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Downregulation of Rice DWARF 14 LIKE Suppress Mesocotyl Elongation via a Strigolactone Independent Pathway in the Dark

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Journal of Genetics and Genomics 2015年第3期42卷 119-124页

作者： Hiromu Kameoka junko Kyozuka Department of Agricultural and Environmental Biology Graduate School of Agricultural and Life SciencesThe University of Tokyo

Strigolactones （SLs） are a class of plant hormones that control plant development in response to environmental conditions. In rice, mesocotyl elongation is regulated by SLs in the dark, while mesocotyls are longer in SL deficient or insensitive mutants. SLs are perceived by DWARF14 （D14）, which is a member of a small gene family. In this study, we examined the function of another D14 family gene in rice, D14 LIKE （D14L）, focusing on mesocotyl growth. The mesocotyls of D14L RNAi lines are longer than those of WT in the dark. This phenotype is enhanced when the D14L RNAi lines are combined with the d14 mutation, suggesting that D14 and D14L work independently to inhibit mesocotyl elongation. This phenotype is alleviated by the exogenous supply of GR24, a synthetic SL, suggesting that D14L is not necessary for SL signaling. D14L mRNA is predominantly expressed in vascular bundles and crown root primordia. Our results suggest that D14L and D14 confer their effects via an SL independent pathway and an SL signaling pathway respectively.

关键词： Strigolactone Mesocotyl Rice DWARF 14 (D14) D14 LIKE (D14L) KARRIKIN INSENSITIVE 2 (KAI2)

RadonPy:automated physical property calculation using all-atom classical molecular dynamics simulations for polymer informatics

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npj Computational Materials 2022年第1期8卷 2155-2169页

作者： Yoshihiro Hayashi Junichiro Shiomi junko Morikawa Ryo Yoshida The Institute of Statistical Mathematics(ISM) Research Organization of Information and Systems10-3 Midori-choTachikawaTokyo190-8562Japan Department of Mechanical Engineering The University of Tokyo7-3-1 HongoBunkyoTokyo113-8656Japan Institute of Engineering Innovation The University of Tokyo2-11 YayoiBunkyo-kuTokyo113-0032Japan Department of Materials Science and Engineering School of Materials and Chemical TechnologyTokyo Institute of Technology2-12-1 OokayamaMeguro-kuTokyo152-8552Japan Research and Services Division of Materials Data and Integrated System(MaDIS) National Institute for Materials Science(NIMS)1-2-1 SengenTsukubaIbaraki305-0047Japan Department of Statistical Science School of Multidisciplinary ScienceThe Graduate University of Advanced Studies(SOKENDAI)10-3 Midori-choTachikawaTokyo190-8562Japan

The spread of data-driven materials research has increased the need for systematically designed materials property ***,the development of polymer databases has lagged far behind other material *** present RadonPy,an open-source library that can automate the complete process of all-atom classical molecular dynamics(MD)simulations applicable to a wide variety of polymeric ***,15 different properties were calculated for more than 1000 amorphous *** MD-calculated properties were systematically compared with experimental data to validate the calculation conditions;the bias and variance in the MD-calculated properties were successfully calibrated by a machine learning *** the high-throughput data production,we identified eight amorphous polymers with extremely high thermal conductivity(>0.4 W∙m^(–1)∙K^(–1))and their underlying *** to the advancement of materials informatics since the advent of computational property databases for inorganic crystals,database construction using RadonPy will promote the development of polymer informatics.

关键词： property calculation dynamics

Integrated Risk Identification, Analysis, and Assessment:A Dynamic Household Economy Analysis Methodology and Example

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International Journal of Disaster Risk Science 2013年第2期4卷 77-88页

作者： Bob Alexander Linda J.Cox junko Mochizuki Rural Livelihood Risk Management Consulting P.O.Box 1251HonoluluHI 96807USA Department of Natural Resource and Environmental Management University of Hawai`i at ManoaHonoluluHI 96822USA

Many methodologies identify, analyze, and assess static risks to quantify potential disaster losses based on past and current events. Static methodologies will not, however, capture how climate change and adaptation are rapidly affecting the natural and social systems in many areas. Local and global changes such as those associated with development investments, livelihood pressures, political stability, and demographic trends are also affecting many areas, especially in emerging economies. Risk identification, analysis, and assessment methodologies must integrate all changes dynamically so that risk reduction and development decisions can be based on future needs. After a theoretical explanation of how to integrate dynamic changes, a static Household Economy Analysis(HEA) completed for a rapidly changing area of East Timor was altered using current trends to make the analysis more dynamic. Some inherent difficulties exist with a more dynamic approach and recommendations for overcoming them are presented. Research, government, and nongovernment personnel interested in integrated approaches to risk reduction and development decision-making in areas subject to rapid change will find the study useful.

关键词： integrate disaster interested

A currency basket and future exchange rate arrangements in Asia

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Economic and Political Studies 2018年第1期6卷 53-68页

作者： junko Shimizu Kiyotaka Sato Faculty of Economics Gakushuin UniversitToykoJapan Department of Economics Yokohama National UniversitYokohamaJapan School of Business and Law Edith Cowan UniversitPerthAustralia

Due not only to a dominant role of the US dollar in regional trade and financial transactions but also to de facto US dollar pegged exchange rate policy,Asian countries cannot avoid exchange rate risks between their own currency and the US *** recent years,however,the Chinese government has actively promoted the Renminbi(RMB)internationalisation especially in intermational *** December 2015,China introduced a new exchange rate index against a basket of 13 trade-weighted currencies,which can be considered a major turning point from the US dollar standard toward a more flexible currency basket ***,the estimated implicit basket weights reveal that several Asian economies still tend to stabilise their currencies against the US dollar,while Malaysia and Singapore have stabilised their currencies against RMB in recent *** the internationalisation of local currencies and regional monetary arrangements are typically facilitated with each other,further progress of RMB internationalisation is expected to promote a leading role of China in establishing regional exchange rate policy coordination.

关键词： Currency basket currency internationalisation regional monetary arrangements exchange ratepolicy Asia

Efect of CNTs on Activation Volume and Mobile Dislocation Exhaustion Rate of CNTs/Al under Compression Loading

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Acta Metallurgica Sinica(English Letters) 2023年第1期36卷 127-132页

作者： Minjie Wang Jianghua Shen Biao Chen Umeda junko Katsuyoshi Kondoh Yulong Li School of Aeronautics Northwestern Polytechnical UniversityXi’an 710000China Shaanxi Key Laboratory of Impact Dynamic and Its Engineering Application Xi’an 710000China School of Materials Science and Engineering Northwestern Polytechnical UniversityXi’an 710000China Joining and Welding Research Institute Osaka University11-1 MihogaokaOsaka 567-0047Japan School of Civil Aviation Northwestern Polytechnical UniversityXi’an 710000China Joint International Research Laboratory of Impact Dynamics and Its Engineering Applications Xi’an 710000China

In this study,stress relaxation compression tests were performed to investigate the strain rate sensitivity,activation volume and mobile dislocations in carbon nanotubes/aluminum(CNTs/Al)*** results reveal that,with the addition of CNTs,the strain rate sensitivity of CNTs/Al ***,a smaller V*of CNTs/Al compared with pure Al was attributed mainly to the CNT-Al interfaces and partly to the increased forest dislocations cutting activities in grain interior,which was related to the tendency of short ranges order formation during plastic *** incorporation of CNTs also improved the dislocation storage capability and reduced the dislocation velocity,leading to a lower mobile dislocation exhaustion rate.

关键词： Metal matrix composites Carbon nanotubes Strain rate sensitivity Activation volume Dislocations exhaustion

Transplantation of olfactory ensheathing cells promotes axonal regeneration in a rat model of spinal cord injury

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Neural Regeneration Research 2010年第9期5卷 651-656页

作者： Xichuan Teng Nozomu Yoshioka junko Kimura-Kuroda Koki Kawamura HitoshiKawano Hongpeng Li Department of Developmental Morphology Tokyo Metropofitan Institute for Neuroscience Fuchu 183-8526 Japan Department of Pathology Medical College Eastern Liaoning University Dandong 118000 Liaoning Province China Department of Human Anatomy College of Basic Medical Sciences China Medical University Shenyang 110001 Liaoning Province China

BACKGROUND：Transplantation of olfactory ensheathing cells （OECs） into the injured spinal cord has been shown to promote axonal regeneration and functional ***,the mechanisms underlying the effects of OEC transplantation remain ***：To observe fibrotic scar formation and axonal regeneration in the damaged spinal cord following OEC transplantation,and to determine whether OEC transplantation promotes neural regeneration by attenuating fibrotic scar ***,TIME AND SETTING：A randomized,controlled animal experiment was performed at the Department of Developmental Morphology,Tokyo Metropolitan Institute for Neuroscience,Fuchu,Japan and at the Department of Human Anatomy,College of Basic Medical Sciences,China Medical University,China between April 2007 and May ***：OECs were obtained from olfactory nerves and olfactory bulbs of male,4-week-old,Sprague Dawley *** anti-serotonin polyclonal antibody,rabbit anti-calcitonin gene-related peptide polyclonal antibody,rabbit anti-glial fibrillary acidic protein polyclonal antibody,rabbit anti-type IV collagen polyclonal antibody,and mouse anti-rat endothelial cell antigen-1 monoclonal antibody were ***：Male,Sprague Dawley rats aged 8 weeks were randomly divided into three groups：sham-surgery （n = 3）,surgery （n = 9）,and OEC transplantation （n = 11）.Spinal cord transection at the T9-10 level was performed and the rats were transplanted with a 2-μL （1 × 105 cells） cell *** OUTCOME MEASURES：Formation of glial and fibrotic scars was examined using immunohistochemistry for glial fibrillary acidic protein and type IV ***-positive and calcitonin gene-related peptide-positive axons were visualized by immunohistochemistry,*** immunofluorescence for type IV collagen and rat endothelial cell antigen-1 was also performed to determine co-localization of type IV collagen deposition and blood ***：At 1 week after spinal cord

关键词： fibrotic scar olfactory ensheathing cell transplantation spinal cord injury neural regeneration rats

Isoflavone Regulates Lipid Metabolism via Expression of Related Genes in OVX Rats Fed on a High-fat Diet

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Biomedical and Environmental Sciences 2008年第5期21卷 357-364页

作者： XIAO-LIN NA junko EZAKI FUMIE SUGIYAMA HONG-BIN CUI AND YOSHIKO ISHIMI Department of Food Nutrition and Hygiene Public Health College Harbin Medical University Harbin 150086 Heilongjiang China Nutritional Epidemiology Program National Institute of Health and Nutrition Tokyo 162-8636 Japan

Objective To investigate the effects of isoflavone on body weight, fat mass, and gene expression in relation to lipid metabolism. Methods Thirty-six female SD rats were ovariectomized or sham-operated and fed on a high-fat diet. Two months later, abdominal incision was made, blood was collected to separate serum, and the liver and adipose tissue were immediately collected and weighed. Some portions of these tissues were frozen in liquid nitrogen and stored at -80℃. Results Ovariectomy （OVX） with a high-fat diet could induce obesity in rats, while treatment with isoflavone significantly inhibited the increase in body weight and fat mass in abdomen. Serum total cholesterol and leptin were significantly decreased in isoflavone group, compared with the OVX group. The mRNA expression of liver fatty acid synthase （FAS） in the OVX group was significantly higher than that in sham-operated group, while this difference was not observed in the isoflavone group. The mRNA expression of liver hormone-sensitive lipase （HSL） in the OVX rats tended to be lower than that in the sham-operated rats. Furthermore, a large amount of isoflavone maintained the mRNA expression at a sham level. Conclusion Isoflavone may prevent obesity induced by ovariectomy with a high-fat diet, in part by modulating gene expression related to lipid metabolism.

关键词： Isoflavone Lipid metabolism Ovariectomy Obesity Gene expression

Actuation and blocking force of stacked nanocarbon polymer actuators

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International Journal of Smart and Nano Materials 2018年第3期9卷 184-198,I0003页

作者： Ken Mukai Masahiro Yamamura junko Kamata Hirosato Monobe Kinji Asaka Inorganic Functional Material Research institute National Institute of Advanced Industrial Science and Technology(AIST)OsakaJapan

We have developed stacked nanocarbon polymer actuators that are composed of several nanocarbon polymer actuator films using nonwoven fabric as insulation *** nonwoven fabric prepared through electrospinning methods has extremely-low-density structures,which do not significantly prevent the motions of each nanocarbon actuator ***,stacking several thin nanocarbon polymer actuators using nonwoven fabric as insulation layers is expected to increase generated force without decreasing the displacement of a one-layer *** have prepared stacked actuators with one,two,three,four,and seven layers using this *** displacement and blocking force of these actuators are measured and compared with those of one-layer actuators of different *** is weakly dependent on the thickness of the actuator films of the stacked *** the contrary,it decreases considerably as the thickness of the actuator film of the one-layer actuator *** both cases,blocking force is proportional to the thickness of actuator *** have developed a stacked actuator model based on a trilayer actuator model and confirmed the experimental results using the model.

关键词： Nanocarbon actuator polymer stacking model

Embryonal sarcoma of the liver with chondroid differentiation

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World Journal of Gastrointestinal Oncology 2010年第5期2卷 247-250页

作者： Sawako Kinjo Shinji Sakurai junko Hirato Yutaka Sunose Department of Pathology Gunma University Hospital Department of Diagnostic Pathology Gunma University Graduate School of Medicine Department of Visceral and Thoracic Organ Surgery Gunma University Hospital

A 31-year-old female complained of upper abdominal and back pain. Laboratory tests showed elevated levels of aspartate aminotransferase, alanine aminotransferase and α-fetoprotein. Computed tomography revealed that the tumor, measuring 14.5 cm × 10.4 cm, occupied the anterior and medial segments of the liver and consisted of multicystic and solid lesions. The preoperative diagnosis was a hepatic cystadenocarcinoma. The operation was performed urgently because of tumor rupture. Histo- pathologically, spindle and asteroid cells were found to have proliferated diffusely. There were no neoplastic epithelial tumor cells. Tumor cells had periodic acid- Schiff-positive hyalin globules. At the periphery, trapped normal bile duct cells were observed. The final diagnosis was embryonal sarcoma of the liver (ESL). Interestingly, irregular islands of chondrosarcoma-like lesions were found in the tumor and the tumor-associated vascular endothelium showed immunoreactivity for KIT. Two months after the operation, the tumor recurred. At 6 mo follow-up, the patient is alive with the disease and undergoing chemotherapy. This is the first report of ESL with chondroid differentiation.

关键词： Chondroid differentiation Undifferentiated sarcoma Adult Liver tumor Immunohistochemistry