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Delayed diagnosis of pulmonary embolism

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Open Journal of Clinical Diagnostics 2012年第4期2卷 81-83页

作者： Chia-jung hsieh Meng-jung Chen Department of Emergency Medicine Chi-Mei Medical Center Tainan Chinese Taipei Department of Medical Technology Chung-Hwa University of Medical Technology Tainan Chinese Taipei

Pulmonary embolism is a common and potentially life threatening condition. Delays in pulmonary embolism diagnosis represent an important problem. It is crucial to have early diagnosis of pulmonary embolism if one wishes to reduce its complication. We retrospectively reviewed our patients who visited our emergency department with a final diagnosis of pulmonary embolism. We found that delayed diagnosis of pulmonary embolism usually happened when patients did not present with the classical symptoms and signs leading to other medical diagnosis at first. Clinical signs and symptoms for pulmonary embolism are mostly non-specific;therefore, patients suspected of having pulmonary embolism—because of unexplained chest pain, shortness of breath or tachycardia with or without the risk factors for pulmonary embolism—must undergo diagnostic tests including D-dimer or CT pulmonary angiography if indicated until the diagnosis is ruled out.

关键词： Delayed Diagnosis Emergency Department Pulmonary Embolism

Patterning of Poly（3,4-Ethylenedioxythiophene）： Poly（Styrenesulfonate） Films via the Rubbing Method in Organic Photovoltaic Cells

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Journal of Physical Science and Application 2014年第8期4卷 475-483页

作者： Li-Chen Huang Hung-Wei Liu Tsu-Ruey Chou jung hsieh Wen-Yen Chiu Leeyih Wang Chih-Yu Chao Department of Physics National Taiwan University Taipei 10617 Taiwan Institute of Polymer Science and Engineering National Taiwan University Taipei 10617 Taiwan Institute of Applied Physics National Taiwan University Taipei 10617 Taiwan Department of Chemical Engineering National Taiwan University Taipei 10617 Taiwan Center for Condensed Matter Sciences National Taiwan University Taipei 10617 Taiwan

OPV （Organic photovoltaic） cells represent a compelling candidate for renewable energy by solar energy conversion. In recent years, versatile light-trapping measures via structures have been intensively explored to optimize photovoltaic performance. In this work, a unique rubbing technique is demonstrated to create nanoscale grooves on the PEDOT：PSS [poly（3,4-ethylenedioxythiophene）： poly（styrenesulfonate）] surface and the grating-like features are 500 nm wide and 10 nm deep. The PEDOT：PSS film with grooved surface is used as buffer layers for OPV cell devices based on a P3HT：PCBM bulk heterojunction. The patterned surface has a profound effect on carrier mobility, light trapping, and hole collection efficiency, leading to an increase in the short circuit density, filling factor, and power conversion efficiency. These results indicate the feasibility of the rubbing method can be applicable to high-efficiency OPV cells.

关键词： Rubbing technique grooved surface organic photovoltaic cells bulk heterojunction solar cells.

The regulatory pathways leading to stem-like cells underlie prostate cancer progression

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Asian Journal of Andrology 2019年第3期21卷 233-240页

作者： Chun-jung Lin U-Ging Lo Jer-Tsong hsieh Department of Urology UT Southwestern Medical Center Dallas TX 75390 USA

Prostate cancer (PCa) is the most common cause of malignancy in males and the third leading cause of cancer mortality in the United States. The standard care for primary PCa with local invasive disease mainly is surgery and radiation. For patients with distant metastases, androgen deprivation therapy (ADT) is a gold standard. Regardless of a favorable outcome of ADT, patients inevitably relapse to an end-stage castration-resistant prostate cancer (CRPC) leading to mortality. Therefore, revealing the mechanism and identifying cellular components driving aggressive PCa is critical for prognosis and therapeutic intervention. Cancer stem cell (CSC) phenotypes characterized as poor differentiation, cancer initiation with self-renewal capabilities, and therapeutic resistance are proposed to contribute to the onset of CRPC. In this review, we discuss the role of CSC in CRPC with the evidence of CSC phenotypes and the possible underlying mechanisms.

关键词： cancer stem cell castration-resistant prostate cancer neuroendocrine differentiation transdifferentiation

Study on the Amperometric Glucose Biosensor Based on Tin Oxide Electrode

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稀有金属材料与工程 2006年第S3期 291-294页

作者： jung-Chuan Chou Shen-Kan Hsiung Jui-Hsiang hsieh Graduate School of Electronic Engineering National Yunlin University of Science and TechnologyDouliouTaiwan 640China Institute of Electronic Engineering Chung Yuan Christian UniversityChung-LiTaiwan 320China Institute of Biomedical Engineering Chung Yuan Christian UniversityChung-LiTaiwan 320China

An amperometric glucose biosensor based on a tin oxide （SnO2） electrode has been *** SnO2electrode is prepared by depositing the SnO2thin film onto a carbon *** fabricate the SnO2amperometric glucose biosensor,the glucose oxidase and electron transfer mediator （ferrocenecarboxylic acid,FcA） are coimmobilized on the SnO2electrode using *** detection range is up to glucose concentration of 520mg/dl as the applied potential is set at 300mV. Moreover,the most merit for the SnO2electrode as the base electrode of the SnO2amperometric glucose biosensor is that it can be operated at 150mV constant applied *** interference reduction,detection range,sensitivity and linearity are improved as the SnO2thin film is deposited onto a carbon ***,due to the low cost substrate and simple fabrication characteristics,a disposable amperometric glucose biosensor based on the SnO2electrode has been realized in this study.

关键词： amperometric glucose oxidase tin oxide carbon mediator

Study on the Amperometric Glucose Biosensor Based on Tin Oxide Electrode

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稀有金属材料与工程 2006年第A03期35卷 291-294页

作者： Cheng-Wei Liao jung-Chuan Chou Tai-Ping Sun Shen-Kan Hsiung Jui-Hsiang hsieh Institute of Biomedical Engineering Chung Yuan Christian University Chung-Li Taiwan 320 China Graduate School of Electronic Engineering National Yunlin University of Science and Technology Douliou Taiwan 640 China Department of Electrical Engineering National Chi Nan University Nantou Taiwan 545 China Institute of Electronic Engineering Chung Yuan Christian University Chung-Li Taiwan 320 China

An amperometric glucose biosensor based on a tin oxide (SnO_2) electrode has been *** SnO_2 electrode is prepared by depositing the SnO_2 thin film onto a carbon *** fabricate the SnO_2 amperometric glucose biosensor,the glucose oxidase and electron transfer mediator (ferrocenecarboxylic acid,FcA) are coimmobilized on the SnO_2 electrode using *** detection range is up to glucose concentration of 520mg/dl as the applied potential is set at 300mV. Moreover,the most merit for the SnO_2 electrode as the base electrode of the SnO_2 amperometric glucose biosensor is that it can be operated at 150mV constant applied *** interference reduction,detection range,sensitivity and linearity are improved as the SnO_2 thin film is deposited onto a carbon ***,due to the low cost substrate and simple fabrication characteristics,a disposable amperometric glucose biosensor based on the SnO_2 electrode has been realized in this study.

关键词： amperometric glucose oxidase tin oxide carbon mediator

Hypocaloric peripheral parenteral nutrition with lipid emulsion in postoperative gastrointestinal cancer patients

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World Journal of Gastrointestinal Oncology 2010年第1期2卷 51-55页

作者： Chien-Yu Lu Fang-jung Yu Ying-Ling Shih Jan-Sing hsieh Jaw-Yuan Wang Nutrition Support Team Kaohsiung Medical University Hospital Division of Gastroenterology Department of Internal MedicineKaohsiung Medical University Hospital Department of Internal Medicine Pingtung Hospital Faculty of Medicine College of Medicine Kaohsiung Medical University Division of Gastroenterology Department of Internal Medicine Kaohsiung Medical University Hospital Department of Nursing Kaohsiung Medical University Hospital Division of Gastroenterologic and General Surgery Department of SurgeryKaohsiung Medical University Hospital

AIM:To investigate the use of lipid emulsion substitutingfor glucose in postoperative hypocaloric peripheral parenteral nutrition (HPPN).METHODS:This prospective, randomized study was conducted on 20 postoperative gastrointestinal cancer patients. They were randomized and equally divided into interventional group and control group, and both were administered isocaloric and isonitrogenous diets with for lipid emulsion substituting for partial glucose loads in the interventional ***: Nutritional parameters and biochemical data were compared between the two groups before and after 6-d of HPPN. Most investigated variables showed no significant changes after administration of HPPN with lipid emulsion. However, the postoperative triglyceride level was significantly lower in the interventional group than in the control group (P < 0.05). In comparison with lipid emulsion, glucose administration resulted in less decrease in postoperative prealbumin level (P < 0.05).CONCLUSION: In addition to supplementing with essential fatty acid, it seems that HPPN with lipid emulsion is well-tolerated and beneficial to postoperative gastrointestinal cancer patients.

关键词： Hypocaloric peripheral parenteral nutrition Lipid emulsion Dextrose

Psychological Distress in the Association between Medical Education Changes and Clinical Learning Worry among Students Receiving Clinical Education during the COVID-19 Pandemic in Taiwan

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International Journal of Mental Health Promotion 2024年第12期26卷 987-996页

作者： Shikha Kukreti Min-Chi hsieh Musheer AAljaberi Ru-Yi Huang I-Ting Hwang Carol Strong jung-Sheng Chen Ming-Ta hsieh Mark DGriffiths Chung-Ying Lin Nai-Ying Ko Department of Nursing College of MedicineNational Cheng Kung UniversityTainan701401Taiwan Department of Public Health College of MedicineNational Cheng Kung UniversityTainan701401Taiwan Department of Internal Medicine Section Nursing ScienceErasmus University Medical Center(Erasmus MC)Rotterdam3015 GDThe Netherlands Division of Family Medicine Taipei Tzu Chi HospitalBuddhist Tzu Chi Medical FoundationNew Taipei231405Taiwan School of Medicine Tzu Chi UniversityHualien231036Taiwan Data Science Degree Program National Taiwan University and Academia SinicaTaipei106319Taiwan Department of Occupational Therapy College of MedicineNational Cheng Kung UniversityTainan701401Taiwan Department of Medical Research E-Da HospitalI-Shou UniversityKaohsiung824005Taiwan Department of Family Medicine and Community Medicine E-Da HospitalI-Shou UniversityKaohsiung824005Taiwan School of Medicine College of MedicineI-Shou UniversityKaohsiung824005Taiwan International Gaming Research Unit Psychology DepartmentNottingham Trent UniversityNottinghamNG118NSUK Institute of Allied Health Sciences College of MedicineNational Cheng Kung UniversityTainan701401Taiwan Biostatistics Consulting Center National Cheng Kung University HospitalCollege of MedicineNational Cheng Kung UniversityTainan701401Taiwan

Background:The COVID-19 pandemic profoundly impacted medical education and caused psychological distress and worry about clinical learning for those who received clinical medical education during this *** the acute phase of COVID-19 has now ended,understanding its impact is essential for strengthening medical system ***,the present study examined the association between changes in medical education and worry about clinical learning,considering the mediating role of psychological distress among participants who received clinical ***:A cross-sectional online survey was conducted with 542 post-graduate year(PGY)doctors and allied health students from the 2020 and 2021 cohorts in *** survey assessed changes in clinical training modes,direct patient care,learning stress,psychological distress,and worry about clinical ***:Among the participants,76.0%experienced changes in clinical training mode,and 84.3%had direct patient care *** patient care/contact was significantly correlated with lower levels of worry about clinical *** stress was positively correlated with increased psychological distress and worry about clinical *** distress partially mediated the relationship between learning stress and worry about clinical ***:The findings highlight the importance of direct contact with patients because it was associated with lower levels of worry about clinical ***,increased learning stress was associated with psychological distress and worry about clinical ***,effective support systems are essential to mitigate these impacts and enhance clinical training during national health *** findings provide valuable insights for improving medical education and support systems in future health ***,the present study used a cross-sectional study ***,the mediation findings should be interpreted with cau

关键词： Psychological distress allied health patient care worry about clinical learning

Aberrant activation of nuclear factor of activated T cell 2 in lamina propria mononuclear cells in ulcerative colitis

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World Journal of Gastroenterology 2008年第11期14卷 1759-1767页

作者： Tsung-Chieh Shih Sen-Yung hsieh Yi-Yueh hsieh Tse-Chin Chen Chien-Yu Yeh Chun-jung Lin Deng-Yn Lin Cheng-Tang Chiu Clinical Proteomics Center Chang Gung Memorial HospitalTaoyuan 333Taiwan Clinical Proteomics Center Chang Gung Memorial HospitalTaoyuan 333Taiwan Department of Hepato-GastroenterologyChang Gung Memorial HospitalChang Gung University School of Medicine Taoyuan 333Taiwan Department of Anatomic Pathology Chang Gung Memorial HospitalTaoyuan 333Taiwan Department of Colorecto-Surgery Chang Gung Memorial HospitalTaoyuan 333Taiwan Department of Hepato-Gastroenterology Chang Gung Memorial HospitalChang Gung University School of Medicine Taoyuan 333Taiwan

AIM:To investigate the role of nuclear factor of activated T cell 2(NFAT2),the major NFAT protein in peripheral T cells,in sustained T cell activation and intractable inflammation in human ulcerative colitis(UC). METHODS:We used two-dimensional gel-electrophoresis, immunohistochemistry,double immunohistochemical staining,and confocal microscopy to inspect the expression of NFAT2 in 107,15,48 and 5 cases of UC, Crohn's disease(CD),non-specific colitis,and 5 healthy individuals,respectively. RESULTS:Up-regulation with profound nucleo- translocation/activation of NFAT2 of lamina propria mononuclear cells(LPMC)of colonic mucosa was found specifically in the affected colonic mucosa from patients with UC,as compared to CD or NC(P<0.001,Kruskal- Wallis test).Nucleo-translocation/activation of NFAT2 primarily occurred in CD8+T,but was less prominent in CD4+T cells or CD20+B *** was strongly associated with the disease activity,including endoscopic stage (τ=0.2145,P=0.0281)and histologic grade(τ=0.4167, P<0.001). CONCLUSION:We disclose for the first time the nucleo-translocation/activatin of NFAT2 in lamina propria mononuclear cells in ulcerative *** of NFAT2 was specific for ulcerative colitis and highly associated with disease *** activation of NFAT2is implicated in an auto-regulatory positive feedback loop of sustained T-cell activation and NFAT proteins play key roles in the calcium/calcineurin signaling pathways,our results not only provide new insights into the mechanism for sustained intractable inflammation,but also suggest the calcium-calcineurin/NFAT pathway as a new therapeutic target for ulcerative colitis.

关键词： Nuclear factor of activated T cells Ulcerative colitis Inflammatory bowel disease Nuclear factor of activated T cells cl Nuclear factor of activated T cells 2

A High Matrix Tolerance Cadmium Determination Method: An Analysis Method Combining Microextraction and Laser Ablation Inductively Coupled Plasma Mass Spectrometry

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Journal of Geoscience and Environment Protection 2014年第2期2卷 89-95页

作者： Chu-Fang Wang Tsing Hai Wang Yi-jung Sung Yi-Kong hsieh Biomedical Engineering and Environment Sciences National Tsing Hua University Taiwan

Herein, we proposed a high matrix tolerance analytical method, using a combination of ammonium pyrrolidine dithiocarbamate/methyl isobutyl ketone (APDC-MIBK) microextraction and laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS), for Cd concentration determination in aqueous samples. Only 200 μL of organic solvent was used throughout the entire analysis process, with enhancement factors as high as 25. Recoveries from replicate analyses of natural water [ NIST 1 640(a)] c ontaining m ean c oncentrations o f 3 .1 μ g C d L –1 were 95 ± 3. The corresponding Cd detection limit was 0.6 μg L–1. The main advantage of this approach is its simplicity in terms of sample preparation, as demonstrated by quantifying the Cd levels in tap water, groundwater, and seawater, using a standard addition method.

关键词： Microextraction LA-ICP-MS Green Chemistry APDC MINEQL