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International Journal of Ophthalmology(English edition) 2019年第3期12卷 393-400页

作者： Won choi Jun Young Ha Ying Li jung han choi Yong Sok Ji Kyung Chul Yoon Department of Ophthalmology and Research Institute of Medical Sciences Chonnam National University Medical School and Hospital

AIM: To investigate the abnormalities in the meibomian gland in patients with dry eye disease(DED) associated with chronic ocular graft-versus-host disease(coGVHD) in comparison with Sj?gren's syndrome(SS), a major form of aqueous deficient DED and meibomian gland dysfunction(MGD), a common cause of evaporative ***: A total 135 eyes of 135 subjects included in this study: patients with DED associated with coGVHD(n=30), patients with SS(n=35), patients with MGD(n=35), and normal controls(n=35). All participants completed the Ocular Surface Disease Index(OSDI) questionnaire, ocular surface examination [Schirmer test, tear film breakup time(TFBUT), and ocular surface staining], and meibomian gland assessment [meiboscore(gland dropout detected on meibography using infrared camera of the Keratograph 5 M), meibum expressibility score(MES), meibum quality score(MQS), lid margin abnormality]. In addition, correlations of meibomian gland characteristics with ocular surface parameters as well as disease severity score were investigated in coGVHD ***: The coGVHD group showed significantly higher meiboscore, MES, and MQS than the other 3 groups(all Phan other types of DED. In addition, meibomian gland damage is not only associated with ocular surface damage but also disease severity of coGVHD.

关键词： chronic ocular graft-versus-host disease Sjogren's syndrome dry eye disease meibomian gland dysfunction meibography

CoolVox:Advanced 3D convolutional neural network models for predicting solar radiation on building facades

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Building Simulation 2022年第5期15卷 755-768页

作者： jung Min han Eun Seuk choi Ali Malkawi Harvard University Graduate School of Design CambridgeUSA Harvard Center for Green Buildings and Cities CambridgeUSA Harvard John A.Paulson School of Engineering and Applied Sciences CambridgeUSA

Data-driven models have become increasingly prominent in the building,architecture,and construction *** area ideally suited to exploit this powerful new technology is building performance ***-based models have traditionally been used to estimate the energy flow,air movement,and heat balance of ***,physics-based models require many assumptions,significant computational power,and a considerable amount of time to output *** neural networks(ANNs)with prefabricated or simulated data are likely to be a more feasible option for environmental analysis conducted by designers during the early design *** ANNs require fewer inputs and shorter computation times and offer superior performance and potential for data augmentation,they have received increased attention for predicting the surface solar radiation on ***,ANNs can provide innovative and quick design solutions,enabling designers to receive instantaneous feedback on the effects of a proposed change to a building's *** research introduces deep learning methods as a means of simulating the annual radiation intensities and exposure level of buildings without the need for physics-based *** propose the CoolVox model to demonstrate the feasibility of using 3D convolutional neural networks to predict the surface radiation on building *** CoolVox model accurately predicted the radiation intensities of building facades under different boundary conditions and performed better than ARINet(with average mean square errors of 0.01 and 0.036,respectively)in predicting the radiation intensity both with(validation error=0.0165)and without(validation error=0.0066)the presence of boundary buildings.

关键词： artificial neural networks 3D convolutional neural networks solar radiation simulation building performance simulation

Development of gelatin-sodium caseinate high-oxygen-barrier film containing elderberry(Sambucus nigra L.)extract and its antioxidant capacity on pork

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Food Bioscience 2023年第3期53卷 1192-1199页

作者： Jieun choi jung-Soo Lee Jaejoon han Yoonjee Chang Department of Food and Nutrition College of Science and TechnologyKookmin UniversitySeoul02707Republic of Korea Department of Biotechnology College of Life Sciences and BiotechnologyKorea UniversitySeoul02841Republic of Korea

The use of biodegradable polymers and natural additives is a sustainable strategy to prevent oxidation and extend food shelf *** this study,a gelatin-sodium caseinate composite film containing elderberry extract was newly developed and *** film with the most optimal oxygen permeability and water vapor permeability was selected by blending gelatin(G)and sodium caseinate(S)at a 50:50 ratio(w/w).The addition of 0.5%(w/w)elderberry extract(EE)improved the oxygen barrier properties and gave the edible film a high potential for food quality *** was improved(105.82%±9.36%)and DPPH radical scav-enging analysis revealed a significantly strong antioxidant activity(Phanisms,including radical scavenging and oxygen contact ***,protein-based films containing natural extract have the potential for an antioxidant packaging strategy.

关键词： Gelatin Sodium caseinate Antioxidant Elderberry extract Oxygen permeability

Dual function of a high-contrast hydrophobic-hydrophilic coating for enhanced stability of perovskite solar cells in extremely humid environments

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Nano Research 2017年第11期10卷 3885-3895页

作者： Jin Sun Yoo Gill Sang han Seongha Lee Min Cheol Kim Mansoo choi Hyun Suk jung jung-Kun Lee School of Advanced Materials Science amp Engineering Sungkyunkwan University Suwon 440-746 Republic of Korea Department of Mechanical Engineering and Materials Science University of Pittsburgh Pittsburgh Pennsylvania 15261 USA Department of Mechanical and Aerospace Engineering Seoul National University Seoul 08826 Republic of Korea

In spite of a continuous increase in their power conversion efficiency （PCE） and an economically viable fabrication process,organic-inorganic perovskite solar cells （PSCs） pose a significant problem when used in practical applications：They show fast degradation of the PCE when exposed to very humid *** this study,the stability of PSCs under very humid conditions is greatly enhanced by coating the surface of the PSC devices with a multi-layer film consisting of ultrahydrophobic and relatively hydrophilic layers.A hydrophobic composite of poly（methyl methacrylate）（PMMA）,polyurethane （PU）,and SiO2 nanoparticles successfully retards the water molecules from very humid ***,the hydrophilic layer with moderately PMMA captures the residual moisture within the perovskite layer;subsequently,the perovskite layer *** dual function of the coating film keeps the PCE of PSCs at 17.3% for 180 min when exposed to over 95% humidity.

关键词： perovskite solar cell stability surface coating ultrahydrophobic self-recovery

Advanced metal–organic frameworks for aqueous sodium-ion rechargeable batteries

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Journal of Energy Chemistry 2021年第2期30卷 396-406,I0014页

作者： Dongkyu choi Seonguk Lim Dongwook han School of Nano Convergence Technology Hallym UniversityChuncheon 24252Gangwon-doRepublic of Korea Nano Convergence Technology Center Hallym UniversityChuncheon 24252Gangwon-doRepublic of Korea

Inexpensive and abundant sodium resources make energy storage systems using sodium chemistry promising replacements for typical lithium-ion rechargeable batteries(LIBs).Fortuitously,aqueous sodium-ion rechargeable batteries(ASIBs),which operate in aqueous electrolytes,are cheaper,safer,and more ionically conductive than batteries that operate in conventional organic electrolytes;furthermore,they are suitable for grid-scale energy storage *** electrode materials for storing Na~+ ions in ASIBs,a variety of multifunctional metal-organic frameworks(MOFs) have demonstrated great potential in terms of having porous 3 D crystal structures,compatibility with aqueous solutions,long cycle lives(≥1000 cycles),and ease of *** present review describes MOF-derived technologies for the successful application of MOFs to ASIBs and suggests future challenges in this area of research based on the current understanding.

关键词： Metal–Organic Framework(MOF) Prussian blue Metal hexacyanoferrate Aqueous electrolyte Sodium-ion Rechargeable battery

High-Throughput Pb Recycling for Perovskite Solar Cells Using Biomimetic Whitlockite

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Energy & Environmental Materials 2023年第3期6卷 170-176页

作者： jung Sug Hong Hee jung Kim Chang Hwun Sohn Oh Yeong Gong Jin Hyuk choi Kang Hee Cho Gill Sang han Ki Tae Nam Hyun Suk jung Department of Materials Science and Engineering Seoul National UniversitySeoul 08826Korea School of Advanced Materials Science and Engineering Sungkyunkwan UniversitySuwon 16419Korea

Pb contamination in aquatic environments causes severe pollution;therefore,harmless absorbents are *** this study,we report a novel synthesis of whitlockite(WH,Ca_(18)Mg_(2)(HPO_(4))_(2)(PO_(4))_(12)),which is the second most abundant biomineral in human bone,and its application as a high-performing Pb^(2+)***(HAP)and WH are prepared via a simple precipitation *** Pb2+absorption performance and mechanism of the synthesized biominerals are investigated in aqueous solutions at neutral *** results demonstrate that WH exhibits an excellent Pb2+absorption capacity of 2339 mg g^(−1),which is 1.68 times higher than the recorded value for ***,the absorbed Pb^(2+) ions are recycled into high-purity PbI_(2).This is employed as a precursor for the fabrication of perovskite solar cells(PSCs),resulting in a conversion efficiency of 19.00%comparable to that of commercial PbI2 powder(99.99%purity).Our approach provides an efficient way to remove Pb^(2+)ions from water and reuse them in the recycling of PSCs.

关键词： Pb absorption Pb recycling perovskite solar cells water purification whitlockite

Differential transcriptional regulation of the NANOG gene in chicken primordial germ cells and embryonic stem cells

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Journal of Animal Science and Biotechnology 2021年第3期12卷 877-890页

作者： Hee jung choi So Dam Jin Deivendran Rengaraj Jin Hwa Kim Bertrand Pain Jae Yong han Department of Agricultural Biotechnology and Research Institute of Agriculture and Life Sciences Seoul National UniversitySeoul 08826South Korea Univ Lyon UniversitéLyon 1INSERMINRAEStem Cell and Brain Research InstituteU1208USC136169500 BronFrance Institute for Biomedical Sciences Shinshu UniversityMinamiminowaNagano 399-4598Japan

Background:NANOG is a core transcription factor(TF)in embryonic stem cells(ESCs)and primordial germ cells(PGCs).Regulation of the NANOG gene by TFs,epigenetic factors,and autoregulatory factors is well characterized in ESCs,and transcriptional regulation of NANOG is well established in these *** NANOG plays a key role in germ cells,the molecular mechanism underlying its transcriptional regulation in PGCs has not been ***,we investigated the mechanism that regulates transcription of the chicken NANOG(cNANOG)gene in PGCs and ***:We first identified the transcription start site of cNANOG by 5′-rapid amplification of cDNA ends PCR ***,we measured the promoter activity of various 5′flanking regions of cNANOG in chicken PGCs and ESCs using the luciferase reporter *** expression required transcriptional regulatory elements,which were positively regulated by POU5F3(OCT4)and SOX2 and negatively regulated by TP53 in *** proximal region of the cNANOG promoter contains a positive transcriptional regulatory element(CCAAT/enhancer-binding protein(CEBP)-binding site)in ***,small interfering RNA-mediated knockdown demonstrated that POU5F3,SOX2,and CEBP played a role in cell type-specific transcription of ***:We show for the first time that different trans-regulatory elements control transcription of cNANOG in a cell type-specific *** finding might help to elucidate the mechanism that regulates cNANOG expression in PGCs and ESCs.

关键词： Chicken Embryonic stem cells NANOG gene Primordial germ cells Regulatory elements

A Cu-Pd alloy catalyst with partial phase separation for the electrochemical CO_(2) reduction reaction

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Journal of Energy Chemistry 2024年第6期93卷 8-15,I0001页

作者： Gyeong Ho han jung Yong Seo Minji Kang Myung-gi Seo Youngheon choi Soo Young Kim Sang Hyun Ahn School of Chemical Engineering and Material Science Chung-Ang UniversitySeoul 06974Republic of Korea Lotte Chemical Institute of Technology Daejeon 34110Republic of Korea Department of Materials Science and Engineering Korea UniversitySeoul 02841Republic of Korea

Cu catalysts can convert CO_(2) through an electrochemical reduction reaction into a variety of useful carbon-based ***,this capability provides an obstacle to increasing the selectivity for a single ***,we report a simple fabrication method for a Cu-Pd alloy catalyst for use in a membrane electrode assembly(MEA)-based CO_(2) electrolyzer for the electrochemical CO_(2) reduction reaction(ECRR)with high selectivity for CO *** the composition of the Cu-Pd alloy catalyst was fabricated at 6:4,the selectivity for CO increased and the production of multi-carbon compounds and hydrogen is *** a Cu-Pd alloy catalyst with 6:4 ratio as the cathode of the MEAbased CO_(2) electrolyzer showed a CO faradaic efficiency of 92.8%at 2.4 V_(cell).We assumed that these results contributed from the crystal planes on the surface of the Cu-Pd *** phases of the Cu-Pd alloy catalyst were partially separated through annealing to fabricate a catalyst with high selectivity for CO at low voltage and C_(2)H_4 at high *** results of CO-stripping testing confirmed that when Cu partially separates from the lattice of the Cu-Pd alloy,the desorption of~*CO is suppressed,suggesting that C-C coupling reaction is favored.

关键词： Cu-Pd catalyst Electrodeposition Electrochemical carbon dioxide reduction Partial phase separation Membrane electrode assembly-based electrolyzer

Chemotherapy for colorectal cancer in the elderly

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World Journal of Gastroenterology 2015年第17期21卷 5158-5166页

作者： jung han Kim Division of Hemato-Oncology Department of Internal MedicineKangnam Sacred-Heart HospitalHallym University Medical CenterHallym University College of MedicineSeoul 150-950South Korea

Colorectal cancer(CRC) is one of the leading causes of cancer-related death in the ***,elderly patients with CRC tend to be under-presented in clinical trials and undertreated in clinical *** age alone should not be the only criteria to preclude effective therapy in elderly patients with *** best guide about optimal cancer treatment can be provided by comprehensive geriatric *** patients with stage Ⅲ colon cancer can enjoy the same benefit from adjuvant chemotherapy with 5-fluorouracil/leucovorin or capecitabine as younger patients,without a substantial increase in *** conflicting results of retrospective studies and a lack of data available from randomized studies,combined modality treatment should be used with great caution in elderly patients with locally advanced rectal *** chemotherapy can be considered for older patients with metastatic *** elderly patients who are frail or vulnerable,however,monotherapy or a stopand-go strategy may be *** use of targeted therapies in older patients with metastatic CRC appears to be promising in view of their better efficacy and *** should be individualized based on the nature of the disease,the physiologic or functional status,and the patient's preference.

关键词： Adjuvant chemotherapy Colorectal cancer Elderly Palliative chemotherapy Review

Effect of Temperature on a Two-Phase Clock-Driven Discrete-Time Chaotic Circuit

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Chinese Physics Letters 2013年第2期30卷 46-48页

作者： ZHOU Ji-Chao SONG han-jung Department of Nano Systems Engineering Inje UniversityGimhae 621-749Korea Center for Nano Manufacturing Inje UniversityGimhae 621-749Korea

The effects of temperature on a two-phase clock-driven discrete-time chaotic circuit are *** circuit for temperature analysis consists of two switches for sample and hold,a source follower,and a nonlinear function for nonlinearity in the *** chaotic dynamics of this circuit,such as time series,state transitions,frequency spectra bifurcation diagrams and Lyapunov exponents are analyzed as functions of the *** is confirmed that the dynamics of the chaotic circuit have a temperature ***,we find that the circuit can generate discrete chaotic signals only within specific temperature regions.

关键词： temperature. chaotic bifurcation