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A novel indocyanine green-based fluorescent marker for guiding surgical tumor resection

Journal of Innovative Optical Health Sciences 2021年第3期4卷 77-87页

作者： Jiawei Ge justin d.opfermann Hamed Saeidi Katherine A.Huenerberg Christopher d.Badger Jaepyeong Cha Martin J.Schnermann Arjun S.Joshi Axel Krieger department of Mechanical Engineering Johns Hopkins University BaltimoreMD 21218USA department of Mechanical Engineering University of Maryland College Park MD 20742USA Sheikh Zayed Institute for Pediatric Surgical Innovation Children's National Hospital WashingtonDC 20010USA department of Pathology George Washington University WashingtonDC 20052USA division of Otolaryngology-Head and Neck Surgery George Washington University Washington DC 20052USA Chemical Biology Laboratory Center for Cancer Research National Cancer InstituteNational Institutes of HealthFrederickMD 21702USA

Surgical tumor resection is a common approach to cancer *** Ink tattoos are widely used to aid tumor resection by localizing and mapping the tumor edge at the ***,India Ink tattoos are easily obscured during electrosurgical resection,and fade in intensity over *** this work,a novel near-infrared(NIR)fluorescent marker is introduced as an *** NIR marker was made by mixing indocyanine green(ICG),biocompatible cyanoacrylate,and *** marking strategy was evaluated in a chronic ex vivo feasibility study using porcine tissues,followed by a chronic in vivo mouse study while compared with India *** both studies,signal-to-noise(SNR)ratios and dimensions of the NIR markers and/or India Ink over the study period were calculated and *** was performed on the last day of the mouse study after mice were euthanized,and SNR ratios and dimensions were quantified and *** was performed at all injection sites and slides were examined by a *** proposed NIR marker achieved(i)consistent visibility in the 26-day feasibility study and(ii)improved durability,visibility,and biocompatibility when compared to traditional India Ink over the six-week period in an in vivo mouse *** effects persist after electrocautery whereas the India Ink markers were *** use of a NIR fluorescent presurgical marking strategy has the potential for intraoperative tracking during long-term treatment protocols.

关键词： Near-infrared fluorescent marker surgical tumor resection fluorescence-guided sur-gery electrosurgery India ink

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Unveiling a new regulator: Vacuolar V-ATPase mediates brassinosteroid signaling in Arabidopsis

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Molecular Plant 2024年第2期17卷 227-229页

作者： Shikha Malik justin W.Walley department of Plant Pathology Entomologyand Microbiologylowa State UniversityAmesIA 50011USA

Plant growth and development are intricately regulated by hormones such as auxins,gibberellins,jamonates,cytokinins,and brassinosteroids(BRs).BRs are a group of plant steroid hormones that play a vital role in plant growth and response to the *** regulate many biological processes including cell elongation,cell division,and male fertility,as well as abiotic and biotic stress responses.

关键词： media fertility brassinosteroid

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Spirotetramat reduces fitness of the spotted-wing drosophila,drosophila suzukii

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Insect Science 2024年第4期31卷 1222-1230页

作者： Jing Yang justin Flaven-Pouchon Yiwen Wang Bernard Moussian Section of Animal Genetics Interfaculty Institute of Cell BiologyUniversity of TübingenTübingenGermany School of Pharmaceutical Science and Technology Tianjin UniversityTianjinChina INRAE CNRSUniversitéCôte d'AzurInstitut Sophia AgrobiotechSophia AntipolisFrance

With climate change,the spotted-wing drosophila(SWd,drosophila suzukii)invades a great number of fruit production regions worldwide.A plethora of insecticides are being applied for management of this *** expected,SWd develops resistance against some potent insecticides or is rather insensitive to some ***,there is an urgent need to identify and characterize alternative insecticides to control SWd ***,we have studied the effects of the orally applied inhibitor of the fatty acid synthesis pathway spirotetramat on SWd fitness with respect to fecundity and surface barrier function at different *** our experiments,we applied spirotetramat mixed with baker's yeast and showed that females and males were not repelled by effective concentrations of this *** found that spirotetramat,by trend,lowers egg numbers laid by fed *** eggs rapidly desiccate,and only a few larvae *** is lethal to larvae and reduces survival of adult flies under low-humidity *** together,based on our data,we propose to use yeast supplemented with spirotetramat and additional SWd-specific attractants in traps in non-crop areas in order to eradicate SWd populations before they infest crop production sites.

关键词： desiccation drosophila suzuki insecticide lipids

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Astrocytes integrate time and space

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Neural Regeneration Research 2025年第2期20卷 467-468页

作者： justin Lines department of Biological Sciences Columbia UniversityNew YorkNYUSA

Astrocytes read and react to synaptic transmission through tripartite synapses,where the binding of neurotransmitters onto astrocytic receptors triggers an increase in intracellular *** investigations have revealed that astrocytes exhibit two distinct states of intracellular calcium activity:(1)graded subcellular localized clusters with independently active microdomains,likely influenced by nearby synaptic events,and(2)whole-cell astrocyte calcium surges,believed to result from the coordinated activation of multiple ***,astrocyte calcium responses are not solely graded;instead,a spatial threshold of intracellular calcium activity can be overcome to elicit an astrocyte calcium *** these calcium responses,in turn,initiate downstream signaling pathways capable of modifying synaptic communication and overall network *** summary,astrocytes can function as integrators of local synaptic events,actively contributing to information processing within the brain.

关键词： graded integrate instead

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Unraveling the potential of acute intermittent hypoxia as a strategy for inducing robust repair in multiple sclerosis

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Neural Regeneration Research 2024年第11期19卷 2339-2340页

作者： Valerie M.K.Verge Nataliya Tokarska justin M.Naniong department of Anatomy Physiology and PharmacologyUniversity of SaskatchewanSaskatoonSKCanada Cameco MS Neuroscience Research Center University of SaskatchewanSaskatoonSKCanada

Multiple sclerosis(MS)is a debilitating inflammatory disease of the central nervous system characterized by immune-mediated segmental demyelination and variable degrees of axonal and neuronal degeneration that contribute to *** efficient and effective repair programs following demyelination is a major goal and challenge in *** MS therapies focus largely on modulating the immune aspects of the disease contributing to *** this alleviates some symptoms and mitigates damage,it does not tackle the fundamental challenge of effective remyelination,which few MS patients experience,especially in the progressive phase of the disease.

关键词： sclerosis degeneration damage

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Pelvic fractures in blunt trauma patients:A comparative study

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World Journal of Orthopedics 2024年第5期15卷 418-434页

作者： Alexander A Fokin Joanna Wycech Knight Madison E Tharp Kyler C Brinton Phoebe K Gallagher justin Fengyuan Xie Russell d Weisz Ivan Puente Trauma and Critical Care Services Delray Medical CenterDelray BeachFL 33484United States Charles E Schmidt College of Medicine Department of SurgeryFlorida Atlantic UniversityBoca RatonFL 33431United States Trauma and Critical Care Services Broward Health Medical CenterFort LauderdaleFL 33316United States Charles E Schmidt College of Medicine Florida Atlantic UniversityBoca RatonFL 33431United States Herbert Wertheim College of Medicine Department of SurgeryFlorida International UniversityMiamiFL 33199United States

BACKGROUNd Pelvic fractures(PF)with concomitant injuries are on the rise due to an increase of high-energy *** of the elderly population with age related comorbidities further complicates the *** organ injuries are kindred with PF due to the proximity to pelvic *** of contrast blush(CB)on computed tomography in patients with PF is considered a sign of active bleeding,however,its clinical significance and association with outcomes is *** To analyze polytrauma patients with PF with a focus on the geriatric population,co-injuries and the value of contrast *** This retrospective cohort study included 558 patients with PF admitted to level 1 trauma center(01/2017-01/2023).Analyzed variables included:Age,sex,mechanism of injury(MOI),injury severity score(ISS),Glasgow coma scale(GCS),abbreviated injury scale(AIS),co-injuries,transfusion requirements,pelvic angiography,embolization,laparotomy,orthopedic pelvic surgery,intensive care unit and hospital lengths of stay,discharge disposition and *** study compared geriatric and non-geriatric patients,patients with and without CB and abdominal *** score matching was implemented in comparison *** PF comprised 4%of all trauma admissions.89 patients had CB.286(52%)patients had concomitant injuries including 93(17%)patients with abdominal *** patients compared to non-geriatric had more falls as MOI,lower ISS and AIS pelvis,higher GCS,less abdominal co-injuries,similar CB and angio-embolization rates,less orthopedic pelvic surgeries,shorter lengths of stay and higher *** propensity matching,orthopedic pelvic surgery rates remained lower(8%vs 19%,Pd mortality higher(13%vs 4%,Pd to without CB had more pelvic angiography(71%vs 12%,P<0.001),hi

关键词： Pelvic fractures Geriatric trauma patients Abdominal co-injuries Contrast blush Contrast extravasation Angioembolization Polytrauma patients Surgical interventions Blunt trauma External and internal fixation for pelvic stabilization

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Evaluation of a hepatic biomarker of nutritional imbalance in juvenile red drum ( Sciaenops ocellatus ) fed 60% soybean meal-based diets using NMR-based metabolomics

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Animal Nutrition 2024年第1期16卷 45-61页

作者： Fabio Casu Aaron M. Watson justin Yost T. Gibson Gaylord daniel W. Bearden Michael R. denson Marine Resources Research Institute South Carolina Department of Natural Resources 217 Fort Johnson Road Charleston SC 29412 USA Bozeman Fish Technology Center United States Fish and Wildlife Service 4050 Bridger Canyon Road Bozeman MT 59715 USA Marine Biochemical Sciences Group Chemical Sciences Division National Institute of Standards and Technology Hollings Marine Laboratory 331 Fort Johnson Road Charleston SC 29412 USA

A 12-week feeding trial with juvenile red drum ( Sciaenops ocellatus ) fed high-soybean meal (SBM) diets was conducted to investigate a putative biomarker of nutritional imbalance, N-formimino-L-glutamate (FIGLU). Three fishmeal-free, 60% SBM pelleted diets (named B12, Fol, and Met, respectively) were tested to evaluate the effects on growth performance and tissue metabolite profiles of supplementation of vitamin B 12 (0.012 mg/kg), folate (10 mg/kg), methionine (1 g/kg) respectively, above basal supplementation levels. A fourth SBM-based diet (named B12/Fol/Met) was formulated with a combination of B 12 , folate, and methionine to attain the above-mentioned target concentrations. A fifth 60% SBM diet (named FWS) with methionine supplementation (1 g/kg above basal supplementation levels), enriched with taurine, lysine and threonine as well as minerals, was also tested. This diet contained formulation targets and additives which have allowed for replacing fishmeal with plant proteins in rainbow trout feeds. Control diets included a fishmeal-based diet (named FM), an unsupplemented basal 60% SBM diet (named SBM60), and a “natural” diet (named N) made up of equal parts of fish (cigar minnows), squid and shrimp as a positive reference for growth performance. Formulated feeds contained approximately 37% total crude protein, approximately 14% total crude lipid and were energetically balanced. Standard growth performance metrics were measured, and tissues (liver, muscle) were collected at week 12 to evaluate diet-induced metabolic changes using nuclear magnetic resonance (NMR)-based metabolomics. Our results show that the FWS diet outperformed all other SBM diets and the FM diet under all performance metrics ( P detected in fish fed the N diet but was detected in those fed the SBM diets and the FM diet. Fish fed the FWS diet and the Met diet showed lower hepatic levels of FIGLU compared with the other SBM-based diets ( P < 0.05), suggesting that am

关键词： Aquaculture Metabolomics Nuclear magnetic resonance Red drum Soybean meal N-Formimino-L-glutamate

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Systematic Analysis of Post-Translational Modifications for Increased Longevity of Biotherapeutic Proteins

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Computational Molecular Bioscience 2024年第3期14卷 125-145页

作者： justin Kim Karanveer Sadiora Thomas Jefferson High School for Science and Technology Alexandria VA USA

Protein-based therapeutics (PPTs) are drugs used to treat a variety of different conditions in the human body by alleviating enzymatic deficiencies, augmenting other proteins and drugs, modulating signal pathways, and more. However, many PPTs struggle from a short half-life due to degradation caused by irreversible protein aggregation in the bloodstream. Currently, the most researched strategies for improving the efficiency and longevity of PPTs are post-translational modifications (PTMs). The goal of our research was to determine which type of PTM increases longevity the most for each of three commonly-used therapeutic proteins by comparing the docking scores (dS) and binding free energies (BFE) from protein aggregation and reception simulations. dS and BFE values were used to create a quantitative index that outputs a relative number from −1 to 1 to show reduced performance, no change, or increased performance. Results showed that methylation was the most beneficial for insulin (p d human growth hormone (p d both phosphorylation and methylation were somewhat optimal for erythropoietin (p d p ded the worst benefits with the most negative indices, while methylation had the most positive indices throughout. However, PTM efficacy varied between PPTs, supporting previous studies regarding how each PTM can confer different benefits based on the unique structures of recipient proteins.

关键词： Post-Translational Modification Protein-Based Therapeutics Therapeutic Half-Life Protein Aggregation Protein Reception

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A Rare Case of Aortic Valve Endocarditis and Acute Meningitis due to Haemophilus influenzae

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Case Reports in Clinical Medicine 2024年第6期13卷 207-211页

作者： Zachary M. Visinoni justin d. Tse Christopher F. Pease department of Graduate Medical Education Internal Medicine Residency Sutter Roseville Medical Center Roseville USA Sutter Medical Group Roseville USA

HACEK organisms represent a rare but important group of causative pathogens in endocarditis. These bacteria have historically been associated with culture-negative endocarditis;however, modern laboratory techniques have made this less common. In this case, we present a 74-year-old man who presented with acute onset altered mentation, fever, and sepsis. He was ultimately found to have Haemophilus influenzae meningitis, cerebral empyema, aortic valve endocarditis, psoas myositis, and L2 - L3 diskitis with osteomyelitis. Although HACEK organisms are commonly found in the oropharynx and upper respiratory tract in humans, our patient did not report recent preceding dental or ENT procedures. H. influenzae is responsible for approximately 0.16% of all cases of bacterial endocarditis, representing a very limited subset. Although generally considered low virulent pathogens, this case demonstrates the unusual extent of infection from a HACEK organism, H. influenzae, causing aortic valve endocarditis as well as atypical non-cardiac sequelae, including acute meningitis.

关键词： HACEK Haemophilus influenzae Aortic Valve Endocarditis Bacterial Meningitis Cerebral Empyema

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Feeding behavior and hormoligosis associated with imidacloprid resistance in Asian citrus psyllid,diaphorina citri

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Insect Science 2024年第4期31卷 1211-1221页

作者： Xue dong Chen justin George Lauren M.diepenbrock Hunter Gossett Guoping Liu Jawwad A.Qureshi Lukasz L.Stelinski Entomology and Nematology department University of FloridaCitrus Research and Education CenterLake AlfredFloridaUSA Southern Insect Management Research Unit USDA-ARSStonevilleMississippiUSA Entomology and Nematology department University of FloridaSouthwest Florida Research and Education CenterImmokaleeFloridaUSA

Imidacloprid is a neonicotinoid insecticide used for managing the Asian citrus psyllid,diaphorina citri Kuwayama,which serves as vector of phytopathogens causing citrus ***,development of resistance to neonicotinoids among populations of *** has coincided with occasional control failures in the *** objectives of this research were to(1)survey current levels of imidacloprid resistance in Florida citrus;(2)compare feeding behavior between imidacloprid-resistant and susceptible *** using electrical penetration graph recordings,and(3)investigate the possible amplification of insecticide hormoligosis associated with *** surveys confirmed that the susceptibility of *** populations to imidacloprid has decreased in commercial Florida citrus groves compared with a laboratory-susceptible *** 12 generations of selection,resistance to imidacloprid increased by 438 fold compared with the susceptible ***-susceptible *** feeding on citrus exhibited significantly more bouts associated with intercellular pathway(C),phloem penetration(d),phloem salivation(E1),and nonprobing(Np)activities than imidacloprid-resistant ***,there were no differences observed in the frequency or duration of phloem ingestion or xylem feeding between susceptible and resistant *** was no statistical difference in fecundity between resistant and susceptible ***,the fecundity of imidacloprid-susceptible female *** treated with a sublethal concentration of imidacloprid(LC_(25))increased significantly compared with controls,while such hormoligosis was less pronounced among imidacloprid-resistant *** results suggest that imidacloprid-resistant psyllids may cease feeding sooner than susceptible counterparts following sublethal exposure to this insecticide,indicative of a behavioral resistance mechanism.

关键词： artificial selection electrical penetration graph feeding behavior hormoligosis insecticide resistance sublethal exposure

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