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Using live vegetation volume to analyze the effects of plot Pinus massoniana Lamb on water and soil conservation under natural rainfall events

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International Journal of Sediment Research 2013年第4期28卷 579-587页

作者： zhu-jun GU Xiao-xia WU Xiao-lei WANG Shao-yun PENG Hao LUO Xue-zheng SHI Dong-sheng YU School of Bio-Chemical and Environmental Engineering Nanjing Xiaozhuang University Fujian Changting Bureau of soil and water conservation Institute of Hydro-geophysical prospecting Chongqing Research Institute of China Coal Technology&Engineering Group Corporation State Key Laboratory of Soil and Sustainable Agriculture Institute of Soil ScienceChinese Academy of Sciences

The 3-D spatial distributions of vegetation arc of great significance for water and soil conservation but arc rarely concerned in *** live vegetation volume(LVV) was used to relate to water/soil loss under 144 natural erosive rainlall events from 2007 to 2010 in a typical water-eroded area of southern *** polynomial regression models were established for five pure tree(Pinus massoniana Lamb) plots between LVV and water(runoff)/soil conservation effects(RE/SE).RE/SE corresponds to the ratios of runoff depth/soil loss of the pure tree plots to that of the control plot under each rainfall *** LVV exhibits descending(DS),descending-ascending(DA),ascending-descending(AD),and ascending(AS) trends in the LVV-RE and LVV-SE *** effects of soil conservation on the plots were generally more noticeable than the effects of water conservation,and most of the RE and SE values reflected the positive effects of water and soil *** effects were mainly positive under heavy rains(e.g.,rainfall erosivity,R = 140 MJ mm *** 30min intensity,I30= 16 mm h-1),whereas the effects were mainly negative under light rains(e.g.,R = 45 MJ mm ha-1,I30= 8 mm h-1).The trees’ water/soil conservation effects notably transformed when rainfall erosivity and intensity were lower than the positive or negative effects to a certain *** 50%rainfall events led to obvious transform effects when LVVs were near 0.5 or *** results are able to aid in the decision making on the forest reconstruction in water-eroded areas.

关键词： Erosion Forest Runoff Transform live vegetation volume Water and soil conservation

Dantrolene enhances the protective effect of hypothermia on cerebral cortex neurons

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Neural Regeneration Research 2015年第8期10卷 1279-1285页

作者： Sui-yi Xu Feng-yun Hu Li-jie Ren Lei Chen zhu-qing Zhou Xie-jun Zhang Wei-ping Li Postdoctoral Workstation Zhongshan School of Medicine Sun Yat-sen University Department of Brain Center Shenzhen Key Laboratory of Neurosurgery Shenzhen Second People’s Hospital Shenzhen University First Affiliated Hospital Department of Neurology Shanxi Provincial People’s Hospital Shanxi Medical University

Therapeutic hypothermia is the most promising non-pharmacological neuroprotective strategy against ischemic injury. However, shivering is the most common adverse reaction. Many studies have shown that dantrolene is neuroprotective in in vitro and in vivo ischemic injury models. In addition to its neuroprotective effect, dantrolene neutralizes the adverse reaction of hypothermia. Dantrolene may be an effective adjunctive therapy to enhance the neuroprotection of hypothermia in treating ischemic stroke. Cortical neurons isolated from rat fetuses were exposed to 90 minutes of oxygen-glucose deprivation followed by reoxygenation. Neurons were treated with 40 μM dantrolene, hypothermia（at 33°C）, or the combination of both for 12 hours. Results revealed that the combination of dantrolene and hypothermia increased neuronal survival and the mitochondrial membrane potential, and reduced intracellular active oxygen cytoplasmic histone-associated DNA fragmentation, and apoptosis. Furthermore, improvements in cell morphology were observed. The combined treatment enhanced these responses compared with either treatment alone. These findings indicate that dantrolene may be used as an effective adjunctive therapy to enhance the neuroprotective effects of hypothermia in ischemic stroke.

关键词： nerve regeneration ischemic stroke oxygen-glucose deprivation fluorescent probe neurons flow cytometry apoptosis calcium overload reactive oxygen neural regeneration

Replacement of Forage Fiber Sources with Dried Distillers Grains with Solubles and Corn Germ Meal in Holstein Calf Diets

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Journal of Integrative Agriculture 2014年第8期13卷 1753-1758页

作者： XU jun HOU Yu-jie ZHAO Guo-qi YU Ai-bing SU Yan-jing HUO Yong-jiu zhu Jian-ming College of Animal Science and Technology Yangzhou University Dairy Farm of Yangzhou University

This study was carried out to determine the effect of replacement of forage fiber sources from alfalfa and Leymus chinensis with nonforage fiber sources（NFFS） from dried distillers grains with solubles and corn germ meal on calves growth, rumen development and blood parameters. 48 female and 12 male calves（（110.55±15.36） kg of body weight and 12 wk of age） were assigned randomly to four dietary treatments（15 calves/treatment） in a completely randomized design. Experimental diets were： 0% NFFS（control）, 9% NFFS（group 1）, 18% NFFS（group 2）, 27% NFFS（group 3）, and contained equivalent neutral detergent fiber and total digestible nutrients, respectively. The dry matter intake was similar among diets, averaging 3.33 kg d-1, and no differences were detected for body weight, withers height, body length and heart girth. In addition, the development of rumen, reticulum, omasum and abomasum also were similar among diets. Dry matter, crude protein, and neutral detergent fiber digestibilities increased with the increasing levels of NFFS in the experimental diets, but had no significant effect. Blood urea nitrogen, total protein and glubulin were not affected by the dietary treatment, but group 3 resulted in the highest（P〈0.05） concentrations of glucose and the lowest（P〈0.05） concentrations of triglycerides and albumin. In conclusion, dried distillers grains with solubles（DDGS） and corn germ meal（CGM） were available and alternative fiber sources for Holstein calf diets.

关键词： neutral detergent fiber dried distillers grains with solubles corn germ meal nonforage fiber sources

Estrogen receptor a gene PvulI polymorphism and coronary artery disease： a meta-analysis of 21 studies

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2014年第3期15卷 243-255页

作者： Jie DING Hui XU Xiang YIN Fu-rong ZHANG Xiao-ping PAN Yi-an GU jun-zhu CHEN Xiao-gang GUO Department of Cardiology the First Affiliated Hospital School of Medicine Zhejiang University Hangzhou 310003 China Xiuzhou District Gaozhao Street Community Health Service Center Jiaxing 314031 China State Key Laboratory for Diagnosis and Treatment of Infectious Diseases the First Affiliated Hospital School of Medicine Zhejiang University Hangzhou 310003 China Columbia University Medical Center New York NY l0032 USA

The association between the estrogen receptor a gene （ESR1） Pvull polymorphism （c.454-397T〉C） and coronary artery disease （CAD） is controversial. Thus, we conducted a meta-analysis to evaluate the relationship. Data were collected from 21 studies encompassing 9926 CAD patients and 16710 controls. Odds ratios （ORs） with 95% confidence intervals （CIs） were used to assess the relationship between Pvull polymorphism and CAD. The poly- morphism in control populations in all studies followed Hardy-Weinberg equilibrium. We found a significant association between ESR1 Pvull polymorphism and CAD risk in all subjects. When the data were stratified by region, a significant association between ESR1 Pvull polymorphism and CAD risk was observed in Asian populations but not in Western populations. The current study suggests that ESR1 Pvull polymorphism has an important role in CAD susceptibility.

关键词： Estrogen receptor a gene Polymorphism Meta-analysis Coronary artery disease (CAD)

End-binding protein 1 stimulates paclitaxel sensitivity in breast cancer by promoting its actions toward microtubule assembly and stability

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Protein & Cell 2014年第6期5卷 469-479页

作者： Youguang Luo Dengwen Li Jie Ran Bing Yan Jie Chen Xin Dong zhu Liu Ruming Liu jun Zhou Min Liu State Key Laboratory of Medicinal Chemical Biology College of Life Sciences Nankai University Tianjin 300071 China Tianjin Key Laboratory of Medical Epigenetics and Department of Biochemistry School of Basic Medical Sciences Tianjin Medical University Tianjin 300070 China

Paclitaxel is a microtubule-targeting agent widely used for the treatment of many solid tumors. However, patients show variable sensitivity to this drug, and effective diagnostic tests predicting drug sensitivity remain to be investigated. Herein, we show that the expression of end-binding protein 1 （EB1）, a regulator of microtubule dynamics involved in multiple cellular activities, in breast tumor tissues correlates with the pathological response of tumors to paclitaxel-based chemotherapy. In vitro cell proliferation assays reveal that EB1 stimulates paclitaxel sensitivity in breast cancer cell lines. Our data further demonstrate that EB1 increases the activity of paclitaxel to cause mitotic arrest and apoptosis in cancer cells. In addition, microtubule binding affinity analysis and polymerization/ depolymerization assays show that EB1 enhances paclitaxel binding to microtubules and stimulates the ability of paclitaxel to promote microtubule assembly and stabilization. These findings thus reveal EB1 as a critical regulator of paclitaxel sensitivity and have important implications in breast cancer chemotherapy.

关键词： breast cancer paclitaxel microtubule cell proliferation apoptosis end-binding protein 1,chemotherapy

Vasospastic angina with J waves formation in patients with sudden loss of consciousness

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Journal of Geriatric Cardiology 2015年第3期12卷 313-318页

作者： Dan zhu Yi-Ming LUO Ke-Hu A Ling-Yun ZU Yan-Hui ZHANG Li-jun GUO Wei GAO Yuan ZHANG Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides Department of Cardiology Peking University Third Hospital Beijing China

Vasospastic angina is caused by sudden occlusive vasoconstriction of a segment of an epicardial artery, which can present with a wide spectrum of clinical scenario. We report the cases of two patients diagnosed with vasospastic angina, with one of which presenting with sudden cardiac arrest, while the other presenting with a relatively benign syncope. But both of them have J waves formation on ECG during active ischemia. The diagnosis and management of vasospastic angina, as well as the proposed clinical significance of J waves during coro- nary soasm are discussed.

关键词： Angina Consciousness loss J wave Osbom wave

Detection of QTLs for Important Agronomic Traits and Analysis of Their Stabilities Using SSSLs in Rice

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Agricultural Sciences in China 2007年第7期6卷 769-778页

作者： ZHAO Fang-ming zhu Hai-tao DING Xiao-hua ZENG Rui-zhen ZHANG Ze-min LI Wen-tao ZHANG Gui-quan Guangdong Provincial Key Laboratory of Plant Molecular Breeding South China Agricultural University Guangzhou 510642 P.R.China

Single segment substitution lines （SSSLs） each with a single chromosome segment from a donor under the same genetic background as the recipient were developed in rice by advanced backcrossing and molecular marker-assisted selection. Using the SSSLs, the QTLs for the important agronomic traits in rice would be detected under different environmental conditions. Detection of the QTLs controlling 22 important traits in rice was done with 32 SSSLs by the randomized block design in 2-4 cropping seasons. 59 QTLs were detected and distributed on chromosomes 1, 2, 3, 4, 6, 7, 8, 10, and 11, of which 18 QTLs were detected more than twice. Only 30.5% of the QTLs were detected repeatedly in different cropping seasons. Most of the QTLs of important agronomic traits were of little additive effects and instability. The QTLs controlling the traits, such as grain weight, grain length, ratio of grain length to width, and heading date were relatively stable. The stable QTLs usually had larger additive effects and were less affected by environment. The QTLs for the important agronomic traits were detected using the SSSLs in rice with high resolution under different environmental conditions. The instability of the QTLs may be the basis of the variation of rice plants during growth and development. It would be the genetic basis for improving yield and quality in rice cultivars by farming methods.

关键词： rice single segment substitution line quantitative trait locus agronomic trait

QSAR Models for Predicting Additive and Synergistic Toxicities of Binary Pesticide Mixtures on Scenedesmus Obliquus

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Chinese Journal of Structural Chemistry 2022年第3期41卷 166-177,I0011页

作者： MO Ling-Yun YUAN Bai-Kang zhu Jie QIN Li-Tang DAI jun-Feng College of Environmental Science and Engineering Guilin University of TechnologyGuilin 541004China Guangxi Key Laboratory of Environmental Pollution Control Theory and Technology Guilin University of TechnologyGuilinGuangxi 541004China Technical Innovation Center of Mine Geological Environmental Restoration Engineering in Southern Karst Area MNRNanning 530023China Guangxi Collaborative Innovation Center for Water Pollution Control and Water Safety in Karst Area Guilin University of TechnologyGuilin 541004China

Pesticides released into the environment may pose potential risks to the ecological system and hu-man ***,existing toxicity data on pesticide mixtures still lack,especially regarding the toxic interac-tions of their *** study aimed to determine the toxic interactions of binary mixtures of pesticides on Scenedesmus Obliquus(***)and to build quantitative structure-activity relationship models(QASR)for predicting the mixture *** applying direct equipartition ray method to design binary mixtures of five pes-ticides(linuron,dimethoate,dichlorvos,trichlorfon and metribuzin),the toxicity of a single pesticide and its mix-ture was tested by microplate toxicity analysis on *** QASR models were built for combined toxicity of binary mixtures of pesticides at the half-maximal effective concentration(EC_(50)),30%maximal effective concen-tration(EC_(30))and 10%maximal effective concentration(EC_(10)).The results showed that the single toxicity follows:metribuzin>linuron>dichlorvos>trichlorfon>*** mixtures of linuron and trichlorfon,dichlorvos and metribuzin,dimethoate and metribuzin induced synergetic effects,while the remaining binary mixtures exhib-ited *** developed QSAR models were internally validated using the leave-one-out cross-validation(LOO),leave-many-out cross-validation(LMO),bootstrapping,and y-randomization test,and externally validated by the test *** three QSAR models satisfied well with the experimental values for all mixture toxicities,and presented high internally(R^(2)and Q^(2)>0.85)and externally(Q^(2)_(F1),Q^(2)_(F2),and Q^(2)_(F3)>0.80)predictive *** developed QSAR models could accurately predict the toxicity values of EC_(50),EC_(30)and EC_(10)and were superior to the concentration addition model's results(CA).Compared to the additive effect,the QSAR model could more ac-curately predict the binary mixture toxicities of pesticides with synergistic effects.

关键词： pesticide QSAR toxicity prediction binary mixture algae

Design Rules of the Mixing Phase and Impacts on Device Performance in High-Efficiency Organic Photovoltaics

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Research 2022年第4期2022卷 621-631页

作者： Jingnan Song Ming Zhang Tianyu Hao jun Yan Lei zhu Guanqing Zhou Rui Zeng Wenkai Zhong Jinqiu Xu Zichun Zhou Xiaonan Xue Chun-Chao Chen Weihua Tang Haiming zhu Zaifei Ma Zheng Tang Yongming Zhang Feng Liu School of Chemistry and Chemical Engineering Frontiers Science Center for Transformative MoleculesCenter of Hydrogen ScienceShanghai Key Lab of Electrical Insulation Thermal AgingShanghai Jiao Tong UniversityShanghai 200240China Department of Physics Imperial Collge LondonLondon SW72AZUK School of Materials Science and Engineering Shanghai Jiao Tong UniversityShanghai 200240China Institute of Flexible Electronics(IFE Future Technologies)Xiamen UniversityXiamen 361005China Department of Chemistry Zhejiang UniversityHangzhou 310027China Center for Advanced Low-Dimension Materials State Key Laboratory for Modification of Chemical Fibers and Polymer MaterialsCollege of Materials Science and EngineeringDonghua UniversityShanghai 201620China State Key Laboratory of Fluorinated Functional Membrane Materials and Dongyue Future Hydrogen Energy Materials Company ZiboCityShandongProvince 256401China

In nonfullerene acceptor-(NFA-)based solar cells,the exciton splitting takes place at both domain interface and donor/acceptor mixture,which brings in the state of mixing phase into *** energetics and morphology are key parameters dictating the charge generation,diffusion,and *** is revealed that tailoringthe electronic properties of the mixing region by doping with larger-bandgap components could reduce the density of state but elevate the filling state level,leading to improved open-circuit voltage(V_(OC))and reduced *** monomolecular and bimolecular recombinations are shown to be intercorrelated,which show a Gaussian-like relationship with V_(OC) and linear relationship with short-circuit current density(JSC)and fill factor(FF).The kinetics of hole transfer and exciton diffusion scale with JSC similarly,indicating the carrier generation in mixing region and crystalline domain are equally *** the morphology perspective,the crystalline order could contribute to V_(OC) improvement,and the fibrillar structure strongly affects the *** observations highlight the importance of the mixing region and its connection with crystalline domains and point out the design rules to optimize the mixing phase structure,which is an effective approach to further improve device performance.

关键词： mixing crystalline diffusion