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Tuning the Structure of Fe-Tetracarboxylate Frameworks Through Linker-Symmetry Reduction

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CCS Chemistry 2021年第2期3卷 1701-1709页

作者： Jiandong Pang Christina T.Lollar Sai Che jun-sheng qin Jialuo Li Peiyu Cai Mingyan Wu Daqiang Yuan Maochun Hong Hong-Cai Zhou Department of Chemistry Texas A&M UniversityCollege StationTX 77843-3255 State Key Laboratory of Structure Chemistry Fujian Institute of Research on the Structure of MatterChinese Academy of SciencesFuzhouFujian 350002 State Key Laboratory of Inorganic Synthesis and Preparative Chemistry College of ChemistryInternational Center of Future ScienceJilin UniversityChangchun 130012 University of Chinese Academy of Sciences Beijing 100049

The design and synthesis of stable metal–organic frameworks(MOFs)have been a core obstacle in the widespread application of these functional crystalline porous materials,because of the stability limitations of MOFs under harsh operating ***,a highly stable microporous MOF based on the Fe_(3)O cluster(PCN-678)has been synthesized using a tetracarboxylate *** symmetry reduced tetratopic carboxylate ligand,a mesoporous MOF(PCN-668)could be obtained in which nanoscale cage-like building units and one-dimensional(1D)channels *** neighboring cages were mutual diastereomers in PCN-668 due to the further reduction of the Cs symmetry of the free ligand to C1 symmetry after ***,the acid stability of this mesoporous MOF was improved via postsynthetic metal exchange to chromium(PCN-668-Cr).The PCN-668-Cr exhibited very high stability in both acidic and basic aqueous solutions(pH=1–11).Additionally,the mesoporous MOF showed a high total gravimetric methane uptake(∼500 cm^(3) g^(−1) at 100 bar),while the microporous MOF showed a high volumetric methane storage capacity of 147 cm3 cm−3 at room temperature.

关键词： metal–organic framework mesoporous,highly stable diastereomeric cage methane uptake

How to explore the effects of sex hormone on blood vessels

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生殖医学杂志 2004年第Z1期13卷 75-78页

作者： Sun Mei-li Nie Min Liu Bing Du Zhi-jun Ge qin-sheng Peking Union Medical College Hospital CAMS and PUMCBejing 100730 China Peking Union Medical College HospitalCAMS and PUMCBejing 100730 China Peking Union Medical College HospitalCAMS and PUMCBejing 100730 China Peking Union Medical College HospitalCAMS and PUMCBejing 100730 China Peking Union Medical College HospitalCAMS and PUMCBejing 100730 China

The risk of cardiovascular disease increases along with aging. There are increasing interests in researches on the protective effects of hormone replacement therapy (HRT)on cardiovascular system in postmenopausal women. In this article we will review how we have explored the evidence of different sex hormones on blood vessels since 1996. The results showed that low-dose HRT significantly protected cardiovascular system in postmenopausal ***, the high-dose 17β-estradiol (E2), with or without progesterone (P) or testosterone (T), or any hormone alone, as their concentrations increase, may even inhibit the protective effects of low-dose HRT on blood vessels.

关键词： Hormone replacement therapy 17β-estradiol Progesterone Testosterone Tissue factor Postmenopausal women

On-column Refolding of an Insoluble His6-tagged Recombinant EC-SOD Overexpressed in Escherichia coli

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Acta Biochimica et Biophysica Sinica 2005年第4期37卷 265-269页

作者： Xi-Qiang ZHU Su-Xia LI Hua-jun HE qin-sheng YUAN State Key Laboratory of Bioreactor Engineering and Institute of Biochemistry,East China University of Science and Technology,Shanghai 200237,China StateKeyLaboratoryofBioreactorEngineeringandInstituteofBiochemistry EastChinaUniversityofScienceandTechnologyShanghai200237

The EC-SOD cDNA was cloned by polymerase chain reaction （PCR） and inserted into theEscherichia coli expression plasmid pET-28a（+） and transformed into *** BL21 （DE3）.The correspondingprotein that was overexpressed as a recombinant His6-tagged EC-SOD was present in the form of inactiveinclusion *** structure was first solubilized under denaturant conditions （8.0 M urea）.Then,after acapture step using immobilized metal affinity chromatography （IMAC）,a gradual refolding of the protein wasperformed on-column using a linear urea gradient from 8.0 M to 1.5 M in the presence of glutathione（GSH）and oxidized glutathione（GSSG）.The mass ratio of GSH to GSSG was 4:*** purified enzyme was active,showing that at least part of the protein was properly *** protein was made concentrated byultrafiltration,and then isolated using Sephacryl S-200 *** were two protein peaks in the A280 *** on the results of electrophoresis,we concluded that the two fractions were formed by protein subunitsof the same mass,and in the fraction where the molecular weight was higher,the dimer was formed throughthe disulfide bond between *** were detected in the two fractions,but the activity of thedimer was much higher than that of the single *** special activities of the two fractions werefound to be 3475 U/mg protein and 510 U/mg protein,respectively.

关键词： refolding His6 tag recombinant EC-SOD inclusion body protein subunit structure

CO2 Adsorptions of N-rich Metal-organic Frameworks:Theoretical Prediction and Experimental Studies

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老年男性高血压患者睾酮水平与颈动脉内膜-中层厚度的相关性研究

中国化学会第六届全国结构化学学术会议

作者： jun-sheng qin,~a Ya-Qian Lan~b and Zhong-Min Su~(*a,b) a State Key Laboratory of Supramolecular Structure and Materials,Jilin University, Changchun 130012

＜正＞b Faculty of Chemistry,Northeast Normal University,Changchun 130024 Metal-organic frameworks（MOFs） have drawn considerable attention in recent years and are being evaluated for diverse potential applications.1,2 Remarkably,the permanent porosity,tunable pore sizes and shape,as well as exceptional thermal and chemical stability of MOFs permit their potential applications in gas adsorption and selective ***,great efforts have been devoted to developing versatile

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实用老年医学 2014年第5期28卷 386-388页

作者：盛骏骎谈世进上海交通大学附属第六人民医院老年病科上海市200233

目的探讨老年男性高血压患者的血浆睾酮(T)水平与颈动脉内膜-中层厚度(IMT)的相关性。方法选取90例老年男性原发性高血压患者,根据有无颈动脉粥样硬化斑块,分为有斑块组(n=56)和无斑块组(n=34);另选取80例健康老年男性作为对照组。检测... 详细信息

目的探讨老年男性高血压患者的血浆睾酮(T)水平与颈动脉内膜-中层厚度(IMT)的相关性。方法选取90例老年男性原发性高血压患者,根据有无颈动脉粥样硬化斑块,分为有斑块组(n=56)和无斑块组(n=34);另选取80例健康老年男性作为对照组。检测所有受试对象的血浆T水平、颈动脉IMT,分析指标间的相关性。结果有斑块组收缩压(SBP)、舒张压(DBP)、IMT水平均高于无斑块组和对照组(P<0.05或P<0.01),而血浆T水平均低于这2组(P<0.05或P<0.01);老年男性高血压患者血压、血浆T水平与颈动脉IMT之间均具有相关性,血浆T水平与SBP、DBP、IMT均呈负相关(P<0.01)。结论老年男性高血压患者的T水平与动脉粥样硬化程度呈负性相关,其血浆T水平可为疾病评估、激素替代治疗等提供理论参考依据。

关键词：老年男性高血压睾酮内膜-中层厚度

THE STUDY OF ELASTIC RESONANCE SCATTERING AT CIAE

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THE STUDY OF ELASTIC RESONANCE SCATTERING AT CIAE

白术中内酯类成分的TLC鉴别与UPLC含量测定

第十三届全国核结构研讨会暨第九次全国“核结构与量子力学”专题讨论会

作者： WANG You-Bao~(1)) WANG Bao-Xiang JIN Sun-jun BAI Xi-Xiang LIU Wei-Ping LI Zhi-Hong LIAN Gang GUO Bing ZENG sheng SU jun YAN sheng-Quan qin Xing LI Yun-Ju LI Er-Tao (Department of Nuclear Physics,China Institute of Atomic Energy(CIAE),Beijing 102413,China)

The proton elastic resonance scattering induced by radioactive nuclear beams has been studied in inverse kinematics at CIAE since *** so-called thick-target method is applied to obtain the excitation function in a one-shot experiment of a single beam *** to now,several light nuclei systems including N+p,F+p,and He+p have been successfully investigated with this method.A general introduction of the method and a summary of our results will be given in this presentation.

关键词： radioactive secondary beam elastic resonance scattering excitation function thick-target method

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中国中药杂志 2017年第3期42卷 531-535页

作者：赵玉娇徐文慧沈小丽田俊生秦雪梅山西大学中医药现代研究中心山西太原030006 太原天中益耀科技有限公司山西太原030006 长治医学院附属和济医院山西长治046000

建立白术的薄层鉴别与其中3种内酯类成分含量同时测定方法。使用硅胶GF_(254)薄层板对白术进行定性鉴别;利用UPLC-PDA梯度洗脱法同时测定白术内酯Ⅰ,Ⅱ,Ⅲ,选用Waters BEH C_(18)色谱柱(2.1 mm×100 mm,1.7μm),流动相为乙腈-水,检测波... 详细信息

建立白术的薄层鉴别与其中3种内酯类成分含量同时测定方法。使用硅胶GF_(254)薄层板对白术进行定性鉴别;利用UPLC-PDA梯度洗脱法同时测定白术内酯Ⅰ,Ⅱ,Ⅲ,选用Waters BEH C_(18)色谱柱(2.1 mm×100 mm,1.7μm),流动相为乙腈-水,检测波长235 nm。薄层鉴别特征明显,专属性强;含量测定的方法学考察结果符合规定,白术内酯Ⅰ,Ⅱ,Ⅲ线性关系良好(r>0.999 9),平均回收率分别为93.48%(RSD 1.4%),94.97%(RSD 1.6%),92.71%(RSD 1.2%)。所建立的白术薄层鉴别方法专属性强、重复性好,3种内酯类成分同时测定方法操作简单、灵敏度高,两者结合可以更好的用于白术的质量评价。

关键词：白术白术内酯薄层鉴别超高效液相色谱质量评价

BNP与老年心力衰竭患者LVEF、心功能分级及预后相关性研究

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中国循证心血管医学杂志 2014年第4期6卷 464-466页

作者：林琳李俊龚青盛骏骎席蓓莉上海市徐汇区中心医院老年病科上海200031

目的：分析老年心力衰竭（心衰）患者血浆脑钠肽（BNP）水平与左室射血分数（LVEF）、6分钟步行试验距离（6MWT）、NYHA心功能分级及预后的相关性。方法选取2009年2月至2013年11月在上海市徐汇区中心医院老年病科治疗的老年心衰患者100... 详细信息

目的：分析老年心力衰竭（心衰）患者血浆脑钠肽（BNP）水平与左室射血分数（LVEF）、6分钟步行试验距离（6MWT）、NYHA心功能分级及预后的相关性。方法选取2009年2月至2013年11月在上海市徐汇区中心医院老年病科治疗的老年心衰患者100例，男性48例，女性52例，年龄55-72岁，平均年龄（68.26±5.23）岁。根据血浆BNP水平分为4组，A组[（8.0-93.9）pg/mL]22例；B组[（94.0-349.9）pg/mL]30例；C组[（350.0-988.9）pg/mL]21例；D组[（989.0-5000.0）pg/mL]27例。检测患者血浆BNP水平，测量各组患者LVEF、6MWT、心功能分级以及随访出院2个月后不良心脏事件发生情况。结果与A组[（135.13±32.24）pg/mL]比较，B组[（323.14±52.37）pg/mL]、C组[（568.47±132.13）pg/mL]、D组[（1687.57±432.66）pg/mL]血浆BNP水平呈逐渐增高趋势，差异具有统计学意义（P均＜0.05）。与A组[（49.56±8.63）%]比较，C组[（42.24±4.41）%]、D组[（35.03±3.87）%]下降，差异具有统计学意义（P均＜0.05）。随着血浆BNP水平升高，6MWT呈下降的趋势，差异具有统计学意义（P均＜0.05），心功能也逐渐下降，MACE发生率增加。老年心衰患者血浆BNP水平与LVEF呈负相关（r=-0.893，P＜0.05），与6MWT呈负相关（r=-0.913，P＜0.05），与心功能NYHA分级呈正相关（r=0.927，P＜0.05），与2个月MACE发生率呈正相关（r=0.909，P＜0.05）。结论老年心衰患者血浆BNP水平与LVEF、心功能分级、6MWT及预后密切相关，为临床诊断老年心衰以及评估心衰严重程度提供重要参考。

关键词：心力衰竭 BNP LVEF 心功能分级相关性

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白术中3种内酯成分一测多评方法的建立

中国药学杂志 2018年第7期53卷 499-503页

作者：赵玉娇梁国锐宫文霞田俊生秦雪梅山西大学中医药现代研究中心太原030006 太原天中益耀科技有限公司太原030006

目的建立白术中3种内酯成分的一测多评方法。方法采用超高效液相色谱法,以乙腈-水为流动相进行梯度洗脱,检测波长为235 nm,进样量为2μL,流速为0.2 mL·min^(-1),柱温30℃。以白术内酯Ⅲ为内参物,测定其与白术内酯Ⅰ、Ⅱ的相对校正因子... 详细信息

目的建立白术中3种内酯成分的一测多评方法。方法采用超高效液相色谱法,以乙腈-水为流动相进行梯度洗脱,检测波长为235 nm,进样量为2μL,流速为0.2 mL·min^(-1),柱温30℃。以白术内酯Ⅲ为内参物,测定其与白术内酯Ⅰ、Ⅱ的相对校正因子,利用该相对校正因子计算其他2种成分的含量,同时利用外标法测定3种内酯的含量,比较2种结果的差异,验证一测多评法的可行性和准确性。结果在线性范围内,白术内酯Ⅲ与白术内酯Ⅰ、Ⅱ的相对校正因子分别为0.633、1.895,在不同实验条件下重现性良好,3种成分含量计算值与实测值间无显著性差异。结论所建立的一测多评法可用于白术中3种内酯成分的含量测定,可为白术的质量控制提供科学的理论依据。

关键词：白术相对校正因子一测多评白术内酯质量控制