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Development and Validation of a Metabolic-related Prognostic Model for Hepatocellular Carcinoma

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Journal of Clinical and Translational Hepatology 2021年第2期9卷 169-179页

作者： junyu huo Liqun Wu Yunjin Zang Liver Disease Center The Affiliated Hospital of Qingdao UniversityQingdaoShandongChina

Background and Aims:Growing evidence suggests that metabolic-related genes have a significant impact on the occurrence and development of hepatocellular carcinoma(HCC).However,the prognostic value of metabolic-related genes for HCC has not been fully ***:mRNA sequencing and clinical data were obtained from The Cancer Genome Atlas and the GTEx Genotype-Tissue Expression comprehensive *** expressed metabolic-related genes in tumor tissues(n=374)and normal tissues(n=160)were identified by the Wilcoxon ***-dependent receiver operating characteristic curve analysis,univariate multivariate Cox regression analysis and Kaplan-Meier survival analysis were used to evaluate the predictive effectiveness and independence of the prognostic *** independent cohorts(International Cancer Genome Consortiums and GSE14520)were applied to verify the prognostic ***:Our study included a total of 793 patients with *** constructed a risk score consisting of five metabolic-genes(BDH1,RRM2,CYP2C9,PLA2G7,and TXNRD1).For the overall survival rate,the low-risk group had a considerably higher rate than the high-risk *** and multivariate Cox regression analyses indicated that the risk score was an independent predictor for the prognosis of ***:We constructed and validated a novel prognostic model,which may provide support for the precise treatment of HCC.

关键词： Hepatocellular carcinoma Metabolic Prognostic Signature

Establishment of the Initial Sandplay Picture System for Chinese Young Internet Addicts: Based on Valence Assessment of Normal Adolescents

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Health 2021年第3期13卷 273-282页

作者： Ying Ge junyu huo Jingyi Yuan Huiyong Fan Key Laboratory of Emotion and Mental Health in Chongqing Chongqing University of Arts and Sciences Chongqing Collaborative Innovation Center for Brain Science Chongqing China College of Transportation Engineering Tongji University Shanghai China College of Education and Sciences Bohai University Jinzhou China

To develop the initial sandplay picture system for Chinese young internet addicts (ISPSCYIA) for the diagnosis and testing studies on internet addiction, 22 pictures were selected from the used pictures of initial sandplay in existing research results of initial sandplay of Chinese young Internet addicts. 54 normal adolescents were recruited to evaluate the valence of the pictures on a nine-point scale in terms of clarity, pleasure and arousal. Results were shown that there were no significant differences between addiction pictures and non-addiction pictures in clarity, while there were significant differences in pleasure and arousal, as the scores of non-addiction pictures were higher. Correlation analysis indicated that there was obvious positive correlation among clarity, pleasure and arousal of addiction pictures & non-addiction pictures. The coefficients of internal consistency reliability and split-half reliability of 22 pictures’ scores exhibited both over 0.90. ISPSCYIA has proved typical and distinctive through valence assessment, which could be preliminarily applied to measure the characteristics of Chinese adolescents’ internet addiction.

关键词： Chinese Adolescents Internet Addiction Initial Sandplay Picture System Valence Assessment

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工程造价管理中BIM技术的应用

建设科技 2023年第10期 98-100页

作者：霍俊宇中蓝连海设计研究院有限公司连云港市222000

近年来,BIM技术快速发展,被广泛应用到建筑领域,发挥着重要的作用。BIM的核心是信息,工程造价管理中通过搭建信息平台,对造价信息动态化更新,实现信息的有效共享,助力工程造价管理工作的高质量开展,具有推广应用的价值。现针对工程造价... 详细信息

近年来,BIM技术快速发展,被广泛应用到建筑领域,发挥着重要的作用。BIM的核心是信息,工程造价管理中通过搭建信息平台,对造价信息动态化更新,实现信息的有效共享,助力工程造价管理工作的高质量开展,具有推广应用的价值。现针对工程造价管理中BIM技术的应用,展开具体的论述,提出BIM技术应用的策略。

关键词： BIM 工程造价管理数据共享

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网络成瘾青少年初始沙盘特征

中国学校卫生 2018年第3期39卷 383-386页

作者：葛缨霍俊妤王鑫强重庆文理学院重庆市情绪与心理健康重点实验室重庆402160 江西师范大学心理学院

目的探讨青少年网络成瘾者的初始沙盘特征,丰富沙盘游戏治疗的理论和实践,为青少年网络成瘾者的临床诊断提供参考。方法使用青少年病理性互联网使用量表(Adolescent Pathological Internet Use Scale,APIUS)选取重庆市60名初中生被试(3... 详细信息

目的探讨青少年网络成瘾者的初始沙盘特征,丰富沙盘游戏治疗的理论和实践,为青少年网络成瘾者的临床诊断提供参考。方法使用青少年病理性互联网使用量表(Adolescent Pathological Internet Use Scale,APIUS)选取重庆市60名初中生被试(30名网络成瘾青少年,30名正常青少年),探究青少年网络成瘾者初始沙盘特征。结果青少年网络成瘾者多使用军事类沙具(t=2.079,P=0.046),少使用自然元素(t=-1.979,P=0.050)和生活元素类(t=-2.375,P=0.024);在沙盘主题上多出现分裂和混乱2个创伤主题,少出现整合和深入2个治愈主题(χ~2值分别为4.504,2.079,7.878,5.271,P值均<0.05)。沙盘主题特征的Logistic回归分析显示,整合、深入2个主题特征是青少年网络成瘾者的保护因素(B值分别为-0.591,-0.548,F=3.005,P<0.05,△R^2=0.211)。结论青少年网络成瘾者在沙具使用、沙盘的主题2个维度上有特征表现。初始沙盘对青少年网络成瘾者具有临床心理筛查与测评的功能和参考价值。

关键词：计算机通信网络行为,成瘾精神卫生青少年

农村留守与非留守儿童的心理健康、虐待经历比较及其关系研究——基于两维四象心理健康结构的分析与对策建议

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中国特殊教育 2018年第1期 58-64页

作者：王鑫强霍俊妤张大均刘培杰江西师范大学心理健康教育研究中心心理学院南昌330022 西南大学心理健康教育研究中心重庆400715 济阳县第二实验中学济南251400

文章运用问卷调查法,全面比较分析农村留守与非留守儿童在积极心理健康、心理问题及各种虐待经历上的差异。研究结果表明,农村留守儿童在快乐感、生活满意度、亲社会行为等积极心理健康指标上显著低于非留守农村儿童;情感忽视、情感虐... 详细信息

文章运用问卷调查法,全面比较分析农村留守与非留守儿童在积极心理健康、心理问题及各种虐待经历上的差异。研究结果表明,农村留守儿童在快乐感、生活满意度、亲社会行为等积极心理健康指标上显著低于非留守农村儿童;情感忽视、情感虐待和躯体忽视为农村留守儿童的主要虐待经历,能对内化心理问题、外化心理问题、内化积极心理健康、外化积极心理健康等指标起到较广泛的显著预测作用。文章在调查结果的基础上提出了加强农村留守儿童的积极心理健康教育,构建留守儿童隐性虐待的防护体系等对策建议。

关键词：农村留守儿童心理健康虐待经历积极心理健康教育

胃肠道肿瘤切除术后全肠外营养与胃肠道早期营养的疗效对比分析

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中国医学创新 2019年第29期16卷 137-140页

作者：霍俊宇任文豪冯仰荣青岛大学山东青岛266071 山东省青岛市市立医院山东第一医科大学

目的:比较胃肠道肿瘤切除治疗患者开展术后全肠外营养与胃肠道早期营养的疗效。方法:将2016年4月-2018年4月本院收治的胃肠道肿瘤切除术治疗患者84例作为研究对象,依据随机数字表法分为观察组和对照组,每组42例。观察组给予胃肠道早期营... 详细信息

目的:比较胃肠道肿瘤切除治疗患者开展术后全肠外营养与胃肠道早期营养的疗效。方法:将2016年4月-2018年4月本院收治的胃肠道肿瘤切除术治疗患者84例作为研究对象,依据随机数字表法分为观察组和对照组,每组42例。观察组给予胃肠道早期营养,对照组给予术后全肠外营养支持,观察两组恢复速度、机体营养及免疫功能改善情况。结果:观察组术后通气时间、发热消失时间、肛门排气时间及住院时间均显著短于对照组(P<0.05),观察组术后体重、白蛋白及前白蛋白水平均显著优于对照组(P<0.05),观察组术后7 d淋巴细胞总数、T淋巴细胞亚群比例恢复均显著优于对照组(P<0.05)。结论:在胃肠道肿瘤切除治疗患者中实施胃肠道早期营养支持对加快术后恢复有明显效果,尤其可调节机体营养状态和免疫指标,利于机体功能恢复,值得推广应用。

关键词：胃肠道肿瘤切除术全肠外营养胃肠道早期营养

Establishment of the Initial Sandplay Picture System for Chinese Young Internet Addicts: Based on Valence Assessment of Normal Adolescents

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Health（健康） 2021年第3期

作者： Ying Ge junyu huo Jingyi Yuan Huiyong Fan

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基于性别的服装购买经验与品牌视觉感知关联

国际纺织导报 2021年第1期49卷 31-35,45页

作者：葛缨何吉波霍俊妤重庆文理学院重庆市情绪与心理健康重点试验室暨用户体验与人机交互技术研究所(中国)

采用访谈与眼动追踪的方法,定性与定量相结合分析不同性别大学生的服装购买经验和品牌视觉感知的特点与关联。100名参与测试的大学生的数据分析表明:女性大学生的服装品牌知识和购买经验较丰富,购衣频率较高,对服装品牌的视觉感知更敏感... 详细信息

采用访谈与眼动追踪的方法,定性与定量相结合分析不同性别大学生的服装购买经验和品牌视觉感知的特点与关联。100名参与测试的大学生的数据分析表明:女性大学生的服装品牌知识和购买经验较丰富,购衣频率较高,对服装品牌的视觉感知更敏感;男性大学生则偏好非名牌服装。服装购买经验与服装品牌视觉感知的性别差异趋同,两者具有正关联性。本研究有助于根据特定人群的需求进行服装设计、营销及品牌塑造。

关键词：服装品牌品牌视觉视觉感知购买频率品牌知识性别差异

Pembrolizumab combined with lenvatinib as non-first-line therapy in patients with refractory biliary tract carcinoma

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Hepatobiliary Surgery and Nutrition 2020年第4期9卷 414-424页

作者： Jianzhen Lin Xu Yang junyu Long Songhui Zhao Jinzhu Mao Dongxu Wang Yi Bai Jin Bian Lei Zhang Xiaobo Yang Anqiang Wang Fucun Xie Weiwei Shi Huayu Yang Jie Pan Ke Hu Mei Guan Lin Zhao Li huo Yilei Mao Xinting Sang Kai Wang Haitao Zhao Department of Liver Surgery Peking Union Medical College HospitalChinese Academy of Medical Sciences&Peking Union Medical College(CAMS&PUMC)Beijing 100730China OrigiMed Shanghai 200135China Department of Gastrointestinal Surgery Peking University Cancer Hospital&InstituteBeijing 100142China Department of Radiology Peking Union Medical College HospitalBeijing 100730China Center of Radiotherapy Peking Union Medical College HospitalBeijing 100730China Department of Medical Oncology Peking Union Medical College HospitalBeijing 100730China Department of Nuclear Medicine Peking Union Medical College HospitalBeijing 100730China

Background:A therapeutic strategy involving combined treatment with lenvatinib plus pembrolizumab(LEP)has demonstrated a relatively high antitumor response in several solid tumors;however,the efficacy and safety of LEP in patients with refractory bile tract carcinoma(BTC)remains ***:This is a single-arm study for a preliminary assessment of the efficacy and tolerability of LEP in patients who experienced progression from prior systemic ***-treatment tumor tissues were collected to retrospectively evaluate the expression status of ***:Thirty-two patients received second-line and above treatment with ***,the objective response rate(ORR)was 25%,the disease control rate(DCR)was 78.1%,and the clinical benefit rate(CBR)was 40.5%.The median progression-free survival(PFS)was 4.9 months(95%CI:4.7–5.2 months),and the median overall survival(OS)was 11.0 months(95%CI:9.6–12.3 months).For tolerability,no grade 5 serious adverse events(AEs)were *** patients had any-grade AEs,and 59.3%of the patients experienced grade 3 AEs,while only 1 patient experienced a grade 4 AE of stomach *** was the most common AE,followed by hypertension and elevated aminotransferase *** analysis for PDL1 expression revealed that PDL1 positive tumor cells were associated with improved clinical benefits and survival ***:LEP is a promising alternative as a non-first-line therapeutic regimen for patients with refractory ***,well-designed prospective clinical trials with a control arm are still needed to obtain more evidences to confirm the efficacy and safety of this particular regimen as well as the role of PDL1 expression.

关键词： Pembrolizumab lenvatinib bile tract cancer PD1 PDL1