How to explore the effects of sex hormone on blood vessels

作     者：Sun Mei-li Nie Min Liu Bing Du Zhi-jun Ge Qin-sheng 

作者机构：Peking Union Medical College HospitalCAMS and PUMCBejing 100730 China Peking Union Medical College HospitalCAMS and PUMCBejing 100730 China Peking Union Medical College HospitalCAMS and PUMCBejing 100730 China Peking Union Medical College HospitalCAMS and PUMCBejing 100730 China Peking Union Medical College HospitalCAMS and PUMCBejing 100730 China 

出 版 物：《生殖医学杂志》 (Journal of Reproductive Medicine)

年 卷 期：2004年第13卷第Z1期

页      面：75-78页

学科分类：1002[医学-临床医学] 100211[医学-妇产科学] 10[医学] 

主　　题：Hormone replacement therapy 17β-estradiol Progesterone Testosterone Tissue factor Postmenopausal women 

摘      要：The risk of cardiovascular disease increases along with aging. There are increasing interests in researches on the protective effects of hormone replacement therapy (HRT)on cardiovascular system in postmenopausal women. In this article we will review how we have explored the evidence of different sex hormones on blood vessels since 1996. The results showed that low-dose HRT significantly protected cardiovascular system in postmenopausal ***, the high-dose 17β-estradiol (E2), with or without progesterone (P) or testosterone (T), or any hormone alone, as their concentrations increase, may even inhibit the protective effects of low-dose HRT on blood vessels.