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Chemical surface tuning of zinc metal anode toward stable,dendrite-less aqueous zinc-ion batteries

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Journal of Energy Chemistry 2023年第11期86卷 1-8,I0001页

作者： Pranav Kulkarni Sun-sik Kim Hyun Young jung Department of Energy Engineering Gyeongsang National UniversityJinju-siGyeongnam 52725South Korea Department of Energy System Engineering Gyeongsang National UniversityJinju-siGyeongnam 52725South Korea

The commercialization of Zn batteries is confronted with urgent challenges in the metal anode,such as dendrite formation,capacity loss,and cracking or ***,surface interfacial engineering of the Zn anode is introduced for achieving safety and dendritic-free cycling for high-performance aqueous Zn batteries through a simple but highly effective chemical etching-substitution *** chemical modification induces a rough peak-valley surface with a thin fluorine-rich interfacial layer on the Zn anode surface,which regulates the growth orientation via guiding uniform Zn plating/stripping,significantly enhances accessibility to aqueous electrolytes and improves wettability by reducing surface *** a result,such a synergetic surface effect enables uniform Zn plating/stripping with low polarization of 29 m V at a current density of 0.5 m A cm^(-2) with stable cyclic performance up to 1000 ***,a full cell composed of a fluorine-substituted Zn anode coupled with aβ-MnO_(2)or Ba-V_(6)O_(13)cathode demonstrates improved capacity retention to 1000 cycles compared to the pristine-Zn *** proposed valley deposition model provides the practical direction of surface-modified interfacial chemistries for improving the electrochemical properties of multivalent metal anodes via surface tuning.

关键词： Dendrite free Peak-Valley surface Zinc-ion batteries Surface modification Fluorinated interface

Hydrogen sulfide controls peripheral nerve degeneration and regeneration:a novel therapeutic strategy for peripheral demyelinating disorders or nerve degenerative diseases

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Neural Regeneration Research 2014年第24期9卷 2119-2121页

作者： Junyang jung na Young Jeong Department of Anatomy and Neurobiology School of Medicine Biomedical Science Institution Kyung Hee University Department of Anatomy and Cell Biology College of Medicine Dong-A University

After peripheral nerve injury, the process of Wallerian degeneration is initiated in the distal stump of injured nerves. Wallerian degeneration in peripheral nerves involves axonal degeneration and degradation of the myelin sheath in Schwann cells. This provides the necessary conditions for axonal regeneration and remyelination. After nerve injury, macrophages are also recruited to the distal nerve stump and, together with Schwann cells, play a role in the clearance of myelin debris.

关键词： Hydrogen sulfide controls peripheral nerve degeneration and regeneration Figure

Forecasting promising technology using analysis of patent information:Focused on next generation mobile communications

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Journal of Central South University 2014年第11期21卷 4303-4310页

作者： CHOI Seung-Wook YOU Yen-Yoo na Kwan-sik Department of Knowledge Service & Consulting Hansung UniversitySeoul Korea Department of Management Information Systems Seowon UniversityCheongju Korea

In order to forecast promising technologies in the field of next generation mobile communication, various patent indicators were analyzed such as citation per patent, patent family information, patent share, increase rate, and patent activity. These indicators were quantified into several indexes and then integrated into an evaluation score to provide promising technologies. As a result of the suggested patent analysis, four technologies out of twenty two in details classification were selected, which showed outstanding technology competitiveness, high patent share and increasing rates as well as high recent-patent-ratios and triad-patent-family-ratios. Each of the selected technologies scored more than 10 points in total, and the following four technologies were suggested as promising ones in the field of next generation mobile communication: 1) 3GPP based mobile communication, 2) beyond 4G mobile communication, 3) IEEE 802.16 based mobile communication, which are in medium classification of broadband mobile communication system, and 4) testing/certification system of mobile communication, which is in medium classification of mobile communication testing/certification system.

关键词： next generation mobile communication promising technology forecasting patent information patent analysis patent indicators

Protective effect of hydrogen sulfide on oxidative stress-induced neurodegenerative diseases

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Neural Regeneration Research 2020年第2期15卷 232-241页

作者： Rubaiya Tabassum na Young Jeong Junyang jung Department of Anatomy and Cell Biology College of MedicineDong-A UniversitySeo-guBusanKorea Department of Medicine Graduate SchoolDong-A UniversitySeo-guBusanKorea Department of Anatomy and Neurobiology College of MedicineKyung Hee UniversityDongdaemun-guSeoulKorea

Hydrogen sulfide is an antioxidant molecule that has a wide range of biological effects against oxidative stress. Balanced oxidative stress is also vital for maintaining cellular function in biological system, where reactive oxygen species are the main source of oxidative stress. When the normal redox balance is disturbed, deoxyribonucleic acid, lipid, and protein molecules are oxidized under pathological conditions, like diabetes mellitus that leads to diabetic peripheral neuropathy. In diabetes mellitus-induced diabetic peripheral neuropathy, due to hyperglycemia, pancreatic beta cell(β cell) shows resistance to insulin secretion. As a consequence, glucose metabolism is disturbed in neuronal cells which are distracted from providing proper cell signaling pathway. Not only diabetic peripheral neuropathy but also other central damages occur in brain neuropathy. Neurological studies regarding type 1 diabetes mellitus patients with Alzheimer’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis have shown changes in the central nervous system because high blood glucose levels(HbA1 c) appeared with poor cognitive function. Oxidative stress plays a role in inhibiting insulin signaling that is necessary for brain function. Hydrogen sulfide exhibits antioxidant effects against oxidative stress, where cystathionine β synthase, cystathionine γ lyase, and 3-mercaptopyruvate sulfurtransferase are the endogenous sources of hydrogen sulfide. This review is to explore the pathogenesis of diabetes mellitus-induced diabetic peripheral neuropathy and other neurological comorbid disorders under the oxidative stress condition and the anti-oxidative effects of hydrogen sulfide.

关键词： Alzheimer's disease amyotrophic lateral sclerosis antioxidant diabetic peripheral neuropathy Dna oxidation hydrogen sulfide mitochondrial dysfunction oxidative stress Parkinson's disease reactive oxygen species

Therapeutic importance of hydrogen sulfide in age-associated neurodegenerative diseases

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Neural Regeneration Research 2020年第4期15卷 653-662页

作者： Rubaiya Tabassum na Young Jeong Junyang jung Department of Anatomy and Cell Biology College of MedicineDong-A UniversityBusanKorea Department of Medicine Graduate SchoolDong-A UniversityBusanKorea Department of Anatomy and Neurobiology College of MedicineKyung Hee UniversitySeoulKorea

Hydrogen sulfide(H2S)is a gasotransmitter that acts as an antioxidant and exhibits a wide variety of cytoprotective and physiological functions in age-associated *** of the major causes of age-related diseases is oxidative *** recent years,the importance of H2S has become clear,although its antioxidant function has not yet been fully *** enzymes cystathionineβ-synthase,cystathionineγ-lya-se,and 3-mercaptopyruvate sulfurtransferase are involved in the enzymatic production of ***,H2S was considered a neuromodulator,given its role in long-term hippocampal potentiation,but it is now also recognized as an antioxidant in age-related *** to aerobic metabolism,the central nervous system is vulnerable to oxidative stress in brain aging,resulting in age-associated degenerative diseases.H2S exerts its antioxidant effect by limiting free radical reactions through the activation of antioxidant enzymes,including superoxide dismutase,catalase,and glutathione peroxidase,which protect against the effects of aging by regulating apoptosis-related genes,including p53,Bax,and *** review explores the implications and mechanisms of H2S as an antioxidant in age-associated neurodegenerative diseases,including Alzheimer’s disease,Parkinson’s disease,Huntington’s disease,and Down syndrome.

关键词： 3-mercaptopyruvate sulfurtransferase aging antioxidant cystathionineβ-synthase cystathionineγ-lyase glutathione hydrogen sulfide neurodegenerative disease oxidative stress reactive oxygen species

Customizable design ofmultiple-biomolecule delivery platform for enhanced osteogenic responses via‘tailored assembly system’

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Bio-Design and Manufacturing 2022年第3期5卷 451-464页

作者： Hyun Lee Min-Kyu Lee Ginam Han Hyoun-Ee Kim Juha Song Yuhyeon na Chang-Bun Yoon SeKwon Oh Tae-sik Jang Hyun-Do jung Department of Biomedical-Chemical Engineering Catholic University of KoreaBucheon 14662Republic of Korea Department of Biotechnology The Catholic University of KoreaBucheon 14662Republic of Korea Department of Materials Science and Engineering Seoul National UniversitySeoul 08826Republic of Korea Querrey Simpson Institute for Bioelectronics Northwestern UniversityEvanstonIL 60208USA Biomedical Implant Convergence Research Center Advanced Institutes of Convergence TechnologySuwon 443-270Republic of Korea School of Chemical and Biomedical Engineering Nanyang Technological University70 Nanyang DriveSingapore 637457Singapore Department of Advanced Materials Engineering Korea Polytechnic UniversitySiheung-siGyeonggi-do 15073Republic of Korea Surface R&D Group Korea Institute of Industrial TechnologyIncheon 21999Republic of Korea Department of Materials Science and Engineering Chosun UniversityGwangju 61452Republic of Korea

Porous titanium(Ti)scaffolds have been extensively utilized as bone substitute scaffolds due to their superior biocompatibility and excellent mechanical ***,naturally formed TiO2 on the surface limits fast *** biomolecules have been widely utilized to overcome this issue;however,homogeneous porous Ti scaffolds could not simultaneously deliver multiple biomolecules that have different release *** this study,functionally graded porous Ti scaffolds(FGPTs)with dense inner and porous outer parts were fabricated using a two-body combination and densification *** with growth factor(BMP-2)and antibiotics(TCH)exhibited suitable mechanical properties as bone substituting material and presented good structural *** release of BMP-2 was considerably prolonged,whereas the release of TCH was comparable to that of homogenous porous titanium scaffolds(control group).The osteogenic differentiation obtained using FGPTs was maintained due to the prolonged release of *** antimicrobial properties of these scaffolds were verified using *** in terms of prior release *** addition,various candidates for graded porous Ti scaffolds with altered pore characteristics were presented.

关键词： Functionally graded porous titanium scaffold Tailored assembly system Mechanical tunability Multiplebiomolecule delivery Bone tissue engineering

An Experimental Study on the Behavior of Square Concrete-Filled High Strength Steel Tube Columns

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Journal of Iron and Steel Research International 2011年第S1期18卷 878-882页

作者： Hyung-suk jung Chang-sik Choi Department of sustainable architectural engineering Hanyang UniversitySeoulKorea Department of architectural engineering Hanyang UniversitySeoulKorea

The paper presents an experimental study on the behavior of square concrete-filled high strength steel tube columns until *** specimens were tested to investigate the effect of high strength steel and plain strength concrete on the load carrying capacity of the square concrete-filled steel tube *** effect of the concrete which filled in the steel tube was also ***,the effect of high strength steel and the presence of concrete were also *** main parameters in the tests were:(1) the ultimate strength of steel (800 Mpa),(2) the presence of concrete in steel tube (hollow steel tube and concrete-filled steel tube),and (3) slender *** main objectives of these tests were three-step:(1) to describe a series of tests on composite columns,(2) to analyze the influence of several parameters,and (3) to compare the accuracy of the predictions by using the specifications in the code (AISC-LRFD,EC4 and AIJ etc.) for the design of high-strength composite *** results indicate that the ultimate strength of steel and presence of concrete had significant influence on both the axial compressive load capacity and the ductile of the square steel tube.

关键词： square concrete-filled steel tubes high strength steel axial compression

Anatomical distributional defects in mutant genes associated with dominant intermediate Charcot-Marie-Tooth disease type C in an adenovirus-mediated mouse model

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Neural Regeneration Research 2017年第3期12卷 486-492页

作者： Seo Jin Lee Sandesh Panthi Hyun Woo Jo Jaeyoung Cho Min-sik Kim na Young Jeong In Ok Song Junyang jung Youngbuhm Huh Department of Biomedical Science Graduate SchoolKyung Hee UniversityDongdaemun-guSeoulKorea Department of Medicine Graduate SchoolKyung Hee UniversityDongdaemun-guSeoulKorea Department of Applied Chemistry College of Applied ScienceKyung Hee UniversityYongin-siGyeonggi-doKorea Department of Anatomy and Cell Biology College of MedicineDong-A UniversitySeo-guBusanKorea Department of Reproductive Endocrinology and Infertility Department of Obstetrics and GynecologyCheil General HospitalDankook University College of MedicineJung-guSeoulKorea Department of Anatomy and Neurobiology College of MedicineKyung Hee UniversityDongdaemun-guSeoulKorea

Dominant intermediate Charcot-Marie-Tooth disease type C（DI-CMTC） is a dominantly inherited neuropathy that has been classified primarily based on motor conduction velocity tests but is now known to involve axonal and demyelination ***-CMTC is linked to tyrosyl-t Rna synthetase（YARS）-associated neuropathies,which are caused by E196 K and G41 R missense mutations and a single de novo deletion（153-156 del VKQV）.It is well-established that these YARS mutations induce neuronal dysfunction,morphological symptoms involving axonal degeneration,and impaired motor *** present study is the first to describe a novel mouse model of YARS-mutation-induced neuropathy involving a neuron-specific promoter with a deleted mitochondrial targeting sequence that inhibits the expression of YARS protein in the *** adenovirus vector system and in vivo techniques were utilized to express YARS fusion proteins with a Flag-tag in the spinal cord,peripheral axons,and dorsal root *** transfection of YARS-expressing viruses,the distributions of wild-type（WT） YARS and E196 K mutant proteins were compared in all expressed regions; G41 R was not *** proportion of Flag/green fluorescent protein（GFP） double-positive signaling in the E196 K mutant-type mice did not significantly differ from that of WT mice in dorsal root ganglion *** adenovirus genes,and even the empty vector without the YARS gene,exhibited GFP-positive signaling in the ventral horn of the spinal cord because GFP in an adenovirus vector is driven by a cytomegalovirus *** present study demonstrated that anatomical differences in tissue can lead to dissimilar expressions of YARS ***,use of this novel animal model will provide data regarding distributional defects between mutant and WT genes in neurons,the DICMTC phenotype,and potential treatment approaches for this disease.

关键词： nerve regeneration tyrosyl-tRna synthetase YARS-associated neuropathy YARS mutation Charcot-Marie- Tooth Disease adenoviral vector-mediated mouse models neural regeneration

Altered physiology of mesenchymal stem cells in the pathogenesis of adolescent idiopathic scoliosis

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World Journal of Clinical Cases 2020年第11期8卷 2102-2110页

作者： Dai sik Ko Yun Hak Kim Tae sik Goh jung Sub Lee Division of Vascular Surgery Department of SurgeryGachon University Gil Medical CenterIncheoz 21565South Korea Department of Anatomy and Department of Biomedical Informatics School of MedicinePusan National UniversityYangsan 50612South Korea Department of Orthopaedic Surgery and Biomedical Research Institute Pusan National University HospitalBusan 49241South Korea

Adolescent idiopathic scoliosis is the most common spinal deformity during puberty,especially in *** is characterized by aberrant skeletal growth and generalized reduced bone density,which is associated with impaired bone mineral *** recent progress in multidisciplinary research to support various hypotheses,the pathogenesis of Adolescent idiopathic scoliosis is still not clearly *** of the hypothesis is to study the role of mesenchymal stem cells due to its involvement in the above-mentioned bone metabolic *** this review,we will summarize reported literatures on the role of mesenchymal stem cells,particularly in the pathogenesis of Adolescent idiopathic *** addition,we will describe the research on mesenchymal stem cells of Adolescent idiopathic scoliosis performed using bioinformatics tools.

关键词： Adolescent idiopathic scoliosis Mesenchymal stem cell Bioinformatics Transcriptome Proteome