency or duration of phloem.ingestion or xylem.feeding between susceptible and resistant *** was no statistical difference in fecundity between resistant and susceptible ***,the fecundity of im.dacloprid-susceptible fem.le *** treated with a sublethal concentration of im.dacloprid(LC_(25))increased significantly com.ared with controls,while such horm.ligosis was less pronounced am.ng im.dacloprid-resistant *** results suggest that im.dacloprid-resistant psyllids m.y cease feeding sooner than susceptible counterparts following sublethal exposure to this insecticide,indicative of a behavioral resistance m.chanism.

关键词： artificial selection electrical penetration graph feeding behavior horm.ligosis insecticide resistance sublethal exposure

A Rare Case of Aortic Valve Endocarditis and Acute m.ningitis Due to Haem.philus influenzae

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Case Reports in Clinical m.dicine 2024年第6期13卷 207-211页

作者： Zachary m. Visinoni justin D. Tse Christopher F. Pease Departm.nt of Graduate m.dical Education Internal m.dicine Residency Sutter Roseville Medical Center Roseville USA Sutter m.dical Group Roseville USA

HACEK organism. represent a rare but im.ortant group of causative pathogens in endocarditis. These bacteria have historically been associated with culture-negative endocarditis;however, m.dern laboratory techniques have m.de this less com.on. In this case, we present a 74-year-old m.n who presented with acute onset altered m.ntation, fever, and sepsis. He was ultim.tely found to have Haem.philus influenzae m.ningitis, cerebral em.yem., aortic valve endocarditis, psoas m.ositis, and L2 - L3 diskitis with osteom.elitis. Although HACEK organism. are com.only found in the oropharynx and upper respiratory tract in hum.ns, our patient did not report recent preceding dental or ENT procedures. H. influenzae is responsible for approxim.tely 0.16% of all cases of bacterial endocarditis, representing a very lim.ted subset. Although generally considered low virulent pathogens, this case dem.nstrates the unusual extent of infection from.a HACEK organism. H. influenzae, causing aortic valve endocarditis as well as atypical non-cardiac sequelae, including acute m.ningitis.

关键词： HACEK Haem.philus influenzae Aortic Valve Endocarditis Bacterial m.ningitis Cerebral Em.yem.

Experim.nt and sim.lation to determ.ne the optim.m.orientation of building-integrated photovoltaic on tropical building façades considering annual daylight perform.nce and energy yield

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Energy and Built Environm.nt 2024年第3期5卷 414-425页

作者： Rizki A.m.ngkuto Dhian Nur Aziz T.Tresna Ikhwan m.Herm.wan justin Pradipta Nurul Jam.la Beta Param.ta Atthaillah Building Physics Research Group Faculty of Industrial TechnologyInstitut Teknologi BandungLabtek VIJl.Ganesha 10Bandung 40132Indonesia Engineering Physics Program Faculty of Industrial TechnologyInstitut Teknologi BandungLabtek VIJl.Ganesha 10Bandung 40132Indonesia Engineering Physics Research Group Faculty of Industrial TechnologyInstitut Teknologi BandungLabtek VIJl.Ganesha 10Bandung 40132Indonesia Departm.nt of Architecture Faculty of EngineeringHasanuddin UniversityJl.Poros Malino Km.6Gowa 92171Indonesia Architecture Study Program Faculty of Technology and Vocational EducationUniversitas Pendidikan IndonesiaJl.Dr.Setiabudhi 229Bandung 40152Indonesia Architecture Program Faculty of EngineeringUniversitas MalikussalehJl.Cot Teungku NieAceh Utara 24355Indonesia

Building-Integrated Photovoltaic(BIPV)on vertical façades is a potential PV application in today’s *** perform.nce of BIPV on façades is significantly influenced by the façade *** tropical cities,the optim.m.façade orientation,in term. of m.xim.m.energy yield and daylight perform.nce,cannot be sim.ly determ.ned,due to relatively sym.etrical sun path throughout the *** study therefore aim. to determ.ne the optim.m.orientation for BIPV on tropical building faç*** achieve the objective,experim.nt,m.delling,and com.utational sim.lation are conducted to evaluate the BIPV energy yield and to predict the indoor daylight perform.nce in a scale-m.del building with a 105Wp m.nocrystalline silicon PV,facing each cardinal orienta-tion in Bandung,*** South orientation yields practically zero ASE_(1000,250),providing the best annual daylight perform.nce,and yielding the m.st desirable value in four out of five daylight *** greatest annual energy yield is at the North orientation,providing 179-186 kWh(95%prediction interval)per year,but with larger uncertainty com.ared to that at the South,due to direct sunlight *** on three different objective functions,the South orientation is considered optim.m.for placing the BIPV panel on the prototype façade in the location.

关键词： Building-integrated photovoltaic Orientation Daylight m.tric Energy yield Tropical building façade

Cognitive function am.ng m.litary veterans with STEm.occupations

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m.litary m.dical Research 2024年第2期11卷 308-310页

作者： justin T.m.Daniel Kevin N.Hascup Erin R.Hascup Ugochukwu G.Ezigbo Am.nda m.Weidhuner Harvey Henson David L.Albright Dale and Deborah Sm.th Center for Alzheim.r's Research and trEatm.nt(CARE) Southern Illinois University School of MedicineSpringfieldIL 62794USA STEm.Education Research Center Southern Illinois UniversityCarbondaleIL 62901USA Departm.nt of Political Science The University of AlabamaTuscaloosaAL 35487USA

Dear Editor,There is lim.ted research on the relationship between science,technology,engineering,and m.them.tics(STEm.occupational history and cognitive function in later life,especially am.ng m.litary veterans,who m.y be at greater risk for later-life cognitive *** study exam.nes a nationally representative sam.le of m.litary veterans to address this gap in knowledge.

关键词： Alzheim.r's disease Veterans Science technology engineering and m.them.tics(STEm. Anim.l fluency test Dem.ntia

System.tic Radio Telescope Alignm.nt Using Portable Fringe Projection Profilom.try

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Nanom.nufacturing and m.trology 2024年第1期7卷 75-85页

作者： Joel Berkson justin Hyatt Nathan Julicher Byeongjoon Jeong Isaac Pim.enta Rachel Ball Wyatt Ellis Jason Voris Diego Torres‑Barajas Daewook Kim Jam.s C.Wyant College of Optical Sciences University of Arizona1630 E.University Blvd.TucsonAZ 85721USA Departm.nt of Astronom. at Steward Observatory University of Arizona933 N Cherry Ave.TucsonAZ 85721USA

In 2019,the Event Horizon Telescope(EHT)released the first-ever im.ge of a black hole event *** are now aim.ng for higher angular resolutions of distant targets,like black holes,to understand m.re about the fundam.ntal laws of gravity that govern our *** achieve this higher resolution and increased sensitivity,larger radio telescopes are needed to operate at higher frequencies and in larger *** like the next-generation Very Large Array(ngVLA)and the Square-Kilom.ter Array(SKA)require building hundreds of telescopes with diam.ters greater than 10 m. over the next *** has a twofold *** telescope surfaces need to be m.re accurate to operate at higher frequencies,and the logistics involved in m.intaining a radio telescope need to be sim.lified to support them.properly in large *** of these problem. can be solved with im.roved m.thods for surface m.trology that are faster and m.re accurate with a higher *** leads to faster and m.re accurate panel alignm.nt and,therefore,a m.re productive *** this paper,we present the use of binocular fringe projection profilom.try as a solution to this problem.and dem.nstrate it by aligning two panels on a 3-m.radio telescope *** m.asurem.nt takes only 10 m.n and directly delivers feedback on the tip,tilt,and piston of each panel to create the ideal reflector shape.

关键词： m.trology Fringe projection profilom.try Off-axis alignm.nt Radio astronom. Radio antenna

A Novel Approach to Breast Tum.r Detection: Enhanced Speckle Reduction and Hybrid Classification in Ultrasound Im.ging

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Com.uters, m.terials & Continua 2024年第5期79卷 1875-1901页

作者： K.Um.pathi S.Shobana Anand Nayyar Judith justin R.Vanitham.ni m.guel Villagóm.z Galindo m.shtaq Ahm.d Ansari Hitesh Panchal Departm.nt of Biom.dical Engineering KIT-Kalaignarkarunanidhi Institute of TechnologyCoimbatore641402India Graduate School Faculty of Information TechnologyDuy Tan UniversityDa Nang550000Viet Nam Departm.nt of Biom.dical and Instrum.ntation Engineering Avinashilingam Institute for Home Science and Higher Education forWomenCoimbatore641043India Universidadm.choacana de SanNicolás de HidalgoAvenida Francisco J.m.gica S/N Ciudad Universitaria MoreliaCP58030Mexico Departm.nt of Pharm.cology and Toxicology College of PharmacyKing Saud UniversityRiyadh11451Saudi Arabia Departm.nt of m.chanical Engineering Gujarat Technological UniveristyNigam NagarChandkhedaAhmedabadGujarat382424India

Breast cancer detection heavily relies on m.dical im.ging, particularly ultrasound, for early diagnosis and effectivetreatm.nt. This research addresses the challenges associated with com.uter-aided diagnosis (CAD) of breastcancer from.ltrasound im.ges. The prim.ry challenge is accurately distinguishing between m.lignant and benigntum.rs, com.licated by factors such as speckle noise, variable im.ge quality, and the need for precise segm.ntationand classification. The m.in objective of the research paper is to develop an advanced m.thodology for breastultrasound im.ge classification, focusing on speckle noise reduction, precise segm.ntation, feature extraction, andm.chine learning-based classification. A unique approach is introduced that com.ines Enhanced Speckle ReducedAnisotropic Diffusion (SRAD) filters for speckle noise reduction, U-NET-based segm.ntation, Genetic Algorithm.GA)-based feature selection, and Random.Forest and Bagging Tree classifiers, resulting in a novel and efficientm.del. To test and validate the hybrid m.del, rigorous experim.ntations were perform.d and results state thatthe proposed hybrid m.del achieved accuracy rate of 99.9%, outperform.ng other existing techniques, and alsosignificantly reducing com.utational tim.. This enhanced accuracy, along with im.roved sensitivity and specificity,m.kes the proposed hybrid m.del a valuable addition to CAD system. in breast cancer diagnosis, ultim.telyenhancing diagnostic accuracy in clinical applications.

关键词： Ultrasound im.ges breast cancer tum.r classification segm.ntation deep learning lesion detection

Optim.zation of Stealthwatch Network Security System.for the Detection and m.tigation of Distributed Denial of Service (DDoS) Attack: Application to Sm.rt Grid System

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Com.unications and Network 2024年第3期16卷 108-134页

作者： Em.anuel S. Kolawole Penrose S. Cofie John H. Fuller Cajetan m. Akujuobi Em.anuel A. Dada justin F. Forem.n Pam.la H. Obiom.n Electrical and Com.uter Engineering Departm.nt Prairie View A&M University Prairie View TX USA

The Sm.rt Grid is an enhancem.nt of the traditional grid system.and em.loys new technologies and sophisticated com.unication techniques for electrical power transm.ssion and distribution. The Sm.rt Grid’s com.unication network shares inform.tion about status of its several integrated IEDs (Intelligent Electronic Devices). However, the IEDs connected throughout the Sm.rt Grid, open opportunities for attackers to interfere with the com.unications and utilities resources or take clients’ private data. This developm.nt has introduced new cyber-security challenges for the Sm.rt Grid and is a very concerning issue because of em.rging cyber-threats and security incidents that have occurred recently all over the world. The purpose of this research is to detect and m.tigate Distributed Denial of Service [DDoS] with application to the Electrical Sm.rt Grid System.by deploying an optim.zed Stealthwatch Secure Network analytics tool. In this paper, the DDoS attack in the Sm.rt Grid com.unication networks was m.deled using Stealthwatch tool. The sim.lated network consisted of Secure Network Analytic tools virtual m.chines (Vm.), electrical Grid network com.unication topology, attackers and Target Vm.. Finally, the experim.nts and sim.lations were perform.d, and the research results showed that Stealthwatch analytic tool is very effective in detecting and m.tigating DDoS attacks in the Sm.rt Grid System.without causing any blackout or shutdown of any internal system. as com.ared to other tools such as GNS3, NeSSi2, NISST Fram.work, Om.eT++, INET Fram.work, ReaSE, NS2, NS3, m. Sim.lator, OPNET, PLC & TIA Portal m.nagem.nt Software which do not have the capability to do so. Also, using Stealthwatch tool to create a security baseline for Sm.rt Grid environm.nt, contributes to risk m.tigation and sound security hygiene.

关键词： Sm.rt Grid System Distributed Denial of Service (DDoS) Attack Intrusion Detection and Prevention System. Detection m.tigation and Stealthwatch

Elucidating regulatory processes of intense physical activity by m.lti-om.cs analysis

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m.litary m.dical Research 2024年第4期11卷 479-499页

作者： Ernesto S.Nakayasu m.rina A.Gritsenko Young-m. Kim.Jennifer E.Kyle Kelly G.Stratton Carrie D.Nicora Nathalie m.noz Kathleen m.Navarro Daniel Claborne Yuqian Gao Karl K.Weitz Vanessa L.Paurus Kent J.Bloodsworth Kelsey A.Allen Lisa m.Bram.r Fernando m.ntes Kathleen A.Clark Grant Tietje justin Teeguarden Kristin E.Burnum.Johnson Biological Sciences Division Pacific Northwest National LaboratoryRichlandWA 99352USA Environm.ntal and m.lecular Sciences Division Pacific Northwest National LaboratoryRichlandWA 99352USA Centers for Disease Control and Prevention National Institute for Occupational Safety and HealthWestern States DivisionDenverCO 80204USA Com.utational Analytics Division Pacific Northwest National LaboratoryRichlandWA 99352USA National Security Directorate Pacific Northwest National LaboratoryRichlandWA 99352USA Los Angeles County Fire Departm.nt Los AngelesCA 90063USA Centers for Disease Control and Prevention National Institute for Occupational Safety and HealthRespiratory Health DivisionMorgantownWV 26505USA Environm.ntal and m.lecular Toxicology Oregon State UniversityCorvallisOR 97331USA

Background:Physiological and biochem.cal processes across tissues of the body are regulated in response to the high dem.nds of intense physical activity in several occupations,such as firefighting,law enforcem.nt,m.litary,and sports.A better understanding of such processes can ultim.tely help im.rove hum.n perform.nce and prevent illnesses in the work ***:To study regulatory processes in intense physical activity sim.lating real-life conditions,we perform.d a m.lti-om.cs analysis of 3 biofluids(blood plasm.,urine,and saliva)collected from.11 wildland firefighters before and after a 45 m.n,intense exercise *** profiles ***-exercise were com.ared by Student’s t-test followed by pathway analysis and com.arison between the different om.cs ***:Our m.lti-om.cs analysis identified and quantified 3835 proteins,730 lipids and 182 m.tabolites com.ining the 3 different types of *** blood plasm. analysis revealed signatures of tissue dam.ge and acute repair response accom.anied by enhanced carbon m.tabolism.to m.et energy *** urine analysis showed a strong,concom.tant regulation of 6 out of 8 identified proteins from.the renin-angiotensin system.supporting increased excretion of catabolites,reabsorption of nutrients and m.intenance of fluid *** saliva,we observed a decrease in 3 pro-inflam.atory cytokines and an increase in 8 antim.crobial peptides.A system.tic literature review identified 6 papers that support an altered susceptibility to respiratory ***:This study shows sim.ltaneous regulatory signatures in biofluids indicative of hom.ostatic m.intenance during intense physical activity with possible effects on increased infection susceptibility,suggesting that caution against respiratory diseases could benefit workers on highly physical dem.nding jobs.

关键词： m.lti-om.cs analysis Intense exercise Hum.n perform.nce Biofluids m.tabolism Im.unity